{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:36:28Z","timestamp":1793392588516,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800819"],"award-info":[{"award-number":["81800819"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873694"],"award-info":[{"award-number":["81873694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900925"],"award-info":[{"award-number":["81900925"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8192010801"],"award-info":[{"award-number":["8192010801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130030"],"award-info":[{"award-number":["82130030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010580","name":"Hubei Province Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["2021BCA119"],"award-info":[{"award-number":["2021BCA119"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.jaci.2022.09.036","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T03:06:39Z","timestamp":1666926399000},"page":"991-1004.e20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Perturbated glucose metabolism augments epithelial cell proinflammatory function in chronic rhinosinusitis"],"prefix":"10.1016","volume":"151","author":[{"given":"Cai-Ling","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-Yu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Fang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Jian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4168-6702","authenticated-orcid":false,"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2022.09.036_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"issue":"Suppl 1","key":"10.1016\/j.jaci.2022.09.036_bib2","first-page":"S22","article-title":"International consensus statement on allergy and rhinology: rhinosinusitis","volume":"6","author":"Orlandi","year":"2016","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2022.09.036_bib3","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.jaci.2020.04.024","article-title":"Environmental factors in epithelial barrier dysfunction","volume":"145","author":"Celebi Sozener","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jaci.2020.12.628","article-title":"IL-25 (IL-17E) in epithelial immunology and pathophysiology","volume":"148","author":"Borowczyk","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jaci.2021.03.024","article-title":"Rethinking neutrophils and eosinophils in chronic rhinosinusitis","volume":"148","author":"Delemarre","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib6","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1111\/all.14612","article-title":"Stromal cells and B cells orchestrate ectopic lymphoid tissue formation in nasal polyps","volume":"76","author":"Wang","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2022.09.036_bib7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/all.14287","article-title":"Cold-inducible RNA-binding protein contributes to tissue remodeling in chronic rhinosinusitis with nasal polyps","volume":"76","author":"Shi","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2022.09.036_bib8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-pathol-052016-100401","article-title":"Immunopathogenesis of chronic rhinosinusitis and nasal polyposis","volume":"12","author":"Schleimer","year":"2017","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jaci.2022.09.036_bib9","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3390\/ijms23010417","article-title":"Cytokine signature and involvement in chronic rhinosinusitis with nasal polyps","volume":"23","author":"Carsuzaa","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2022.09.036_bib10","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","article-title":"Aerobic glycolysis: meeting the metabolic requirements of cell proliferation","volume":"27","author":"Lunt","year":"2011","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.jaci.2022.09.036_bib11","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1146\/annurev.ph.54.030192.004403","article-title":"Mammalian facilitative glucose transporter family: structure and molecular regulation","volume":"54","author":"Pessin","year":"1992","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jaci.2022.09.036_bib12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.4049\/jimmunol.1200718","article-title":"Proinflammatory mediators disrupt glucose homeostasis in airway surface liquid","volume":"189","author":"Garnett","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13280","article-title":"PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation","volume":"7","author":"Xie","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2022.09.036_bib14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.aaf6284","article-title":"Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism","volume":"354","author":"Peng","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jaci.2022.09.036_bib15","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jaci.2022.09.036_bib16","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1152\/japplphysiol.01425.2006","article-title":"Hyperglycemia and cystic fibrosis alter respiratory fluid glucose concentrations estimated by breath condensate analysis","volume":"102","author":"Baker","year":"2007","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.jaci.2022.09.036_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jcf.2006.03.009","article-title":"Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosis","volume":"6","author":"Brennan","year":"2007","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jaci.2022.09.036_bib18","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jaci.2017.10.017","article-title":"Role of airway glucose in bacterial infections in patients with chronic obstructive pulmonary disease","volume":"142","author":"Mallia","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib19","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1172\/JCI72094","article-title":"Bitter and sweet taste receptors regulate human upper respiratory innate immunity","volume":"124","author":"Lee","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2022.09.036_bib20","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jaci.2017.08.043","article-title":"IL-1\/inhibitory kappaB kinase epsilon-induced glycolysis augment epithelial effector function and promote allergic airways disease","volume":"142","author":"Qian","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib21","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/all.13153","article-title":"Interferon-gamma-induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps","volume":"72","author":"Wang","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2022.09.036_bib22","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.jaci.2020.12.623","article-title":"Defective STING\u00a0expression potentiates IL-13 signaling in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps","volume":"147","author":"Wang","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib23","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jaci.2020.02.010","article-title":"Common fibrin deposition and tissue plasminogen activator downregulation in nasal polyps with distinct inflammatory endotypes","volume":"146","author":"Chen","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib24","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.jaci.2017.12.972","article-title":"The activation and function of IL-36gamma in neutrophilic inflammation in chronic rhinosinusitis","volume":"141","author":"Wang","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100537","article-title":"Reconstituted human upper airway epithelium as 3-D in\u00a0vitro model for nasal polyposis","volume":"9","author":"de Borja Callejas","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2022.09.036_bib26","doi-asserted-by":"crossref","first-page":"L1056","DOI":"10.1152\/ajplung.00050.2020","article-title":"Strong correlation between air-liquid interface cultures and in\u00a0vivo transcriptomics of nasal brush biopsy","volume":"318","author":"Ghosh","year":"2020","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2022.09.036_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117188","article-title":"Resveratrol bidirectionally regulates insulin effects in skeletal muscle through alternation of intracellular redox homeostasis","volume":"242","author":"Quan","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.jaci.2022.09.036_bib28","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jaci.2019.07.009","article-title":"The IL-37-Mex3B-Toll-like receptor 3 axis in epithelial cells in patients with eosinophilic chronic rhinosinusitis with nasal polyps","volume":"145","author":"Liu","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib29","doi-asserted-by":"crossref","DOI":"10.1172\/JCI150595","article-title":"YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload","volume":"132","author":"Kashihara","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2022.09.036_bib30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature24057","article-title":"Glucose feeds the TCA cycle via circulating lactate","volume":"551","author":"Hui","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2022.09.036_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl4923","article-title":"High-throughput glycolytic inhibitor discovery targeting glioblastoma by graphite dots-assisted LDI mass spectrometry","volume":"8","author":"Shi","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.jaci.2022.09.036_bib32","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.scitotenv.2018.05.159","article-title":"Fipronil-induced toxic effects in zebrafish (Danio rerio) larvae by using digital gene expression profiling","volume":"639","author":"Xu","year":"2018","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jaci.2022.09.036_bib33","doi-asserted-by":"crossref","first-page":"L1158","DOI":"10.1152\/ajplung.00414.2019","article-title":"Real-time measurement of cellular bioenergetics in fully differentiated human nasal epithelial cells grown at air-liquid-interface","volume":"318","author":"Mavin","year":"2020","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2022.09.036_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016166","article-title":"Glucose depletion in the airway surface liquid is essential for sterility of the airways","volume":"6","author":"Pezzulo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2022.09.036_bib35","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1080\/09553002.2019.1589653","article-title":"The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression","volume":"95","author":"Vaupel","year":"2019","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.jaci.2022.09.036_bib36","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1158\/0008-5472.CAN-14-1428","article-title":"Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes","volume":"75","author":"Robertson-Tessi","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaci.2022.09.036_bib37","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.immuni.2019.09.003","article-title":"Metabolic\u00a0profiling using stable isotope tracing reveals distinct patterns of glucose utilization by physiologically activated CD8(+) T cells","volume":"51","author":"Ma","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2022.09.036_bib38","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell Res"},{"key":"10.1016\/j.jaci.2022.09.036_bib39","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1126\/science.abb2683","article-title":"Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity","volume":"371","author":"Xu","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jaci.2022.09.036_bib40","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaci.2021.03.033","article-title":"CD4(+) T-cell differentiation and function: unifying glycolysis, fatty acid oxidation, polyamines NAD mitochondria","volume":"148","author":"Almeida","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib41","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.jaci.2012.01.079","article-title":"Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy","volume":"129","author":"Wen","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib42","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/all.13411","article-title":"Multidimensional endotypes of chronic rhinosinusitis and their association with treatment outcomes","volume":"73","author":"Liao","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2022.09.036_bib43","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00066-005-1320-z","article-title":"Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme","volume":"181","author":"Singh","year":"2005","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.jaci.2022.09.036_bib44","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00280-012-2045-1","article-title":"A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors","volume":"71","author":"Raez","year":"2013","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.jaci.2022.09.036_bib45","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.20110278","article-title":"HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells","volume":"208","author":"Shi","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2022.09.036_bib46","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2022.09.036_bib47","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/gut.50.3.307","article-title":"Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease","volume":"50","author":"Soderholm","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.jaci.2022.09.036_bib48","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1471-230X-12-76","article-title":"Comparative analysis of inflamed and non-inflamed colon biopsies reveals strong proteomic inflammation profile in patients with ulcerative colitis","volume":"12","author":"Poulsen","year":"2012","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jaci.2022.09.036_bib49","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1053\/j.gastro.2013.07.015","article-title":"Mitochondrial gene polymorphisms that protect mice from colitis","volume":"145","author":"Bar","year":"2013","journal-title":"Gastroenterology"},{"issue":"Suppl S29","key":"10.1016\/j.jaci.2022.09.036_bib50","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"issue":"Suppl 1","key":"10.1016\/j.jaci.2022.09.036_bib51","first-page":"S22","article-title":"International consensus statement on allergy and rhinology: rhinosinusitis","volume":"6","author":"Orlandi","year":"2016","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2022.09.036_bib52","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1111\/all.12963","article-title":"Allergic rhinitis control test questionnaire-driven stepwise strategy to improve allergic rhinitis control: a prospective study","volume":"71","author":"Wang","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2022.09.036_bib53","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jaci.2017.03.050","article-title":"Allergic rhinitis and its impact on asthma (ARIA) guidelines\u20142016 revision","volume":"140","author":"Brozek","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib54","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1183\/09031936.00138707","article-title":"Global strategy for asthma management and prevention: GINA executive summary","volume":"31","author":"Bateman","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2022.09.036_bib55","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1164\/rccm.201103-0456OC","article-title":"Overexpression of miR-125b, a novel regulator of innate immunity, in eosinophilic chronic rhinosinusitis with nasal polyps","volume":"185","author":"Zhang","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2022.09.036_bib56","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/all.13153","article-title":"Interferon-gamma-induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps","volume":"72","author":"Wang","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2022.09.036_bib57","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1172\/JCI72094","article-title":"Bitter and sweet taste receptors regulate human upper respiratory innate immunity","volume":"124","author":"Lee","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2022.09.036_bib58","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.jaci.2020.12.623","article-title":"Defective STING expression potentiates IL-13 signaling in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps","volume":"147","author":"Wang","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib59","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.jaci.2017.12.972","article-title":"The activation and function of IL-36gamma in neutrophilic inflammation in chronic rhinosinusitis","volume":"141","author":"Wang","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib60","doi-asserted-by":"crossref","first-page":"863","DOI":"10.4168\/aair.2021.13.6.863","article-title":"Inflammatory endotypes and tissue remodeling features in antrochoanal polyps","volume":"13","author":"Chen","year":"2021","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2022.09.036_bib61","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jaci.2020.02.010","article-title":"Common fibrin deposition and tissue plasminogen activator downregulation in nasal polyps with distinct inflammatory endotypes","volume":"146","author":"Chen","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib62","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41591-018-0003-0","article-title":"Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis","volume":"24","author":"Zhang","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2022.09.036_bib63","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jaci.2022.09.036_bib64","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jaci.2019.07.009","article-title":"The IL-37-Mex3B-Toll-like receptor 3 axis in epithelial cells in patients with eosinophilic chronic rhinosinusitis with nasal polyps","volume":"145","author":"Liu","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.09.036_bib65","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/cea.12758","article-title":"CD8(+) T cells with distinct cytokine-producing features and low cytotoxic activity in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps","volume":"46","author":"Ma","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2022.09.036_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117188","article-title":"Resveratrol bidirectionally regulates insulin effects in skeletal muscle through alternation of intracellular redox homeostasis","volume":"242","author":"Quan","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.jaci.2022.09.036_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2020.108709","article-title":"Focal transcranial magnetic stimulation in awake rats: Enhanced glucose uptake in deep cortical layers","volume":"339","author":"Cermak","year":"2020","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jaci.2022.09.036_bib68","doi-asserted-by":"crossref","DOI":"10.1172\/JCI150595","article-title":"YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload","volume":"132","author":"Kashihara","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2022.09.036_bib69","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature24057","article-title":"Glucose feeds the TCA cycle via circulating lactate","volume":"551","author":"Hui","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2022.09.036_bib70","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl4923","article-title":"High-throughput glycolytic inhibitor discovery targeting glioblastoma by graphite dots-assisted LDI mass spectrometry","volume":"8","author":"Shi","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.jaci.2022.09.036_bib71","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167492201421X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167492201421X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:40:45Z","timestamp":1758793245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167492201421X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S009167492201421X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2022.09.036","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perturbated glucose metabolism augments epithelial cell proinflammatory function in chronic rhinosinusitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2022.09.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}