{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:37:21Z","timestamp":1790775441414,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K08AI103038"],"award-info":[{"award-number":["K08AI103038"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI130459"],"award-info":[{"award-number":["R01AI130459"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI123307"],"award-info":[{"award-number":["R21AI123307"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002322","name":"Schlumberger Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"publisher","award":["CTSA UL1TR000445"],"award-info":[{"award-number":["CTSA UL1TR000445"]}],"id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.jaci.2022.05.022","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T20:47:11Z","timestamp":1656103631000},"page":"1525-1533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Human IgE mAbs identify major antigens of\u00a0parasitic worm infection"],"prefix":"10.1016","volume":"150","author":[{"given":"Azadeh","family":"Hadadianpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin W.","family":"Spiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asta","family":"Makaraviciute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa M.","family":"DeWitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather S.","family":"Walden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"R. Stokes","family":"Peebles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B.","family":"Nutman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-8662","authenticated-orcid":false,"given":"Scott A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2022.05.022_bib1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/251613a0","article-title":"Elevation of total serum IgE in rats following helminth parasite infection","volume":"251","author":"Jarrett","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2022.05.022_bib2","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1096\/fj.05-3936fje","article-title":"Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals","volume":"19","author":"Bethony","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.jaci.2022.05.022_bib3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-3024.1995.tb00968.x","article-title":"Immunity in humans to Necator americanus: IgE, parasite weight and fecundity","volume":"17","author":"Pritchard","year":"1995","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.jaci.2022.05.022_bib4","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1086\/339005","article-title":"Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: the importance of IgE","volume":"185","author":"Faulkner","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2022.05.022_bib5","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.micinf.2005.03.036","article-title":"Allergen-specific IgE and IgG4 are markers of resistance and susceptibility in a human intestinal nematode infection","volume":"7","author":"Turner","year":"2005","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jaci.2022.05.022_bib6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/IAI.67.2.484-489.1999","article-title":"Natural immunity to Ascaris lumbricoides associated with immunoglobulin E antibody to ABA-1 allergen and inflammation indicators in children","volume":"67","author":"McSharry","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2022.05.022_bib7","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1128\/IAI.00641-12","article-title":"Progressive cross-reactivity in IgE responses: an explanation for the slow development of human immunity to schistosomiasis?","volume":"80","author":"Fitzsimmons","year":"2012","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2022.05.022_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000820","article-title":"Analysis of complex patterns of human exposure and immunity to Schistosomiasis mansoni: the influence of age, sex, ethnicity and IgE","volume":"4","author":"Pinot de Moira","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.jaci.2022.05.022_bib9","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1128\/IAI.00012-09","article-title":"Immunoglobulin E (IgE) responses to paramyosin predict resistance to reinfection with Schistosoma japonicum and are attenuated by IgG4","volume":"77","author":"Jiz","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2022.05.022_bib10","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/eji.1830220622","article-title":"Immunity after treatment of human schistosomiasis: association between IgE antibodies to adult worm antigens and resistance to reinfection","volume":"22","author":"Dunne","year":"1992","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2022.05.022_bib11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1365-3024.1997.d01-186.x","article-title":"The isolation of a 22 kDa band after SDS-PAGE of Schistosoma mansoni adult worms and its use to demonstrate that IgE responses against the antigen(s) it contains are associated with human resistance to reinfection","volume":"19","author":"Dunne","year":"1997","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.jaci.2022.05.022_bib12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/349243a0","article-title":"Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium","volume":"349","author":"Hagan","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2022.05.022_bib13","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1002\/eji.1830211106","article-title":"Evidence for an association between human resistance to Schistosoma mansoni and high anti-larval IgE levels","volume":"21","author":"Rihet","year":"1991","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2022.05.022_bib14","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/283302a0","article-title":"Parasite-induced \u201cnonspecific\u201d IgE does not protect against allergic reactions","volume":"283","author":"Jarrett","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2022.05.022_bib15","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pt.2008.03.006","article-title":"Helminths and allergy: the example of tropomyosin","volume":"24","author":"Sereda","year":"2008","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.jaci.2022.05.022_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009337","article-title":"House dust mite sensitization drives cross-reactive immune responses to homologous helminth proteins","volume":"17","author":"Gazzinelli-Guimaraes","year":"2021","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jaci.2022.05.022_bib17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jaci.2010.11.007","article-title":"Structural and immunologic cross-reactivity among filarial and mite tropomyosin: implications for the hygiene hypothesis","volume":"127","author":"Santiago","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.05.022_bib18","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jaci.2017.04.019","article-title":"Glycans and glycan-specific IgE in clinical and molecular allergology: sensitization, diagnostics, and clinical symptoms","volume":"140","author":"Homann","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.05.022_bib19","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1111\/all.14802","article-title":"Carbohydrate epitopes currently recognized as targets for IgE antibodies","volume":"76","author":"Platts-Mills","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2022.05.022_bib20","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/pim.12194","article-title":"Looking beyond the induction of Th2 responses to explain immunomodulation by helminths","volume":"37","author":"Nutman","year":"2015","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.jaci.2022.05.022_bib21","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.me.43.020192.002221","article-title":"Tropical pulmonary eosinophilia","volume":"43","author":"Ottesen","year":"1992","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jaci.2022.05.022_bib22","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123387","article-title":"Human IgE mAbs define variability in commercial aspergillus extract allergen composition","volume":"3","author":"Wurth","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaci.2022.05.022_bib23","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.4049\/jimmunol.157.4.1645","article-title":"Anaphylaxis mediated through a humanized high affinity IgE receptor","volume":"157","author":"Dombrowicz","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2022.05.022_bib24","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.aau2599","article-title":"High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes","volume":"362","author":"Croote","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jaci.2022.05.022_bib25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molbiopara.2008.02.007","article-title":"The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products","volume":"160","author":"Hewitson","year":"2008","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.jaci.2022.05.022_bib26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41588-018-0262-1","article-title":"Comparative genomics of the major parasitic worms","volume":"51","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2022.05.022_bib27","first-page":"5","article-title":"First analysis of the secretome of the canine heartworm, Dirofilaria immitis","volume":"10","author":"Geary","year":"2012","journal-title":"Parasit Vectors"},{"key":"10.1016\/j.jaci.2022.05.022_bib28","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.meegid.2010.07.024","article-title":"First transcriptomic analysis of the economically important parasitic nematode, Trichostrongylus colubriformis, using a next-generation sequencing approach","volume":"10","author":"Cantacessi","year":"2010","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.jaci.2022.05.022_bib29","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1006\/geno.1997.4989","article-title":"Analysis of protein domain families in Caenorhabditis elegans","volume":"42","author":"Sonnhammer","year":"1997","journal-title":"Genomics"},{"key":"10.1016\/j.jaci.2022.05.022_bib30","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/nph.13701","article-title":"A novel nematode effector suppresses plant immunity by activating host reactive oxygen species\u2013scavenging system","volume":"209","author":"Lin","year":"2016","journal-title":"New Phytol"},{"key":"10.1016\/j.jaci.2022.05.022_bib31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0166-6851(92)90176-K","article-title":"A cloned antigen for serological diagnosis of Wuchereria bancrofti microfilaremia with daytime blood samples","volume":"56","author":"Dissanayake","year":"1992","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.jaci.2022.05.022_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0166-6851(99)00231-5","article-title":"The Wuchereria bancrofti orthologue of Brugia malayi SXP1 and the diagnosis of bancroftian filariasis","volume":"107","author":"Rao","year":"2000","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.jaci.2022.05.022_bib33","first-page":"1","article-title":"Pan LF-ELISA using BmR1 and BmSXP\u00a0recombinant antigens for detection of lymphatic filariasis","volume":"6","author":"Rahman","year":"2007","journal-title":"Filaria J"},{"key":"10.1016\/j.jaci.2022.05.022_bib34","doi-asserted-by":"crossref","first-page":"e2735","DOI":"10.1371\/journal.pntd.0002735","article-title":"Relationships between IgE\/IgG4 epitopes, structure and function in Anisakis simplex Ani s 5, a member of the SXP\/RAL-2 protein family","volume":"8","author":"Garc\u00eda-Mayoral","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.jaci.2022.05.022_bib35","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.1128\/IAI.71.9.5314-5323.2003","article-title":"Mice intranasally immunized with a recombinant 16-kilodalton antigen from roundworm Ascaris parasites are protected against larval migration of Ascaris suum","volume":"71","author":"Tsuji","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2022.05.022_bib36","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0166-6851(98)00173-X","article-title":"Molecular cloning of the 22-24 kDa excretory\u2013secretory 22U protein of Dirofilaria immitis and other filarial nematode parasites","volume":"98","author":"Frank","year":"1999","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.jaci.2022.05.022_bib37","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1128\/IAI.66.12.5955-5963.1998","article-title":"Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor","volume":"66","author":"Pastrana","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2022.05.022_bib38","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1006\/expr.1993.1018","article-title":"Brugia pahangi and Brugia malayi: a surface-associated glycoprotein (Gp15\/400) is composed of multiple tandemly repeated units and processed from a 400-kDa precursor","volume":"76","author":"Tweedie","year":"1993","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.jaci.2022.05.022_bib39","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41586-019-0934-8","article-title":"High frequency of shared clonotypes in human B cell receptor repertoires","volume":"566","author":"Soto","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2022.05.022_bib40","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jaci.2009.09.054","article-title":"Differential roles for IL-9\/IL-9 receptor \u03b1-chain pathway in systemic and oral antigen-induced anaphylaxis","volume":"125","author":"Osterfeld","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.05.022_bib41","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0091-6749(74)90026-8","article-title":"Possible role of IgE-mediated reaction in immunity","volume":"54","author":"Steinberg","year":"1974","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.05.022_bib42","doi-asserted-by":"crossref","first-page":"343","DOI":"10.7883\/yoken1952.10.343","article-title":"Studies on the relationship between toxin anaphylaxis and antitoxic immunity. III. Significance of allergic reaction on the neutralization of toxin injected intracutaneously","volume":"10","author":"Ishizaka","year":"1957","journal-title":"Jpn J Med Sci Biol"},{"key":"10.1016\/j.jaci.2022.05.022_bib43","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1128\/br.11.4.275-302.1947","article-title":"Dynamics and mechanism of immunity reactions in\u00a0vivo","volume":"11","author":"Friedemann","year":"1947","journal-title":"Bacteriol Rev"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674922008430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674922008430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:39:38Z","timestamp":1758793178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674922008430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0091674922008430"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2022.05.022","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human IgE mAbs identify major antigens of\u00a0parasitic worm infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2022.05.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}