{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:27:11Z","timestamp":1786991231623,"version":"build-2736575974"},"reference-count":109,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jaci.2026.02.014","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T16:50:51Z","timestamp":1771865451000},"page":"1099-1113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comprehensive single-cell transcriptomic profiling of the scalp from patients with moderate-to-severe alopecia areata"],"prefix":"10.1016","volume":"157","author":[{"given":"Benjamin D.","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swaroop","family":"Bose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Digpal","family":"Gour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monali","family":"Nandymazumdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anudeep","family":"Golla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"del Duca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Beaziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Avallone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey","family":"Pfeifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"DeGrange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Taliercio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anusha","family":"Pasumarthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeriel","family":"Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-324X","authenticated-orcid":false,"given":"Emma","family":"Guttman-Yassky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2026.02.014_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2019.08.032","article-title":"Epidemiology of alopecia areata, ophiasis, totalis, and universalis: a systematic review and meta-analysis","volume":"82","author":"Lee","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2026.02.014_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.11","article-title":"Alopecia areata","volume":"3","author":"Pratt","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jaci.2026.02.014_bib3","doi-asserted-by":"crossref","DOI":"10.1093\/bjd\/ljaf189","article-title":"Psychosocial burden and the impact of illness perceptions and stigma on quality of life, anxiety and depression in alopecia areata: results from the Alopecia + Me study","volume":"193","author":"Christou","year":"2025","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2026.02.014_bib4","article-title":"Psychosocial and psychiatric comorbidities and health-related quality of life in alopecia areata: a systematic review","volume":"85","author":"Toussi","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2026.02.014_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/jdv.18926","article-title":"The burden of alopecia areata: a scoping review focusing on quality of life, mental health and work productivity","volume":"37","author":"Muntyanu","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaci.2026.02.014_bib6","doi-asserted-by":"crossref","DOI":"10.1007\/s40257-023-00808-1","article-title":"Alopecia areata: current treatments and new directions","volume":"24","author":"Dahabreh","year":"2023","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jaci.2026.02.014_bib7","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/j.jisp.2017.10.014","article-title":"Hair follicle immune privilege revisited: the key to alopecia areata management","volume":"19","author":"Paus","year":"2018","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1016\/j.jaci.2026.02.014_bib8","doi-asserted-by":"crossref","DOI":"10.1007\/s40265-023-01873-w","article-title":"Baricitinib for the treatment of alopecia areata","volume":"83","author":"Freitas","year":"2023","journal-title":"Drugs"},{"key":"10.1016\/j.jaci.2026.02.014_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/nm.3645","article-title":"Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition","volume":"20","author":"Xing","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2026.02.014_bib10","article-title":"Deciphering the complex immunopathogenesis of alopecia areata","volume":"25","author":"Udovi\u0107","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2026.02.014_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.955035","article-title":"An overview of JAK\/STAT pathways and JAK inhibition in alopecia areata","volume":"13","author":"Lensing","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2015.06.032","article-title":"Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17\/TH22 skewing","volume":"136","author":"Su\u00e1rez-Fari\u00f1as","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2016.03.036","article-title":"Molecular signatures define alopecia areata subtypes and transcriptional biomarkers","volume":"7","author":"Jabbari","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jaci.2026.02.014_bib14","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.89790","article-title":"Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata","volume":"1","author":"Mackay-Wiggan","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaci.2026.02.014_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/bjd.16808","article-title":"Alopecia areata: a review of disease pathogenesis","volume":"179","author":"Rajabi","year":"2018","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2026.02.014_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygeno.2010.05.002","article-title":"Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures","volume":"96","author":"Subramanya","year":"2010","journal-title":"Genomics"},{"key":"10.1016\/j.jaci.2026.02.014_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2018.06.029","article-title":"An integrated model of alopecia areata biomarkers highlights both TH1 and TH2 upregulation","volume":"142","author":"Song","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/all.16268","article-title":"Alopecia areata exhibits cutaneous and systemic OX40 activation across atopic backgrounds","volume":"79","author":"Kim","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2026.02.014_bib19","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2110343","article-title":"Two phase 3 trials of baricitinib for alopecia areata","volume":"386","author":"King","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2026.02.014_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2021.10.036","article-title":"Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers","volume":"149","author":"Guttman-Yassky","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib21","article-title":"Scalp biomarkers during dupilumab treatment support Th2 pathway pathogenicity in alopecia areata","volume":"78","author":"Renert-Yuval","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2026.02.014_bib22","article-title":"Phase 2a randomized clinical trial of dupilumab (anti\u2013IL-4R\u03b1) for alopecia areata patients","volume":"77","author":"Guttman-Yassky","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2026.02.014_bib23","doi-asserted-by":"crossref","DOI":"10.1080\/1744666X.2022.2096590","article-title":"Translational impact of omics studies in alopecia areata: recent advances and future perspectives","volume":"18","author":"Basmanav","year":"2022","journal-title":"Exp Rev Clin Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/all.14814","article-title":"An integrated scalp and blood biomarker approach suggests the systemic nature of alopecia areata","volume":"76","author":"Glickman","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2026.02.014_bib25","article-title":"Identification of SLC40A1, LCN2, CREB5, and SLC7A11 as ferroptosis-related biomarkers in alopecia areata through machine learning","volume":"14","author":"Xu","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2026.02.014_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygeno.2011.08.009","article-title":"Integration of genome-wide transcriptional and genetic profiles provides insights into disease development and clinical heterogeneity in alopecia areata","volume":"98","author":"Coda","year":"2011","journal-title":"Genomics"},{"key":"10.1016\/j.jaci.2026.02.014_bib27","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2305764120","article-title":"Functional interrogation of lymphocyte subsets in alopecia areata using single-cell RNA sequencing","volume":"120","author":"Lee","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2026.02.014_bib28","article-title":"A transcriptomic map of murine and human alopecia areata","volume":"5","author":"Borcherding","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaci.2026.02.014_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115798","article-title":"Single-cell analysis of temporal immune cell dynamics in alopecia areata reveals a causal role for clonally expanded CD8+ T cells in disease","volume":"44","author":"Dai","year":"2025","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2026.02.014_bib30","article-title":"The involvement of RIPK1 in alopecia areata","volume":"26","author":"Kim","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2026.02.014_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1565241","article-title":"Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata","volume":"16","author":"Gay-Mimbrera","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib32","doi-asserted-by":"crossref","unstructured":"Mori-Ichioka A, Shigeta H, Seno S, Matsuda H. Communication analysis between human hair-follicles and immune cells with single-cell RNA-Seq. In: Proceedings of the 2024 11th International Conference on Biomedical and Bioinformatics Engineering. https:\/\/doi.org\/10.1145\/3707127.3707168","DOI":"10.1145\/3707127.3707168"},{"key":"10.1016\/j.jaci.2026.02.014_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1444777","article-title":"Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing","volume":"15","author":"An","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib34","article-title":"Epidermal \u03b3\u03b4 T cells, CD8 T cells and macrophages are increased in number in alopecia areata and express BST2 as part of an interferon-driven antiviral gene signature","author":"Coast","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.jaci.2026.02.014_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.955038","article-title":"Induction of T cell exhaustion by JAK1\/3 inhibition in the treatment of alopecia areata","volume":"13","author":"Dai","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.mucimm.2024.10.003","article-title":"A reappraisal of IL-9 in inflammation and cancer","volume":"18","author":"Bick","year":"2025","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2018.01.065","article-title":"Porcine IFI30 inhibits PRRSV proliferation and host cell apoptosis in vitro","volume":"649","author":"Guo","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.jaci.2026.02.014_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(22)02037-2","article-title":"An anti-OX40 antibody to treat moderate-to-severe atopic dermatitis: a multicentre, double-blind, placebo-controlled phase 2b study","volume":"401","author":"Guttman-Yassky","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2026.02.014_bib39","doi-asserted-by":"crossref","DOI":"10.1080\/1750743X.2025.2464528","article-title":"ROCKET: a phase 3 program evaluating the efficacy and safety of rocatinlimab in moderate-to-severe atopic dermatitis","volume":"17","author":"Guttman-Yassky","year":"2025","journal-title":"Immunotherapy"},{"key":"10.1016\/j.jaci.2026.02.014_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2024.07.006","article-title":"CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis","volume":"42","author":"Zhang","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jaci.2026.02.014_bib41","article-title":"Targeting Wnt\/\u03b2-catenin pathway for developing therapies for hair loss","volume":"21","author":"Choi","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2026.02.014_bib42","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2015.2190","article-title":"CCN5 attenuates profibrotic phenotypes of fibroblasts through the Smad6-CCN2 pathway: potential role in epidural fibrosis","volume":"36","author":"Xu","year":"2015","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jaci.2026.02.014_bib43","doi-asserted-by":"crossref","DOI":"10.4161\/cc.20849","article-title":"Human fidgetin is a microtubule severing the enzyme and minus-end depolymerase that regulates mitosis","volume":"11","author":"Mukherjee","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jaci.2026.02.014_bib44","doi-asserted-by":"crossref","DOI":"10.7150\/ijms.15571","article-title":"Wnt5a suppresses \u03b2-catenin signaling during hair follicle regeneration","volume":"13","author":"Xing","year":"2016","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.jaci.2026.02.014_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-44994-w","article-title":"Single-cell analysis of psoriasis resolution demonstrates an inflammatory fibroblast state targeted by IL-23 blockade","volume":"15","author":"Francis","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2026.02.014_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077166","article-title":"Smooth muscle \u03b1 actin (Acta2) and myofibroblast function during hepatic wound healing","volume":"8","author":"Rockey","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2026.02.014_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2022.03.011","article-title":"LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma","volume":"185","author":"Gur","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2026.02.014_bib48","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.jid.2020.11.028","article-title":"Human dermal fibroblast subpopulations are conserved across single-cell RNA sequencing studies","volume":"141","author":"Ascensi\u00f3n","year":"2021","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2026.02.014_bib49","doi-asserted-by":"crossref","DOI":"10.1111\/exd.12918","article-title":"Biomarkers of alopecia areata disease activity and response to corticosteroid treatment","volume":"25","author":"Fuentes-Duculan","year":"2016","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaci.2026.02.014_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003122","article-title":"Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia","volume":"4","author":"Garza","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2026.02.014_bib51","article-title":"A disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif 9 (ADAMTS9) regulates fibronectin fibrillogenesis and turnover","volume":"294","author":"Wang","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2026.02.014_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jamcollsurg.2018.08.347","article-title":"Acta2, Tnc, and Col24a1 expression are associated with abdominal adhesion formation","volume":"227","author":"Marshall","year":"2018","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.jaci.2026.02.014_bib53","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041245","article-title":"Keloid disorder: genetic basis, gene expression profiles, and immunological modulation of the fibrotic processes in the skin","volume":"15","author":"Cohen","year":"2023","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jaci.2026.02.014_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.it.2025.01.008","article-title":"Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine","volume":"46","author":"Shojaei","year":"2025","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jid.2017.04.035","article-title":"Systemic sclerosis dermal fibroblasts suppress Th1 cytokine production via galectin-9 overproduction due to Fli1 deficiency","volume":"137","author":"Saigusa","year":"2017","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2026.02.014_bib56","doi-asserted-by":"crossref","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.jaci.2026.02.014_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155242","article-title":"Multiple pathophysiological roles of midkine in human disease","volume":"135","author":"Cai","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.jaci.2026.02.014_bib58","article-title":"CXCL12 neutralizing antibody promotes hair growth in androgenic alopecia and alopecia areata","volume":"25","author":"Zheng","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2026.02.014_bib59","article-title":"CXCL12 inhibits hair growth through CXCR4","volume":"150","author":"Zheng","year":"2022","journal-title":"Biomed Pharmcother"},{"key":"10.1016\/j.jaci.2026.02.014_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.272re3","article-title":"CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior","volume":"2","author":"Silverstein","year":"2009","journal-title":"Sci Signal"},{"key":"10.1016\/j.jaci.2026.02.014_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2004.08.004","article-title":"Desmin: a major intermediate filament protein essential for the structural integrity and function of muscle","volume":"301","author":"Paulin","year":"2004","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jaci.2026.02.014_bib62","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M111.304436","article-title":"Neuroepithelial transforming gene 1 (Net1) binds to caspase activation and recruitment domain (CARD)- and membrane-associated guanylate kinase-like domain-containing (CARMA) proteins and regulates nuclear factor \u03baB activation","volume":"287","author":"Vessichelli","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2026.02.014_bib63","doi-asserted-by":"crossref","DOI":"10.1172\/JCI58978","article-title":"Periostin promotes chronic allergic inflammation in response to Th2 cytokines","volume":"122","author":"Masuoka","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2026.02.014_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2005.02.010","article-title":"CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells","volume":"22","author":"Marsland","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2026.02.014_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00749","article-title":"Transcription factor SOX5 promotes the migration and invasion of fibroblast-like synoviocytes in part by regulating MMP-9 expression in collagen-induced arthritis","volume":"9","author":"Shi","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib66","doi-asserted-by":"crossref","DOI":"10.1161\/01.RES.78.2.196","article-title":"Myocyte enhancer binding factor-2 expression and activity in vascular smooth muscle cells","volume":"78","author":"Firulli","year":"1996","journal-title":"Circ Res"},{"key":"10.1016\/j.jaci.2026.02.014_bib67","article-title":"MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells","volume":"35","author":"Rodr\u00edguez","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jaci.2026.02.014_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109708","article-title":"Positive and negative feedback regulation of the TGF-\u03b21 explains two equilibrium states in skin aging","volume":"27","author":"Haga","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.jaci.2026.02.014_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030982","article-title":"The transcription factor SOX18 regulates the expression of matrix metalloproteinase 7 and guidance molecules in human endothelial cells","volume":"7","author":"Hoeth","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2026.02.014_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.02.033","article-title":"Inhibition of MMPs and ADAM\/ADAMTS","volume":"165","author":"Malemud","year":"2019","journal-title":"Biochemical Pharmacol"},{"key":"10.1016\/j.jaci.2026.02.014_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113501","article-title":"P-selectin\u2013dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2","volume":"42","author":"Goretzko","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2026.02.014_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2005.01.018","article-title":"Human CC chemokine CCL23, a ligand for CCR1, induces endothelial cell migration and promotes angiogenesis","volume":"30","author":"Hwang","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.jaci.2026.02.014_bib73","series-title":"Clinical immunology","first-page":"186","article-title":"Cytokines and cytokine receptors","author":"O\u2019Shea","year":"2023"},{"key":"10.1016\/j.jaci.2026.02.014_bib74","article-title":"Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region","volume":"106","author":"Tazi-Ahnini","year":"2000","journal-title":"Hum Genet"},{"key":"10.1016\/j.jaci.2026.02.014_bib75","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01682-12","article-title":"Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly","volume":"86","author":"Verhelst","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.jaci.2026.02.014_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2016.10.003","article-title":"Regulation of endothelial migration and proliferation by ephrin-A1","volume":"29","author":"Wiedemann","year":"2017","journal-title":"Cell Signal"},{"key":"10.1016\/j.jaci.2026.02.014_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2014.09.024","article-title":"Cdh5\/VE-cadherin promotes endothelial cell interface elongation via cortical actin polymerization during angiogenic sprouting","volume":"9","author":"Sauteur","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2026.02.014_bib78","article-title":"Interleukin-18: a novel cytokine that augments both innate and acquired immunity","volume":"70","author":"Okamura","year":"1998","journal-title":"Adv Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib79","doi-asserted-by":"crossref","DOI":"10.1111\/imr.12606","article-title":"The family of the interleukin-1 receptors","volume":"281","author":"Boraschi","year":"2018","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2026.02.014_bib80","doi-asserted-by":"crossref","DOI":"10.1034\/j.1600-0625.2003.00089.x","article-title":"Regulation of PDGF and PDGF receptor in cultured dermal papilla cells and follicular keratinocytes of the human hair follicle","volume":"12","author":"Kamp","year":"2003","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaci.2026.02.014_bib81","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.96.25.14470","article-title":"CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells","volume":"96","author":"Morales","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2026.02.014_bib82","article-title":"Systematic assessment of chemokine signaling at chemokine receptors CCR4, CCR7 and CCR10","volume":"22","author":"Lim","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2026.02.014_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpath.2012.06.043","article-title":"Eph\/Ephrin signaling in injury and inflammation","volume":"181","author":"Coulthard","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2026.02.014_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2004.09.006","article-title":"Diverse roles of Eph receptors and ephrins in the regulation of cell migration and tissue assembly","volume":"7","author":"Poliakov","year":"2004","journal-title":"Dev Cell"},{"key":"10.1016\/j.jaci.2026.02.014_bib85","doi-asserted-by":"crossref","DOI":"10.1038\/ni.2454","article-title":"The CD46 and Jagged1 interaction is critical for human T helper 1 immunity","volume":"13","author":"Friec","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.jid.2021.02.250","article-title":"Single cell transcriptomics identifies a potential role for Arg1+ macrophages in alopecia areata pathogenesis","volume":"141","author":"Lee","year":"2021","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2026.02.014_bib87","doi-asserted-by":"crossref","DOI":"10.1038\/s41588-023-01445-4","article-title":"Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases","volume":"55","author":"Ober-Reynolds","year":"2023","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2026.02.014_bib88","doi-asserted-by":"crossref","DOI":"10.1111\/all.13346","article-title":"Alopecia areata is characterized by expansion of circulating Th2\/Tc2\/Th22, within the skin-homing and systemic T-cell populations","volume":"73","author":"Czarnowicki","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2026.02.014_bib89","article-title":"Impaired autophagy promotes hair loss in the C3H\/HeJ mouse model of alopecia areata","volume":"19","author":"Gund","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.jaci.2026.02.014_bib90","doi-asserted-by":"crossref","DOI":"10.1111\/bjd.12396","article-title":"T-helper and regulatory T-cell cytokines in the peripheral blood of patients with active alopecia areata","volume":"169","author":"Tembhre","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2026.02.014_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.114259","article-title":"Changes and significance of Th1\/Th2 and Treg\/Th17 cells and their cytokines in patients with alopecia areata","volume":"442","author":"Yang","year":"2024","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jaci.2026.02.014_bib92","doi-asserted-by":"crossref","DOI":"10.2147\/CCID.S493584","article-title":"Unveiling the effect of age and IgE level on alopecia areata: insights from comparative RNAseq analysis","volume":"18","author":"Liu","year":"2025","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"10.1016\/j.jaci.2026.02.014_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2018.08.022","article-title":"Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis","volume":"143","author":"Guttman-Yassky","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib94","doi-asserted-by":"crossref","DOI":"10.1093\/bjd\/ljae230","article-title":"The role of OX40 ligand\/OX40 axis signalling in atopic dermatitis","volume":"191","author":"Guttman-Yassky","year":"2024","journal-title":"Br J Dermatol"},{"issue":"suppl 1","key":"10.1016\/j.jaci.2026.02.014_bib95","article-title":"CD4+ Treg expansion arrests disease progression in a pre-clinical model of alopecia areata","volume":"210","author":"Lensing","year":"2023","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib96","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1111547","article-title":"The potential of regulatory T cell-based therapies for alopecia areata","volume":"14","author":"Wan","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib97","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.122167","article-title":"OX40L\/OX40 axis impairs follicular and natural Treg function in human SLE","volume":"3","author":"Jacquemin","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaci.2026.02.014_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2007.03.006","article-title":"Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis","volume":"119","author":"Guttman-Yassky","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2011.05.016","article-title":"Lesional dendritic cells in patients with chronic atopic dermatitis and psoriasis exhibit parallel ability to activate T-cell subsets","volume":"128","author":"Fujita","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib100","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/jdv.12932","article-title":"Plasmacytoid dendritic cells in alopecia areata: missing link?","volume":"30","author":"Abou Rahal","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaci.2026.02.014_bib101","article-title":"The role of collagen VI \u03b16 chain gene in atopic dermatitis","volume":"34","author":"Jung","year":"2022","journal-title":"Ann Dermotol"},{"key":"10.1016\/j.jaci.2026.02.014_bib102","article-title":"A fragment of type VI collagen alpha-6 chain is elevated in serum from patients with atopic dermatitis, psoriasis, hidradenitis suppurativa, systemic lupus erythematosus and melanoma","volume":"13","author":"Nielsen","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2026.02.014_bib103","doi-asserted-by":"crossref","DOI":"10.1002\/ar.23330","article-title":"Type V collagen in health, disease, and fibrosis","volume":"299","author":"Mak","year":"2016","journal-title":"Anat Rec"},{"key":"10.1016\/j.jaci.2026.02.014_bib104","doi-asserted-by":"crossref","DOI":"10.1111\/cea.13954","article-title":"Dupilumab suppresses type 2 inflammatory biomarkers across multiple atopic, allergic diseases","volume":"51","author":"Hamilton","year":"2021","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2026.02.014_bib105","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.722170","article-title":"Periostin in allergy and inflammation","volume":"12","author":"Sonnenberg-Riethmacher","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2023.11.922","article-title":"IL-13 and IL-13\u2013induced periostin levels are specifically decreased in patients following endoscopic sinus surgery for chronic rhinosinusitis","volume":"153","author":"Harmon","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.02.014_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2020.04.138","article-title":"Cross-sectional study of blood biomarkers of patients with moderate to severe alopecia areata reveals systemic immune and cardiovascular biomarker dysregulation","volume":"84","author":"Glickman","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2026.02.014_bib108","doi-asserted-by":"crossref","DOI":"10.2340\/actadv.v104.40971","article-title":"Complete blood collection\u2013based systemic inflammation biomarkers as a severity biomarker in alopecia areata: a cross-sectional study","volume":"104","author":"Deng","year":"2024","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jaci.2026.02.014_bib109","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26199662","article-title":"Integrated meta-analysis of scalp transcriptomics and serum proteomics defines alopecia areata subtypes and core disease pathways","volume":"26","author":"Xi","year":"2025","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926000941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926000941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:39:53Z","timestamp":1781685593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674926000941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":109,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0091674926000941"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2026.02.014","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive single-cell transcriptomic profiling of the scalp from patients with moderate-to-severe alopecia areata","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2026.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}