{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T17:30:14Z","timestamp":1792949414456,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"am","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R44AI126987"],"award-info":[{"award-number":["R44AI126987"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["CIA160008"],"award-info":[{"award-number":["CIA160008"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jaci.2023.04.012","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T11:26:10Z","timestamp":1683199570000},"page":"400-407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["An eosinophil peroxidase activity assay accurately predicts eosinophilic chronic rhinosinusitis"],"prefix":"10.1016","volume":"152","author":[{"given":"Kristine A.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarbir S.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea E.","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorgen S.","family":"Sumsion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedieh","family":"Saffari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaelene","family":"Ashby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige A.","family":"Shipman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Gabrielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Yim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen M.","family":"Oakley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald J.","family":"Gleich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-5028","authenticated-orcid":false,"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Pulsipher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2023.04.012_bib1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2500\/ajra.2016.30.4297","article-title":"Chronic rhinosinusitis: epidemiology and burden of disease","volume":"30","author":"DeConde","year":"2016","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaci.2023.04.012_bib2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/alr.22741","article-title":"International consensus statement on allergy and rhinology: rhinosinusitis 2021","volume":"11","author":"Orlandi","year":"2021","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2023.04.012_bib3","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.jaci.2015.12.1324","article-title":"Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers","volume":"137","author":"Tomassen","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.012_bib4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4193\/Rhin20.601","article-title":"Executive summary of EPOS 2020 including integrated care pathways","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2023.04.012_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2023.04.012_bib6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11882-017-0696-z","article-title":"The role of macrolides in chronic rhinosinusitis (CRSsNP and CRSwNP)","volume":"17","author":"Oakley","year":"2017","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2023.04.012_bib7","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/alr.22369","article-title":"Long-term outcomes of endoscopic sinus surgery in the management of adult chronic rhinosinusitis","volume":"9","author":"Smith","year":"2019","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2023.04.012_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4193\/Rhin17.049","article-title":"Characteristics of macrolide responders in persistent post-surgical rhinosinusitis","volume":"56","author":"Oakley","year":"2018","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2023.04.012_bib9","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/alr.21047","article-title":"Corticosteroid nasal irrigations after endoscopic sinus surgery in the management of chronic rhinosinusitis","volume":"2","author":"Snidvongs","year":"2012","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2023.04.012_bib10","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s40265-020-01298-9","article-title":"Dupilumab: a review in chronic rhinosinusitis with nasal polyps","volume":"80","author":"Hoy","year":"2020","journal-title":"Drugs"},{"key":"10.1016\/j.jaci.2023.04.012_bib11","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S2213-2600(21)00097-7","article-title":"Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"9","author":"Han","year":"2021","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaci.2023.04.012_bib12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jaci.2020.09.024","article-title":"Omalizumab or dupilumab for chronic rhinosinusitis with nasal polyposis","volume":"147","author":"Lipworth","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.012_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaci.2020.11.013","article-title":"EUFOREA expert board meeting on uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) and biologics: definitions and management","volume":"147","author":"Bachert","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.012_bib14","first-page":"CD010834","article-title":"Anti-IL5 therapies for asthma","volume":"9","author":"Farne","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jaci.2023.04.012_bib15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.alit.2019.07.002","article-title":"Eosinophilic chronic rhinosinusitis","volume":"68","author":"Fujieda","year":"2019","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaci.2023.04.012_bib16","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/alr.22214","article-title":"Highlights of eosinophilic chronic rhinosinusitis with nasal polyps in definition, prognosis, and advancement","volume":"8","author":"Lou","year":"2018","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2023.04.012_bib17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/dote.12304","article-title":"Prospective assessment of the diagnostic utility of esophageal brushings in adults with eosinophilic esophagitis","volume":"29","author":"Kern","year":"2016","journal-title":"Dis Esophagus"},{"key":"10.1016\/j.jaci.2023.04.012_bib18","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1080\/1744666X.2020.1679626","article-title":"Endotype-driven precision medicine in chronic rhinosinusitis","volume":"15","author":"Lou","year":"2019","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.012_bib19","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/ajg.2016.184","article-title":"Measurement of inflammation in eosinophilic esophagitis using an eosinophil peroxidase assay","volume":"111","author":"Saffari","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jaci.2023.04.012_bib20","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/all.13730","article-title":"Siglec-7 on peripheral blood eosinophils: surface expression and function","volume":"74","author":"Legrand","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2023.04.012_bib21","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/all.15074","article-title":"Endotypes of chronic rhinosinusitis: relationships to disease phenotypes, pathogenesis, clinical findings, and treatment approaches","volume":"77","author":"Kato","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2023.04.012_bib22","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/j.jaci.2019.01.038","article-title":"Eosinophil peroxidase, GATA3, and T-bet as tissue biomarkers in chronic rhinosinusitis","volume":"143","author":"Lal","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.012_bib23","first-page":"S1","article-title":"Clinical practice guideline (update): adult sinusitis","volume":"152","author":"Rosenfeld","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2023.04.012_bib24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.otohns.2009.10.005","article-title":"Impact of mucosal eosinophilia and nasal polyposis on quality-of-life outcomes after sinus surgery","volume":"142","author":"Soler","year":"2010","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2023.04.012_bib25","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund","year":"1993","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2023.04.012_bib26","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0194-5998(97)70005-6","article-title":"Staging for rhinosinusitis","volume":"117","author":"Lund","year":"1997","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2023.04.012_bib27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1749-4486.2009.01995.x","article-title":"Psychometric validity of the 22-item Sinonasal Outcome Test","volume":"34","author":"Hopkins","year":"2009","journal-title":"Clin Otolaryngol"},{"key":"10.1016\/j.jaci.2023.04.012_bib28","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1099\/00222615-46-5-430","article-title":"Microbiology of chronic maxillary sinusitis: comparison between specimens obtained by sinus endoscopy and by surgical drainage","volume":"46","author":"Brook","year":"1997","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jaci.2023.04.012_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejpb.2022.04.009","article-title":"In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery","volume":"175","author":"Nizic Nodilo","year":"2022","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.jaci.2023.04.012_bib30","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1002\/alr.23005","article-title":"Use of intraoperative frontal sinus mometasone-eluting stents decreased interleukin 5 and interleukin 13 in patients with chronic rhinosinusitis with nasal polyps","volume":"12","author":"Schneider","year":"2022","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2023.04.012_bib31","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/cea.14119","article-title":"Topographic distribution of gene expression and sinonasal inflammation in chronic\u00a0rhinosinusitis without nasal polyposis","volume":"52","author":"Gill","year":"2022","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2023.04.012_bib32","first-page":"185","article-title":"Comparison of swabs versus suction traps for endoscopically guided sinus cultures","volume":"37","author":"Javer","year":"2008","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2023.04.012_bib33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fpubh.2017.00307","article-title":"Sensitivity, specificity, and predictive values: foundations, pliabilities, and pitfalls in research and practice","volume":"5","author":"Trevethan","year":"2017","journal-title":"Front Public Health"},{"key":"10.1016\/j.jaci.2023.04.012_bib34","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.jaip.2017.04.024","article-title":"Biotherapeutics in chronic rhinosinusitis with and without nasal polyps","volume":"5","author":"Bachert","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2023.04.012_bib35","doi-asserted-by":"crossref","first-page":"368","DOI":"10.14639\/0392-100X-N0711","article-title":"Exploring the role of nasal cytology in chronic rhinosinusitis","volume":"40","author":"Gallo","year":"2020","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"10.1016\/j.jaci.2023.04.012_bib36","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.bjorl.2021.03.003","article-title":"Guideline for the use of immunobiologicals in chronic rhinosinusitis with nasal polyps (CRSwNP) in Brazil","volume":"88","author":"Anselmo-Lima","year":"2022","journal-title":"Braz J Otorhinolaryngol"},{"key":"10.1016\/j.jaci.2023.04.012_bib37","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/alr.22633","article-title":"Guidance for contemporary use of biologics in management of chronic rhinosinusitis with nasal polyps: discussion from a National Institutes of Health-sponsored workshop","volume":"10","author":"Roland","year":"2020","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2023.04.012_bib38","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/alr.21378","article-title":"The utility of routine polyp histopathology after endoscopic sinus surgery","volume":"4","author":"Yeh","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2023.04.012_bib39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.7812\/TPP\/20.110","article-title":"Trends in endoscopic sinonasal debridement in the Medicare population","volume":"25","author":"Xiong","year":"2021","journal-title":"Perm J"},{"key":"10.1016\/j.jaci.2023.04.012_bib40","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1001\/archotol.127.9.1102","article-title":"Tissue eosinophilia in chronic sinusitis: quantification techniques","volume":"127","author":"Bhattacharyya","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2023.04.012_bib41","doi-asserted-by":"crossref","first-page":"8061","DOI":"10.1038\/s41598-019-44627-z","article-title":"Eosinophil extracellular trap formation is closely associated with disease severity in chronic rhinosinusitis regardless of nasal polyp status","volume":"9","author":"Hwang","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2023.04.012_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bmcl.2018.11.031","article-title":"The development of myeloperoxidase inhibitors","volume":"29","author":"Galijasevic","year":"2019","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jaci.2023.04.012_bib43","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/humrep\/deaa328","article-title":"Myeloperoxidase inhibitor AZD5904 enhances human sperm function in\u00a0vitro","volume":"36","author":"Campbell","year":"2021","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jaci.2023.04.012_bib44","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/alr.22743","article-title":"Olfactory cleft mucus proteome in chronic rhinosinusitis: a case-control pilot study","volume":"11","author":"Soler","year":"2021","journal-title":"Int Forum Allergy Rhinol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674923005602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674923005602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:41:41Z","timestamp":1758793301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674923005602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0091674923005602"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2023.04.012","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An eosinophil peroxidase activity assay accurately predicts eosinophilic chronic rhinosinusitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2023.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}