{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:43:37Z","timestamp":1784803417087,"version":"3.55.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015633","name":"The University of Alabama at Birmingham Kaul Pediatric Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002136","name":"Histiocytosis Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HD-098428"],"award-info":[{"award-number":["R01-HD-098428"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AI-121250-A1"],"award-info":[{"award-number":["R01-AI-121250-A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jaci.2024.10.004","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T05:48:25Z","timestamp":1729144105000},"page":"1015-1026.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of DOCK8 in cytokine storm syndromes"],"prefix":"10.1016","volume":"155","author":[{"given":"Mingce","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy R.","family":"Cron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niansheng","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junior","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa M.","family":"Eloseily","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Prescott","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Weiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Portia A.","family":"Kreiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W.","family":"Canna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2661-3086","authenticated-orcid":false,"given":"Randy Q.","family":"Cron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2024.10.004_bib1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jaci.2020.09.016","article-title":"Highways to hell: mechanism-based management of cytokine storm syndromes","volume":"146","author":"Canna","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib2","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1182\/blood-2011-03-278127","article-title":"How I treat hemophagocytic lymphohistiocytosis","volume":"118","author":"Jordan","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2024.10.004_bib3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev-med-041610-134208","article-title":"Familial and acquired hemophagocytic lymphohistiocytosis","volume":"63","author":"Janka","year":"2012","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jaci.2024.10.004_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s40272-019-00367-1","article-title":"Macrophage activation syndrome and secondary hemophagocytic lymphohistiocytosis in childhood inflammatory disorders: diagnosis and management","volume":"22","author":"Henderson","year":"2020","journal-title":"Paediatr Drugs"},{"key":"10.1016\/j.jaci.2024.10.004_bib5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s11926-014-0439-2","article-title":"Genetic defects in cytolysis in macrophage activation syndrome","volume":"16","author":"Zhang","year":"2014","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.jaci.2024.10.004_bib6","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jaci.2023.07.023","article-title":"Severe adult hemophagocytic lymphohistiocytosis (HLHa) correlates with HLH-related gene variants","volume":"153","author":"Bloch","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib7","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1002\/art.38793","article-title":"Whole-exome sequencing reveals overlap between macrophage activation syndrome in systemic juvenile idiopathic arthritis and familial hemophagocytic lymphohistiocytosis","volume":"66","author":"Kaufman","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jaci.2024.10.004_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/infdis\/jiad059","article-title":"Mycobacterial immune reconstitution inflammatory syndrome in HIV is associated with protein-altering variants in hemophagocytic lymphohistiocytosis-related genes","volume":"228","author":"Rocco","year":"2023","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2024.10.004_bib9","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/infdis\/jiv550","article-title":"Whole-exome sequencing reveals mutations in genes linked to hemophagocytic lymphohistiocytosis and macrophage activation syndrome in fatal cases of H1N1 influenza","volume":"213","author":"Schulert","year":"2016","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2024.10.004_bib10","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1002\/art.23734","article-title":"Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms","volume":"58","author":"Zhang","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2024.10.004_bib11","doi-asserted-by":"crossref","first-page":"5794","DOI":"10.1182\/blood-2011-07-370148","article-title":"Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial hemophagocytic lymphohistiocytosis","volume":"118","author":"Zhang","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2024.10.004_bib12","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3899\/jrheum.121233","article-title":"Reaching the threshold: a multilayer pathogenesis of macrophage activation syndrome","volume":"40","author":"Strippoli","year":"2013","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jaci.2024.10.004_bib13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1182\/blood-2017-11-814244","article-title":"Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis","volume":"132","author":"Chinn","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2024.10.004_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/imr.12723","article-title":"Insights into immunity from clinical and basic science studies of DOCK8 immunodeficiency syndrome","volume":"287","author":"Su","year":"2019","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2024.10.004_bib15","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.4049\/jimmunol.1700751","article-title":"DOCK8 drives Src-dependent NK cell effector function","volume":"199","author":"Kearney","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib16","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.jaci.2012.12.1568","article-title":"Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency","volume":"131","author":"Mizesko","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib17","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1084\/jem.20190147","article-title":"A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function","volume":"216","author":"Lam","year":"2019","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2024.10.004_bib18","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/art.38690","article-title":"Development and validation of a score for the diagnosis of reactive hemophagocytic syndrome (HScore)","volume":"66","author":"Fardet","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jaci.2024.10.004_bib19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jaci.2024.10.004_bib20","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.4049\/jimmunol.1501284","article-title":"A heterozygous RAB27A mutation associated with delayed cytolytic granule polarization and hemophagocytic lymphohistiocytosis","volume":"196","author":"Zhang","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib21","first-page":"417","article-title":"Hemophagocytic lymphohistiocytosis gene variants in multisystem inflammatory syndrome in children","volume":"11","author":"Vagrecha","year":"2022","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.jaci.2024.10.004_bib22","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1517\/14712590903246388","article-title":"Foamy virus vectors for gene transfer","volume":"9","author":"Trobridge","year":"2009","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.jaci.2024.10.004_bib23","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.4049\/jimmunol.1103129","article-title":"Host factor transcriptional regulation contributes to preferential expression of HIV type 1 in IL-4-producing CD4 T cells","volume":"189","author":"Zhang","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jim.2006.01.023","article-title":"Effective gene suppression using small interfering RNA in hard-to-transfect human T cells","volume":"312","author":"Yin","year":"2006","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jaci.2024.10.004_bib25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ymeth.2017.03.021","article-title":"Simplified CRISPR tools for efficient genome editing and streamlined protocols for their delivery into mammalian cells and mouse zygotes","volume":"121\/122","author":"Jacobi","year":"2017","journal-title":"Methods"},{"key":"10.1016\/j.jaci.2024.10.004_bib26","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/ni.1820","article-title":"Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production","volume":"10","author":"Randall","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib27","doi-asserted-by":"crossref","first-page":"7014","DOI":"10.4049\/jimmunol.166.12.7014","article-title":"Cutting edge: IL-18-transgenic mice: in\u00a0vivo evidence of a broad role for IL-18 in modulating immune function","volume":"166","author":"Hoshino","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib28","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/art.41591","article-title":"Amelioration of murine macrophage activation syndrome by monomethyl fumarate in both a heme oxygenase 1-dependent and heme oxygenase 1-independent manner","volume":"73","author":"Biswas","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jaci.2024.10.004_bib29","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.4049\/jimmunol.1202792","article-title":"Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity","volume":"190","author":"Ham","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib30","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41423-019-0277-2","article-title":"NK cell detachment from target cells is regulated by successful cytotoxicity and influences cytokine production","volume":"17","author":"Anft","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1084\/jem.20140964","article-title":"Failed CTL\/NK cell killing and cytokine hypersecretion are\u00a0directly linked through prolonged synapse time","volume":"212","author":"Jenkins","year":"2015","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2024.10.004_bib32","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2281","article-title":"Assaying the effects of splice site variants by exon trapping in a mammalian cell line","volume":"7","author":"Tompson","year":"2017","journal-title":"Bio Protoc"},{"key":"10.1016\/j.jaci.2024.10.004_bib33","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1084\/jem.20141307","article-title":"DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity","volume":"211","author":"Zhang","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2024.10.004_bib34","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1182\/blood-2003-10-3413","article-title":"An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder","volume":"104","author":"Jordan","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2024.10.004_bib35","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.4049\/jimmunol.2200808","article-title":"The multifaceted immunology of cytokine storm syndrome","volume":"210","author":"Lee","year":"2023","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib36","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.4049\/jimmunol.1500774","article-title":"Kill or be killed","volume":"194","author":"Behrens","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib37","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1126\/science.286.5446.1957","article-title":"Perforin gene defects in familial hemophagocytic lymphohistiocytosis","volume":"286","author":"Stepp","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jaci.2024.10.004_bib38","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1182\/blood.2019003846","article-title":"Interleukin-18 and cytotoxic impairment are independent and synergistic causes of murine virus-induced hyperinflammation","volume":"136","author":"Tsoukas","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2024.10.004_bib39","doi-asserted-by":"crossref","first-page":"6949","DOI":"10.1182\/bloodadvances.2023010502","article-title":"Complementary HLH susceptibility factors converge on CD8 T-cell hyperactivation","volume":"7","author":"Landy","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.jaci.2024.10.004_bib40","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1182\/blood.2020009499","article-title":"T-cell activation profiles distinguish hemophagocytic lymphohistiocytosis and early sepsis","volume":"137","author":"Chaturvedi","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2024.10.004_bib41","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1182\/blood.2021013549","article-title":"Expansion of CD4dimCD8+ T cells characterizes macrophage activation syndrome and other secondary HLH","volume":"140","author":"De Matteis","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2024.10.004_bib42","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1084\/jem.20110345","article-title":"DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice","volume":"208","author":"Randall","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2024.10.004_bib43","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1182\/blood-2014-11-610816","article-title":"Hemophagocytic lymphohistiocytosis caused by dominant-negative mutations in STXBP2 that inhibit SNARE-mediated membrane fusion","volume":"125","author":"Spessott","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2024.10.004_bib44","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41435-020-0098-4","article-title":"The genetics of macrophage activation syndrome","volume":"21","author":"Schulert","year":"2020","journal-title":"Genes Immun"},{"key":"10.1016\/j.jaci.2024.10.004_bib45","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.jaci.2011.12.1003","article-title":"Novel mutation in STXBP2 prevents IL-2-induced natural killer cell cytotoxicity","volume":"129","author":"Saltzman","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib46","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/01.TP.0000107285.86939.37","article-title":"Hemophagocytic syndrome in renal transplant recipients: report of 17 cases and review of literature","volume":"77","author":"Karras","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.jaci.2024.10.004_bib47","doi-asserted-by":"crossref","first-page":"E83","DOI":"10.1111\/petr.12235","article-title":"Bartonella henselae infection inducing hemophagocytic lymphohistiocytosis in a kidney transplant recipient","volume":"18","author":"Poudel","year":"2014","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.jaci.2024.10.004_bib48","first-page":"953","article-title":"Development of spondyloarthropathy following episodes of macrophage activation syndrome in children with heterozygous mutations in haemophagocytic lymphohistiocytosis-associated genes","volume":"34","author":"Cron","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jaci.2024.10.004_bib49","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-med-042921-112837","article-title":"Cytokine storm syndrome","volume":"74","author":"Cron","year":"2023","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jaci.2024.10.004_bib50","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1086\/379615","article-title":"Candidiasis-associated hemophagocytic lymphohistiocytosis in a patient infected with human immunodeficiency virus","volume":"37","author":"Bhatia","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaci.2024.10.004_bib51","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/art.40438","article-title":"Brief report: novel UNC13D intronic variant disrupting an NF-kappaB enhancer in a patient with recurrent macrophage activation syndrome and systemic juvenile idiopathic arthritis","volume":"70","author":"Schulert","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jaci.2024.10.004_bib52","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jaci.2014.01.023","article-title":"A case of partial dedicator of cytokinesis 8 deficiency with altered effector phenotype and impaired CD8(+) and natural killer cell cytotoxicity","volume":"134","author":"Ruiz-Garcia","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib53","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1056\/NEJMoa0905506","article-title":"Combined immunodeficiency associated with DOCK8 mutations","volume":"361","author":"Zhang","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2024.10.004_bib54","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.immuni.2007.05.007","article-title":"The hyper IgE syndrome and mutations in TYK2","volume":"26","author":"Woellner","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2024.10.004_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.985433","article-title":"MIS-C: a COVID-19-associated condition between hypoimmunity and hyperimmunity","volume":"13","author":"Gelzo","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2024.10.004_bib56","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.3390\/v15102036","article-title":"Prediction of survival by IL-6 in a randomized placebo-controlled trial of anakinra in COVID-19 cytokine storm","volume":"15","author":"Jackson","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.jaci.2024.10.004_bib57","doi-asserted-by":"crossref","unstructured":"Canny SP, Stanaway IB, Holton SE, Mitchem M, O\u2019Rourke AR, Pribitzer S, et\u00a0al. Identification of biomarkers for COVID-19 associated secondary hemophagocytic lymphohistiocytosis [preprint August 15, 2024]. bioRxiv. https:\/\/doi.org\/10.1101\/2024.08.13.607855.","DOI":"10.1101\/2024.08.13.607855"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674924010613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674924010613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T13:16:34Z","timestamp":1744722994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674924010613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0091674924010613"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2024.10.004","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of DOCK8 in cytokine storm syndromes","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2024.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}