{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:50:19Z","timestamp":1791942619338,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jaci.2023.04.009","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T20:43:13Z","timestamp":1682628193000},"page":"408-419","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["The neglected twin: Nummular eczema is a variant of atopic dermatitis with codominant TH2\/TH17 immune response"],"prefix":"10.1016","volume":"152","author":[{"given":"Alexander","family":"B\u00f6hner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6051-4036","authenticated-orcid":false,"given":"Manja","family":"Jargosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola S.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Garzorz-Stark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Pilz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Lauffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Roenneberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian J.","family":"Theis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilo","family":"Biedermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Eyerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kilian","family":"Eyerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2023.04.009_bib1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/jdv.14673","article-title":"Immune response patterns in non-communicable inflammatory skin diseases","volume":"32","author":"Eyerich","year":"2018","journal-title":"J Eur Acad Dermatol Venerol"},{"key":"10.1016\/j.jaci.2023.04.009_bib2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/DER.0b013e318260d5a0","article-title":"Nummular eczema and contact allergy: a retrospective study","volume":"23","author":"Bonamonte","year":"2012","journal-title":"Dermatitis"},{"key":"10.1016\/j.jaci.2023.04.009_bib3","first-page":"36","article-title":"Clinical features and aggravating factors in nummular eczema in Thais","volume":"31","author":"Jiamton","year":"2013","journal-title":"Asian Pac J Allergy Immunol"},{"key":"10.1016\/j.jaci.2023.04.009_bib4","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1365-2133.2012.11072.x","article-title":"Features of Staphylococcus aureus colonization in patients with nummular eczema","volume":"168","author":"Kim","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2023.04.009_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1600-0536.1997.tb00214.x","article-title":"Patch testing in discoid eczema","volume":"36","author":"Fleming","year":"1997","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jaci.2023.04.009_bib6","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1525-1470.2012.01739.x","article-title":"Less common clinical manifestations of atopic dermatitis: prevalence by age","volume":"29","author":"Juli\u00e1n-G\u00f3nzalez","year":"2012","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.jaci.2023.04.009_bib7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.5415\/apallergy.2011.1.2.80","article-title":"Clinical features of the extrinsic and intrinsic types of adult-onset atopic dermatitis","volume":"1","author":"Kulthanan","year":"2011","journal-title":"Asia Pac Allergy"},{"key":"10.1016\/j.jaci.2023.04.009_bib8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1001\/archderm.1973.01620160028006","article-title":"IgE levels in nummular eczema and ichthyosis","volume":"107","author":"Krueger","year":"1973","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaci.2023.04.009_bib9","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1056\/NEJMc1700366","article-title":"Two phase 3 trials of dupilumab versus placebo in atopic dermatitis","volume":"376","author":"Simpson","year":"2017","journal-title":"N Engl J Med"},{"issue":"10148","key":"10.1016\/j.jaci.2023.04.009_bib10","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0140-6736(18)31713-6","article-title":"Efficacy and safety of risankizumab in moderate-to-severe plaque psoriasis (UltIMMa-1 and UltIMMa-2): results from two double-blind, randomised, placebo-controlled and ustekinumab-controlled phase 3 trials","volume":"392","author":"Gordon","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2023.04.009_bib11","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/pde.13568","article-title":"Methotrexate for severe nummular eczema in children: efficacy and tolerability in a retrospective study of 28 patients","volume":"35","author":"Kn\u00f6pfel","year":"2018","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.jaci.2023.04.009_bib12","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-Seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2023.04.009_bib13","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1093\/nar\/gks042","article-title":"Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation","volume":"40","author":"McCarthy","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2023.04.009_bib14","doi-asserted-by":"crossref","unstructured":"Korotkevich G, Sukhov V, Budin N, Shpak B, Artyomov MN, Sergushichev A. Fast gene set enrichment analysis. bioRxiv, February 1, 2021. https:\/\/doi.org\/10.1101\/060012","DOI":"10.1101\/060012"},{"key":"10.1016\/j.jaci.2023.04.009_bib15","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2023.04.009_bib16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"key":"10.1016\/j.jaci.2023.04.009_bib17","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/exd.13077","article-title":"A novel molecular disease classifier for psoriasis and eczema","volume":"25","author":"Garzorz-Stark","year":"2016","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaci.2023.04.009_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaci.2018.10.032","article-title":"Atopic dermatitis endotypes and implications for targeted therapeutics","volume":"143","author":"Czarnowicki","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.009_bib19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.coi.2017.08.008","article-title":"Atopic dermatitis and psoriasis: two different immune diseases or one spectrum?","volume":"48","author":"Guttman-Yassky","year":"2017","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2023.04.009_bib20","first-page":"156","article-title":"[Atopic neurodermatitis]","volume":"139","author":"W\u00fcthrich","year":"1989","journal-title":"Wien Med Wochenschr"},{"key":"10.1016\/j.jaci.2023.04.009_bib21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jaci.2013.04.046","article-title":"Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis","volume":"132","author":"Suarez-Farinas","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.009_bib22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/exd.12967","article-title":"Distinct molecular signatures of mild extrinsic and intrinsic atopic dermatitis","volume":"25","author":"Martel","year":"2016","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaci.2023.04.009_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaci.2008.10.031","article-title":"IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response","volume":"123","author":"Eyerich","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.009_bib24","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.jaci.2016.07.013","article-title":"Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin","volume":"138","author":"Esaki","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.009_bib25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.anai.2018.08.024","article-title":"Atopic dermatitis in African American patients is TH2\/TH22-skewed with TH1\/TH17 attenuation","volume":"122","author":"Sanyal","year":"2019","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2023.04.009_bib26","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.jaci.2015.08.015","article-title":"The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization","volume":"136","author":"Noda","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.009_bib27","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/1346-8138.14787","article-title":"Atopic dermatitis disease registry in Japanese adult patients with moderate to severe atopic dermatitis (ADDRESS-J): baseline characteristics, treatment history and disease burden","volume":"46","author":"Katoh","year":"2019","journal-title":"J Dermatol"},{"key":"10.1016\/j.jaci.2023.04.009_bib28","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.jaci.2021.01.013","article-title":"Biomarkers in atopic dermatitis\u2014a review on behalf of the International Eczema Council","volume":"147","author":"Renert-Yuval","year":"2021","journal-title":"J Allergy Clin Immunol"},{"issue":"3 suppl\u00a02","key":"10.1016\/j.jaci.2023.04.009_bib29","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1016\/j.jaci.2009.07.012","article-title":"Cytokine modulation of atopic dermatitis filaggrin skin expression","volume":"124","author":"Howell","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.009_bib30","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/jid.2008.295","article-title":"Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling","volume":"129","author":"Zheng","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2023.04.009_bib31","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jaci.2015.07.052","article-title":"Staphylococcus aureus density on lesional and nonlesional skin is strongly associated with disease severity in atopic dermatitis","volume":"137","author":"Tauber","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.009_bib32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1046\/j.1365-4362.1999.00686.x","article-title":"Comparative study of staphylococci from the skin of atopic dermatitis patients and from healthy subjects","volume":"38","author":"Higaki","year":"1999","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jaci.2023.04.009_bib33","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1038\/jid.2014.308","article-title":"IL-19 is a component of the pathogenetic IL-23\/IL-17 cascade in psoriasis","volume":"134","author":"Witte","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2023.04.009_bib34","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.4049\/jimmunol.1800013","article-title":"Discovery of the IL-23\/IL-17 signaling pathway and the treatment of psoriasis","volume":"201","author":"Hawkes","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2023.04.009_bib35","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1073\/pnas.1416922112","article-title":"IL-4 abrogates TH17 cell\u2013mediated inflammation by selective silencing of IL-23 in antigen-presenting cells","volume":"112","author":"Guenova","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2023.04.009_bib36","first-page":"1092","article-title":"Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways","volume":"159","author":"Nograles","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2023.04.009_bib37","article-title":"Interleukin-17A drives IL-19 and IL-24 expression in skin stromal cells regulating keratinocyte proliferation","volume":"12","author":"Xu","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2023.04.009_bib38","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/exd.12710","article-title":"Evidence that a neutrophil\u2013keratinocyte crosstalk is an early target of IL-17A inhibition in psoriasis","volume":"24","author":"Reich","year":"2015","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaci.2023.04.009_bib39","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.jaad.2019.12.054","article-title":"Dupilumab treatment of nummular dermatitis: a retrospective cohort study","volume":"82","author":"Choi","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2023.04.009_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/dth.13290","article-title":"Effectiveness of dupilumab for the treatment of nummular eczema phenotype of atopic dermatitis in adults","volume":"33","author":"Patruno","year":"2020","journal-title":"Dermatol Ther"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674923005146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674923005146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:41:47Z","timestamp":1758793307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674923005146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0091674923005146"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2023.04.009","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The neglected twin: Nummular eczema is a variant of atopic dermatitis with codominant TH2\/TH17 immune response","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2023.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}