{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:36:53Z","timestamp":1785832613632,"version":"3.56.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009090","name":"Fundacion de la Sociedad Espanola de Alergologia e Inmunologia Clinica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI23\/01566"],"award-info":[{"award-number":["PI23\/01566"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/01540"],"award-info":[{"award-number":["PI20\/01540"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD24\/0007\/0024"],"award-info":[{"award-number":["RD24\/0007\/0024"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD21\/0002\/0008"],"award-info":[{"award-number":["RD21\/0002\/0008"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018780","name":"Servicio Andaluz de Salud","doi-asserted-by":"publisher","award":["C1-0006-2022"],"award-info":[{"award-number":["C1-0006-2022"]}],"id":[{"id":"10.13039\/501100018780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023731","name":"Consejer\u00eda de Salud y Consumo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jaci.2025.11.005","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:52:00Z","timestamp":1763765520000},"page":"419-428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nonsteroidal anti-inflammatory drug\u2013induced acute urticaria\/angioedema associated with atopy-related genes\u2019 genetic variants"],"prefix":"10.1016","volume":"157","author":[{"given":"Isabel Mar\u00eda","family":"Jim\u00e9nez-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Jurado-Escobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Do\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"S\u00e1enz de Santa Mar\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Triano-Cornejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Cort\u00e9s-Collado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 J.","family":"Laguna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Loli-Ausejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Vega-Rioja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 D.","family":"L\u00f3pez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3465-8735","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Cornejo-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2025.11.005_bib1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/pds.1592","article-title":"The pattern of use of non-steroidal anti-inflammatory drugs (NSAIDs) from 1997 to 2005: a nationwide study on 4.6 million people","volume":"17","author":"Fosbol","year":"2008","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jaci.2025.11.005_bib2","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00296-011-2263-6","article-title":"A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity","volume":"32","author":"Conaghan","year":"2012","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.jaci.2025.11.005_bib3","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/bcp.12239","article-title":"Usage patterns of \u201cover-the-counter\u201d vs prescription-strength nonsteroidal anti-inflammatory drugs in France","volume":"77","author":"Duong","year":"2014","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jaci.2025.11.005_bib4","first-page":"363","article-title":"Drug hypersensitivity reactions: response patterns, drug involved, and temporal variations in a large series of patients","volume":"22","author":"Do\u00f1a","year":"2012","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib5","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jaip.2014.03.014","article-title":"Nonsteroidal anti-inflammatory drugs are major causes of drug-induced anaphylaxis","volume":"2","author":"Aun","year":"2014","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2025.11.005_bib6","first-page":"40","article-title":"Drug-induced anaphylaxis survey in Portuguese allergy departments","volume":"24","author":"Faria","year":"2014","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib7","article-title":"Drug-induced hypersensitivity reactions in a Lebanese outpatient population: a decade-long retrospective analysis (2012-2021)","volume":"3","author":"Dagher","year":"2024","journal-title":"J Allergy Clin Immunol Glob"},{"key":"10.1016\/j.jaci.2025.11.005_bib8","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/all.12260","article-title":"Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs","volume":"68","author":"Kowalski","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.11.005_bib9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/bmj.1.5949.67","article-title":"Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients","volume":"1","author":"Szczeklik","year":"1975","journal-title":"Br Med J"},{"key":"10.1016\/j.jaci.2025.11.005_bib10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/all.14032","article-title":"Progress in understanding hypersensitivity reactions to nonsteroidal anti-inflammatory drugs","volume":"75","author":"Do\u00f1a","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.11.005_bib11","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/all.13725","article-title":"Eicosanoid mediator profiles in different phenotypes of nonsteroidal anti-inflammatory drug-induced urticaria","volume":"74","author":"Do\u00f1a","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.11.005_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jaci.2022.08.021","article-title":"Updates on immune mechanisms in aspirin-exacerbated respiratory disease","volume":"151","author":"Laidlaw","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-34668-1","article-title":"NSAIDs-hypersensitivity often induces a blended reaction pattern involving multiple organs","volume":"8","author":"Do\u00f1a","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2025.11.005_bib14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jaci.2013.07.004","article-title":"Certain subphenotypes of aspirin-exacerbated respiratory disease distinguished by latent class analysis","volume":"133","author":"Bochenek","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib15","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/all.14141","article-title":"Subphenotypes of nonsteroidal antiinflammatory disease\u2013exacerbated respiratory disease identified by latent class analysis","volume":"75","author":"Celejewska-Wojcik","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.11.005_bib16","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/all.13075","article-title":"Identification of phenotypic clusters of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease","volume":"72","author":"Lee","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.11.005_bib17","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1081-1206(10)61782-6","article-title":"Aspirin intolerance and allergy to house dust mites: important factors associated with development of severe asthma","volume":"92","author":"Kupczyk","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib18","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3389\/fphar.2020.00503","article-title":"Evaluation of subjects experiencing allergic reactions to non-steroidal anti-inflammatory drugs: clinical characteristics and drugs involved","volume":"11","author":"P\u00e9rez-S\u00e1nchez","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jaci.2025.11.005_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1081-1206(10)62748-2","article-title":"Atopy is a risk factor for non-steroidal anti-inflammatory drug sensitivity","volume":"84","author":"S\u00e1nchez-Borges","year":"2000","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib20","first-page":"277","article-title":"NSAID facial angioedema in a selected pediatric atopic population","volume":"10","author":"Capriles-Behrens","year":"2000","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2500\/aap.2024.45.230081","article-title":"Evaluation of different protocols for classification of pediatric hypersensitivity reactions to nonsteroidal anti-inflammatory drugs: children with underlying allergic disease should be a separate subgroup","volume":"45","author":"Arikoglu","year":"2024","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaci.2025.11.005_bib22","first-page":"139","article-title":"Increased total and mite-specific immunoglobulin E in patients with aspirin-induced urticaria and angioedema","volume":"20","author":"S\u00e1nchez-Borges","year":"2010","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib23","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1365-2222.2010.03651.x","article-title":"Characteristics of subjects experiencing hypersensitivity to non-steroidal anti-inflammatory drugs: patterns of response","volume":"41","author":"Do\u00f1a","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2025.11.005_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/pai.12039","article-title":"Drug provocation tests in the diagnosis of hypersensitivity reactions to non-steroidal anti-inflammatory drugs in children","volume":"24","author":"Zambonino","year":"2013","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib25","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1111\/all.13147","article-title":"Natural evolution in patients with nonsteroidal anti-inflammatory drug\u2013induced urticaria\/angioedema","volume":"72","author":"Do\u00f1a","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.11.005_bib26","doi-asserted-by":"crossref","first-page":"11356","DOI":"10.1074\/jbc.271.19.11356","article-title":"Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35","volume":"271","author":"Penrose","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2025.11.005_bib27","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/all.14119","article-title":"Medical algorithm: diagnosis and treatment of nonsteroidal antiinflammatory drugs hypersensitivity","volume":"75","author":"Do\u00f1a","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.11.005_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/4d0bcb4c-ade9-4393-918f-daa5e7e5f6f6","article-title":"Assessing the validity of asthma associations for eight candidate genes and age at diagnosis effects","volume":"8","author":"Pino-Yanes","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2025.11.005_bib29","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/bioinformatics\/btq671","article-title":"Tabix: fast retrieval of sequence features from generic TAB-delimited files","volume":"27","author":"Li","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2025.11.005_bib30","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1093\/bioinformatics\/btr330","article-title":"The variant call format and VCFtools","volume":"27","author":"Danecek","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2025.11.005_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.667824","article-title":"Genetic variants in cytosolic phospholipase A2 associated with nonsteroidal anti-inflammatory drug-induced acute urticaria\/angioedema","volume":"12","author":"Jurado-Escobar","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jaci.2025.11.005_bib32","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/bjd.20440","article-title":"Polymorphisms in eicosanoid-related biosynthesis enzymes associated with acute urticaria\/angioedema induced by nonsteroidal anti-inflammatory drug hypersensitivity","volume":"185","author":"Jurado-Escobar","year":"2021","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2025.11.005_bib33","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2025.11.005_bib34","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/ng1669","article-title":"Efficiency and power in genetic association studies","volume":"37","author":"de Bakker","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2025.11.005_bib35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bioinformatics\/19.1.149","article-title":"Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits","volume":"19","author":"Purcell","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2025.11.005_bib36","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/bioinformatics\/btm025","article-title":"SNPassoc: an R package to perform whole genome association studies","volume":"23","author":"Gonz\u00e1lez","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2025.11.005_bib37","first-page":"143","article-title":"Trends in hypersensitivity drug reactions: more drugs, more response patterns, more heterogeneity","volume":"24","author":"Do\u00f1a","year":"2014","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib38","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.2500\/ar.2012.3.0025","article-title":"Mite-induced inflammation: more than allergy","volume":"3","author":"S\u00e1nchez-Borges","year":"2012","journal-title":"Allergy Rhinol (Providence)"},{"key":"10.1016\/j.jaci.2025.11.005_bib39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/mi.2009.138","article-title":"New insights into innate immune mechanisms underlying allergenicity","volume":"3","author":"Wills-Karp","year":"2010","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib40","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jaci.2022.10.027","article-title":"Recent progress in the genetic and epigenetic underpinnings of atopy","volume":"151","author":"Baloh","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib41","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1365-2133.2005.06851.x","article-title":"Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant","volume":"154","author":"Mastalerz","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2025.11.005_bib42","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/pai.12300","article-title":"NSAID hypersensitivity in twins","volume":"25","author":"Caimmi","year":"2014","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib43","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1177\/01945998221102085","article-title":"Inheritance of NSAID-exacerbated respiratory disease","volume":"168","author":"Suikkila","year":"2023","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2025.11.005_bib44","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/472","article-title":"Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma","volume":"19","author":"Mitsuyasu","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2025.11.005_bib45","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/jid.2009.300","article-title":"Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort","volume":"130","author":"Biagini Myers","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2025.11.005_bib46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1476-7961-8-5","article-title":"Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma","volume":"8","author":"Knutsen","year":"2010","journal-title":"Clin Mol Allergy"},{"key":"10.1016\/j.jaci.2025.11.005_bib47","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3109\/02770903.2012.660294","article-title":"Gene\u2013gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma","volume":"49","author":"Choi","year":"2012","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2025.11.005_bib48","article-title":"The heterogeneity of asthma phenotypes in children and young adults","volume":"2012","author":"Hesselmar","year":"2012","journal-title":"J Allergy (Cairo)"},{"key":"10.1016\/j.jaci.2025.11.005_bib49","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1398-9995.2009.02167.x","article-title":"Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease","volume":"65","author":"Beghe","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.11.005_bib50","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1164\/rccm.200607-992OC","article-title":"Ethnicity-specific gene\u2013gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma","volume":"175","author":"Battle","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2025.11.005_bib51","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4168\/aair.2013.5.6.371","article-title":"IL-4 receptor alpha polymorphisms may be a susceptible factor for work-related respiratory symptoms in bakery workers","volume":"5","author":"Hur","year":"2013","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2025.11.005_bib52","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/01.fpc.0000230409.00276.44","article-title":"Gene\u2013gene interactions of IL13 and IL4RA variants in immediate allergic reactions to betalactam antibiotics","volume":"16","author":"Gu\u00e9ant-Rodr\u00edguez","year":"2006","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.jaci.2025.11.005_bib53","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jaci.2008.10.058","article-title":"Gene variants of IL13, IL4, and IL4RA are predictors of beta-lactam allergy","volume":"123","author":"Gu\u00e9ant","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib54","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/j.1398-9995.2012.02867.x","article-title":"Biological and genetic determinants of atopy are predictors of immediate-type allergy to betalactams, in Spain","volume":"67","author":"Cornejo-Garc\u00eda","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2025.11.005_bib55","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.4049\/jimmunol.0803266","article-title":"An atopy-associated polymorphism in the ectodomain of the IL-4R\u03b1 chain (V50) regulates the persistence of STAT6 phosphorylation","volume":"183","author":"Ford","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib56","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1073\/pnas.0903103106","article-title":"Potential etiologic and functional implications of genome-wide association loci for human diseases and traits","volume":"106","author":"Hindorff","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"suppl 1","key":"10.1016\/j.jaci.2025.11.005_bib57","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1471-2350-8-S1-S1","article-title":"The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports","volume":"8","author":"Cupples","year":"2007","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.jaci.2025.11.005_bib58","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jaci.2006.04.022","article-title":"Changes in specific IgE and IgG and monocyte chemoattractant protein-1 in workers with occupational asthma caused by diisocyanates and removed from exposure","volume":"118","author":"Malo","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib59","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1164\/rccm.2109018","article-title":"Diisocyanate antigen\u2013stimulated monocyte chemoattractant protein-1 synthesis has greater test efficiency than specific antibodies for identification of diisocyanate asthma","volume":"166","author":"Bernstein","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2025.11.005_bib60","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.4049\/jimmunol.170.5.2680","article-title":"Synthesis and secretion of monocyte chemotactic protein-1 stimulated by the high affinity receptor for IgE","volume":"170","author":"Eglite","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib61","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1084\/jem.20021806","article-title":"Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells","volume":"197","author":"Gonz\u00e1lez-Espinosa","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2025.11.005_bib62","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1182\/blood.V90.11.4438","article-title":"The c-kit ligand stem cell factor and anti-IgE promote expression of monocyte chemoattractant protein-1 in human lung mast cells","volume":"90","author":"Baghestanian","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2025.11.005_bib63","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.jaci.2005.08.042","article-title":"Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response","volume":"116","author":"Matsuda","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib64","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0091-6749(99)70504-X","article-title":"Production of chemokines and proinflammatory and antiinflammatory cytokines by human alveolar macrophages activated by IgE receptors","volume":"103","author":"Gosset","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib65","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jaci.2006.10.006","article-title":"Significant association of FcepsilonRIalpha promoter polymorphisms with aspirin-intolerant chronic urticaria","volume":"119","author":"Bae","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib66","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-2567.1999.00705.x","article-title":"The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction","volume":"96","author":"Kruse","year":"1999","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2025.11.005_bib67","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1056\/NEJM199712113372403","article-title":"The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor","volume":"337","author":"Hershey","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2025.11.005_bib68","doi-asserted-by":"crossref","first-page":"9504","DOI":"10.3390\/ijms16059504","article-title":"An exploratory pilot study of genetic marker for IgE-mediated allergic diseases with expressions of FcepsilonR1alpha and Cepsilon","volume":"16","author":"Liao","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2025.11.005_bib69","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1744-313X.2010.00901.x","article-title":"FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients","volume":"37","author":"Niwa","year":"2010","journal-title":"Int J Immunogenet"},{"key":"10.1016\/j.jaci.2025.11.005_bib70","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3346\/jkms.2011.26.7.870","article-title":"FCepsilonRI gene promoter polymorphisms and total IgE levels in susceptibility to atopic dermatitis in Korea","volume":"26","author":"Park","year":"2011","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.jaci.2025.11.005_bib71","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/pai.12083","article-title":"Different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics","volume":"24","author":"Potaczek","year":"2013","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2025.11.005_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000166","article-title":"Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus","volume":"4","author":"Weidinger","year":"2008","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jaci.2025.11.005_bib73","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.4049\/jimmunol.171.4.1927","article-title":"A novel -66T\/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases","volume":"171","author":"Hasegawa","year":"2003","journal-title":"J Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167492501142X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167492501142X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:55:40Z","timestamp":1781006140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167492501142X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":73,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S009167492501142X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2025.11.005","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonsteroidal anti-inflammatory drug\u2013induced acute urticaria\/angioedema associated with atopy-related genes\u2019 genetic variants","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2025.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}