{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T09:47:00Z","timestamp":1785923220268,"version":"3.56.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,8,5]],"date-time":"2027-08-05T00:00:00Z","timestamp":1817424000000},"content-version":"am","delay-in-days":369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jaci.2026.04.007","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T22:59:19Z","timestamp":1776985159000},"page":"356-367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Update on environmental determinants of allergic diseases"],"prefix":"10.1016","volume":"158","author":[{"given":"Naina","family":"Monga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aswini","family":"Poyyakkara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7364-8703","authenticated-orcid":false,"given":"Magdalena M.","family":"Gorska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2026.04.007_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.alit.2015.12.001","article-title":"Does epigenetics play a role in human asthma?","volume":"65","author":"Vercelli","year":"2016","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaci.2026.04.007_bib2","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1038\/ncomms6965","article-title":"Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma","volume":"6","author":"Igartua","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2026.04.007_bib3","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJMoa1007302","article-title":"Exposure to environmental microorganisms and childhood asthma","volume":"364","author":"Ege","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2026.04.007_bib4","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.jaci.2024.01.016","article-title":"Impact of climate change on immune responses and barrier defense","volume":"153","author":"Skevaki","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib5","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.jaci.2021.10.011","article-title":"Climate change and global issues in allergy and immunology","volume":"148","author":"Pacheco","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib6","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/all.15240","article-title":"Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease","volume":"77","author":"Celebi Sozener","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2026.04.007_bib7","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41579-024-01048-8","article-title":"The gut\u2013airway microbiome axis in health and respiratory diseases","volume":"22","author":"\u00d6z\u00e7am","year":"2024","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jaci.2026.04.007_bib8","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41577-023-00874-w","article-title":"Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease","volume":"23","author":"Donald","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib9","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jaci.2025.02.036","article-title":"Child Opportunity Index at birth and asthma with recurrent exacerbations in the US ECHO program","volume":"156","author":"Miller","year":"2025","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib10","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jaip.2025.02.031","article-title":"Life stressors, resilience resources, and asthma among adults in the Hispanic Community Health Study\/Study of Latinos","volume":"13","author":"Han","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2026.04.007_bib11","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jaci.2023.05.013","article-title":"Asthma-protective agents in dust from traditional farm environments","volume":"152","author":"Marques dos Santos","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66497-y","article-title":"Assembly of the infant gut microbiome and resistome are linked to bacterial strains in mother\u2019s milk","volume":"16","author":"Ferretti","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2026.04.007_bib13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/jn\/nxaa310","article-title":"Maternal diet shapes the breast milk microbiota composition and diversity: impact of mode of delivery and antibiotic exposure","volume":"151","author":"Cortes-Mac\u00edas","year":"2021","journal-title":"J Nutr"},{"key":"10.1016\/j.jaci.2026.04.007_bib14","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.immuni.2023.03.002","article-title":"Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection","volume":"56","author":"Sikder","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2026.04.007_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114974","article-title":"A maternal high-fat diet predisposes to infant lung disease via increased neutrophil-mediated IL-6 trans-signaling","volume":"43","author":"Curren","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2026.04.007_bib16","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.immuni.2024.06.010","article-title":"Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood","volume":"57","author":"Perdijk","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2026.04.007_bib17","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20212397","article-title":"A dysregulated sebum\u2013microbial metabolite\u2013IL-33 axis initiates skin inflammation in atopic dermatitis","volume":"219","author":"Qiu","year":"2022","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2026.04.007_bib18","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/j.jid.2019.02.009","article-title":"Inverse association between the skin and oral microbiota in atopic dermatitis","volume":"139","author":"Li","year":"2019","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2026.04.007_bib19","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.jaci.2016.01.010","article-title":"Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis","volume":"137","author":"Jones","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116054","article-title":"Epicutaneous Staphylococcus aureus initiates cross-tissue IL-36R signaling for neutrophilic lung inflammation in a model of the atopic march","volume":"44","author":"Kline","year":"2025","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2026.04.007_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adp6231","article-title":"Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation","volume":"10","author":"Radhouani","year":"2025","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib22","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1164\/rccm.201504-0658OC","article-title":"Prenatal particulate air pollution and asthma onset in urban children: identifying sensitive windows and sex differences","volume":"192","author":"Hsu","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2026.04.007_bib23","doi-asserted-by":"crossref","first-page":"e723","DOI":"10.1111\/j.1399-3038.2010.01034.x","article-title":"Intrauterine exposure to polycyclic aromatic hydrocarbons, fine particulate matter and early wheeze. Prospective birth cohort study in 4-year olds","volume":"21","author":"Jedrychowski","year":"2010","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib24","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1365-3016.2010.01136.x","article-title":"Effect of prenatal exposure to fine particulate matter on ventilatory lung function of preschool children of non-smoking mothers","volume":"24","author":"Jedrychowski","year":"2010","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.jaci.2026.04.007_bib25","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.rmed.2010.11.022","article-title":"Prenatal exposure to polycyclic aromatic hydrocarbons, environmental tobacco smoke and asthma","volume":"105","author":"Rosa","year":"2011","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2026.04.007_bib26","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jaci.2013.09.023","article-title":"Effects of prenatal community violence and ambient air pollution on childhood wheeze in an urban population","volume":"133","author":"Chiu","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib27","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1016\/j.jaci.2017.07.017","article-title":"Prenatal fine particulate exposure and early childhood asthma: effect of maternal stress and fetal sex","volume":"141","author":"Lee","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib28","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.0535","article-title":"Early-life exposure to air pollution and childhood asthma cumulative incidence in the ECHO CREW Consortium","volume":"7","author":"Zanobetti","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jaci.2026.04.007_bib29","first-page":"4133","article-title":"Maternal diesel particle exposure promotes offspring asthma through NK cell\u2013derived granzyme B","volume":"130","author":"Qian","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2026.04.007_bib30","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.jaci.2017.09.002","article-title":"Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-1\u03b2 and IL-17A","volume":"141","author":"Lenberg","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaci.2013.10.047","article-title":"A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust","volume":"134","author":"Manners","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib32","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1038\/s41467-025-61392-y","article-title":"Air pollution\u2013induced proteomic alterations increase the risk of child respiratory infections","volume":"16","author":"Brustad","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2026.04.007_bib33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jaci.2026.04.007_bib34","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.it.2018.08.006","article-title":"Canonical and non-canonical Wnt signaling in immune cells","volume":"39","author":"Chae","year":"2018","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib35","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s42003-021-02118-w","article-title":"Wnt signaling in lung development, regeneration, and disease progression","volume":"4","author":"Aros","year":"2021","journal-title":"Commun Biol"},{"key":"10.1016\/j.jaci.2026.04.007_bib36","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/j.celrep.2016.11.001","article-title":"Emergence of a wave of Wnt signaling that regulates lung alveologenesis by controlling epithelial self-renewal and differentiation","volume":"17","author":"Frank","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2026.04.007_bib37","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1242\/dev.082131","article-title":"\u03b2-Catenin\u2013SOX2 signaling regulates the fate of developing airway epithelium","volume":"139","author":"Hashimoto","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.jaci.2026.04.007_bib38","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41392-024-01978-y","article-title":"AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation","volume":"9","author":"Dai","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jaci.2026.04.007_bib39","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/mmi.14995","article-title":"Axin1: a novel scaffold protein joins the antiviral network of interferon","volume":"118","author":"Guo","year":"2022","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jaci.2026.04.007_bib40","doi-asserted-by":"crossref","first-page":"8626","DOI":"10.1128\/MCB.21.24.8626-8637.2001","article-title":"Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice","volume":"21","author":"Ishii","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jaci.2026.04.007_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100961","article-title":"SIRT2: controversy and multiple roles in disease and physiology","volume":"55","author":"Wang","year":"2019","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jaci.2026.04.007_bib42","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jaci.2022.08.020","article-title":"Prenatal exposure to ambient air pollution is associated with early life immune perturbations","volume":"151","author":"Tingskov Pedersen","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib43","doi-asserted-by":"crossref","DOI":"10.1093\/eep\/dvaf013","article-title":"Prenatal ambient air pollution associations with DNA methylation in asthma- and allergy-relevant genes: findings from ECHO","volume":"11","author":"Palmore","year":"2025","journal-title":"Environ Epigenet"},{"key":"10.1016\/j.jaci.2026.04.007_bib44","doi-asserted-by":"crossref","first-page":"7452","DOI":"10.1074\/jbc.M116.771667","article-title":"SCFFBXO17 E3 ligase modulates inflammation by regulating proteasomal degradation of glycogen synthase kinase-3\u03b2 in lung epithelia","volume":"292","author":"Suber","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2026.04.007_bib45","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12931-018-0910-0","article-title":"FBXO17 promotes cell proliferation through activation of Akt in lung adenocarcinoma cells","volume":"19","author":"Suber","year":"2018","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2026.04.007_bib46","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1111\/all.15692","article-title":"Proinflammatory polarization of monocytes by particulate air pollutants is mediated by induction of trained immunity in pediatric asthma","volume":"78","author":"Movassagh","year":"2023","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2026.04.007_bib47","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41573-025-01172-x","article-title":"The aryl hydrocarbon receptor: a rehabilitated target for therapeutic immune modulation","volume":"24","author":"Polonio","year":"2025","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jaci.2026.04.007_bib48","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1182\/blood-2017-09-806844","article-title":"SETD1A protects HSCs from activation-induced functional decline in vivo","volume":"131","author":"Arndt","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2026.04.007_bib49","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12185-015-1761-9","article-title":"Regulation of myelopoiesis by the transcription factor IRF8","volume":"101","author":"Tamura","year":"2015","journal-title":"Int J Hematol"},{"key":"10.1016\/j.jaci.2026.04.007_bib50","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/FJC.0000000000001484","article-title":"Transcription factor TCF3 promotes macrophage-mediated inflammation and MMP secretion in abdominal aortic aneurysm by regulating miR-143-5p\/ CCL20","volume":"82","author":"Li","year":"2023","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jaci.2026.04.007_bib51","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1038\/s41591-025-03777-6","article-title":"Immune impacts of fire smoke exposure","volume":"31","author":"Johnson","year":"2025","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2026.04.007_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102846","article-title":"CCR6-CCL20 axis as a therapeutic target for autoimmune diseases","volume":"20","author":"Meitei","year":"2021","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaci.2026.04.007_bib53","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1165\/rcmb.2002-0272OC","article-title":"CCL20 is an inducible product of human airway epithelia with innate immune properties","volume":"29","author":"Starner","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2026.04.007_bib54","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/s41590-023-01510-4","article-title":"CD4+ T cell memory","volume":"24","author":"K\u00fcnzli","year":"2023","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib55","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.4049\/jimmunol.1900745","article-title":"The prostaglandin D2 receptor CRTH2 promotes IL-33\u2013induced ILC2 accumulation in the lung","volume":"204","author":"Oyesola","year":"2020","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib56","article-title":"Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias","volume":"2","author":"Gauthier","year":"2017","journal-title":"CI Insight"},{"key":"10.1016\/j.jaci.2026.04.007_bib57","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1172\/JCI80911","article-title":"High IFN-\u03b3 and low SLPI mark severe asthma in mice and humans","volume":"125","author":"Raundhal","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2026.04.007_bib58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jaci.2024.02.022","article-title":"Landscape fire smoke airway exposure impairs respiratory and cardiac function and worsens experimental asthma","volume":"154","author":"Gomez","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib59","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1016\/j.jaci.2018.11.016","article-title":"Laundry detergents and detergent residue after rinsing directly disrupt tight junction barrier integrity in human bronchial epithelial cells","volume":"143","author":"Wang","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib60","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jaci.2022.10.020","article-title":"Gut epithelial barrier damage caused by dishwasher detergents and rinse aids","volume":"151","author":"Ogulur","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib61","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/all.15457","article-title":"Detergent exposure induces epithelial barrier dysfunction and eosinophilic inflammation in the esophagus","volume":"78","author":"Doyle","year":"2023","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2026.04.007_bib62","article-title":"The anionic surfactant sodium dodecyl benzene sulfonate alleviates inflammatory responses in atopic dermatitis via NF\u03baB\/MAPK pathways in a STAT3-dependent manner","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2026.04.007_bib63","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1038\/s41591-025-03902-5","article-title":"Health impacts of microplastic and nanoplastic exposure","volume":"31","author":"Lamoree","year":"2025","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2026.04.007_bib64","article-title":"PVC nanoplastics exposure exacerbates asthma through R-loop accumulation and subsequent STING activation in macrophages","volume":"12","author":"Bao","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jaci.2026.04.007_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116357","article-title":"Polystyrene microplastics induce pulmonary fibrosis by promoting alveolar epithelial cell ferroptosis through cGAS\/STING signaling","volume":"277","author":"Zhang","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.jaci.2026.04.007_bib66","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrg3961","article-title":"R loops: new modulators of genome dynamics and function","volume":"16","author":"Santos-Pereira","year":"2015","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jaci.2026.04.007_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.874253","article-title":"Copper oxide nanoparticles stimulate the immune response and decrease antioxidant defense in mice after six-week inhalation","volume":"13","author":"Tulinska","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.04.007_bib68","article-title":"Copper oxide nanoparticles induce pulmonary inflammation and exacerbate asthma via the TXNIP signaling pathway","volume":"25","author":"Kim","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2026.04.007_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103863","article-title":"Thioredoxin-interacting protein as a crucial regulator in asthma exacerbation induced by copper oxide nanoparticles in a mouse model","volume":"86","author":"Kim","year":"2025","journal-title":"Redox Biol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926002873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926002873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T09:18:06Z","timestamp":1785921486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674926002873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0091674926002873"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2026.04.007","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Update on environmental determinants of allergic diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2026.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}