{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:17:34Z","timestamp":1790957854824,"version":"4.1.0"},"reference-count":154,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jaci.2025.02.011","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T12:32:31Z","timestamp":1739881951000},"page":"1435-1450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["From rare to more common: The emerging role of omics in improving understanding and treatment of severe inflammatory and hyperinflammatory conditions"],"prefix":"10.1016","volume":"155","author":[{"given":"Salla","family":"Keskitalo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko R.J.","family":"Sepp\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"del Sol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Varjosalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2025.02.011_bib1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1006\/taap.1994.1169","article-title":"Acute inflammatory response to sheep red blood cells in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: the role of proinflammatory cytokines, IL-1 and TNF","volume":"127","author":"Moos","year":"1994","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jaci.2025.02.011_bib2","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/bjo-2022-321825","article-title":"Functional consequences of pathogenic variant c.61G>C in the inflammasome gene NLRP3 underlying keratitis fugax hereditaria","volume":"108","author":"Kawan","year":"2024","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jaci.2025.02.011_bib3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41586-024-07501-1","article-title":"A disease-associated gene desert directs macrophage inflammation through ETS2","volume":"630","author":"Stankey","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2025.02.011_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/86280","article-title":"Autoimmunity versus horror autotoxicus: the struggle for recognition","volume":"2","author":"Silverstein","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0092-8674(00)80721-7","article-title":"Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes","volume":"97","author":"McDermott","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2025.02.011_bib6","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.jaci.2019.06.003","article-title":"Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy","volume":"144","author":"G\u00f6\u00f6s","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib7","article-title":"A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency","volume":"8","author":"Fornes","year":"2023","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ajhg.2017.06.005","article-title":"10 years of GWAS discovery: biology, function, and translation","volume":"101","author":"Visscher","year":"2017","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaci.2025.02.011_bib9","article-title":"Whole genome DNA and RNA sequencing of whole blood elucidates the genetic architecture of gene expression underlying a wide range of diseases","volume":"12","author":"Liu","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2025.02.011_bib10","doi-asserted-by":"crossref","first-page":"D896","DOI":"10.1093\/nar\/gkw1133","article-title":"The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)","volume":"45","author":"MacArthur","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2025.02.011_bib11","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/s10875-017-0443-1","article-title":"Effective immunological guidance of genetic analyses including exome sequencing in patients evaluated for hemophagocytic lymphohistiocytosis","volume":"37","author":"Ammann","year":"2017","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-3-031-59815-9_8","article-title":"Genetics of acquired cytokine storm syndromes: secondary HLH genetics","volume":"1448","author":"Schulert","year":"2024","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jaci.2025.02.011_bib13","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1007\/s10875-022-01352-z","article-title":"The 2022 update of IUIS phenotypical classification for human inborn errors of immunity","volume":"42","author":"Bousfiha","year":"2022","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib14","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0092-8674(00)80539-5","article-title":"Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium","volume":"90","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2025.02.011_bib15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrrheum.2013.174","article-title":"A clinical guide to autoinflammatory diseases: familial Mediterranean fever and next-of-kin","volume":"10","author":"Ozen","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jaci.2025.02.011_bib16","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/ACI.0000000000000396","article-title":"NLRC4 inflammasomopathies","volume":"17","author":"Romberg","year":"2017","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib17","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.jaci.2016.10.022","article-title":"Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition","volume":"139","author":"Canna","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006177","article-title":"Nod2: the intestinal gate keeper","volume":"13","author":"Al Nabhani","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jaci.2025.02.011_bib19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2147\/JIR.S137606","article-title":"NOD2 and inflammation: current insights","volume":"11","author":"Negroni","year":"2018","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.jaci.2025.02.011_bib20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.clim.2009.05.005","article-title":"NOD2-associated diseases: bridging innate immunity and autoinflammation","volume":"134","author":"Borzutzky","year":"2010","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib21","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1093\/ibd\/izy165","article-title":"Infantile onset intractable inflammatory bowel disease due to novel heterozygous mutations in TNFAIP3 (A20)","volume":"24","author":"Zheng","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jaci.2025.02.011_bib22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/ng.3459","article-title":"Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease","volume":"48","author":"Zhou","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2025.02.011_bib23","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00011-012-0455-5","article-title":"Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis","volume":"61","author":"Lee","year":"2012","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jaci.2025.02.011_bib24","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1007\/s10875-021-01051-1","article-title":"STAT3 hyper-IgE syndrome\u2014an update and unanswered questions","volume":"41","author":"Tsilifis","year":"2021","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib25","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jaci.2009.10.059","article-title":"Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome","volume":"125","author":"Woellner","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib26","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/MD.0b013e31825f95b9","article-title":"Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey","volume":"91","author":"Chandesris","year":"2012","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jaci.2025.02.011_bib27","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/ng.3040","article-title":"Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease","volume":"46","author":"Flanagan","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2025.02.011_bib29","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jaci.2022.09.002","article-title":"Monogenic early-onset lymphoproliferation and autoimmunity: natural history of STAT3 gain-of-function syndrome","volume":"151","author":"Leiding","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib30","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1016\/j.jaip.2020.06.034","article-title":"A novel complete autosomal-recessive STAT1 LOF variant causes immunodeficiency with hemophagocytic lymphohistiocytosis-like hyperinflammation","volume":"8","author":"Boehmer","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2025.02.011_bib31","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3233\/JAD-200056","article-title":"IL-1\u03b2, IL-6, IL-10, and TNF\u03b1 single nucleotide polymorphisms in human influence the susceptibility to Alzheimer\u2019s disease pathology","volume":"75","author":"Babi\u0107 Leko","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jaci.2025.02.011_bib32","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/jdv.18770","article-title":"Polymorphisms in some proinflammatory genes (TNF\u03b1 and \u03b2, IL-1\u03b2, IL-6, ADAM17) in severe chronic venous disease","volume":"37","author":"Slonkov\u00e1","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaci.2025.02.011_bib33","doi-asserted-by":"crossref","first-page":"552","DOI":"10.5114\/aoms.2010.14467","article-title":"IL-1\u03b2, IL-6 promoter, TNF-\u03b1 promoter and IL-1RA gene polymorphisms and the risk of preterm delivery due to preterm premature rupture of membranes in a population of Polish women","volume":"6","author":"Bitner","year":"2010","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.jaci.2025.02.011_bib34","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1093\/infdis\/jiac093","article-title":"Hyperinflammatory syndrome, natural killer cell function, and genetic polymorphisms in the pathogenesis of severe dengue","volume":"226","author":"Vuong","year":"2022","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2025.02.011_bib35","first-page":"417","article-title":"Hemophagocytic lymphohistiocytosis gene variants in multisystem inflammatory syndrome in children","volume":"11","author":"Vagrecha","year":"2022","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.jaci.2025.02.011_bib36","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1177\/1352458520963937","article-title":"PRF1 mutation alters immune system activation, inflammation, and risk of autoimmunity","volume":"27","author":"Sidore","year":"2021","journal-title":"Mult Scler"},{"key":"10.1016\/j.jaci.2025.02.011_bib37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/intimm\/dxy012","article-title":"Convergent pathways of the hyperferritinemic syndromes","volume":"30","author":"Schulert","year":"2018","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib38","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/01.bor.0000381996.69261.71","article-title":"Macrophage activation syndrome: advances towards understanding pathogenesis","volume":"22","author":"Grom","year":"2010","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jaci.2025.02.011_bib39","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.hoc.2015.06.010","article-title":"Macrophage activation syndrome","volume":"29","author":"Ravelli","year":"2015","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.jaci.2025.02.011_bib40","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s11926-014-0439-2","article-title":"Genetic defects in cytolysis in macrophage activation syndrome","volume":"16","author":"Zhang","year":"2014","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.jaci.2025.02.011_bib41","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/art.42938","article-title":"Enrichment of rare variants of hemophagocytic lymphohistiocytosis genes in systemic juvenile idiopathic arthritis","volume":"76","author":"Correia Marques","year":"2024","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jaci.2025.02.011_bib42","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1365-2249.2005.02821.x","article-title":"Immunological profile of peripheral blood lymphocytes and monocytes\/macrophages in Kawasaki disease","volume":"141","author":"Matsubara","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/art.43052","article-title":"Macrophage activation syndrome","author":"Nigrovic","year":"2025","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jaci.2025.02.011_bib44","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/MPH.0000000000000872","article-title":"Kawasaki disease complicated with macrophage activation syndrome: a systematic review","volume":"39","author":"Garc\u00eda-Pav\u00f3n","year":"2017","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.jaci.2025.02.011_bib45","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.autrev.2012.07.018","article-title":"Autoinflammation and autoimmunity: bridging the divide","volume":"12","author":"Doria","year":"2012","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaci.2025.02.011_bib46","first-page":"3591","article-title":"VEXAS syndrome","volume":"137","author":"Grayson","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2025.02.011_bib47","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/BOR.0000000000001068","article-title":"VEXAS syndrome: an adult-onset autoinflammatory disorder with underlying somatic mutation","volume":"37","author":"K\u00f6tter","year":"2025","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jaci.2025.02.011_bib48","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-med-061813-012806","article-title":"Pathogenesis of macrophage activation syndrome and potential for cytokine-directed therapies","volume":"66","author":"Schulert","year":"2015","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jaci.2025.02.011_bib49","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2025.02.011_bib50","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1056\/NEJMra2026131","article-title":"Cytokine storm","volume":"383","author":"Fajgenbaum","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2025.02.011_bib51","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12969-016-0130-4","article-title":"Macrophage activation syndrome: different mechanisms leading to a one clinical syndrome","volume":"15","author":"Bracaglia","year":"2017","journal-title":"Pediatr Rheumatol Online J"},{"key":"10.1016\/j.jaci.2025.02.011_bib52","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1136\/adc.2009.176610","article-title":"Review of haemophagocytic lymphohistiocytosis","volume":"96","author":"Freeman","year":"2011","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2025.02.011_bib53","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nature01510","article-title":"From genomics to proteomics","volume":"422","author":"Tyers","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2025.02.011_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-94474-0","article-title":"Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock","volume":"11","author":"de Azambuja Rodrigues","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2025.02.011_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800335","article-title":"Proteomic approaches to decipher mechanisms underlying pathogenesis in multiple sclerosis patients","volume":"19","author":"Singh","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.jaci.2025.02.011_bib56","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41584-021-00694-z","article-title":"Targeting interferon-\u03b3 in hyperinflammation: opportunities and challenges","volume":"17","author":"De Benedetti","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jaci.2025.02.011_bib57","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201600079","article-title":"Towards comprehensive and quantitative proteomics for diagnosis and therapy of human disease","volume":"17","author":"Cifani","year":"2017","journal-title":"Proteomics"},{"key":"10.1016\/j.jaci.2025.02.011_bib58","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-60761-780-8_12","article-title":"Quantification of proteins by iTRAQ","volume":"658","author":"Unwin","year":"2010","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jaci.2025.02.011_bib59","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1021\/ac0262560","article-title":"Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS\/MS","volume":"75","author":"Thompson","year":"2003","journal-title":"Anal Chem"},{"key":"10.1016\/j.jaci.2025.02.011_bib60","article-title":"Identification of novel biomarkers for sepsis diagnosis via serum proteomic analysis using iTRAQ-2D-LC-MS\/MS","volume":"36","author":"Li","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.jaci.2025.02.011_bib61","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1038\/s41598-019-42287-7","article-title":"Role of vimentin in modulating immune cell apoptosis and inflammatory responses in sepsis","volume":"9","author":"Su","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2025.02.011_bib62","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1097\/TA.0b013e31828272c5","article-title":"Urinary proteomics analysis for sepsis biomarkers with iTRAQ labeling and two-dimensional liquid chromatography\u2013tandem mass spectrometry","volume":"74","author":"Su","year":"2013","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jaci.2025.02.011_bib63","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1586\/14789450.2016.1172481","article-title":"Proteomic study of acute respiratory distress syndrome: current knowledge and implications for drug development","volume":"13","author":"Levitt","year":"2016","journal-title":"Expert Rev Proteomics"},{"key":"10.1016\/j.jaci.2025.02.011_bib64","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M110.002980","article-title":"Proteomic pathway analysis reveals inflammation increases myeloid-derived suppressor cell resistance to apoptosis","volume":"10","author":"Chornoguz","year":"2011","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jaci.2025.02.011_bib65","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s10875-020-00908-1","article-title":"Targeted proteomics reveals inflammatory pathways that classify immune dysregulation in common variable immunodeficiency","volume":"41","author":"Berbers","year":"2021","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib66","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/14789450.2021.1911652","article-title":"An overview of proteomic methods for the study of \u201ccytokine storms.\u201d","volume":"18","author":"David","year":"2021","journal-title":"Expert Rev Proteomics"},{"key":"10.1016\/j.jaci.2025.02.011_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pdig.0000007","article-title":"A proteomic survival predictor for COVID-19 patients in intensive care","volume":"1","author":"Demichev","year":"2022","journal-title":"PLOS Digit Health"},{"key":"10.1016\/j.jaci.2025.02.011_bib68","article-title":"Mapping protein\u2013protein interactions by mass spectrometry","author":"Liu","year":"2025","journal-title":"Mass Spectrom Rev"},{"key":"10.1016\/j.jaci.2025.02.011_bib69","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2018-000740","article-title":"Haploinsufficiency of A20 impairs protein\u2013protein interactome and leads into caspase-8\u2013dependent enhancement of NLRP3 inflammasome activation","volume":"4","author":"Rajam\u00e4ki","year":"2018","journal-title":"RMD Open"},{"key":"10.1016\/j.jaci.2025.02.011_bib70","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/s41467-018-03523-2","article-title":"An AP-MS\u2013 and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations","volume":"9","author":"Liu","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2025.02.011_bib71","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jaci.2016.10.054","article-title":"Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes","volume":"140","author":"Kaustio","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib72","article-title":"Truncating NFKB1 variants cause combined NLRP3 inflammasome activation and type I interferon signaling and predispose to necrotizing fasciitis","volume":"5","author":"Nurmi","year":"2024","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.jaci.2025.02.011_bib73","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1080\/14789450.2021.1976152","article-title":"Phosphoproteomics: a valuable tool for uncovering molecular signaling in cancer cells","volume":"18","author":"Gerritsen","year":"2021","journal-title":"Expert Rev Proteomics"},{"key":"10.1016\/j.jaci.2025.02.011_bib74","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-60327-834-8_4","article-title":"Enrichment and characterization of phosphopeptides by immobilized metal affinity chromatography (IMAC) and mass spectrometry","volume":"527","author":"Thingholm","year":"2009","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jaci.2025.02.011_bib75","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41392-022-01048-1","article-title":"SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein\u2013protein interaction-mediated intracellular Cl\u2212 accumulation in respiratory epithelium","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jaci.2025.02.011_bib76","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12964-020-00603-z","article-title":"Phospho-Tyr705 of STAT3 is a therapeutic target for sepsis through regulating inflammation and coagulation","volume":"18","author":"Xu","year":"2020","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jaci.2025.02.011_bib77","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.gpb.2023.04.002","article-title":"Novel time-dependent multi-omics integration in sepsis-associated liver dysfunction","volume":"21","author":"Na","year":"2023","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10.1016\/j.jaci.2025.02.011_bib78","doi-asserted-by":"crossref","first-page":"709","DOI":"10.17219\/acem\/61034","article-title":"The activity of JAK\/STAT and NF-\u03baB in patients with rheumatoid arthritis","volume":"25","author":"\u015awierkot","year":"2016","journal-title":"Adv Clin Exp Med"},{"key":"10.1016\/j.jaci.2025.02.011_bib81","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cell.2020.06.034","article-title":"The global phosphorylation landscape of SARS-CoV-2 infection","volume":"182","author":"Bouhaddou","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2025.02.011_bib80","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/msb.2010.29","article-title":"The phosphoproteome of Toll-like receptor\u2013activated macrophages","volume":"6","author":"Weintz","year":"2010","journal-title":"Mol Syst Biol"},{"key":"10.1016\/j.jaci.2025.02.011_bib82","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202302520R","article-title":"Proteome characterization of liver\u2013kidney comorbidity after microbial sepsis","volume":"38","author":"Gui","year":"2024","journal-title":"FASEB J"},{"key":"10.1016\/j.jaci.2025.02.011_bib83","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1074\/mcp.RA120.002235","article-title":"Global proteome and phosphoproteome characterization of sepsis-induced kidney injury","volume":"19","author":"Lin","year":"2020","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jaci.2025.02.011_bib84","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1021\/acs.jproteome.1c00657","article-title":"Advances and utility of the human plasma proteome","volume":"20","author":"Deutsch","year":"2021","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jaci.2025.02.011_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.110252","article-title":"Serum proteomics reveals hemophagocytic lymphohistiocytosis-like phenotype in a subset of patients with multisystem inflammatory syndrome in children","volume":"264","author":"Tulling","year":"2024","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib86","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/s41591-022-01724-3","article-title":"Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19","volume":"28","author":"Sacco","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2025.02.011_bib87","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1074\/mcp.R120.002234","article-title":"Single-cell proteomics: progress and prospects","volume":"19","author":"Kelly","year":"2020","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jaci.2025.02.011_bib88","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/d41586-021-02530-6","article-title":"Single-cell proteomics takes centre stage","volume":"597","author":"Perkel","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2025.02.011_bib89","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13059-018-1547-5","article-title":"SCoPE-MS: mass spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation","volume":"19","author":"Budnik","year":"2018","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2025.02.011_bib90","doi-asserted-by":"crossref","first-page":"e118","DOI":"10.1002\/cpz1.118","article-title":"CyTOF: an emerging technology for single-cell proteomics in the mouse","volume":"1","author":"Tracey","year":"2021","journal-title":"Curr Protoc"},{"key":"10.1016\/j.jaci.2025.02.011_bib91","doi-asserted-by":"crossref","first-page":"5.11.1","DOI":"10.1002\/cpim.31","article-title":"High-dimensional single-cell analysis with mass cytometry","volume":"118","author":"Brodie","year":"2017","journal-title":"Curr Protoc Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib92","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41584-019-0338-z","article-title":"Immune monitoring using mass cytometry and related high-dimensional imaging approaches","volume":"16","author":"Hartmann","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jaci.2025.02.011_bib93","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13059-021-02267-5","article-title":"Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2","volume":"22","author":"Specht","year":"2021","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2025.02.011_bib94","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/bib\/bbx141","article-title":"Proteomics and phosphoproteomics in precision medicine: applications and challenges","volume":"20","author":"Giudice","year":"2019","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.jaci.2025.02.011_bib95","article-title":"Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19","volume":"3","author":"Feyaerts","year":"2022","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.jaci.2025.02.011_bib96","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/eji.201847862","article-title":"High-dimensional single-cell proteomics analysis identifies immune checkpoint signatures and therapeutic targets in ulcerative colitis","volume":"49","author":"Fuchs","year":"2019","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib97","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/ecco-jcc\/jjy158","article-title":"Clinical usefulness of proteomics in inflammatory bowel disease: a comprehensive review","volume":"13","author":"Gisbert","year":"2019","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jaci.2025.02.011_bib98","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cels.2020.05.012","article-title":"Ultra-high\u2013throughput clinical proteomics reveals classifiers of COVID-19 infection","volume":"11","author":"Messner","year":"2020","journal-title":"Cell Syst"},{"key":"10.1016\/j.jaci.2025.02.011_bib99","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cels.2021.05.005","article-title":"A time-resolved proteomic and prognostic map of COVID-19","volume":"12","author":"Demichev","year":"2021","journal-title":"Cell Syst"},{"key":"10.1016\/j.jaci.2025.02.011_bib100","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.1038\/s41598-021-85877-0","article-title":"Proteomic blood profiling in mild, severe and critical COVID-19 patients","volume":"11","author":"Patel","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2025.02.011_bib101","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.immuni.2020.10.008","article-title":"Plasma proteomics identify biomarkers and pathogenesis of COVID-19","volume":"53","author":"Shu","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2025.02.011_bib102","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.immuni.2021.04.003","article-title":"Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children","volume":"54","author":"Ramaswamy","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2025.02.011_bib103","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/prca.200700067","article-title":"Clinical proteomics in chronic inflammatory diseases: a review","volume":"1","author":"Bons","year":"2007","journal-title":"Proteomics Clin Appl"},{"key":"10.1016\/j.jaci.2025.02.011_bib104","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/eurheartj\/ehac185","article-title":"Inflammation, targeted proteomics, and microvascular dysfunction: the new frontiers of ischaemic heart disease","volume":"43","author":"Crea","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jaci.2025.02.011_bib105","doi-asserted-by":"crossref","first-page":"9386","DOI":"10.3390\/ijms24119386","article-title":"A current state of proteomics in adult and pediatric inflammatory bowel diseases: a systematic search and review","volume":"24","author":"Fabian","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2025.02.011_bib106","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2180373","article-title":"Inflammation-related mechanisms in chronic kidney disease prediction, progression, and outcome","volume":"2018","author":"Mihai","year":"2018","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jaci.2025.02.011_bib107","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2020.05.032","article-title":"Proteomic and metabolomic characterization of COVID-19 patient sera","volume":"182","author":"Shen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2025.02.011_bib108","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cels.2020.10.003","article-title":"Large-scale multi-omic analysis of COVID-19 severity","volume":"12","author":"Overmyer","year":"2021","journal-title":"Cell Syst"},{"key":"10.1016\/j.jaci.2025.02.011_bib109","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2021.01.004","article-title":"Multi-organ proteomic landscape of COVID-19 autopsies","volume":"184","author":"Nie","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2025.02.011_bib110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12014-024-09457-w","article-title":"Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients","volume":"21","author":"Kaneko","year":"2024","journal-title":"Clin Proteomics"},{"key":"10.1016\/j.jaci.2025.02.011_bib111","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00003246-200301001-00001","article-title":"Proteomics and systems biology approaches to signal transduction in sepsis","volume":"31","author":"Nguyen","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jaci.2025.02.011_bib112","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/14789450.2022.2070476","article-title":"An overview of technologies for MS-based proteomics-centric multi-omics","volume":"19","author":"Rajczewski","year":"2022","journal-title":"Expert Rev Proteomics"},{"key":"10.1016\/j.jaci.2025.02.011_bib113","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Johnson","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaci.2025.02.011_bib114","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1093\/bib\/bbx170","article-title":"Metabolomics technology and bioinformatics for precision medicine","volume":"20","author":"Azad","year":"2019","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.jaci.2025.02.011_bib115","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2025.02.011_bib116","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41586-018-0052-z","article-title":"Electrophilic properties of itaconate and derivatives regulate the I\u03baB\u03b6-ATF3 inflammatory axis","volume":"556","author":"Bambouskova","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2025.02.011_bib117","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2025.02.011_bib118","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cell.2020.05.054","article-title":"Origin and function of stress-induced IL-6 in murine models","volume":"182","author":"Qing","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2025.02.011_bib119","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/s41591-019-0510-7","article-title":"Metabolic perturbations and cellular stress underpin susceptibility to symptomatic live-attenuated yellow fever infection","volume":"25","author":"Chan","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2025.02.011_bib120","doi-asserted-by":"crossref","unstructured":"Dean DA, Klechka L, Hossain E, Parab AR, Eaton K, Hinsdale M, et al. Spatial metabolomics reveals localized impact of influenza virus infection on the lung tissue metabolome. mSystems. 2022;7:e0035322.","DOI":"10.1128\/msystems.00353-22"},{"key":"10.1016\/j.jaci.2025.02.011_bib121","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cmet.2020.06.016","article-title":"Omics-driven systems interrogation of metabolic dysregulation in COVID-19 pathogenesis","volume":"32","author":"Song","year":"2020","journal-title":"Cell Metab"},{"key":"10.1016\/j.jaci.2025.02.011_bib122","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1038\/s41467-018-07635-7","article-title":"Metabolite changes in blood predict the onset of tuberculosis","volume":"9","author":"Weiner","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2025.02.011_bib123","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s42255-021-00404-9","article-title":"Metabolome modulation of the host adaptive immunity in human malaria","volume":"3","author":"Abdrabou","year":"2021","journal-title":"Nat Metab"},{"key":"10.1016\/j.jaci.2025.02.011_bib124","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.739514","article-title":"Circulating metabolomic signature in generalized pustular psoriasis blunts monocyte hyperinflammation by triggering amino acid response","volume":"12","author":"Yu","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib125","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1038\/s41467-021-21907-9","article-title":"Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications","volume":"12","author":"Xiao","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2025.02.011_bib126","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11306-024-02195-y","article-title":"Untargeted metabolomics and lipidomics in COVID-19 patient plasma reveals disease severity biomarkers","volume":"21","author":"Sun","year":"2024","journal-title":"Metabolomics"},{"key":"10.1016\/j.jaci.2025.02.011_bib127","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tmaid.2007.07.002","article-title":"Understanding the role of inflammatory cytokines in malaria and related diseases","volume":"6","author":"Clark","year":"2008","journal-title":"Travel Med Infect Dis"},{"key":"10.1016\/j.jaci.2025.02.011_bib128","doi-asserted-by":"crossref","first-page":"e536","DOI":"10.1097\/CCM.0000000000006391","article-title":"Modulation of metabolomic profile in sepsis according to the state of immune activation","volume":"52","author":"Kranidioti","year":"2024","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jaci.2025.02.011_bib129","doi-asserted-by":"crossref","first-page":"967","DOI":"10.12688\/f1000research.11823.1","article-title":"Analytical challenges of untargeted GC-MS\u2013based metabolomics and the critical issues in selecting the data processing strategy","volume":"6","author":"Han","year":"2017","journal-title":"F1000Res"},{"key":"10.1016\/j.jaci.2025.02.011_bib130","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/ni.3745","article-title":"S100-alarmin\u2013induced innate immune programming protects newborn infants from sepsis","volume":"18","author":"Ulas","year":"2017","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib131","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nbt.2348","article-title":"An accelerated workflow for untargeted metabolomics using the METLIN database","volume":"30","author":"Tautenhahn","year":"2012","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jaci.2025.02.011_bib132","doi-asserted-by":"crossref","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","article-title":"HMDB 4.0: the human metabolome database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2025.02.011_bib133","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.it.2015.11.006","article-title":"Systems approaches towards molecular profiling of human immunity","volume":"37","author":"Burel","year":"2016","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib134","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41590-018-0121-3","article-title":"Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses","volume":"19","author":"Bakker","year":"2018","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib135","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/eji.202048882","article-title":"Resolving trained immunity with systems biology","volume":"51","author":"Koeken","year":"2021","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib136","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.imlet.2020.09.007","article-title":"\u201cCytokine storm,\u201d not only in COVID-19 patients","volume":"228","author":"Lukan","year":"2020","journal-title":"Mini-review. Immunol Lett"},{"key":"10.1016\/j.jaci.2025.02.011_bib137","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/MMBR.05015-11","article-title":"Into the eye of the cytokine storm","volume":"76","author":"Tisoncik","year":"2012","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.jaci.2025.02.011_bib138","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.it.2021.06.001","article-title":"The \u201ccytokine storm\u201d: molecular mechanisms and therapeutic prospects","volume":"42","author":"Karki","year":"2021","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib139","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S2213-2600(20)30404-5","article-title":"Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes","volume":"8","author":"Leisman","year":"2020","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaci.2025.02.011_bib140","doi-asserted-by":"crossref","first-page":"7866","DOI":"10.1038\/ncomms8866","article-title":"A draft network of ligand-receptor\u2013mediated multicellular signalling in human","volume":"6","author":"Ramilowski","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2025.02.011_bib141","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14049","article-title":"Massively parallel digital transcriptional profiling of single cells","volume":"8","author":"Zheng","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2025.02.011_bib142","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41592-020-0737-8","article-title":"Cell-type\u2013specific signaling networks in heterocellular organoids","volume":"17","author":"Qin","year":"2020","journal-title":"Nat Methods"},{"key":"10.1016\/j.jaci.2025.02.011_bib143","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe9599","article-title":"Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in\u00a0vitro","volume":"13","author":"Reyes","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2025.02.011_bib144","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4049\/jimmunol.1800454","article-title":"Computational analysis supports IL-17A as a central driver of neutrophil extracellular trap\u2013mediated injury in liver ischemia reperfusion","volume":"202","author":"Tohme","year":"2019","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2025.02.011_bib145","doi-asserted-by":"crossref","first-page":"9703","DOI":"10.1038\/s41598-021-88936-8","article-title":"A putative \u201cchemokine switch\u201d that regulates systemic acute inflammation in humans","volume":"11","author":"Azhar","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2025.02.011_bib146","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe5735","article-title":"Leveraging systems biology for predicting modulators of inflammation in patients with COVID-19","volume":"7","author":"Jung","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.jaci.2025.02.011_bib147","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/s41591-020-0939-8","article-title":"Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis","volume":"26","author":"Alivernini","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2025.02.011_bib148","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s44161-023-00278-y","article-title":"Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis","volume":"2","author":"Amadori","year":"2023","journal-title":"Nat Cardiovasc Res"},{"key":"10.1016\/j.jaci.2025.02.011_bib149","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/art.41516","article-title":"Multiomics and machine learning accurately predict clinical response to adalimumab and etanercept therapy in patients with rheumatoid arthritis","volume":"73","author":"Tao","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jaci.2025.02.011_bib150","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1039\/C9SC04336E","article-title":"Target identification among known drugs by deep learning from heterogeneous networks","volume":"11","author":"Zeng","year":"2020","journal-title":"Chem Sci"},{"key":"10.1016\/j.jaci.2025.02.011_bib151","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A next generation connectivity map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2025.02.011_bib152","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s41467-021-21056-z","article-title":"Causal network models of SARS-CoV-2 expression and aging to identify candidates for drug repurposing","volume":"12","author":"Belyaeva","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2025.02.011_bib153","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41580-020-0231-2","article-title":"Proteomic and interactomic insights into the molecular\u00a0basis of cell functional diversity","volume":"21","author":"Bludau","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaci.2025.02.011_bib154","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nature19949","article-title":"Mass-spectrometric exploration of proteome structure and function","volume":"537","author":"Aebersold","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2025.02.011_bib155","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1016\/j.csbj.2020.09.033","article-title":"Deep metabolome: applications of deep learning in metabolomics","volume":"18","author":"Pomyen","year":"2020","journal-title":"Comput Struct Biotechnol J"},{"key":"10.1016\/j.jaci.2025.02.011_bib156","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1093\/bib\/bbaa204","article-title":"Deep learning meets metabolomics: a methodological perspective","volume":"22","author":"Sen","year":"2021","journal-title":"Brief Bioinform"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674925002076?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674925002076?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:31:00Z","timestamp":1777264260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674925002076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":154,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S0091674925002076"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2025.02.011","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From rare to more common: The emerging role of omics in improving understanding and treatment of severe inflammatory and hyperinflammatory conditions","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2025.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}