{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:09:17Z","timestamp":1792012157613,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100019944","name":"Sanofi-Aventis Deutschland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019944","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017268","name":"Berlin Institute of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.jaci.2022.10.034","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T20:25:56Z","timestamp":1670271956000},"page":"1015-1026","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Neutrophilic granulocyte-derived B-cell activating factor supports B cells in skin lesions in hidradenitis suppurativa"],"prefix":"10.1016","volume":"151","author":[{"given":"Robert","family":"Sabat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deimant\u0117","family":"\u0160imait\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann Eli","family":"Gudjonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa-Charlotte","family":"Brembach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Kokolakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckart","family":"Bartnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Nikolaou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascha","family":"Rill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9ma","family":"Coulibaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Leeuw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Dieter","family":"Volk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Ghoreschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7689-4130","authenticated-orcid":false,"given":"Kerstin","family":"Wolk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2022.10.034_bib1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-020-0149-1","article-title":"Hidradenitis suppurativa","volume":"6","author":"Sabat","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jaci.2022.10.034_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200683","article-title":"Hidradenitis suppurativa (HS) prevalence, demographics and management pathways in Australia: a population-based cross-sectional study","volume":"13","author":"Calao","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2022.10.034_bib3","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/bjd.16101","article-title":"Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa","volume":"178","author":"Ingram","year":"2018","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib4","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1111\/jdv.16783","article-title":"Hidradenitis suppurativa\u2014prevalence analyses of German statutory health insurance data","volume":"35","author":"Schneider-Burrus","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaci.2022.10.034_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031810","article-title":"Increased prevalence of metabolic syndrome in patients with acne inversa","volume":"7","author":"Sabat","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2022.10.034_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jaad.2016.03.025","article-title":"Increased prevalence of subclinical atherosclerosis in patients with hidradenitis suppurativa (HS)","volume":"75","author":"Gonzalez-Lopez","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib7","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3899\/jrheum.130977","article-title":"Hidradenitis suppurativa associated with spondyloarthritis\u2014results from a multicenter national prospective study","volume":"41","author":"Richette","year":"2014","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib8","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1159\/000448838","article-title":"High prevalence of back pain and axial spondyloarthropathy in patients with hidradenitis suppurativa","volume":"232","author":"Schneider-Burrus","year":"2016","journal-title":"Dermatology"},{"key":"10.1016\/j.jaci.2022.10.034_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jaad.2016.08.031","article-title":"Inflammatory bowel disease is associated with hidradenitis suppurativa: results from a multicenter cross-sectional study","volume":"76","author":"Deckers","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib10","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.jid.2016.11.040","article-title":"Prevalence and risk of inflammatory bowel disease in patients with hidradenitis suppurativa","volume":"137","author":"Egeberg","year":"2017","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib11","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2340\/00015555-0866","article-title":"Psychophysical aspects of hidradenitis suppurativa","volume":"90","author":"Matusiak","year":"2010","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jaci.2022.10.034_bib12","first-page":"743","article-title":"Depression is a frequent co-morbidity in patients with acne inversa","volume":"11","author":"Kurek","year":"2013","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1016\/j.jaci.2022.10.034_bib13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/jdv.12567","article-title":"Psychiatric comorbidities in 3207 patients with hidradenitis suppurativa","volume":"29","author":"Shavit","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaci.2022.10.034_bib14","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jaad.2011.10.024","article-title":"Profound disturbances of sexual health in patients with acne inversa","volume":"67","author":"Kurek","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1001\/jamadermatol.2017.6058","article-title":"Association of hidradenitis suppurativa with body image","volume":"154","author":"Schneider-Burrus","year":"2018","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib16","article-title":"Features associated with quality of life impairment in hidradenitis suppurativa patients","volume":"8","author":"Schneider-Burrus","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jaci.2022.10.034_bib17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jaad.2018.05.040","article-title":"Long-term adalimumab efficacy in patients with moderate-to-severe hidradenitis suppurativa\/acne inversa: 3-year results of a phase 3 open-label extension study","volume":"80","author":"Zouboulis","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib18","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/bjd.19556","article-title":"Aetiology and pathogenesis of hidradenitis suppurativa","volume":"183","author":"Wolk","year":"2020","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib19","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.4049\/jimmunol.0903907","article-title":"Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa","volume":"186","author":"Wolk","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2022.10.034_bib20","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1111\/bjd.14075","article-title":"Dysregulated cytokine expression in lesional and nonlesional skin in hidradenitis suppurativa","volume":"173","author":"Kelly","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib21","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/bjd.17854","article-title":"A new T helper 17 cytokine in hidradenitis suppurativa: antimicrobial and proinflammatory role of interleukin-26","volume":"181","author":"Scala","year":"2019","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib22","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1111\/jdv.14389","article-title":"Increased expression of the interleukin-36 cytokines in lesions of hidradenitis suppurativa","volume":"31","author":"Thomi","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaci.2022.10.034_bib23","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00403-017-1769-5","article-title":"IL-36 cytokines are increased in acne and hidradenitis suppurativa","volume":"309","author":"Di Caprio","year":"2017","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jaci.2022.10.034_bib24","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/bjd.16019","article-title":"Interleukin-36 in hidradenitis suppurativa: evidence for a distinctive proinflammatory role and a key factor in the development of an inflammatory loop","volume":"178","author":"Hessam","year":"2018","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib25","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jid.2018.11.018","article-title":"The IL-1 pathway is hyperactive in hidradenitis suppurativa and contributes to skin infiltration and destruction","volume":"139","author":"Witte-Handel","year":"2019","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/bjd.19795","article-title":"Activity and components of the granulocyte colony-stimulating factor pathway in hidradenitis suppurativa","volume":"185","author":"Wolk","year":"2021","journal-title":"Br J Dermatol"},{"issue":"10275","key":"10.1016\/j.jaci.2022.10.034_bib27","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0140-6736(21)00184-7","article-title":"Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis","volume":"397","author":"Ghoreschi","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2022.10.034_bib28","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining cell type abundance and expression from bulk tissues with digital cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jaci.2022.10.034_bib29","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.139930","article-title":"Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis","volume":"5","author":"Gudjonsson","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaci.2022.10.034_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav5908","article-title":"Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa","volume":"11","author":"Byrd","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2022.10.034_bib31","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jacbts.2021.01.006","article-title":"B cells in atherosclerosis: mechanisms and potential clinical applications","volume":"6","author":"Pattarabanjird","year":"2021","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.jaci.2022.10.034_bib32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.coi.2021.06.009","article-title":"Function, occurrence and inhibition of different forms of BAFF","volume":"71","author":"Eslami","year":"2021","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2022.10.034_bib33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.coi.2021.06.014","article-title":"BAFF signaling in health and disease","volume":"71","author":"Schweighoffer","year":"2021","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2022.10.034_bib34","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.3389\/fimmu.2018.02988","article-title":"Isotype specific assembly of B cell antigen receptors and synergism with chemokine receptor CXCR4","volume":"9","author":"Maity","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2022.10.034_bib35","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.3389\/fimmu.2018.01644","article-title":"The many and varied roles of tetraspanins in immune cell recruitment and migration","volume":"9","author":"Yeung","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2022.10.034_bib36","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1042\/CBI20100885","article-title":"Modulation of integrin alpha4beta1 by ADAM28 promotes lymphocyte adhesion and transendothelial migration","volume":"35","author":"McGinn","year":"2011","journal-title":"Cell Biol Int"},{"issue":"250","key":"10.1016\/j.jaci.2022.10.034_bib37","doi-asserted-by":"crossref","first-page":"ra82","DOI":"10.1126\/scisignal.2003113","article-title":"The tetraspanin CD37 orchestrates the alpha4beta1 integrin-Akt signaling axis and supports long-lived plasma cell survival","volume":"5","author":"van Spriel","year":"2012","journal-title":"Sci Signal"},{"key":"10.1016\/j.jaci.2022.10.034_bib38","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00430-020-00677-z","article-title":"Tetraspanin CD53: an overlooked regulator of immune cell function","volume":"209","author":"Dunlock","year":"2020","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.jaci.2022.10.034_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101104","article-title":"Tetraspanin CD53 promotes lymphocyte recirculation by stabilizing l-selectin surface expression","volume":"23","author":"Demaria","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.jaci.2022.10.034_bib40","first-page":"280","article-title":"Arf GAPs: a family of proteins with disparate functions that converge on a common structure, the integrin adhesion complex","volume":"10","author":"Vitali","year":"2019","journal-title":"Small GTPases"},{"key":"10.1016\/j.jaci.2022.10.034_bib41","doi-asserted-by":"crossref","first-page":"e548","DOI":"10.1097\/TXD.0000000000000993","article-title":"A review on the function and regulation of ARHGDIB\/RhoGDI2 expression including the hypothetical role of ARHGDIB\/RhoGDI2 autoantibodies in kidney transplantation","volume":"6","author":"Kardol-Hoefnagel","year":"2020","journal-title":"Transplant Direct"},{"key":"10.1016\/j.jaci.2022.10.034_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112399","article-title":"BST-2\/tetherin is involved in BAFF-enhanced proliferation and survival via canonical NF-kappaB signaling in neoplastic B-lymphoid cells","volume":"398","author":"Fu","year":"2021","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jaci.2022.10.034_bib43","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3390\/vaccines9101171","article-title":"Kruppel-like factor 2 (KLF2) in immune cell migration","volume":"9","author":"Wittner","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jaci.2022.10.034_bib44","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.4049\/jimmunol.176.5.2758","article-title":"B cell induction of IL-13 expression in NK cells: role of CD244 and SLAM-associated protein","volume":"176","author":"Gao","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2022.10.034_bib45","article-title":"Unmet medical needs in chronic, non-communicable inflammatory skin diseases","volume":"9","author":"Ujiie","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jaci.2022.10.034_bib46","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1001\/jamadermatol.2017.2392","article-title":"Canakinumab for severe hidradenitis suppurativa: preliminary experience in 2 cases","volume":"153","author":"Houriet","year":"2017","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jaci.2022.10.034_bib47","doi-asserted-by":"crossref","first-page":"9716","DOI":"10.3390\/ijms23179716","article-title":"Immunomodulatory drugs in the treatment of hidradenitis suppurativa\u2014ossibilities and limitations","volume":"23","author":"\u015awierczewska","year":"2022","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674922016219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674922016219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:41:07Z","timestamp":1758793267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674922016219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0091674922016219"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2022.10.034","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophilic granulocyte-derived B-cell activating factor supports B cells in skin lesions in hidradenitis suppurativa","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2022.10.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}