{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T08:21:31Z","timestamp":1788078091570,"version":"build-2784847793"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jaci.2026.04.010","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T15:37:39Z","timestamp":1777131459000},"page":"151-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comprehensive molecular profiling of Hispanic, Black, Asian, and White patients with atopic dermatitis via tape strip RNA sequencing and serum proteomics"],"prefix":"10.1016","volume":"158","author":[{"given":"Daniel","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Del Duca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Avallone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Beaziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragasruti","family":"Metukuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeriel","family":"Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Largen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ungar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-324X","authenticated-orcid":false,"given":"Emma","family":"Guttman-Yassky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2026.04.010_bib1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.jaci.2007.11.004","article-title":"Is eczema really on the increase worldwide?","volume":"121","author":"Williams","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.jaci.2009.10.009","article-title":"Global variations in prevalence of eczema symptoms in children from ISAAC phase three","volume":"124","author":"Odhiambo","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib3","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jid.2018.10.029","article-title":"Racial\/ethnic differences in incidence and persistence of childhood atopic dermatitis","volume":"139","author":"Kim","year":"2019","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2026.04.010_bib4","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1001\/archderm.138.5.634","article-title":"In the United States, blacks and Asian\/Pacific Islanders are more likely than whites to seek medical care for atopic dermatitis","volume":"138","author":"Janumpally","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaci.2026.04.010_bib5","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1136\/jcp.2005.027151","article-title":"My approach to superficial inflammatory dermatoses","volume":"58","author":"Alsaad","year":"2005","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jaci.2026.04.010_bib6","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jaci.2018.02.047","article-title":"Serum from Asian patients with atopic dermatitis is characterized by TH2\/TH22 activation, which is highly correlated with nonlesional skin measures","volume":"142","author":"Wen","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib7","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.jaci.2015.08.015","article-title":"The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization","volume":"136","author":"Noda","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaci.2009.11.008","article-title":"An update on the genetics of atopic dermatitis: scratching the surface in 2009","volume":"125","author":"Barnes","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib9","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/ced\/llad162","article-title":"Atopic dermatitis in skin of colour. Part 2: considerations in clinical presentation and treatment options","volume":"48","author":"Gan","year":"2023","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jaci.2026.04.010_bib10","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.jaip.2020.02.022","article-title":"Endophenotypic variations of atopic dermatitis by age, race, and ethnicity","volume":"8","author":"Nomura","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2026.04.010_bib11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/gepi.21702","article-title":"African ancestry is a risk factor for asthma and high total IgE levels in African admixed populations","volume":"37","author":"Vergara","year":"2013","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.jaci.2026.04.010_bib12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.5414\/CPP42701","article-title":"Pharmacokinetics of immunosuppressants: a perspective on ethnic differences","volume":"42","author":"Dirks","year":"2004","journal-title":"Int J Clin Pharmacol Ther"},{"issue":"1-15","key":"10.1016\/j.jaci.2026.04.010_bib13","article-title":"Adverse effects of topical glucocorticosteroids","volume":"54","author":"Hengge","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2026.04.010_bib14","first-page":"899","article-title":"Role of the epidermal barrier in atopic dermatitis","volume":"7","author":"Proksch","year":"2009","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1016\/j.jaci.2026.04.010_bib15","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.jaci.2010.03.016","article-title":"Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum","volume":"125","author":"Gao","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib16","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1001\/jamadermatol.2013.7954","article-title":"Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis","volume":"150","author":"Margolis","year":"2014","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jaci.2026.04.010_bib17","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/ng.3424","article-title":"Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis","volume":"47","author":"Paternoster","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2026.04.010_bib18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jaci.2009.07.034","article-title":"Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum","volume":"124","author":"Gao","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib19","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1038\/jid.2014.126","article-title":"Exome sequencing of filaggrin and related genes in African-American children with atopic dermatitis","volume":"134","author":"Margolis","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2026.04.010_bib20","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.jid.2018.01.029","article-title":"Uncommon filaggrin variants are associated with persistent atopic dermatitis in African Americans","volume":"138","author":"Margolis","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2026.04.010_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.anai.2018.08.024","article-title":"Atopic dermatitis in African American patients is TH2\/TH22-skewed with TH1\/TH17 attenuation","volume":"122","author":"Sanyal","year":"2019","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib22","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.anai.2021.04.023","article-title":"Immune and barrier characterization of atopic dermatitis skin phenotype in Tanzanian patients","volume":"127","author":"Lang","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib23","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.jaci.2015.03.003","article-title":"RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications","volume":"135","author":"Su\u00e1rez-Fari\u00f1as","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.anai.2019.10.013","article-title":"Increased cardiovascular and atherosclerosis markers in blood of older patients with atopic dermatitis","volume":"124","author":"He","year":"2020","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jaci.2018.08.022","article-title":"Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis","volume":"143","author":"Guttman-Yassky","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib26","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jaci.2011.05.032","article-title":"IL-5 receptor \u03b1 levels in patients with marked eosinophilia or mastocytosis","volume":"128","author":"Wilson","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib27","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.anai.2018.11.015","article-title":"Racial differences in atopic dermatitis","volume":"122","author":"Brunner","year":"2019","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-90105-w","article-title":"Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2\/Th17-centered cutaneous immune activation","volume":"11","author":"Wongvibulsin","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2026.04.010_bib29","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.2105\/AJPH.84.12.1985","article-title":"Who is Hispanic? Definitions and their consequences","volume":"84","author":"Zimmerman","year":"1994","journal-title":"Am J Public Health"},{"key":"10.1016\/j.jaci.2026.04.010_bib30","first-page":"804","article-title":"Efficacy of dupilumab in different racial subgroups of adults with moderate-to-severe atopic dermatitis in three randomized, placebo-controlled phase 3 trials","volume":"18","author":"Alexis","year":"2019","journal-title":"J Drugs Dermatol"},{"key":"10.1016\/j.jaci.2026.04.010_bib31","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1056\/NEJMoa2206714","article-title":"Two phase 3 trials of lebrikizumab for moderate-to-severe atopic dermatitis","volume":"388","author":"Silverberg","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2026.04.010_bib32","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/bjd.19574","article-title":"Tralokinumab for moderate-to-severe atopic dermatitis: results from two 52-week, randomized, double-blind, multicentre, placebo-controlled phase III trials (ECZTRA 1 and ECZTRA 2)","volume":"184","author":"Wollenberg","year":"2021","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2026.04.010_bib33","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/bjd\/ljae230","article-title":"The role of OX40 ligand\/OX40 axis signalling in atopic dermatitis","volume":"191","author":"Guttman-Yassky","year":"2024","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2026.04.010_bib34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s40257-023-00838-9","article-title":"OX40 in the pathogenesis of atopic dermatitis\u2014a new therapeutic target","volume":"25","author":"Croft","year":"2024","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jaci.2026.04.010_bib35","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0140-6736(22)02037-2","article-title":"An anti-OX40 antibody to treat moderate-to-severe atopic dermatitis: a multicentre, double-blind, placebo-controlled phase 2b study","volume":"401","author":"Guttman-Yassky","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2026.04.010_bib36","first-page":"2715","article-title":"Evaluation of the effects of IL-22 on the proliferation and differentiation of keratinocytes in vitro","volume":"22","author":"Zhuang","year":"2020","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jaci.2026.04.010_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jdermsci.2013.04.028","article-title":"The role of IL-22 and Th22 cells in human skin diseases","volume":"72","author":"Fujita","year":"2013","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jaci.2026.04.010_bib38","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/all.15845","article-title":"Intrapatient comparison of atopic dermatitis skin transcriptome shows differences between tape-strips and biopsies","volume":"79","author":"Del Duca","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2026.04.010_bib39","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abe2749","article-title":"Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4R\u03b1 blockade","volume":"6","author":"Bangert","year":"2021","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib40","doi-asserted-by":"crossref","first-page":"9230","DOI":"10.1038\/s41467-024-53384-1","article-title":"The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment of inflammatory skin diseases: two randomized, double-blind, placebo-controlled phase 1b trials","volume":"15","author":"Silverberg","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2026.04.010_bib41","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1093\/jimmun\/vkaf049","article-title":"A translational approach to improve therapeutics in atopic dermatitis and beyond","volume":"214","author":"Liu","year":"2025","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2026.04.010_bib42","first-page":"30","article-title":"Pruritus in Black skin: unique molecular characteristics and clinical features","volume":"113","author":"McColl","year":"2021","journal-title":"J Natl Med Assoc"},{"key":"10.1016\/j.jaci.2026.04.010_bib43","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/exd.13514","article-title":"Atopic dermatitis in diverse racial and ethnic groups\u2014variations in epidemiology, genetics, clinical presentation and treatment","volume":"27","author":"Kaufman","year":"2018","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaci.2026.04.010_bib44","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s13555-021-00516-w","article-title":"Epidemiology and characterization of atopic dermatitis in East Asian populations: a systematic review","volume":"11","author":"Cheng","year":"2021","journal-title":"Dermatol Ther (Heidelb)"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926002903?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926002903?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:33:50Z","timestamp":1783071230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674926002903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0091674926002903"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2026.04.010","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive molecular profiling of Hispanic, Black, Asian, and White patients with atopic dermatitis via tape strip RNA sequencing and serum proteomics","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2026.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}