{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T20:10:50Z","timestamp":1782591050683,"version":"3.54.5"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jaci.2023.09.043","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T07:15:25Z","timestamp":1701760525000},"page":"998-1009.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cannabinoid receptor 2 as a regulator of inflammation induced oleoylethanolamide in eosinophilic asthma"],"prefix":"10.1016","volume":"153","author":[{"given":"Eun-Kyung","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngwoo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoon","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Min","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Seob","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Sim","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga-Young","family":"Ban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2023.09.043_bib2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jaip.2019.11.020","article-title":"Diagnosis and management of T2-high asthma","volume":"8","author":"Coverstone","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2023.09.043_bib3","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.chest.2021.04.013","article-title":"Eosinophilic and noneosinophilic asthm: an expert consensus framework to characterize phenotypes in a global real life severe asthma cohort","volume":"160","author":"Heaney","year":"2021","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2023.09.043_bib4","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S2213-2600(15)00367-7","article-title":"Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study","volume":"3","author":"Price","year":"2015","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaci.2023.09.043_bib5","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4168\/aair.2021.13.3.420","article-title":"Risk factors predicting severe asthma exacerbations in adult asthmatics: a real-world clinical evidence","volume":"13","author":"Ban","year":"2021","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2023.09.043_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11882-022-01058-7","article-title":"Immune metabolism in TH2 responses: new opportunities to improve allergy treatment\u2014cell type\u2013specific findings (part 2)","volume":"23","author":"Lin","year":"2023","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2023.09.043_bib7","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.2147\/JAA.S325499","article-title":"Persistent eosinophilic inflammation in adult asthmatics with high serum and urine levels of leukotriene E4","volume":"14","author":"Ban","year":"2021","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.jaci.2023.09.043_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0240334","article-title":"Increased expression of serine palmitoyl transferase and ORMDL3 polymorphism are associated with eosinophilic inflammation and airflow limitation in aspirin-exacerbated respiratory disease","volume":"15","author":"Ban","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2023.09.043_bib9","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/all.12858","article-title":"Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen-induced pulmonary inflammation in mice","volume":"71","author":"Frei","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2023.09.043_bib10","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/all.13107","article-title":"CB2 receptors regulate natural killer cells that limit allergic airway inflammation in a murine model of asthma","volume":"72","author":"Ferrini","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2023.09.043_bib11","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.jaci.2021.09.037","article-title":"Cannabinoid receptor 2 engagement promotes group 2 innate lymphoid cell expansion and enhances airway hyperreactivity","volume":"149","author":"Hurrell","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.09.043_bib12","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s12276-021-00622-x","article-title":"Oleoylethanolamide induces eosinophilic airway inflammation in bronchial asthma","volume":"53","author":"Kwon","year":"2021","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jaci.2023.09.043_bib13","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01740-2016","article-title":"Metabolomics analysis identifies different metabotypes of asthma severity","volume":"49","author":"Reinke","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2023.09.043_bib14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1159\/000508989","article-title":"The role of cannabinoids in allergic diseases: Collegium Internationale Allergologicum (CIA) update, 2020","volume":"181","author":"Angelina","year":"2020","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2023.09.043_bib15","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00588-2019","article-title":"Management of severe asthma: a European Respiratory Society\/American Thoracic Society guideline","volume":"55","author":"Holguin","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2023.09.043_bib16","first-page":"281","article-title":"CD69 is expressed by human eosinophils activated in\u00a0vivo in asthma and in\u00a0vitro by cytokines","volume":"80","author":"Hartnell","year":"1993","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2023.09.043_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/238482","article-title":"Small molecules from nature targeting G-protein coupled cannabinoid receptors: potential leads for drug discovery and development","volume":"2015","author":"Sharma","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jaci.2023.09.043_bib18","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.3390\/molecules24244626","article-title":"Endocannabinoid system in the airways","volume":"24","author":"Bozkurt","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jaci.2023.09.043_bib19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1432-1033.1995.tb20780.x","article-title":"Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations","volume":"232","author":"Galiegue","year":"1995","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jaci.2023.09.043_bib20","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1189\/jlb.0404252","article-title":"2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils","volume":"76","author":"Oka","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2023.09.043_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/039463201002300103","article-title":"Detailed characterisation of CB2 receptor protein expression in peripheral blood immune cells from healthy human volunteers using flow cytometry","volume":"23","author":"Graham","year":"2010","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.jaci.2023.09.043_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067560","article-title":"Identification of genes expressed by human airway eosinophils after an in\u00a0vivo allergen challenge","volume":"8","author":"Esnault","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2023.09.043_bib23","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1172\/JCI124611","article-title":"Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases","volume":"129","author":"Agache","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2023.09.043_bib24","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.jaci.2013.12.1081","article-title":"Mechanisms of human eosinophil migration induced by the combination of IL-5 and the endocannabinoid 2-arachidonoyl-glycerol","volume":"133","author":"Larose","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2023.09.043_bib25","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1007\/s00018-016-2300-4","article-title":"The CB2 receptor and its role as a regulator of inflammation","volume":"73","author":"Turcotte","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jaci.2023.09.043_bib26","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3109\/10428199209053629","article-title":"EoL-1, a human eosinophilic cell line","volume":"7","author":"Mayumi","year":"1992","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.jaci.2023.09.043_bib27","first-page":"420","article-title":"Acute effects of smoked marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects","volume":"109","author":"Tashkin","year":"1974","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2023.09.043_bib28","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1378\/chest.70.4.480","article-title":"Effect of oral administration of delta-tetrahydrocannabinol on airway mechanics in normal and asthmatic subjects","volume":"70","author":"Abboud","year":"1976","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2023.09.043_bib29","first-page":"57","article-title":"Bronchial effects of aerosolized delta 9-tetrahydrocannabinol in healthy and asthmatic subjects","volume":"115","author":"Tashkin","year":"1977","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2023.09.043_bib30","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/cvr\/cvp240","article-title":"CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages","volume":"84","author":"Han","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jaci.2023.09.043_bib31","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1348-0421.2007.tb03985.x","article-title":"Induction of preferential chemotaxis of unstimulated B-lymphocytes by 2-arachidonoylglycerol in immunized mice","volume":"51","author":"Tanikawa","year":"2007","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.jaci.2023.09.043_bib32","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1111\/all.14526","article-title":"Role of IL-25, IL-33, and TSLP in triggering united airway diseases toward type 2 inflammation","volume":"75","author":"Hong","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2023.09.043_bib33","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1164\/rccm.201712-2468LE","article-title":"Expression of IL-33 and TSLP and their receptors in asthmatic airways after inhaled allergen challenge","volume":"198","author":"Al-Sajee","year":"2018","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674923024065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674923024065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T16:40:07Z","timestamp":1729096807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674923024065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S0091674923024065"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2023.09.043","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabinoid receptor 2 as a regulator of inflammation induced oleoylethanolamide in eosinophilic asthma","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2023.09.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}