{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:05:27Z","timestamp":1793106327443,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T00:00:00Z","timestamp":1689379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.jaci.2023.05.028","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T02:07:13Z","timestamp":1689732433000},"page":"1131-1140.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Sphingosine-1-phosphate induces airway smooth muscle hyperresponsiveness and proliferation"],"prefix":"10.1016","volume":"152","author":[{"given":"Thomas J.A.","family":"Maguire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Yung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ortiz-Zapater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. Stephanie","family":"Kayode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Till","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Corrigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard Q.C.","family":"Siew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Knock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0675-085X","authenticated-orcid":false,"given":"Grzegorz","family":"Woszczek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2023.05.028_bib1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1056\/NEJMcibr1306864","article-title":"Sphingolipids and susceptibility to asthma","volume":"369","author":"Levy","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2023.05.028_bib2","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.4049\/jimmunol.1601848","article-title":"Cutting edge: targeting epithelial ORMDL3 increases, rather than reduces, airway responsiveness and is associated with increased sphingosine-1-phosphate","volume":"198","author":"Miller","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2023.05.028_bib3","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature06014","article-title":"Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma","volume":"448","author":"Moffatt","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2023.05.028_bib4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrm1103","article-title":"Sphingosine-1-phosphate: an enigmatic signalling lipid","volume":"4","author":"Spiegel","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaci.2023.05.028_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/science.aar5551","article-title":"Sphingosine 1-phosphate: lipid signaling in pathology and therapy","volume":"366","author":"Cartier","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jaci.2023.05.028_bib6","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev-immunol-081519-083952","article-title":"Finding a way out: S1P signaling and immune cell migration","volume":"38","author":"Baeyens","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2023.05.028_bib7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nri2400","article-title":"The alliance of sphingosine-1-phosphate and its receptors in immunity","volume":"8","author":"Rivera","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2023.05.028_bib8","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0140-6736(21)00244-0","article-title":"Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions","volume":"398","author":"McGinley","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2023.05.028_bib9","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1096\/fj.00-0742fje","article-title":"Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma","volume":"15","author":"Ammit","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.jaci.2023.05.028_bib10","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1111\/all.12489","article-title":"Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells","volume":"69","author":"Fuerst","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2023.05.028_bib11","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1096\/fj.02-0836com","article-title":"Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells","volume":"17","author":"Rosenfeldt","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.jaci.2023.05.028_bib12","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1165\/rcmb.2009-0108OC","article-title":"Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse","volume":"42","author":"Roviezzo","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2023.05.028_bib13","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1165\/rcmb.2006-0383OC","article-title":"Sphingosine-1-phosphate\/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness","volume":"36","author":"Roviezzo","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2023.05.028_bib14","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1111\/bph.15754","article-title":"Sphingosine-1-phosphate\/TGF-beta axis drives epithelial mesenchymal transition in asthma-like disease","volume":"179","author":"Riemma","year":"2022","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jaci.2023.05.028_bib15","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1254\/jphs.10202FP","article-title":"SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice","volume":"114","author":"Chiba","year":"2010","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jaci.2023.05.028_bib16","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1056\/NEJMoa052643","article-title":"Oral fingolimod (FTY720) for relapsing multiple sclerosis","volume":"355","author":"Kappos","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2023.05.028_bib17","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1164\/rccm.200501-082PP","article-title":"Asthma: is it due to an abnormal airway smooth muscle cell?","volume":"174","author":"Borger","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2023.05.028_bib18","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1164\/ajrccm.164.3.2010109","article-title":"Airway smooth muscle cell proliferation is increased in asthma","volume":"164","author":"Johnson","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2023.05.028_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1113\/JP275033","article-title":"Transforming growth factor-beta enhances Rho-kinase activity and contraction in airway smooth muscle via the nucleotide exchange factor ARHGEF1","volume":"596","author":"Shaifta","year":"2018","journal-title":"J Physiol"},{"key":"10.1016\/j.jaci.2023.05.028_bib20","doi-asserted-by":"crossref","first-page":"6407","DOI":"10.1038\/s41467-022-33882-w","article-title":"Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation","volume":"13","author":"Ortiz-Zapater","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2023.05.028_bib21","doi-asserted-by":"crossref","first-page":"10775","DOI":"10.1073\/pnas.0902295106","article-title":"Diminished sarco\/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma","volume":"106","author":"Mahn","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2023.05.028_bib22","doi-asserted-by":"crossref","first-page":"16394","DOI":"10.1073\/pnas.0603734103","article-title":"Role of ABCC1 in export of sphingosine-1-phosphate from mast cells","volume":"103","author":"Mitra","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2023.05.028_bib23","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1056\/NEJMoa012705","article-title":"Mast-cell infiltration of airway smooth muscle in asthma","volume":"346","author":"Brightling","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2023.05.028_bib24","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4168\/aair.2019.11.3.330","article-title":"Altered sphingolipid metabolism is associated with asthma phenotype in house dust mite-allergic patients","volume":"11","author":"Kowal","year":"2019","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2023.05.028_bib25","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.jaci.2012.02.007","article-title":"Reduced expression of the prostaglandin E2 receptor E-prostanoid 2 on bronchial mucosal leukocytes in patients with aspirin-sensitive asthma","volume":"129","author":"Corrigan","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.05.028_bib26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pupt.2012.08.006","article-title":"Models to study airway smooth muscle contraction in\u00a0vivo, ex\u00a0vivo and in\u00a0vitro: implications in understanding asthma","volume":"26","author":"Wright","year":"2013","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.jaci.2023.05.028_bib27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.2011.01030.x","article-title":"The sentinel role of the airway epithelium in asthma pathogenesis","volume":"242","author":"Holgate","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2023.05.028_bib28","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1165\/rcmb.2020-0194OC","article-title":"Increasing sphingolipid synthesis alleviates airway hyperreactivity","volume":"63","author":"Heras","year":"2020","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2023.05.028_bib29","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/hmg\/ddu479","article-title":"Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB\/ORMDL3 locus","volume":"24","author":"Acevedo","year":"2015","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jaci.2023.05.028_bib30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1113\/JP275033","article-title":"Transforming growth factor-beta enhances Rho-kinase activity and contraction in airway smooth muscle via the nucleotide exchange factor ARHGEF1","volume":"596","author":"Shaifta","year":"2018","journal-title":"J Physiol"},{"key":"10.1016\/j.jaci.2023.05.028_bib31","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1111\/all.12489","article-title":"Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells","volume":"69","author":"Fuerst","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2023.05.028_bib32","doi-asserted-by":"crossref","first-page":"10775","DOI":"10.1073\/pnas.0902295106","article-title":"Diminished sarco\/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma","volume":"106","author":"Mahn","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2023.05.028_bib33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-1-0716-1221-7_13","article-title":"FLIPR calcium mobilization assays in GPCR drug discovery","volume":"2268","author":"Woszczek","year":"2021","journal-title":"Methods Mol Biol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674923008916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674923008916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:44:53Z","timestamp":1758793493000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674923008916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S0091674923008916"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2023.05.028","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sphingosine-1-phosphate induces airway smooth muscle hyperresponsiveness and proliferation","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2023.05.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}