{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:12:48Z","timestamp":1793211168245,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112-2314-B-075-010"],"award-info":[{"award-number":["NSTC 112-2314-B-075-010"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V110B-025"],"award-info":[{"award-number":["V110B-025"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V112C-148"],"award-info":[{"award-number":["V112C-148"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V109B-008"],"award-info":[{"award-number":["V109B-008"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V111B-006"],"award-info":[{"award-number":["V111B-006"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110-2314-B-075-055"],"award-info":[{"award-number":["MOST 110-2314-B-075-055"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jaci.2024.02.021","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T17:15:06Z","timestamp":1710522906000},"page":"325-339.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Murine model of eosinophilic chronic rhinosinusitis with nasal polyposis inducing neuroinflammation and olfactory dysfunction"],"prefix":"10.1016","volume":"154","author":[{"given":"Wei-Hao","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wen","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Ying","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7812-2230","authenticated-orcid":false,"given":"Chien-Fu","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2024.02.021_bib1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1398-9995.2011.02646.x","article-title":"Chronic rhinosinusitis in Europe\u2014an underestimated disease. A\u00a0GA2LEN study","volume":"66","author":"Hastan","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2024.02.021_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jaci.2011.03.017","article-title":"Increased expression of the chemokine CCL23 in eosinophilic chronic rhinosinusitis with nasal polyps","volume":"128","author":"Poposki","year":"2011","journal-title":"J Allergy Clin Immunol"},{"issue":"suppl S29","key":"10.1016\/j.jaci.2024.02.021_bib3","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps, 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2024.02.021_bib4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2332\/allergolint.10-RAI-0231","article-title":"Eosinophilic chronic rhinosinusitis in Japan","volume":"59","author":"Ishitoya","year":"2010","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaci.2024.02.021_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jaci.2021.03.024","article-title":"Rethinking neutrophils and eosinophils in chronic rhinosinusitis","volume":"148","author":"Delemarre","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.02.021_bib6","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.2500\/ar.2012.3.0030","article-title":"Relationships between IL-17A and macrophages or MUC5AC in eosinophilic chronic rhinosinusitis and proposed pathological significance","volume":"3","author":"Ono","year":"2012","journal-title":"Allergy Rhinol (Providence)"},{"key":"10.1016\/j.jaci.2024.02.021_bib7","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0091-6749(97)70218-5","article-title":"Olfactory dysfunction in allergic rhinitis is related to nasal eosinophilic inflammation","volume":"100","author":"Klimek","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.02.021_bib8","first-page":"22","article-title":"Eosinophilic upper airway inflammation in a murine model using an adoptive transfer system induces hyposmia and epithelial layer injury with convex lesions","volume":"7","author":"Kanda","year":"2019","journal-title":"Med Sci (Basel)"},{"key":"10.1016\/j.jaci.2024.02.021_bib9","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1177\/19458924221140965","article-title":"Lipopolysaccharide-initiated rhinosinusitis causes neuroinflammation and olfactory dysfunction in mice","volume":"37","author":"Yeh","year":"2023","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaci.2024.02.021_bib10","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1007\/s00405-017-4717-2","article-title":"Development of a mouse model of eosinophilic chronic rhinosinusitis with nasal polyp by nasal instillation of an Aspergillus protease and ovalbumin","volume":"274","author":"Kim","year":"2017","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jaci.2024.02.021_bib11","doi-asserted-by":"crossref","first-page":"e255","DOI":"10.2500\/ajra.2011.25.3727","article-title":"Staphylococcus aureus enterotoxin B contributes to induction of nasal polypoid lesions in an allergic rhinosinusitis murine model","volume":"25","author":"Kim","year":"2011","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaci.2024.02.021_bib12","article-title":"Simple behavioral assessment of mouse olfaction","author":"Yang","year":"2009","journal-title":"Neurosci"},{"key":"10.1016\/j.jaci.2024.02.021_bib13","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1073\/pnas.0609471104","article-title":"Genomic imprinting mediates sexual experience-dependent olfactory learning in male mice","volume":"104","author":"Swaney","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2024.02.021_bib14","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0952-7915(99)00032-1","article-title":"Animal models of mucosal inflammation and their relation to human inflammatory bowel disease","volume":"11","author":"Blumberg","year":"1999","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2024.02.021_bib15","doi-asserted-by":"crossref","first-page":"396","DOI":"10.21053\/ceo.2019.01837","article-title":"Strain-specific differences in house dust mite (dermatophagoides farinae)-induced mouse models of allergic rhinitis","volume":"13","author":"Lee","year":"2020","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"10.1016\/j.jaci.2024.02.021_bib16","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.otohns.2005.11.048","article-title":"Development of a murine model of chronic rhinosinusitis","volume":"134","author":"Lindsay","year":"2006","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2024.02.021_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/ACI.0000000000000231","article-title":"Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation","volume":"16","author":"Hosoki","year":"2016","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.02.021_bib18","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.jaci.2015.01.003","article-title":"IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis","volume":"135","author":"Shin","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.02.021_bib19","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jaci.2011.07.049","article-title":"Pathogenesis of chronic rhinosinusitis: inflammation","volume":"128","author":"Van Crombruggen","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.02.021_bib20","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.jaci.2022.02.016","article-title":"Mechanisms and pathogenesis of chronic rhinosinusitis","volume":"149","author":"Kato","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.02.021_bib21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.aller.2015.04.004","article-title":"Induction of nasal polyps using house dust mite and staphylococcal enterotoxin B in C57BL\/6 mice","volume":"44","author":"Khalmuratova","year":"2016","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.jaci.2024.02.021_bib22","first-page":"5275","article-title":"Establishment of a mouse model of lipopolysaccharide-induced neutrophilic nasal polyps","volume":"14","author":"Wang","year":"2017","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jaci.2024.02.021_bib23","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1001\/archoto.2010.136","article-title":"Development of an animal model for wound healing in chronic rhinosinusitis","volume":"136","author":"Tansavatdi","year":"2010","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2024.02.021_bib24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4193\/Rhin08.109","article-title":"Relationship between epithelial damage or basement membrane thickness and eosinophilic infiltration in nasal polyps with chronic rhinosinusitis","volume":"47","author":"Saitoh","year":"2009","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2024.02.021_bib25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40463-023-00637-6","article-title":"Murine model for chronic rhinosinusitis: an interventional study","volume":"52","author":"Hamour","year":"2023","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2024.02.021_bib26","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/all.14627","article-title":"A murine model of eosinophilic chronic rhinosinusitis using the topical application of a vitamin D3 analog","volume":"76","author":"Kagoya","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2024.02.021_bib27","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1749-6632.2009.04364.x","article-title":"Analysis of the olfactory mucosa in chronic rhinosinusitis","volume":"1170","author":"Yee","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jaci.2024.02.021_bib28","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2500\/ajra.2010.24.3435","article-title":"Neuropathology of the olfactory mucosa in chronic rhinosinusitis","volume":"24","author":"Yee","year":"2010","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaci.2024.02.021_bib29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/alr.23073","article-title":"Chronic interleukin-13 expression in mouse olfactory mucosa results in regional aneuronal epithelium","volume":"13","author":"Saraswathula","year":"2023","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2024.02.021_bib30","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2500\/ajra.2014.28.4100","article-title":"Development of Aspergillus protease with ovalbumin-induced allergic chronic rhinosinusitis model in the mouse","volume":"28","author":"Kim","year":"2014","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaci.2024.02.021_bib31","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nri.2017.90","article-title":"Type 2 immunity in tissue repair and fibrosis","volume":"18","author":"Gieseck","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2024.02.021_bib32","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.jaci.2004.07.060","article-title":"The role of protease activation of inflammation in allergic respiratory diseases","volume":"114","author":"Reed","year":"2004","journal-title":"J Allergy Clin Immunol"},{"issue":"7090","key":"10.1016\/j.jaci.2024.02.021_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2024.02.021_bib34","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1128\/IAI.05529-11","article-title":"Interleukin-17 drives pulmonary eosinophilia following repeated exposure to Aspergillus fumigatus conidia","volume":"80","author":"Murdock","year":"2012","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2024.02.021_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/968549","article-title":"Pivotal roles of T-helper 17\u2013related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases","volume":"2013","author":"Qu","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.jaci.2024.02.021_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12974-022-02378-1","article-title":"Immunological status of the olfactory bulb in a murine model of Toll-like receptor 3\u2013mediated upper respiratory tract inflammation","volume":"19","author":"Kagoya","year":"2022","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jaci.2024.02.021_bib37","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1038\/s41467-018-07544-9","article-title":"Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map","volume":"9","author":"Albeanu","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2024.02.021_bib38","first-page":"1893","article-title":"Excessive expression of microglia\/macrophage and proinflammatory mediators in olfactory bulb and olfactory dysfunction after stroke","volume":"33","author":"Yeh","year":"2019","journal-title":"In\u00a0Vivo"},{"key":"10.1016\/j.jaci.2024.02.021_bib39","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/all.13559","article-title":"Type 2\/Th2-driven inflammation impairs olfactory sensory neurogenesis in mouse chronic rhinosinusitis model","volume":"74","author":"Rouyar","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2024.02.021_bib40","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3390\/ph14050416","article-title":"Neuroinflammation in sepsis: molecular pathways of microglia activation","volume":"14","author":"Moraes","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"issue":"pt 4","key":"10.1016\/j.jaci.2024.02.021_bib41","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/brain\/awn345","article-title":"Live imaging of Toll-like receptor 2 response in cerebral ischaemia reveals a role of olfactory bulb microglia as modulators of inflammation","volume":"132","author":"Lalancette-Hebert","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.jaci.2024.02.021_bib42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1742-2094-8-77","article-title":"CCL2\/MCP-1 modulation of microglial activation and proliferation","volume":"8","author":"Hinojosa","year":"2011","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jaci.2024.02.021_bib43","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1523\/JNEUROSCI.4507-09.2010","article-title":"A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization","volume":"30","author":"Lane","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.jaci.2024.02.021_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10229-w","article-title":"Lipopolysaccharide-initiated persistent rhinitis causes gliosis and synaptic loss in the olfactory bulb","volume":"7","author":"Hasegawa-Ishii","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2024.02.021_bib45","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1742-2094-9-109","article-title":"Cytokines and olfactory bulb microglia in response to bacterial challenge in the compromised primary olfactory pathway","volume":"9","author":"Herbert","year":"2012","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jaci.2024.02.021_bib46","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1038\/s41598-022-09731-7","article-title":"Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit","volume":"12","author":"Kishimoto-Urata","year":"2022","journal-title":"Sci Rep"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674924002434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674924002434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T11:19:36Z","timestamp":1722856776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674924002434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S0091674924002434"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2024.02.021","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Murine model of eosinophilic chronic rhinosinusitis with nasal polyposis inducing neuroinflammation and olfactory dysfunction","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2024.02.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}