{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:26:41Z","timestamp":1780529201880,"version":"3.54.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jaci.2023.06.022","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T13:21:39Z","timestamp":1689254499000},"page":"927-932","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Difelikefalin suppresses itch and reduces scratching independent of inflammation in a murine model of atopic dermatitis"],"prefix":"10.1016","volume":"152","author":[{"given":"Masato","family":"Tamari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Zamidar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Ver Heul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Nograles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Goncalves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Guttman-Yassky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lebwohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8100-7161","authenticated-orcid":false,"given":"Brian S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2023.06.022_bib1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.immuni.2020.04.008","article-title":"Itch: a paradigm of neuroimmune crosstalk","volume":"52","author":"Wang","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2023.06.022_bib2","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1016\/j.neuron.2022.03.031","article-title":"The translational revolution of itch","volume":"110","author":"Kim","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.jaci.2023.06.022_bib3","series-title":"Korsuva (difelikefalin) [package insert]","year":"2021"},{"key":"10.1016\/j.jaci.2023.06.022_bib4","series-title":"Kapruvia [summary of product characteristics]","year":"2022"},{"key":"10.1016\/j.jaci.2023.06.022_bib20","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.jaci.2023.06.023","article-title":"Oral difelikefalin reduces moderate to severe pruritus and expression of pruritic and inflammatory biomarkers in subjects with atopic dermatitis","volume":"152","author":"Guttman-Yassky","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.06.022_bib5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-4939-6786-5_8","article-title":"A mouse model for atopic dermatitis using topical application of vitamin D3 or of its analog MC903","volume":"1559","author":"Moosbrugger-Martinz","year":"2017","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jaci.2023.06.022_bib6","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.jaci.2021.09.014","article-title":"IL-33 signaling in sensory neurons promotes dry skin itch","volume":"149","author":"Trier","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.06.022_bib7","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2023.06.022_bib8","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1172\/JCI66413","article-title":"Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity","volume":"123","author":"Yin","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2023.06.022_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cell.2017.08.006","article-title":"Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch","volume":"171","author":"Oetjen","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2023.06.022_bib10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.3881","article-title":"Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing","volume":"18","author":"Usoskin","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jaci.2023.06.022_bib11","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.neuron.2018.08.044","article-title":"Kappa opioid receptor distribution and function in primary afferents","volume":"99","author":"Snyder","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.jaci.2023.06.022_bib12","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jaci.2021.08.009","article-title":"JAK inhibitors in the treatment of atopic dermatitis","volume":"148","author":"Chovatiya","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.06.022_bib13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/jcpt.12404","article-title":"Will peripherally restricted kappa-opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential?","volume":"41","author":"Albert-Vartanian","year":"2016","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.jaci.2023.06.022_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-33620-7","article-title":"Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation","volume":"8","author":"Melo","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2023.06.022_bib15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1056\/NEJMoa2210699","article-title":"Phase\u00a02\u00a0trial of difelikefalin in notalgia paresthetica","volume":"388","author":"Kim","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2023.06.022_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0165-5728(95)00159-X","article-title":"Inhibition of primary murine macrophage cytokine production in\u00a0vitro following treatment with the kappa-opioid agonist U50,488H","volume":"64","author":"Alicea","year":"1996","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jaci.2023.06.022_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172702","article-title":"Nalbuphine, a kappa opioid receptor agonist and mu opioid receptor antagonist attenuates pruritus, decreases IL-31, and increases IL-10 in mice with contact dermatitis","volume":"864","author":"Inan","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jaci.2023.06.022_bib18","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/1346-8138.15407","article-title":"Non-neuronal kappa-opioid receptor activation enhances epidermal keratinocyte proliferation, and modulates mast cell functions in human skin ex\u00a0vivo","volume":"47","author":"Ch\u00e9ret","year":"2020","journal-title":"J Dermatol"},{"key":"10.1016\/j.jaci.2023.06.022_bib19","series-title":"Annual Spring Clinical Meetings of the National Kidney Foundation","article-title":"Reduction of pruritus by difelikefalin correlates with reductions in markers for pruritus and inflammation in subjects undergoing hemodialysis [poster 207]","author":"Shirazian","year":"2022"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674923008874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674923008874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:44:18Z","timestamp":1758793458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674923008874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S0091674923008874"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2023.06.022","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Difelikefalin suppresses itch and reduces scratching independent of inflammation in a murine model of atopic dermatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2023.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}