{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:46:47Z","timestamp":1792705607029,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jaci.2023.04.013","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T15:18:20Z","timestamp":1683559100000},"page":"641-655.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["IL-21 induces pyroptosis of Treg cells via Akt\u2013mTOR\u2013NLRP3\u2013caspase 1 axis in eosinophilic chronic rhinosinusitis"],"prefix":"10.1016","volume":"152","author":[{"given":"Lihong","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouzhou","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xifu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1917-0283","authenticated-orcid":false,"given":"Gehua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2023.04.013_bib1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/all.12577","article-title":"Epidemiology of chronic rhinosinusitis: results from a cross-sectional survey in seven Chinese cities","volume":"70","author":"Shi","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2023.04.013_bib2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4168\/aair.2020.12.2.176","article-title":"Chinese Society of Allergy and Chinese Society of Otorhinolaryngology\u2013Head and Neck Surgery guideline for chronic rhinosinusitis","volume":"12","author":"Liu","year":"2020","journal-title":"Allergy Asthma Immunol Res"},{"issue":"suppl S29","key":"10.1016\/j.jaci.2023.04.013_bib3","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2023.04.013_bib4","first-page":"81","volume":"54","year":"2019","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"10.1016\/j.jaci.2023.04.013_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2016.07.010","article-title":"Group 2 innate lymphoid cells are increased in nasal polyps in patients with eosinophilic chronic rhinosinusitis","volume":"170","author":"Tojima","year":"2016","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib6","doi-asserted-by":"crossref","first-page":"350","DOI":"10.2500\/ajra.2015.29.4231","article-title":"Predictive significance of tissue eosinophilia for nasal polyp recurrence in the Chinese population","volume":"29","author":"Lou","year":"2015","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaci.2023.04.013_bib7","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4193\/Rhino15.271","article-title":"Cellular phenotyping of chronic rhinosinusitis with nasal polyps","volume":"54","author":"Lou","year":"2016","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2023.04.013_bib8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jaci.2019.03.026","article-title":"Epithelium-derived cystatin SN enhances eosinophil activation and infiltration through IL-5 in patients with chronic rhinosinusitis with nasal polyps","volume":"144","author":"Yan","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib9","doi-asserted-by":"crossref","unstructured":"Salter BM, Ju X, Sehmi R. Eosinophil lineage-committed progenitors as a therapeutic target for asthma. Cells 2021.","DOI":"10.3390\/cells10020412"},{"key":"10.1016\/j.jaci.2023.04.013_bib10","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.4049\/jimmunol.1400732","article-title":"IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation","volume":"193","author":"Fulkerson","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib11","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.jaci.2007.03.048","article-title":"Eosinophil trafficking in allergy and asthma","volume":"119","author":"Rosenberg","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw4295","article-title":"Protein crystallization promotes type 2 immunity and is reversible by antibody treatment","volume":"364","author":"Persson","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jaci.2023.04.013_bib13","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.3389\/fimmu.2019.03136","article-title":"Molecular mechanisms controlling Foxp3 expression in health and autoimmunity: from epigenetic to post-translational regulation","volume":"10","author":"Colamatteo","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib14","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1084\/jem.20150402","article-title":"TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand","volume":"214","author":"Pattarini","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2023.04.013_bib15","first-page":"33","article-title":"T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients","volume":"11","author":"Baba","year":"2015","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2023.04.013_bib16","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jaci.2013.06.010","article-title":"Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3","volume":"132","author":"Lan","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib17","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1002\/eji.201444963","article-title":"CD4+FoxP3+ regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection","volume":"44","author":"Schulze","year":"2014","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1042\/CS20190388","article-title":"Type 2 inflammation suppression by T-regulatory cells attenuates the eosinophil recruitment in mucosa of chronic sinusitis","volume":"134","author":"Chang","year":"2020","journal-title":"Clin Sci"},{"key":"10.1016\/j.jaci.2023.04.013_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102417","article-title":"Innate inflammation drives NK cell activation to impair Treg activity","volume":"108","author":"Dean","year":"2020","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jaci.2023.04.013_bib20","first-page":"E3246","article-title":"Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1","author":"Yayi","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2023.04.013_bib21","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s10495-019-01548-6","article-title":"Berberine mitigates IL-21\/IL-21R mediated autophagic influx in fibroblast-like synoviocytes and regulates Th17\/Treg imbalance in rheumatoid arthritis","volume":"24","author":"Dinesh","year":"2019","journal-title":"Apoptosis"},{"key":"10.1016\/j.jaci.2023.04.013_bib22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nm.3432","article-title":"Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis","volume":"20","author":"Komatsu","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2023.04.013_bib23","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature05969","article-title":"Essential autocrine regulation by IL-21 in the generation of inflammatory T cells","volume":"448","author":"Nurieva","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2023.04.013_bib24","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/art.40380","article-title":"Blockade of Treg cell differentiation and function by the interleukin-21\u2013mechanistic target of rapamycin axis via suppression of autophagy in patients with systemic lupus erythematosus","volume":"70","author":"Kato","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jaci.2023.04.013_bib25","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1016\/j.jaci.2018.11.047","article-title":"IL-21 promotes allergic airway inflammation by driving apoptosis of FoxP3+ regulatory T cells","volume":"143","author":"Tortola","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/imr.12534","article-title":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases","volume":"277","author":"Man","year":"2017","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2023.04.013_bib27","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.apsb.2021.02.006","article-title":"Gasdermin D in pyroptosis","volume":"11","author":"Burdette","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.jaci.2023.04.013_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.678201","article-title":"Canonical secretomes, innate immune caspase-1-, 4\/11-gasdermin D non-canonical secretomes and exosomes may contribute to maintain Treg-Ness for Treg immunosuppression, tissue repair and modulate anti-tumor immunity via ROS pathways","volume":"12","author":"Ni","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jaci.2022.02.031","article-title":"IL-17A mediates pyroptosis via ERK pathway and contributes to steroid resistance in CRSwNP","volume":"150","author":"Li","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib30","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.3389\/fimmu.2018.02121","article-title":"Tc17\/IL-17A Up-regulated the expression of MMP-9 via NF-kappaB pathway in nasal epithelial cells of patients with chronic rhinosinusitis","volume":"9","author":"Chen","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib31","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1182\/blood-2012-03-419440","article-title":"IL-21 in\u00a0the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia","volume":"120","author":"Hodge","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2023.04.013_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/clt2.12003","article-title":"IL-19 induced by IL-13\/IL-17A in the nasal epithelium of patients with chronic rhinosinusitis upregulates MMP-9 expression via ERK\/NF-kappaB signaling pathway","volume":"11","author":"Li","year":"2021","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.jaci.2023.04.013_bib33","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.3389\/fimmu.2019.01682","article-title":"IL-19 up-regulates mucin 5AC production in patients with chronic rhinosinusitis via STAT3 pathway","volume":"10","author":"Lai","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000507865","article-title":"Interleukin-17A expression correlated with the prognosis of chronic rhinosinusitis with nasal polyps and the anti-interleukin-17A effect in a murine nasal polyps model","volume":"82","author":"Huang","year":"2020","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"10.1016\/j.jaci.2023.04.013_bib35","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-immunol-042718-041717","article-title":"Regulatory T cells and human disease","volume":"38","author":"Sakaguchi","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib36","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.3389\/fimmu.2019.01865","article-title":"IL-21 induces an imbalance of Th17\/Treg cells in moderate-to-severe plaque psoriasis patients","volume":"10","author":"Shi","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib37","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.4049\/jimmunol.2001107","article-title":"IL-21\/IL-21R signaling aggravated respiratory inflammation induced by intracellular bacteria through regulation of CD4+ T cell subset responses","volume":"206","author":"Niu","year":"2021","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14647","article-title":"IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2","volume":"8","author":"Jandl","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2023.04.013_bib39","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1182\/blood-2011-10-388546","article-title":"IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis","volume":"119","author":"Attridge","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2023.04.013_bib40","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/cea.12475","article-title":"Increased IL-21 expression in chronic rhinosinusitis with nasalpolyps","volume":"45","author":"Xiao","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2023.04.013_bib41","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrd4296","article-title":"Interleukin-21: a double-edged sword with therapeutic potential","volume":"13","author":"Spolski","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jaci.2023.04.013_bib42","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature20810","article-title":"Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis","volume":"542","author":"Rao","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2023.04.013_bib43","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jaci.2015.07.025","article-title":"Nasal IL-4+CXCR5+CD4+ T follicular helper cell counts correlate with local IgE\u00a0production in eosinophilic nasal polyps","volume":"137","author":"Zhang","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib44","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.jaci.2019.06.023","article-title":"Cross-talk between TH2 and TH17 pathways in patients with chronic rhinosinusitis with nasal polyps","volume":"144","author":"Wang","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib45","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/cea.12758","article-title":"CD8+ T cells with distinct cytokine-producing features and low cytotoxic activity in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps","volume":"46","author":"Ma","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2023.04.013_bib46","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","article-title":"Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis","volume":"575","author":"Fritsch","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2023.04.013_bib47","doi-asserted-by":"crossref","first-page":"E10888","DOI":"10.1073\/pnas.1809548115","article-title":"Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection","volume":"115","author":"Sarhan","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2023.04.013_bib48","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/ni.3202","article-title":"The receptor NLRP3 is a transcriptional regulator of TH2 differentiation","volume":"16","author":"Bruchard","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2019.01.013","article-title":"Clinical significance and immunobiology of IL-21 in autoimmunity","volume":"99","author":"Long","year":"2019","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jaci.2023.04.013_bib50","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.4049\/jimmunol.1301181","article-title":"Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in\u00a0vivo","volume":"191","author":"Zhang","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2018.11.002","article-title":"Pinellia pedatisecta lectin exerts a proinflammatory activity correlated with ROS-MAPKs\/NF-kappaB pathways and the NLRP3 inflammasome in RAW264.7 cells accompanied by cell pyroptosis","volume":"66","author":"Wang","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jaci.2023.04.013_bib52","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1083\/jcb.201701049","article-title":"p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1","volume":"217","author":"He","year":"2018","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2023.04.013_bib53","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.3389\/fimmu.2018.01920","article-title":"Repositioning of the beta-blocker carvedilol as a novel autophagy inducer that inhibits the NLRP3 inflammasome","volume":"9","author":"Wong","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A\u00a0summary for otorhinolaryngologists","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2023.04.013_bib55","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1042\/CS20190388","article-title":"Type 2 inflammation suppression by T-regulatory cells attenuates the eosinophil recruitment in mucosa of chronic sinusitis","volume":"134","author":"Chang","year":"2020","journal-title":"Clin Sci"},{"key":"10.1016\/j.jaci.2023.04.013_bib56","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.3389\/fimmu.2018.02121","article-title":"Tc17\/IL-17A up-regulated the expression of MMP-9 via NF-kappaB pathway in nasal epithelial cells of patients with chronic rhinosinusitis","volume":"9","author":"Chen","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib57","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nature16962","article-title":"Expanding antigen-specific regulatory networks to treat autoimmunity.","volume":"530","author":"Clemente-Casares","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2023.04.013_bib58","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jaci.2022.02.031","article-title":"IL-17A mediates pyroptosis via ERK pathway and contributes to steroid resistance in CRSwNP","volume":"150","author":"Li","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.04.013_bib59","doi-asserted-by":"crossref","first-page":"274","DOI":"10.4168\/aair.2020.12.2.274","article-title":"Evidence for the presence of long-lived plasma cells in nasal polyps.","volume":"12","author":"Zhang","year":"2020","journal-title":"Allergy Asthma Immunol Res"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674923005638?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674923005638?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T23:34:14Z","timestamp":1724801654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674923005638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0091674923005638"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2023.04.013","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-21 induces pyroptosis of Treg cells via Akt\u2013mTOR\u2013NLRP3\u2013caspase 1 axis in eosinophilic chronic rhinosinusitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2023.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}