{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:22:45Z","timestamp":1789129365584,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013493","name":"Ellen Walter and Lennart Hesselman Foundation for Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013493","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018861","name":"Konsul Th C Berghs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009252","name":"Science for Life Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006285","name":"Magnus Bergvalls Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jaci.2026.03.003","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:44:29Z","timestamp":1773272669000},"page":"1442-1449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Expression of CD25 in human lung mast cells and its regulation by IL-33"],"prefix":"10.1016","volume":"157","author":[{"given":"Yitao","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionut","family":"Atanasoai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premkumar","family":"Siddhuraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Karin","family":"Johnsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueling","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamdoh","family":"Al-Ameri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasra","family":"Vali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Adner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"S\u00e4fholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas S.","family":"Erjef\u00e4lt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar P.","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4628-9968","authenticated-orcid":false,"given":"Elin","family":"R\u00f6nnberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2026.03.003_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/all.14881","article-title":"The ingenious mast cell: contemporary insights into mast cell behavior and function","volume":"77","author":"Dahlin","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2026.03.003_bib2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.it.2021.04.004","article-title":"Understanding mast cell heterogeneity at single cell resolution","volume":"42","author":"Cildir","year":"2021","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2026.03.003_bib3","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.jaci.2024.12.1092","article-title":"Update on mast cell biology","volume":"155","author":"Pahima","year":"2025","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.03.003_bib4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejphar.2015.04.046","article-title":"Mast cells in airway diseases and interstitial lung disease","volume":"778","author":"Cruse","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jaci.2026.03.003_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1183\/09059180.00005014","article-title":"Mast cells in human airways: the culprit?","volume":"23","author":"Erjef\u00e4lt","year":"2014","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.jaci.2026.03.003_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155891","article-title":"Interleukin-33 (IL-33): a critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine","volume":"156","author":"Cayrol","year":"2022","journal-title":"Cytokine"},{"key":"10.1016\/j.jaci.2026.03.003_bib7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejphar.2015.04.047","article-title":"IL-33 and thymic stromal lymphopoietin in mast cell functions","volume":"778","author":"Saluja","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jaci.2026.03.003_bib8","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.3389\/fimmu.2019.01361","article-title":"Divergent effects of acute and prolonged interleukin 33 exposure on mast cell IgE-mediated functions","volume":"10","author":"R\u00f6nnberg","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.03.003_bib9","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.jid.2019.01.013","article-title":"Yin\u2013yang of IL-33 in human skin mast cells: reduced degranulation, but augmented histamine synthesis through p38 activation","volume":"139","author":"Babina","year":"2019","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2026.03.003_bib10","first-page":"77","article-title":"Expression of cell surface antigens on mast cells: mast cell phenotyping","volume":"315","author":"Hauswirth","year":"2006","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jaci.2026.03.003_bib11","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1182\/blood.V91.8.2731.2731_2731_2736","article-title":"Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells and its diagnostic implications","volume":"91","author":"Escribano","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2026.03.003_bib12","doi-asserted-by":"crossref","DOI":"10.1097\/HS9.0000000000000646","article-title":"Updated diagnostic criteria and classification of mast cell disorders: a consensus proposal","volume":"5","author":"Valent","year":"2021","journal-title":"Hemasphere"},{"key":"10.1016\/j.jaci.2026.03.003_bib13","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.3389\/fimmu.2018.02193","article-title":"An optimized protocol for the isolation and functional analysis of human lung mast cells","volume":"9","author":"Ravindran","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.03.003_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1393802","article-title":"An optimized method for IgE-mediated degranulation of human lung mast cells","volume":"15","author":"Gong","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.03.003_bib15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1182\/blood-2013-10-534685","article-title":"A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection","volume":"124","author":"Saleh","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2026.03.003_bib16","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1038\/s41591-023-02327-2","article-title":"An integrated cell atlas of the lung in health and disease","volume":"29","author":"Sikkema","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2026.03.003_bib17","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.immuni.2023.01.032","article-title":"Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir","volume":"56","author":"Wang","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2026.03.003_bib18","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/cea.13027","article-title":"IL-33 and IgE stimulate mast cell production of IL-2 and regulatory T cell expansion in allergic dermatitis","volume":"47","author":"Salamon","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2026.03.003_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.immuni.2015.06.021","article-title":"An interleukin-33\u2013mast cell\u2013interleukin-2 axis suppresses papain-induced allergic inflammation by promoting regulatory T cell numbers","volume":"43","author":"Morita","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2026.03.003_bib20","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.immuni.2011.07.013","article-title":"Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis","volume":"35","author":"Hershko","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2026.03.003_bib21","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1111\/all.70052","article-title":"Microenvironment-driven mast cell plasticity: insights from cytokine-activated gene signatures in skin and respiratory diseases","volume":"80","author":"Tontini","year":"2025","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2026.03.003_bib22","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jaci.2025.01.017","article-title":"Targeting alarmins in asthma: from bench to clinic","volume":"155","author":"Akenroye","year":"2025","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.03.003_bib23","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.4049\/jimmunol.1003383","article-title":"Mast cells as sensors of cell injury through IL-33 recognition","volume":"186","author":"Enoksson","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2026.03.003_bib24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nri3156","article-title":"The role of interleukin-2 during homeostasis and activation of the immune system","volume":"12","author":"Boyman","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2026.03.003_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113314","article-title":"Interleukin-7 optimizes FOXP3+CD4+ regulatory T cells reactivity to interleukin-2 by modulating CD25 expression","volume":"9","author":"Simonetta","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2026.03.003_bib26","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/eji.200737607","article-title":"IL-15 acts as a potent inducer of CD4+CD25hi cells expressing FOXP3","volume":"38","author":"Imamichi","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2026.03.003_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14647","article-title":"IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2","volume":"8","author":"Jandl","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2026.03.003_bib28","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jaci.2021.09.003","article-title":"Demonstration and implications of IL-3 upregulation of CD25 expression on human mast cells","volume":"149","author":"Yin","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.03.003_bib29","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1097\/01.pas.0000138181.89743.7b","article-title":"CD25 indicates the neoplastic phenotype of mast cells: a novel immunohistochemical marker for the diagnosis of systemic mastocytosis (SM) in routinely processed bone marrow biopsy specimens","volume":"28","author":"Sotlar","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jaci.2026.03.003_bib30","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1182\/blood-2006-06-028100","article-title":"Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with \u201cidiopathic\u201d anaphylaxis","volume":"110","author":"Akin","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2026.03.003_bib31","first-page":"1017","article-title":"Benign mast cell hyperplasia and atypical mast cell infiltrates in penile lichen planus in adult men","volume":"29","author":"Regauer","year":"2014","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.jaci.2026.03.003_bib32","doi-asserted-by":"crossref","first-page":"8702","DOI":"10.3390\/ijms24108702","article-title":"The role of IL-33\/ST2 in COPD and its future as an antibody therapy","volume":"24","author":"Riera-Mart\u00ednez","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2026.03.003_bib33","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12931-025-03360-0","article-title":"Safety and tolerability of astegolimab, an anti-ST2 monoclonal antibody: a narrative review","volume":"26","author":"Kelsen","year":"2025","journal-title":"Respir Res"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926001867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926001867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:56:54Z","timestamp":1780567014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674926001867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0091674926001867"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2026.03.003","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of CD25 in human lung mast cells and its regulation by IL-33","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2026.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}