{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:41:11Z","timestamp":1784641271628,"version":"3.55.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"am","delay-in-days":369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jaci.2024.07.021","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T02:01:08Z","timestamp":1722650468000},"page":"1216-1231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders"],"prefix":"10.1016","volume":"154","author":[{"given":"Joseph","family":"Daccache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunsuh","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Junejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Abdelghaffar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitrasen","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John O.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget E.","family":"Shields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline A.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0975-4071","authenticated-orcid":false,"given":"William","family":"Damsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7446","key":"10.1016\/j.jaci.2024.07.021_bib1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2024.07.021_bib2","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jaci.2024.07.021_bib3","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nri3211","article-title":"Revisiting the role of the granuloma in tuberculosis","volume":"12","author":"Ramakrishnan","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2024.07.021_bib4","first-page":"99","article-title":"Macrophage functions in wound healing","volume":"13","author":"Kloc","year":"2019","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.jaci.2024.07.021_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01140","article-title":"The role of monocytes and macrophages in autoimmune diseases: a comprehensive review","volume":"10","author":"Ma","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2024.07.021_bib6","first-page":"187","article-title":"The promise of JAK inhibitors for treatment of sarcoidosis and other inflammatory disorders with macrophage activation: a review of the literature","volume":"93","author":"Wang","year":"2020","journal-title":"Yale J Biol Med"},{"key":"10.1016\/j.jaci.2024.07.021_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ccm.2023.08.004","article-title":"Cutaneous sarcoidosis","volume":"45","author":"Abdelghaffar","year":"2024","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.jaci.2024.07.021_bib8","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/00000372-198911020-00006","article-title":"A comparative histopathologic study of generalized and localized granuloma annulare","volume":"11","author":"Friedman-Birnbaum","year":"1989","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jaci.2024.07.021_bib9","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1001\/archderm.1977.01640120049007","article-title":"Histologic, ultrastructural and histochemical studies of granuloma annulare","volume":"113","author":"Umbert","year":"1977","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaci.2024.07.021_bib10","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1590\/abd1806-4841.20187409","article-title":"Scanning electron microscopy of granuloma annulare","volume":"93","author":"Almeida","year":"2018","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.jaci.2024.07.021_bib11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00561450","article-title":"The ultrastructure of granuloma annulare","volume":"259","author":"Wolff","year":"1977","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jaci.2024.07.021_bib12","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1600-0560.2008.01169.x","article-title":"Collagen-elastic tissue changes and vascular involvement in granuloma annulare: a review of 35 cases","volume":"36","author":"G\u00fcne\u015f","year":"2009","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaci.2024.07.021_bib13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1001\/jamadermatol.2018.5635","article-title":"Clinical features and comorbidities of patients with necrobiosis lipoidica with or without diabetes","volume":"155","author":"Hashemi","year":"2019","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jaci.2024.07.021_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/archderm.1966.01600250007001","article-title":"Necrobiosis lipoidica diabeticorum histopathologic study of 98 cases","volume":"94","author":"Muller","year":"1966","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaci.2024.07.021_bib15","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1001\/jamadermatol.2019.4221","article-title":"A multicenter cross-sectional study and systematic review of necrobiotic xanthogranuloma with proposed diagnostic criteria","volume":"156","author":"Nelson","year":"2020","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jaci.2024.07.021_bib16","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2024.07.021_bib17","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2024.07.021_bib18","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13059-021-02286-2","article-title":"Giotto: a toolbox for integrative analysis and visualization of spatial expression data","volume":"22","author":"Dries","year":"2021","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2024.07.021_bib19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s13059-019-1874-1","article-title":"Normalization and variance stabilization of single-cell RNA-Seq data using regularized negative binomial regression","volume":"20","author":"Hafemeister","year":"2019","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2024.07.021_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giy083","article-title":"Clustering trees: a visualization for evaluating clusterings at multiple resolutions","volume":"7","author":"Zappia","year":"2018","journal-title":"GigaScience"},{"key":"10.1016\/j.jaci.2024.07.021_bib21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13059-021-02362-7","article-title":"SpatialDWLS: accurate deconvolution of spatial transcriptomic data","volume":"22","author":"Dong","year":"2021","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2024.07.021_bib22","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.jaci.2020.10.012","article-title":"Treatment of granuloma annulare and suppression of proinflammatory cytokine activity with tofacitinib","volume":"147","author":"Wang","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.07.021_bib23","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1038\/s41467-022-30615-x","article-title":"Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis","volume":"13","author":"Damsky","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2024.07.021_bib24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.immuni.2023.01.014","article-title":"Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation","volume":"56","author":"Krausgruber","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2024.07.021_bib25","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"MacParland","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2024.07.021_bib26","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1002\/cpz1.90","article-title":"Gene set knowledge discovery with ENRICHR","volume":"1","author":"Xie","year":"2021","journal-title":"Current Protocols"},{"key":"10.1016\/j.jaci.2024.07.021_bib27","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s10753-012-9569-8","article-title":"Evaluation of CHI3L-1 and Chit-1 expression in differentiated and polarized macrophages","volume":"36","author":"Di Rosa","year":"2012","journal-title":"Inflammation"},{"key":"10.1016\/j.jaci.2024.07.021_bib28","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.rmed.2006.12.006","article-title":"A CHI3L1 gene polymorphism is associated with serum levels of YKL-40, a novel sarcoidosis marker","volume":"101","author":"Kruit","year":"2007","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2024.07.021_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145342","article-title":"Novel markers to delineate murine M1 and M2 macrophages","volume":"10","author":"Jablonski","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2024.07.021_bib30","doi-asserted-by":"crossref","first-page":"7203","DOI":"10.1038\/s41467-022-34879-1","article-title":"Spatially aware dimension reduction for spatial transcriptomics","volume":"13","author":"Shang","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2024.07.021_bib31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1186\/s12864-018-4772-0","article-title":"Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics","volume":"19","author":"Street","year":"2018","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jaci.2024.07.021_bib32","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.3389\/fimmu.2020.01768","article-title":"Tape-strip proteomic profiling of atopic dermatitis on dupilumab identifies minimally invasive biomarkers","volume":"11","author":"He","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2024.07.021_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1081\/JAS-120024590","article-title":"Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthma","volume":"41","author":"Kalayci","year":"2004","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2024.07.021_bib34","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1002\/eji.200635972","article-title":"IL-4 induces expression of TARC\/CCL17VIA two STAT6 binding sites","volume":"36","author":"Wirnsberger","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2024.07.021_bib35","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1365-2567.2011.03541.x","article-title":"The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum","volume":"135","author":"Schraufstatter","year":"2012","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2024.07.021_bib36","doi-asserted-by":"crossref","first-page":"6286","DOI":"10.4049\/jimmunol.176.10.6286","article-title":"Involvement of CCL18 in allergic asthma","volume":"176","author":"Nada\u00ef","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2024.07.021_bib37","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.jaci.2014.10.013","article-title":"Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis","volume":"134","author":"Hamilton","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.07.021_bib38","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaad.2019.12.028","article-title":"Granuloma annulare skin profile shows activation of T-helper cell type 1, T-helper cell type 2, and Janus kinase pathways","volume":"83","author":"Min","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2024.07.021_bib39","doi-asserted-by":"crossref","first-page":"eade0385","DOI":"10.1126\/scisignal.ade0385","article-title":"TGF-\u03b2 uncouples glycolysis and inflammation in macrophages and controls survival during sepsis","volume":"16","author":"Gauthier","year":"2023","journal-title":"Sci Signal"},{"key":"10.1016\/j.jaci.2024.07.021_bib40","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/jcb.21558","article-title":"Control of osteopontin signaling and function by post-translational phosphorylation and protein folding","volume":"102","author":"Kazanecki","year":"2007","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jaci.2024.07.021_bib41","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.3390\/ijms21041275","article-title":"Interleukin-17A and keratinocytes in psoriasis","volume":"21","author":"Furue","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2024.07.021_bib42","doi-asserted-by":"crossref","first-page":"11283","DOI":"10.18632\/oncotarget.2207","article-title":"Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4\/CXCL12 axis and promote their polarization toward the M2 phenotype","volume":"5","author":"Beider","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.jaci.2024.07.021_bib43","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1182\/bloodadvances.2017010801","article-title":"Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss","volume":"1","author":"Zahoor","year":"2017","journal-title":"Blood Adv"},{"key":"10.1016\/j.jaci.2024.07.021_bib44","first-page":"1","article-title":"The biology and role of interleukin-32 in tuberculosis","volume":"2018","author":"Li","year":"2018","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jaci.2024.07.021_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.xjidi.2023.100220","article-title":"Molecularly targeted therapies\u00a0for inflammatory cutaneous granulomatous disorders: a review of the evidence and implications for understanding disease pathogenesis","volume":"3","author":"Hwang","year":"2023","journal-title":"JID Innov"},{"key":"10.1016\/j.jaci.2024.07.021_bib46","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1164\/rccm.200205-487OC","article-title":"Expression of macrophage inflammatory protein-3\u03b2\/CCL19 in pulmonary sarcoidosis","volume":"167","author":"Gibejova","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2024.07.021_bib47","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.jaci.2021.01.013","article-title":"Biomarkers in atopic dermatitis\u2014a review on behalf of the International Eczema Council","volume":"147","author":"Renert-Yuval","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.07.021_bib48","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/cea.12065","article-title":"Role of CCL18 in asthma and lung immunity","volume":"43","author":"Tsicopoulos","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2024.07.021_bib49","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jaci.2020.07.012","article-title":"Increased nasal mucosal interferon and CCL13 response to a TLR7\/8 agonist in asthma and allergic rhinitis","volume":"147","author":"Jha","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.07.021_bib50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1600-0560.1985.tb00424.x","article-title":"Eosinophils in the cellular infiltrate of granuloma annulare","volume":"12","author":"Silverman","year":"1985","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaci.2024.07.021_bib51","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00000372-199802000-00006","article-title":"Eosinophils are not a clue to the pathogenesis of granuloma annulare","volume":"20","author":"Romero","year":"1998","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jaci.2024.07.021_bib52","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1001\/jamadermatol.2018.0756","article-title":"Improvement in ulcerative necrobiosis lipoidica after Janus kinase\u2013inhibitor therapy for polycythemia vera","volume":"154","author":"Lee","year":"2018","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jaci.2024.07.021_bib53","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jdcr.2019.11.016","article-title":"Treatment of necrobiosis lipoidica with combination Janus kinase inhibition and intralesional corticosteroid","volume":"6","author":"Damsky","year":"2020","journal-title":"JAAD Case Rep"},{"key":"10.1016\/j.jaci.2024.07.021_bib54","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/ijd.16780","article-title":"Treatment of necrobiosis lipoidica with secukinumab (Cosentyx): a case series","volume":"62","author":"Gibson","year":"2023","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jaci.2024.07.021_bib55","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.3390\/ijms14036044","article-title":"The role of metallothionein in oxidative stress","volume":"14","author":"Ruttkay-Nedecky","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2024.07.021_bib56","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.immuni.2013.09.006","article-title":"Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival","volume":"39","author":"Subramanian Vignesh","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2024.07.021_bib57","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jdcr.2021.11.005","article-title":"Squamous cell carcinoma arising in long-standing necrobiosis lipoidica treated with radical resection and split-thickness skin graft","volume":"19","author":"Xie","year":"2022","journal-title":"JAAD Case Rep"},{"key":"10.1016\/j.jaci.2024.07.021_bib58","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s41591-020-0880-x","article-title":"BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the combat trial","volume":"26","author":"Bockorny","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2024.07.021_bib59","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/1523-1747.ep12525395","article-title":"Necrobiosis lipoidica: ultrastructural and biochemical demonstration of a collagen defect","volume":"88","author":"Oikarinen","year":"1987","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2024.07.021_bib60","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/DAD.0000000000001584","article-title":"CD34 staining in disorders of collagen degeneration other than morphea","volume":"42","author":"Borretta","year":"2019","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jaci.2024.07.021_bib61","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/DAD.0000000000002002","article-title":"CD34 staining as a useful tool in disorders of collagen degeneration","volume":"44","author":"Lee","year":"2021","journal-title":"Am J Dermatopathol"},{"issue":"4","key":"10.1016\/j.jaci.2024.07.021_bib62","doi-asserted-by":"crossref","DOI":"10.4172\/2155-9554.1000226","article-title":"Impairment of angiogenesis in patients with granuloma annulare and necrobiosis lipoidica","volume":"5","author":"Lesiak","year":"2014","journal-title":"J Clin Exp Dermatol Res"},{"key":"10.1016\/j.jaci.2024.07.021_bib63","doi-asserted-by":"crossref","first-page":"e0185346","DOI":"10.1371\/journal.pone.0185346","article-title":"Osteopontin activates mesenchymal stem cells to repair skin wound","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2024.07.021_bib64","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1161\/CIRCULATIONAHA.118.035047","article-title":"IL (interleukin)-10\u2013STAT3\u2013galectin-3 axis is essential for osteopontin-producing reparative macrophage polarization after myocardial infarction","volume":"138","author":"Shirakawa","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jaci.2024.07.021_bib65","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1093\/hmg\/ddz181","article-title":"SPP1 (osteopontin) promotes TGF\u0392 processing in fibroblasts of dystrophin-deficient muscles through matrix metalloproteinases","volume":"28","author":"Kramerova","year":"2019","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jaci.2024.07.021_bib66","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1001\/jamadermatol.2021.1847","article-title":"Incidence and prevalence of granuloma annulare in the United States","volume":"157","author":"Barbieri","year":"2021","journal-title":"JAMA Dermatol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674924007784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674924007784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:17:01Z","timestamp":1730809021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674924007784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0091674924007784"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2024.07.021","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2024.07.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}