{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:14:16Z","timestamp":1778667256200,"version":"3.51.4"},"reference-count":55,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"am","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT084703MA"],"award-info":[{"award-number":["WT084703MA"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["141900"],"award-info":[{"award-number":["141900"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["133605"],"award-info":[{"award-number":["133605"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["LSHB-CT-2006-018996-GABRIEL"],"award-info":[{"award-number":["LSHB-CT-2006-018996-GABRIEL"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010095","name":"R\u00e9gion Nord-Pas de Calais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jaci.2022.05.017","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T01:38:25Z","timestamp":1654479505000},"page":"1168-1177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Identification of novel genes influencing eosinophil-specific protein levels in asthma families"],"prefix":"10.1016","volume":"150","author":[{"given":"Rapha\u00ebl","family":"Vernet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9gis","family":"Matran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farid","family":"Zerimech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Marie","family":"Madore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Eve","family":"Lavoie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Alexandre","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamida","family":"Mohamdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Margaritte-Jeannin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Siroux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Dizier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Demenais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Laprise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Nadif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5756-4286","authenticated-orcid":false,"given":"Emmanuelle","family":"Bouzigon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2022.05.017_bib1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nm.2678","article-title":"Asthma phenotypes: the evolution from clinical to molecular approaches","volume":"18","author":"Wenzel","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2022.05.017_bib2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/cea.12461","article-title":"A common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults","volume":"45","author":"Bouzigon","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2022.05.017_bib3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/ng.323","article-title":"Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction","volume":"41","author":"Gudbjartsson","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2022.05.017_bib4","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1046\/j.1365-2222.1999.00542.x","article-title":"Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease","volume":"29","author":"Venge","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2022.05.017_bib5","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2021.02.016","article-title":"The basic immunology of asthma","volume":"184","author":"Hammad","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2022.05.017_bib6","doi-asserted-by":"crossref","first-page":"17406","DOI":"10.1074\/jbc.R113.546218","article-title":"Eosinophil granule proteins: form and function","volume":"289","author":"Acharya","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2022.05.017_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1084\/jem.20062027","article-title":"Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses","volume":"205","author":"Yang","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2022.05.017_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fmed.2017.00093","article-title":"The biology of eosinophils and their role in asthma","volume":"4","author":"McBrien","year":"2017","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jaci.2022.05.017_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3345\/kjp.2013.56.1.8","article-title":"Eosinophil-derived neurotoxin: a novel biomarker for diagnosis and monitoring of asthma","volume":"56","author":"Kim","year":"2013","journal-title":"Korean J Pediatr"},{"key":"10.1016\/j.jaci.2022.05.017_bib10","doi-asserted-by":"crossref","first-page":"394","DOI":"10.4168\/aair.2019.11.3.394","article-title":"Serum levels of eosinophil-derived neurotoxin: a biomarker for asthma severity in adult asthmatics","volume":"11","author":"Lee","year":"2019","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2022.05.017_bib11","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1111\/cea.12792","article-title":"Simultaneously elevated exhaled nitric oxide and serum-eosinophil cationic protein relate to recent asthma events in asthmatics in a cross-sectional population-based study","volume":"46","author":"Mogensen","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2022.05.017_bib12","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1080\/02770903.2019.1642349","article-title":"Comparison of serum eosinophil\u2013derived neurotoxin levels between wheezing and non-wheezing groups in children with respiratory tract infection","volume":"57","author":"Kim","year":"2020","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2022.05.017_bib13","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1016\/j.jaip.2020.03.035","article-title":"Serum eosinophil\u2013derived neurotoxin better reflect asthma control status than blood eosinophil counts","volume":"8","author":"An","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2022.05.017_bib14","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1136\/thoraxjnl-2021-217343","article-title":"Blood eosinophil cationic protein and eosinophil-derived neurotoxin are associated with different asthma expression and evolution in adults","volume":"77","author":"Granger","year":"2022","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2022.05.017_bib15","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.rmr.2014.12.005","article-title":"[Genetic and environmental factors of asthma and allergy: results of the EGEA study]","volume":"32","author":"Bouzigon","year":"2015","journal-title":"Rev Mal Respir"},{"key":"10.1016\/j.jaci.2022.05.017_bib16","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1164\/ajrccm.156.4.12tac9","article-title":"Epidemiological study of the genetics and environment of asthma, bronchial hyperresponsiveness, and atopy: phenotype issues","volume":"156","author":"Kauffmann","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2022.05.017_bib17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/gene.2014.12","article-title":"The Saguenay-Lac-Saint-Jean asthma familial collection: the genetics of asthma in a young founder population","volume":"15","author":"Laprise","year":"2014","journal-title":"Genes Immun"},{"key":"10.1016\/j.jaci.2022.05.017_bib18","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","article-title":"A large-scale, consortium-based genomewide association study of asthma","volume":"363","author":"Moffatt","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2022.05.017_bib19","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.jaci.2012.01.074","article-title":"Genome-wide association study of lung function decline in adults with and without asthma","volume":"129","author":"Imboden","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.05.017_bib20","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.3656","article-title":"Next-generation genotype imputation service and methods","volume":"48","author":"Das","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2022.05.017_bib21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2307\/2533998","article-title":"Pleiotropic QTL analysis","volume":"54","author":"Mangin","year":"1998","journal-title":"Biometrics"},{"key":"10.1016\/j.jaci.2022.05.017_bib22","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.ajhg.2014.03.016","article-title":"Maximizing the power of principal-component analysis of correlated phenotypes in genome-wide association studies","volume":"94","author":"Aschard","year":"2014","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaci.2022.05.017_bib23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/gene.2009.46","article-title":"Sex-specific effect of IL9 polymorphisms on lung function and polysensitization","volume":"10","author":"Aschard","year":"2009","journal-title":"Genes Immun"},{"key":"10.1016\/j.jaci.2022.05.017_bib24","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00439-007-0363-x","article-title":"Evidence for a pleiotropic QTL on chromosome 5q13 influencing both time to asthma onset and asthma score in French EGEA families","volume":"121","author":"Bouzigon","year":"2007","journal-title":"Hum Genet"},{"key":"10.1016\/j.jaci.2022.05.017_bib25","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"Price","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2022.05.017_bib26","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1111\/j.1420-9101.2011.02297.x","article-title":"Optimally weighted Z-test is a powerful method for combining probabilities in meta-analysis","volume":"24","author":"Zaykin","year":"2011","journal-title":"J Evol Biol"},{"key":"10.1016\/j.jaci.2022.05.017_bib27","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1093\/bioinformatics\/btw018","article-title":"FINEMAP: efficient variable selection using summary data from genome-wide association studies","volume":"32","author":"Benner","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2022.05.017_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jgg.2020.03.002","article-title":"Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naive CD4+ T cells","volume":"47","author":"Madore","year":"2020","journal-title":"J Genet Genomics"},{"key":"10.1016\/j.jaci.2022.05.017_bib29","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1093\/bioinformatics\/btz469","article-title":"PhenoScanner v2: an expanded tool for searching human genotype\u2013phenotype associations","volume":"35","author":"Kamat","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2022.05.017_bib30","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jaci.2022.05.017_bib31","doi-asserted-by":"crossref","first-page":"D877","DOI":"10.1093\/nar\/gkv1340","article-title":"HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease","volume":"44","author":"Ward","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2022.05.017_bib32","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional mapping and annotation of genetic associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2022.05.017_bib33","doi-asserted-by":"crossref","first-page":"D1005","DOI":"10.1093\/nar\/gky1120","article-title":"The NHGRI-EBI GWAS catalog of published genome-wide association studies, targeted arrays and summary statistics, 2019","volume":"47","author":"Buniello","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2022.05.017_bib34","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s42255-020-00287-2","article-title":"Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals","volume":"2","author":"Folkersen","year":"2020","journal-title":"Nat Metab"},{"key":"10.1016\/j.jaci.2022.05.017_bib35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1465-9921-14-8","article-title":"Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses","volume":"14","author":"Koga","year":"2013","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2022.05.017_bib36","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3390\/cells8030264","article-title":"Cysteine cathepsins and their extracellular roles: shaping the microenvironment","volume":"8","author":"Vidak","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jaci.2022.05.017_bib37","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01962-2017","article-title":"Meta-analysis of airway epithelium gene expression in asthma","volume":"51","author":"Tsai","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2022.05.017_bib38","article-title":"Expression of ACE2, TMPRSS2 and CTSL in human airway epithelial cells under physiological and pathological conditions: implications for SARS-CoV-2 infection","author":"Yin","year":"2020","journal-title":"bioRXiv"},{"key":"10.1016\/j.jaci.2022.05.017_bib39","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.cell.2016.10.042","article-title":"The allelic landscape of human blood cell trait variation and links to common complex disease","volume":"167","author":"Astle","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2022.05.017_bib40","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.cell.2020.06.045","article-title":"Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2022.05.017_bib41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ajhg.2018.11.008","article-title":"Leveraging polygenic functional enrichment to improve GWAS power","volume":"104","author":"Kichaev","year":"2019","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaci.2022.05.017_bib42","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.cell.2020.08.008","article-title":"The polygenic and monogenic basis of blood traits and diseases","volume":"182","author":"Vuckovic","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2022.05.017_bib43","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.jaci.2021.08.013","article-title":"JAK inhibitors for asthma","volume":"148","author":"Georas","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.05.017_bib44","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.celrep.2014.03.065","article-title":"A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels","volume":"7","author":"Lanning","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2022.05.017_bib45","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.biocel.2008.12.002","article-title":"Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP\/ATP translocase","volume":"41","author":"Liu","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jaci.2022.05.017_bib46","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nm1617","article-title":"Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells","volume":"13","author":"Idzko","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2022.05.017_bib47","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1182\/blood-2010-12-324053","article-title":"ARHGAP25, a novel Rac GTPase-activating protein, regulates phagocytosis in human neutrophilic granulocytes","volume":"119","author":"Csepanyi-Komi","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2022.05.017_bib48","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.4049\/jimmunol.1502342","article-title":"Rac GTPase activating protein ARHGAP25 regulates leukocyte transendothelial migration in mice","volume":"197","author":"Csepanyi-Komi","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2022.05.017_bib49","doi-asserted-by":"crossref","first-page":"274","DOI":"10.4049\/immunohorizons.2000021","article-title":"Arhgap25 deficiency leads to decreased numbers of peripheral blood B cells and defective germinal center reactions","volume":"4","author":"Lindner","year":"2020","journal-title":"Immunohorizons"},{"key":"10.1016\/j.jaci.2022.05.017_bib50","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1136\/thoraxjnl-2020-216271","article-title":"Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling","volume":"76","author":"Dilasser","year":"2021","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2022.05.017_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001045","article-title":"Signatures of host\u2013pathogen evolutionary conflict reveal MISTR\u2014a conserved MItochondrial STress Response network","volume":"18","author":"Sorouri","year":"2020","journal-title":"PLoS Biol"},{"key":"10.1016\/j.jaci.2022.05.017_bib52","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.cmet.2012.07.015","article-title":"NDUFA4 is a subunit of complex IV of the mammalian electron transport chain","volume":"16","author":"Balsa","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.jaci.2022.05.017_bib53","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1038\/s41467-021-22397-5","article-title":"Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity","volume":"12","author":"Lee","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2022.05.017_bib54","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1096\/fj.11-203273","article-title":"Cytochrome c oxidase subunit 4 isoform 2\u2013knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology","volume":"26","author":"H\u00fctteman","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.jaci.2022.05.017_bib55","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.4049\/jimmunol.181.5.3540","article-title":"Mitochondrial structural changes and dysfunction are associated with experimental allergic asthma","volume":"181","author":"Mabalirajan","year":"2008","journal-title":"J Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167492200762X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167492200762X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:31:40Z","timestamp":1778664700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167492200762X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S009167492200762X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2022.05.017","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of novel genes influencing eosinophil-specific protein levels in asthma families","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2022.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}