{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:49:49Z","timestamp":1792550989277,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030E_224154"],"award-info":[{"award-number":["320030E_224154"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_189334\/1"],"award-info":[{"award-number":["310030_189334\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["SAF-2017-84978-R"],"award-info":[{"award-number":["SAF-2017-84978-R"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011824","name":"European Academy of Allergy and Clinical Immunology","doi-asserted-by":"publisher","award":["UCM-CT18\/22"],"award-info":[{"award-number":["UCM-CT18\/22"]}],"id":[{"id":"10.13039\/501100011824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002911","name":"Universidad Complutense de Madrid","doi-asserted-by":"publisher","award":["FPU21\/01264"],"award-info":[{"award-number":["FPU21\/01264"]}],"id":[{"id":"10.13039\/501100002911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002911","name":"Universidad Complutense de Madrid","doi-asserted-by":"publisher","award":["IND2019\/BMD17182"],"award-info":[{"award-number":["IND2019\/BMD17182"]}],"id":[{"id":"10.13039\/501100002911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["PID2022-138797OB-I00"],"award-info":[{"award-number":["PID2022-138797OB-I00"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023561","name":"Ministerio de Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023561","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Gobierno de Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020-114396RB-I00"],"award-info":[{"award-number":["PID2020-114396RB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jaci.2025.05.002","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T11:00:37Z","timestamp":1747393237000},"page":"651-667","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cannabinoid WIN55,212-2 restores bronchial epithelium by regulating oxidative stress and STAT6 phosphorylation"],"prefix":"10.1016","volume":"156","author":[{"given":"Mario","family":"P\u00e9rez-Diego","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Angelina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u011f\u0131z","family":"Pat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Sevilla-Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Mart\u00edn-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Yazici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"R\u00fcckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Sokolowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Mart\u00edn-Fontecha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fcbeccel","family":"Akdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezmi A.","family":"Akdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4516-0369","authenticated-orcid":false,"given":"Oscar","family":"Palomares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2025.05.002_bib1","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0140-6736(22)02125-0","article-title":"Asthma","volume":"401","author":"Porsbjerg","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2025.05.002_bib2","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1111\/all.16318","article-title":"The epithelial barrier theory and its associated diseases","volume":"79","author":"Sun","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.05.002_bib3","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1111\/all.14318","article-title":"Type 2 immunity in the skin and lungs","volume":"75","author":"Akdis","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.05.002_bib4","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41573-023-00750-1","article-title":"Type 2 chronic inflammatory diseases: targets, therapies and unmet needs","volume":"22","author":"Kolkhir","year":"2023","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jaci.2025.05.002_bib5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jaip.2022.01.006","article-title":"Rhinovirus infections and their roles in asthma: etiology and exacerbations","volume":"10","author":"Jackson","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2025.05.002_bib6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrmicro2801","article-title":"The microbiology of asthma","volume":"10","author":"Edwards","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jaci.2025.05.002_bib7","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1111\/all.16242","article-title":"Therapeutic relevance of eosinophilic inflammation and airway viral interactions in severe asthma","volume":"79","author":"Rupani","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.05.002_bib8","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01397-2023","article-title":"The airway epithelium: an orchestrator of inflammation, a key structural barrier and a therapeutic target in severe asthma","volume":"63","author":"Russell","year":"2024","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2025.05.002_bib9","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1111\/all.16092","article-title":"Skin, gut, and lung barrier: physiological interface and target of intervention for preventing and treating allergic diseases","volume":"79","author":"Berni Canani","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.05.002_bib10","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1038\/s41467-023-37470-4","article-title":"Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19","volume":"14","author":"Radzikowska","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2025.05.002_bib11","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1159\/000508989","article-title":"The role of cannabinoids in allergic diseases: Collegium Internationale Allergologicum (CIA) update 2020","volume":"181","author":"Angelina","year":"2020","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib12","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nri1602","article-title":"Cannabinoid-based drugs as anti-inflammatory therapeutics","volume":"5","author":"Klein","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib13","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrd.2018.115","article-title":"New approaches and challenges to targeting the endocannabinoid system","volume":"17","author":"Di Marzo","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jaci.2025.05.002_bib14","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jaip.2022.10.009","article-title":"Immunomodulatory actions of cannabinoids: clinical correlates and therapeutic opportunities for allergic inflammation","volume":"11","author":"Nayak","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2025.05.002_bib15","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1080\/1744666X.2023.2235082","article-title":"Could we co-opt the cannabinoid system for asthma therapy?","volume":"19","author":"Palomares","year":"2023","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41385-021-00455-x","article-title":"Cannabinoids induce functional Tregs by promoting tolerogenic DCs via autophagy and metabolic reprograming","volume":"15","author":"Angelina","year":"2022","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib17","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/cea.14092","article-title":"Cannabinoid WIN55212-2 impairs peanut-allergic sensitization and promotes the generation of allergen-specific regulatory T cells","volume":"52","author":"Angelina","year":"2022","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2025.05.002_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1147520","article-title":"Cannabinoid WIN55,212-2 reprograms monocytes and macrophages to inhibit LPS-induced inflammation","volume":"14","author":"Perez-Diego","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib19","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/all.15160","article-title":"The cannabinoid WIN55212-2 suppresses effector T-cell responses and promotes regulatory T cells in human tonsils","volume":"77","author":"Angelina","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.05.002_bib20","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jaci.2013.12.1032","article-title":"The expression of cannabinoid receptor 1 is significantly increased in atopic patients","volume":"133","author":"Martin-Fontecha","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1124\/jpet.110.168237","article-title":"Pharmacological effects of cannabinoids on the Caco-2 cell culture model of intestinal permeability","volume":"335","author":"Alhamoruni","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jaci.2025.05.002_bib22","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1111\/j.1476-5381.2011.01589.x","article-title":"Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability","volume":"165","author":"Alhamoruni","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jaci.2025.05.002_bib23","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1038\/s41467-020-15831-7","article-title":"Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis","volume":"11","author":"Tajik","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2025.05.002_bib24","doi-asserted-by":"crossref","first-page":"G565","DOI":"10.1152\/ajpgi.00158.2011","article-title":"Endogenous cannabinoid system regulates intestinal barrier function in vivo through cannabinoid type 1 receptor activation","volume":"302","author":"Zoppi","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jaci.2025.05.002_bib25","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1111\/all.14707","article-title":"The cannabinoid WIN55212-2 restores rhinovirus-induced epithelial barrier disruption","volume":"76","author":"Angelina","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.05.002_bib26","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jaci.2016.01.002","article-title":"The contributions of allergic sensitization and respiratory pathogens to asthma inception","volume":"137","author":"Jackson","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib27","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jaci.2016.03.049","article-title":"Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence","volume":"139","author":"Rubner","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib28","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1111\/all.15279","article-title":"Differentiation of bronchial epithelial spheroids in the presence of IL-13 recapitulates characteristic features of asthmatic airway epithelia","volume":"77","author":"Pat","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.05.002_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009124","article-title":"Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation","volume":"6","author":"Beale","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2025.05.002_bib30","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1164\/rccm.201406-1039OC","article-title":"IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo","volume":"190","author":"Jackson","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2025.05.002_bib31","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jaci.2014.05.049","article-title":"Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation","volume":"134","author":"Georas","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib32","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/all.12627","article-title":"Th2 cytokines impair innate immune responses to rhinovirus in respiratory epithelial cells","volume":"70","author":"Contoli","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.05.002_bib33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.mucimm.2022.12.001","article-title":"Regulation of angiotensin-converting enzyme 2 isoforms by type 2 inflammation and viral infection in human airway epithelium","volume":"16","author":"Stocker","year":"2023","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib34","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.3390\/ijms20133222","article-title":"IL-13 impairs tight junctions in airway epithelia","volume":"20","author":"Schmidt","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2025.05.002_bib35","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.3390\/ijms24032513","article-title":"Cannabinoids in the modulation of oxidative signaling","volume":"24","author":"Pagano","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2025.05.002_bib36","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.immuni.2008.07.019","article-title":"Redox regulation of interleukin-4 signaling","volume":"29","author":"Sharma","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2025.05.002_bib37","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.4049\/jimmunol.1000791","article-title":"Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes","volume":"186","author":"Hirakawa","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib38","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41577-021-00538-7","article-title":"Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?","author":"Akdis","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib39","doi-asserted-by":"crossref","DOI":"10.4161\/tisb.24333","article-title":"Interleukin-4 and interleukin-13 cause barrier dysfunction in human airway epithelial cells","volume":"1","author":"Saatian","year":"2013","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.jaci.2025.05.002_bib40","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jaci.2011.05.038","article-title":"Defective epithelial barrier function in asthma","volume":"128","author":"Xiao","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jaci.2016.03.050","article-title":"Regulation of bronchial epithelial barrier integrity by type 2 cytokines and histone deacetylases in asthmatic patients","volume":"139","author":"Wawrzyniak","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115774","article-title":"GPR120\/FFAR4 stimulation attenuates airway remodeling and suppresses IL-4- and IL-13-induced airway epithelial injury via inhibition of STAT6 and Akt","volume":"168","author":"Moonwiriyakit","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jaci.2025.05.002_bib43","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jaci.2017.02.038","article-title":"Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients","volume":"141","author":"Sugita","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib44","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1159\/000283042","article-title":"The cannabinoid receptor agonist WIN 55,212-2 inhibits antigen-induced plasma extravasation in guinea pig airways","volume":"152","author":"Fukuda","year":"2010","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib45","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.imbio.2010.09.004","article-title":"Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: role of CB1\/CB2 receptors","volume":"216","author":"Braun","year":"2011","journal-title":"Immunobiology"},{"key":"10.1016\/j.jaci.2025.05.002_bib46","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1111\/j.1582-4934.2008.00258.x","article-title":"Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs","volume":"12","author":"Giannini","year":"2008","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jaci.2025.05.002_bib47","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/08923973.2014.976794","article-title":"Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury","volume":"37","author":"Ribeiro","year":"2015","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.jaci.2025.05.002_bib48","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1172\/JCI82925","article-title":"Increased mitochondrial arginine metabolism supports bioenergetics in asthma","volume":"126","author":"Xu","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2025.05.002_bib49","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1089\/ars.2018.7627","article-title":"Bioenergetic differences in the airway epithelium of lean versus obese asthmatics are driven by nitric oxide and reflected in circulating platelets","volume":"31","author":"Winnica","year":"2019","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jaci.2025.05.002_bib50","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.jaci.2020.12.653","article-title":"Metabolic differences between bronchial epithelium from healthy individuals and patients with asthma and the effect of bronchial thermoplasty","volume":"148","author":"Ravi","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib51","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.4049\/jimmunol.0900228","article-title":"Mitochondrial dysfunction increases allergic airway inflammation","volume":"183","author":"Aguilera-Aguirre","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib52","doi-asserted-by":"crossref","DOI":"10.1172\/JCI151685","article-title":"15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation","volume":"132","author":"Nagasaki","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2025.05.002_bib53","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1159\/000516809","article-title":"Metabolism of epithelial cells in health and allergic disease: Collegium Internationale Allergologicum update 2021","volume":"182","author":"Queener","year":"2021","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib54","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1016\/j.febslet.2005.08.002","article-title":"Differential regulation of dual NADPH oxidases\/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium","volume":"579","author":"Harper","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jaci.2025.05.002_bib55","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/j.1365-2222.2008.02969.x","article-title":"IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells","volume":"38","author":"Chibana","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2025.05.002_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090018","article-title":"Elevated exhaled nitric oxide in allergen-provoked asthma is associated with airway epithelial iNOS","volume":"9","author":"Roos","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2025.05.002_bib57","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1002\/eji.200939302","article-title":"Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation","volume":"39","author":"Miyata","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib58","doi-asserted-by":"crossref","first-page":"8970","DOI":"10.1021\/acs.jmedchem.5b01321","article-title":"Targeting the Src homology 2 (SH2) domain of signal transducer and activator of transcription 6 (STAT6) with cell-permeable, phosphatase-stable phosphopeptide mimics potently inhibits Tyr641 phosphorylation and transcriptional activity","volume":"58","author":"Mandal","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.jaci.2025.05.002_bib59","first-page":"917","article-title":"Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis","volume":"123","author":"van den Bogaard","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2025.05.002_bib60","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jid.2023.07.027","article-title":"Benvitimod inhibits IL-4- and IL-13-induced tight junction impairment by activating AHR\/ARNT pathway and inhibiting STAT6 phosphorylation in human keratinocytes","volume":"144","author":"Wang","year":"2024","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2025.05.002_bib61","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nm734","article-title":"Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma","volume":"8","author":"Kuperman","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2025.05.002_bib62","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejphar.2018.11.029","article-title":"Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma","volume":"843","author":"Vuolo","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jaci.2025.05.002_bib63","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0041-008X(03)00010-3","article-title":"Attenuation of the ovalbumin-induced allergic airway response by cannabinoid treatment in A\/J mice","volume":"188","author":"Jan","year":"2003","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jaci.2025.05.002_bib64","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.1038\/s41467-022-34327-0","article-title":"The endocannabinoid anandamide is an airway relaxant in health and disease","volume":"13","author":"Simon","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2025.05.002_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120808","article-title":"Endocannabinoid metabolism inhibition ameliorates ovalbumin-induced allergic airway inflammation and hyperreactivity in Guinea pigs","volume":"306","author":"Abohalaka","year":"2022","journal-title":"Life Sci"},{"key":"10.1016\/j.jaci.2025.05.002_bib66","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1089\/can.2020.0167","article-title":"Cannabinoid receptor subtype-1 regulates allergic airway eosinophilia during lung helminth infection","volume":"6","author":"Wiley","year":"2021","journal-title":"Cannabis Cannabinoid Res"},{"key":"10.1016\/j.jaci.2025.05.002_bib67","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.molimm.2022.06.005","article-title":"WIN55212-2 alleviates acute lung injury by inhibiting macrophage glycolysis through the miR-29b-3p\/FOXO3\/PFKFB3 axis","volume":"149","author":"He","year":"2022","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaci.2025.05.002_bib68","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1007\/s10753-022-01688-z","article-title":"Cannabinoid analogue WIN 55212-2 protects paraquat-induced lung injury and enhances macrophage M2 polarization","volume":"45","author":"He","year":"2022","journal-title":"Inflammation"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674925005512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674925005512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:32:36Z","timestamp":1778664756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674925005512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0091674925005512"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2025.05.002","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabinoid WIN55,212-2 restores bronchial epithelium by regulating oxidative stress and STAT6 phosphorylation","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2025.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}