{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:19:13Z","timestamp":1792451953305,"version":"4.5.0"},"reference-count":97,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024312","name":"LEW Carty Charitable Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009727","name":"Hospital Research Foundation","doi-asserted-by":"publisher","award":["2022-SF-EOI-001"],"award-info":[{"award-number":["2022-SF-EOI-001"]}],"id":[{"id":"10.13039\/100009727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["108818"],"award-info":[{"award-number":["108818"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1154344"],"award-info":[{"award-number":["1154344"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jaci.2024.08.017","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T12:16:55Z","timestamp":1724847415000},"page":"94-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Deep multiomic profiling reveals molecular signatures that underpin preschool wheeze and asthma"],"prefix":"10.1016","volume":"155","author":[{"given":"Matthew","family":"Macowan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9920-1181","authenticated-orcid":false,"given":"C\u00e9line","family":"Pattaroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Bonner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanne","family":"Chatzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel","family":"Daunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy","family":"Gore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Custovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Shields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ultan F.","family":"Power","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Grigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ghazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Schwarze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sejal","family":"Saglani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare M.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Marsland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2024.08.017_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life. The Group Health Medical Associates","volume":"332","author":"Martinez","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2024.08.017_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jaci.2012.05.022","article-title":"Long-term outcomes of early-onset wheeze and asthma","volume":"130","author":"Grad","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib3","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.jaci.2020.12.643","article-title":"Burden of preschool wheeze and progression to asthma in the UK: population-based cohort 2007 to 2017","volume":"147","author":"Bloom","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib4","doi-asserted-by":"crossref","DOI":"10.1111\/pai.14038","article-title":"From preschool wheezing to asthma: immunological determinants","volume":"34","author":"Laubhahn","year":"2023","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib5","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1183\/09031936.97.10020346","article-title":"Factors relating to the severity of symptoms at 5 yrs in children with severe wheeze in the first 2 yrs of life","volume":"10","author":"Wilson","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2024.08.017_bib6","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1183\/13993003.01196-2014","article-title":"Novel concepts in airway inflammation and remodelling in asthma","volume":"46","author":"Saglani","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2024.08.017_bib7","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.jaip.2017.02.003","article-title":"Neutrophilic steroid-refractory recurrent wheeze and eosinophilic steroid-refractory asthma in children","volume":"5","author":"Guiddir","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2024.08.017_bib8","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1056\/NEJMoa052632","article-title":"Childhood asthma after bacterial colonization of the airway in neonates","volume":"357","author":"Bisgaard","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2024.08.017_bib9","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1164\/rccm.202009-3696OC","article-title":"Recurrent severe preschool wheeze: from prespecified diagnostic labels to underlying endotypes","volume":"204","author":"Robinson","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2024.08.017_bib10","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1183\/13993003.00405-2015","article-title":"Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma","volume":"47","author":"Simpson","year":"2016","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2024.08.017_bib11","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/s41385-022-00541-8","article-title":"Lung microbial-host interface through the lens of multi-omics","volume":"15","author":"Singh","year":"2022","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib12","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1111\/all.14438","article-title":"Integration of metagenomics-metabolomics reveals specific signatures and functions of airway microbiota in mite-sensitized childhood asthma","volume":"75","author":"Chiu","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2024.08.017_bib13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11882-022-01056-9","article-title":"Understanding the functional role of the microbiome and metabolome in asthma","volume":"23","author":"Cobos-Uribe","year":"2023","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2024.08.017_bib14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.12688\/wellcomeopenres.14489.1","article-title":"Pulmonary epithelial barrier and immunological functions at birth and in early life\u2014key determinants of the development of asthma? A\u00a0description of the protocol for the Breathing Together study","volume":"3","author":"Turner","year":"2018","journal-title":"Wellcome Open Res"},{"key":"10.1016\/j.jaci.2024.08.017_bib15","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1046\/j.1365-2222.2003.01752.x","article-title":"Non-bronchoscopic sampling and culture of bronchial epithelial cells in children","volume":"33","author":"Doherty","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2024.08.017_bib16","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.jaci.2012.01.059","article-title":"Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines","volume":"129","author":"Bossley","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib17","first-page":"1","article-title":"Immunoglobulin E as a biomarker for the overlap of atopic asthma and chronic obstructive pulmonary disease","volume":"7","author":"Hersh","year":"2020","journal-title":"Chronic Obstr Pulm Dis"},{"key":"10.1016\/j.jaci.2024.08.017_bib18","author":"Patel"},{"key":"10.1016\/j.jaci.2024.08.017_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2024.08.017_bib20","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2024.08.017_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40168-021-01201-y","article-title":"Early life inter-kingdom interactions shape the immunological environment of the airways","volume":"10","author":"Pattaroni","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.jaci.2024.08.017_bib22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41590-020-00856-3","article-title":"Microbial metabolism of L-tyrosine protects against allergic airway inflammation","volume":"22","author":"Wypych","year":"2021","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40168-019-0658-x","article-title":"Sunbeam: an extensible pipeline for analyzing metagenomic sequencing experiments","volume":"7","author":"Clarke","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.jaci.2024.08.017_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/afa5c40d-c604-46ae-84c4-82cb92193a5e","article-title":"A filtering method to generate high quality short reads using Illumina paired-end technology","volume":"8","author":"Eren","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2024.08.017_bib25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13059-019-1891-0","article-title":"Improved metagenomic analysis with Kraken 2","volume":"20","author":"Wood","year":"2019","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2024.08.017_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jaci.2024.08.017_bib27","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.jmb.2015.11.006","article-title":"BlastKOALA and GhostKOALA: KEGG tools for functional characterization of genome and metagenome sequences","volume":"428","author":"Kanehisa","year":"2016","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jaci.2024.08.017_bib28","author":"Lahti"},{"key":"10.1016\/j.jaci.2024.08.017_bib29","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/s41587-020-0531-2","article-title":"A lipidome atlas in MS-DIAL 4","volume":"38","author":"Tsugawa","year":"2020","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jaci.2024.08.017_bib30","doi-asserted-by":"crossref","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","article-title":"HMDB 4.0: the human metabolome database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2024.08.017_bib31","author":"Jankevics"},{"key":"10.1016\/j.jaci.2024.08.017_bib32","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/jms.1777","article-title":"MassBank: a public repository for sharing mass spectral data for life sciences","volume":"45","author":"Horai","year":"2010","journal-title":"J Mass Spectrom"},{"key":"10.1016\/j.jaci.2024.08.017_bib33","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/bioinformatics\/btr597","article-title":"MissForest\u2014non-parametric missing value imputation for mixed-type data","volume":"28","author":"Stekhoven","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2024.08.017_bib35","author":"Wickham"},{"key":"10.1016\/j.jaci.2024.08.017_bib36","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1158\/0008-5472.CAN-17-0344","article-title":"Software for the integration of multi-omics experiments in Bioconductor","volume":"77","author":"Ramos","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaci.2024.08.017_bib37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13059-020-02015-1","article-title":"MOFA+: a statistical framework for comprehensive integration of multi-modal single-cell data","volume":"21","author":"Argelaguet","year":"2020","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2024.08.017_bib38","author":"Oksanen"},{"key":"10.1016\/j.jaci.2024.08.017_bib39","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1038\/s41591-023-02327-2","article-title":"An integrated cell atlas of the lung in health and disease","volume":"29","author":"Sikkema","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2024.08.017_bib40","doi-asserted-by":"crossref","DOI":"10.1093\/bioadv\/vbac016","article-title":"decoupleR: ensemble of computational methods to infer biological activities from omics data","volume":"2","author":"Badia-I-Mompel","year":"2022","journal-title":"Bioinform Adv"},{"key":"10.1016\/j.jaci.2024.08.017_bib41","article-title":"ComBat-seq: batch effect adjustment for RNA-seq count data","volume":"2","author":"Zhang","year":"2020","journal-title":"NAR Genom Bioinform"},{"key":"10.1016\/j.jaci.2024.08.017_bib42","doi-asserted-by":"crossref","first-page":"7706","DOI":"10.1016\/S0021-9258(20)89506-4","article-title":"Identification of p8,14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells","volume":"266","author":"Edgeworth","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2024.08.017_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102195","article-title":"Biochemical characterization of the first step in sulfonolipid biosynthesis in Alistipes finegoldii","volume":"298","author":"Radka","year":"2022","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2024.08.017_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2022.101194","article-title":"Anandamide and other N-acylethanolamines: a class of signaling lipids with therapeutic opportunities","volume":"89","author":"Mock","year":"2023","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.jaci.2024.08.017_bib45","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02086-2016","article-title":"The microbiome in respiratory medicine: current challenges and future perspectives","volume":"49","author":"Faner","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2024.08.017_bib46","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.2147\/IJGM.S304339","article-title":"Diversity of microbial signatures in asthmatic airways","volume":"14","author":"Alamri","year":"2021","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.jaci.2024.08.017_bib47","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.4049\/jimmunol.139.10.3474","article-title":"Purification and partial biochemical characterization of a human monocyte-derived, neutrophil-activating peptide that lacks interleukin 1 activity","volume":"139","author":"Schr\u00f6der","year":"1987","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib48","doi-asserted-by":"crossref","first-page":"9233","DOI":"10.1073\/pnas.84.24.9233","article-title":"Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines","volume":"84","author":"Yoshimura","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2024.08.017_bib49","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.2741\/2853","article-title":"The role of chemokines in neutrophil biology","volume":"13","author":"Kobayashi","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.jaci.2024.08.017_bib50","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cellsig.2018.11.004","article-title":"How do chemokines navigate neutrophils to the target site: dissecting the structural mechanisms and signaling pathways","volume":"54","author":"Rajarathnam","year":"2019","journal-title":"Cell Signal"},{"key":"10.1016\/j.jaci.2024.08.017_bib51","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00827-2019","article-title":"Airway G-CSF identifies neutrophilic inflammation and contributes to asthma progression","volume":"55","author":"Kim","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2024.08.017_bib52","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1165\/rcmb.2004-0196OC","article-title":"Primary human alveolar type II epithelial cell CCL20 (macrophage inflammatory protein-3alpha)-induced dendritic cell migration","volume":"32","author":"Thorley","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2024.08.017_bib53","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cmet.2014.12.002","article-title":"Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability","volume":"21","author":"Lodhi","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.jaci.2024.08.017_bib54","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1165\/ajrcmb.22.3.3713","article-title":"Nonproteolytic role for the urokinase receptor in cellular migration in\u00a0vivo","volume":"22","author":"Waltz","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2024.08.017_bib55","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3389\/fimmu.2019.01068","article-title":"L-selectin: a major regulator of leukocyte adhesion, migration and signaling","volume":"10","author":"Ivetic","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib56","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00441-017-2774-x","article-title":"A head-to-tail view of L-selectin and its impact on neutrophil behaviour","volume":"371","author":"Ivetic","year":"2018","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jaci.2024.08.017_bib57","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1189\/jlb.71.2.212","article-title":"Neutrophil leukocyte motility requires directed water influx","volume":"71","author":"Loitto","year":"2002","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2024.08.017_bib58","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000353229","article-title":"CCR5 and FPR1 mediate neutrophil recruitment in endotoxin-induced lung injury","volume":"6","author":"Grommes","year":"2014","journal-title":"J Innate Immun"},{"key":"10.1016\/j.jaci.2024.08.017_bib59","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.3389\/fmicb.2017.01719","article-title":"FPR2: a novel promising target for the treatment of influenza","volume":"8","author":"Alessi","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jaci.2024.08.017_bib60","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1084\/jem.180.1.253","article-title":"Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor","volume":"180","author":"Fiore","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2024.08.017_bib61","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3389\/fimmu.2018.01298","article-title":"S100A8\/A9 in inflammation","volume":"9","author":"Wang","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib62","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/jlb.53.2.197","article-title":"MRP-8 and MRP-14, two abundant Ca(2+)-binding proteins of neutrophils and monocytes","volume":"53","author":"Hessian","year":"1993","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2024.08.017_bib63","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1021\/acschembio.2c00141","article-title":"Identification and biosynthesis of pro-inflammatory sulfonolipids from an opportunistic pathogen Chryseobacterium gleum","volume":"17","author":"Hou","year":"2022","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.jaci.2024.08.017_bib64","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1164\/rccm.200804-595SO","article-title":"Sphingolipids in the lungs","volume":"178","author":"Uhlig","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2024.08.017_bib65","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.jaci.2020.10.024","article-title":"Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma","volume":"147","author":"James","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib66","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1016\/j.febslet.2005.08.002","article-title":"Differential regulation of dual NADPH oxidases\/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium","volume":"579","author":"Harper","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jaci.2024.08.017_bib67","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s12931-017-0707-6","article-title":"Lack of SOCS3 increases LPS-induced murine acute lung injury through modulation of Ly6C(+) macrophages","volume":"18","author":"Jiang","year":"2017","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2024.08.017_bib68","doi-asserted-by":"crossref","first-page":"L868","DOI":"10.1152\/ajplung.00281.2016","article-title":"Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury","volume":"311","author":"Zhao","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2024.08.017_bib69","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/JLB.4RU0219-051RR","article-title":"Contribution of IDO to human respiratory syncytial virus infection","volume":"106","author":"Benavente","year":"2019","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2024.08.017_bib70","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/bj3260351","article-title":"Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types","volume":"326","author":"Heyes","year":"1997","journal-title":"Biochem J"},{"key":"10.1016\/j.jaci.2024.08.017_bib71","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/391984","article-title":"Remarkable role of indoleamine 2,3-dioxygenase and tryptophan metabolites in infectious diseases: potential role in macrophage-mediated inflammatory diseases","volume":"2013","author":"Murakami","year":"2013","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jaci.2024.08.017_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/abbi.1999.1381","article-title":"Evidence for increased de novo synthesis of NAD in immune-activated RAW264.7 macrophages: a self-protective mechanism?","volume":"372","author":"Grant","year":"1999","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jaci.2024.08.017_bib73","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.iac.2022.05.004","article-title":"Viral infections and wheezing in preschool children","volume":"42","author":"Doss","year":"2022","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaci.2024.08.017_bib74","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/s41385-020-00370-7","article-title":"Cellular and functional heterogeneity of the airway epithelium","volume":"14","author":"Davis","year":"2021","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib75","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12920-022-01241-9","article-title":"Identifying key genes and functionally enriched pathways in Th2-high asthma by weighted gene co-expression network analysis","volume":"15","author":"Cao","year":"2022","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.jaci.2024.08.017_bib76","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.3390\/ijms20164037","article-title":"Consistent biomarkers and related pathogenesis underlying asthma revealed by systems biology approach","volume":"20","author":"Nie","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2024.08.017_bib77","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/cts.13078","article-title":"Type-2 airway inflammation in mild asthma patients with high blood eosinophils and high fractional exhaled nitric oxide","volume":"14","author":"Southworth","year":"2021","journal-title":"Clin Transl Sci"},{"key":"10.1016\/j.jaci.2024.08.017_bib78","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/all.12828","article-title":"Current and future biomarkers in allergic asthma","volume":"71","author":"Zissler","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2024.08.017_bib79","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/jcm6120112","article-title":"Airway mucus and asthma: the role of MUC5AC and MUC5B","volume":"6","author":"Bonser","year":"2017","journal-title":"J Clin Med"},{"key":"10.1016\/j.jaci.2024.08.017_bib80","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1164\/ajrccm.163.2.2004039","article-title":"Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression","volume":"163","author":"Ordo\u00f1ez","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2024.08.017_bib81","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.coph.2004.01.011","article-title":"Airway mucus hypersecretion in asthma: an undervalued pathology?","volume":"4","author":"Rogers","year":"2004","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.jaci.2024.08.017_bib82","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0091-6749(99)70379-9","article-title":"Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma","volume":"104","author":"Hoshino","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107872","article-title":"Single-cell and population transcriptomics reveal pan-epithelial remodeling in type 2-high asthma","volume":"32","author":"Jackson","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2024.08.017_bib84","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1164\/rccm.200409-1185OC","article-title":"Gelsolin secretion in interleukin-4-treated bronchial epithelia and in asthmatic airways","volume":"172","author":"Candiano","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2024.08.017_bib85","first-page":"261","article-title":"Circulating actin-gelsolin complexes following oleic acid-induced lung injury","volume":"130","author":"Smith","year":"1988","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2024.08.017_bib86","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1126\/science.8310295","article-title":"Reduction in viscosity of cystic fibrosis sputum in\u00a0vitro by gelsolin","volume":"263","author":"Vasconcellos","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.jaci.2024.08.017_bib87","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.jaci.2007.10.024","article-title":"IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids","volume":"120","author":"Blanchard","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib88","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/mi.2015.98","article-title":"LRRC31 is induced by IL-13 and regulates kallikrein expression and barrier function in the esophageal epithelium","volume":"9","author":"D\u2019Mello","year":"2016","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib89","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3390\/microorganisms11040939","article-title":"Paediatric asthma and the microbiome: a systematic review","volume":"11","author":"Aldriwesh","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.jaci.2024.08.017_bib90","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10096-006-0166-3","article-title":"Bacterial coinfections in children with viral wheezing","volume":"25","author":"Lehtinen","year":"2006","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jaci.2024.08.017_bib91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008578","article-title":"Disordered microbial communities in asthmatic airways","volume":"5","author":"Hilty","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2024.08.017_bib92","doi-asserted-by":"crossref","DOI":"10.3389\/falgy.2021.692841","article-title":"Respiratory viral and bacterial factors that influence early childhood asthma","volume":"2","author":"Mthembu","year":"2021","journal-title":"Front Allergy"},{"key":"10.1016\/j.jaci.2024.08.017_bib93","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/imm.13195","article-title":"Respiratory microbiome and epithelial interactions shape immunity in the lungs","volume":"160","author":"Invernizzi","year":"2020","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2024.08.017_bib94","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/mi.2016.108","article-title":"The respiratory tract microbiome and lung inflammation: a two-way street","volume":"10","author":"Huffnagle","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2024.08.017_bib95","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fped.2019.00072","article-title":"Cytokines and chemokines as biomarkers of future asthma","volume":"7","author":"Bush","year":"2019","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jaci.2024.08.017_bib96","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1183\/09031936.06.00030605","article-title":"Investigation of young children with severe recurrent wheeze: any clinical benefit?","volume":"27","author":"Saglani","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2024.08.017_bib97","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1164\/rccm.201411-1958OC","article-title":"Airway remodeling in preschool children with severe recurrent wheeze","volume":"192","author":"Lezmi","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2024.08.017_bib98","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/j.jaip.2021.02.045","article-title":"Which wheezing preschoolers should be treated for asthma?","volume":"9","author":"Bacharier","year":"2021","journal-title":"J Allergy Clin Immunol Pract"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674924008698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674924008698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:45:52Z","timestamp":1762231552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674924008698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":97,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0091674924008698"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2024.08.017","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deep multiomic profiling reveals molecular signatures that underpin preschool wheeze and asthma","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2024.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}