{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:03:58Z","timestamp":1788401038038,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","award":["946228"],"award-info":[{"award-number":["946228"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL129735"],"award-info":[{"award-number":["R01 HL129735"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL141826"],"award-info":[{"award-number":["R01 HL141826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018870","name":"Swedish Heart and Lung Association","doi-asserted-by":"publisher","award":["20180290"],"award-info":[{"award-number":["20180290"]}],"id":[{"id":"10.13039\/100018870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018870","name":"Swedish Heart and Lung Association","doi-asserted-by":"publisher","award":["20170734"],"award-info":[{"award-number":["20170734"]}],"id":[{"id":"10.13039\/100018870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007398","name":"Strategiske Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Danish Council for Independent Research Health and Disease","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jaci.2025.07.015","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:06:09Z","timestamp":1754438769000},"page":"1537-1546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic characterization of preschool wheeze phenotypes"],"prefix":"10.1016","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3191-1862","authenticated-orcid":false,"given":"Kasper","family":"Fischer-Rasmussen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Granell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Ulrik","family":"Eliasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eskil","family":"Kreiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper-Emil Tingskov","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Chawes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Stokholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Marie","family":"Malby Schoos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Nybo Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarke","family":"Feenstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Geller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Siroux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Demenais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Bouzigon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Jaddoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf J.P.","family":"van der Valk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Duijts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Sunyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Guxens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Marinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariona","family":"Bustamante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Standl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Curtin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Jacobsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny","family":"Myhre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig E.","family":"Pennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Daley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Ober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Gern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorret I.","family":"Boomsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouke-Jan","family":"Hottenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel","family":"Abdellaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Hasan","family":"Arshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anhar","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Mel\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Bisgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Gorm","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Custovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith M.","family":"Vonk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard H.","family":"Koppelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kabesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"B\u00f8nnelykke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2025.07.015_bib1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0091-6749(99)70075-8","article-title":"The economic burden of asthma in US children: estimates from the National Medical Expenditure Survey","volume":"104","author":"Lozano","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.07.015_bib2","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1378\/chest.125.5.1680","article-title":"Variations in pediatric asthma hospitalization rates and costs between and within Nordic countries","volume":"125","author":"Kocevar","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2025.07.015_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1056\/NEJMe0808951","article-title":"Practice imperfect\u2014treatment for wheezing in preschoolers","volume":"360","author":"Bush","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2025.07.015_bib4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3109\/02770903.2015.1067323","article-title":"Pediatric acute asthma exacerbations: evaluation and management from emergency department to intensive care unit","volume":"53","author":"Pardue Jones","year":"2016","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2025.07.015_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jaci.2005.06.024","article-title":"Rhinovirus illnesses during infancy predict subsequent childhood wheezing","volume":"116","author":"Lemanske","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.07.015_bib6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life. The Group Health Medical Associates","volume":"332","author":"Martinez","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2025.07.015_bib7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/all.12783","article-title":"Heritability and confirmation of genetic association studies for childhood asthma in twins","volume":"71","author":"Ullemar","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.07.015_bib8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1183\/09031936.00065706","article-title":"Genetics of parentally reported asthma, eczema and rhinitis in 5-yr-old twins","volume":"29","author":"van Beijsterveldt","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2025.07.015_bib9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/ng.2830","article-title":"A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations","volume":"46","author":"B\u00f8nnelykke","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2025.07.015_bib10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41588-017-0014-7","article-title":"Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks","volume":"50","author":"Demenais","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2025.07.015_bib11","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1038\/s41467-020-15649-3","article-title":"Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma","volume":"11","author":"Han","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2025.07.015_bib12","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1038\/s41467-020-19814-6","article-title":"FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses","volume":"11","author":"Ahluwalia","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2025.07.015_bib13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S2213-2600(19)30055-4","article-title":"Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies","volume":"7","author":"Pividori","year":"2019","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaci.2025.07.015_bib14","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.ajhg.2019.02.022","article-title":"Genetic architectures of childhood- and adult-onset asthma are partly distinct","volume":"104","author":"Ferreira","year":"2019","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaci.2025.07.015_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/pai.14067","article-title":"Genetics of preschool wheeze and its progression to childhood asthma","volume":"35","author":"Wolters","year":"2024","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2025.07.015_bib17","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.84315","article-title":"A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing","volume":"12","author":"Granell","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.jaci.2025.07.015_bib18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10654-019-00502-9","article-title":"The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects","volume":"34","author":"Middeldorp","year":"2019","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jaci.2025.07.015_bib19","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","article-title":"A large-scale, consortium-based genomewide association study of asthma","volume":"363","author":"Moffatt","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2025.07.015_bib20","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2025.07.015_bib21","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2025.07.015_bib22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng1195-241","article-title":"Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results","volume":"11","author":"Lander","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2025.07.015_bib23","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41467-019-14144-8","article-title":"Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis","volume":"11","author":"Olafsdottir","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2025.07.015_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.xgen.2022.100212","article-title":"Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity","volume":"2","author":"Tsuo","year":"2022","journal-title":"Cell Genomics"},{"key":"10.1016\/j.jaci.2025.07.015_bib25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"LD score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2025.07.015_bib26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s40471-020-00233-6","article-title":"The use of genetic correlation and Mendelian randomization studies to increase our understanding of relationships between complex traits","volume":"7","author":"Kraft","year":"2020","journal-title":"Curr Epidemiol Rep"},{"key":"10.1016\/j.jaci.2025.07.015_bib27","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41467-017-02317-2","article-title":"Causal associations between risk factors and common diseases inferred from GWAS summary data","volume":"9","author":"Zhu","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2025.07.015_bib28","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/s41588-018-0157-1","article-title":"Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis","volume":"50","author":"Waage","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2025.07.015_bib29","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jaci.2021.07.043","article-title":"Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis","volume":"149","author":"Sliz","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.07.015_bib30","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.cell.2020.08.008","article-title":"The polygenic and monogenic basis of blood traits and diseases","volume":"182","author":"Vuckovic","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2025.07.015_bib31","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41588-018-0321-7","article-title":"New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries","volume":"51","author":"Shrine","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2025.07.015_bib32","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1164\/rccm.201912-2338OC","article-title":"Lung development genes and adult lung function","volume":"202","author":"Portas","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2025.07.015_bib33","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2025.07.015_bib34","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/thx.2007.093187","article-title":"Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood","volume":"63","author":"Henderson","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2025.07.015_bib35","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.jaci.2017.12.974","article-title":"A decade of research on the 17q12-21 asthma locus: piecing together the puzzle","volume":"142","author":"Stein","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.07.015_bib36","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1056\/NEJMoa1211592","article-title":"Rhinovirus wheezing illness and genetic risk of childhood-onset asthma","volume":"368","author":"Cal\u0131\u015fkan","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2025.07.015_bib37","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S2213-2600(20)30011-4","article-title":"Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study","volume":"8","author":"Ober","year":"2020","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaci.2025.07.015_bib38","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1165\/rcmb.2022-0043PS","article-title":"New insights relating gasdermin B to the onset of childhood asthma","volume":"67","author":"Schoettler","year":"2022","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2025.07.015_bib39","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1073\/pnas.1421178112","article-title":"Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication","volume":"112","author":"Bochkov","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2025.07.015_bib40","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1164\/rccm.201705-1021OC","article-title":"Cadherin-related family member 3 genetics and rhinovirus C respiratory illnesses","volume":"197","author":"B\u00f8nnelykke","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2025.07.015_bib41","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jaci.2022.03.019","article-title":"Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB","volume":"150","author":"Eliasen","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.07.015_bib42","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1164\/rccm.200307-891OC","article-title":"The relationship between infant airway function, childhood airway responsiveness, and asthma","volume":"169","author":"Turner","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2025.07.015_bib43","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1164\/rccm.201110-1922OC","article-title":"Interaction between asthma and lung function growth in early life","volume":"185","author":"Bisgaard","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2025.07.015_bib44","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jaci.2013.06.004","article-title":"Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes","volume":"133","author":"Kerkhof","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.07.015_bib45","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/aps.2010.90","article-title":"Hepatocyte growth factor in lung repair and pulmonary fibrosis","volume":"32","author":"Panganiban","year":"2011","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jaci.2025.07.015_bib46","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mam.2018.08.004","article-title":"Developmental pathways in the pathogenesis of lung fibrosis","volume":"65","author":"Chanda","year":"2019","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.jaci.2025.07.015_bib47","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.1016\/j.cell.2022.11.005","article-title":"A human fetal lung cell atlas uncovers proximal\u2013distal gradients of differentiation and key regulators of epithelial fates","volume":"185","author":"He","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2025.07.015_bib48","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1164\/rccm.202003-0820OC","article-title":"Chromosome 17q12-21 variants are associated with multiple wheezing phenotypes in childhood","volume":"203","author":"Hallmark","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2025.07.015_bib49","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1164\/rccm.202108-1821OC","article-title":"Modeling wheezing spells identifies phenotypes with different outcomes and genetic associates","volume":"205","author":"Haider","year":"2022","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674925008036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674925008036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T04:32:53Z","timestamp":1780201973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674925008036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0091674925008036"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2025.07.015","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic characterization of preschool wheeze phenotypes","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2025.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}