{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:40:38Z","timestamp":1792708838437,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007265","name":"Boston University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006691","name":"Harvard Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005292","name":"Brigham and Women's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005292","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011625","name":"Marshfield Clinic Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008028","name":"University of Wisconsin Madison School of Medicine and Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006474","name":"Columbia University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006474","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007278","name":"Henry Ford Health System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007234","name":"The University of Chicago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jaci.2026.06.003","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:43:36Z","timestamp":1781624616000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic gestational age acceleration in cord blood is associated with activated inflammatory gene pathways and childhood asthma"],"prefix":"10.1016","author":[{"given":"Adriana Y.","family":"Prichina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Seroogy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy A.","family":"Eapen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweta","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M.","family":"Visness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard B.","family":"Bacharier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane R.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie B.","family":"Herbstman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meyer","family":"Kattan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George T.","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Rivera-Spoljaric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"VanWormer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott T.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Oken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lasky-Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Schoettler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert M.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Gern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn L.","family":"DeMeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"McKennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Ober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9562-6414","authenticated-orcid":false,"given":"Emma E.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2026.06.003_bib1","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2026.06.003_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101348","article-title":"A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration","volume":"69","author":"Oblak","year":"2021","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jaci.2026.06.003_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102552","article-title":"Breaking new ground on human health and well-being with epigenetic clocks: a systematic review and meta-analysis of epigenetic age acceleration associations","volume":"102","author":"Chervova","year":"2024","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jaci.2026.06.003_bib4","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.3390\/genes14091724","article-title":"A review of the epigenetic clock: emerging biomarkers for asthma and allergic disease","volume":"14","author":"Vasileva","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.jaci.2026.06.003_bib5","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.jaci.2019.01.034","article-title":"Epigenetic age acceleration is associated with allergy and asthma in children in Project Viva","volume":"143","author":"Peng","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.06.003_bib6","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1038\/s41467-019-11058-3","article-title":"The nasal methylome as a biomarker of asthma and airway inflammation in children","volume":"10","author":"Cardenas","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2026.06.003_bib7","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13059-016-1068-z","article-title":"An epigenetic clock for gestational age at birth based on blood methylation data","volume":"17","author":"Knight","year":"2016","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2026.06.003_bib8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s13059-016-1063-4","article-title":"Prediction of gestational age based on genome-wide differentially methylated regions","volume":"17","author":"Bohlin","year":"2016","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2026.06.003_bib9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13148-018-0520-1","article-title":"Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics","volume":"10","author":"Khouja","year":"2018","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.jaci.2026.06.003_bib10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13148-022-01374-9","article-title":"Gestational age acceleration is associated with epigenetic biomarkers of prenatal physiologic stress exposure","volume":"14","author":"Euclydes","year":"2022","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.jaci.2026.06.003_bib11","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1080\/15592294.2022.2102846","article-title":"Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort","volume":"17","author":"Daredia","year":"2022","journal-title":"Epigenetics"},{"key":"10.1016\/j.jaci.2026.06.003_bib12","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.0672","article-title":"Analysis of pregnancy complications and epigenetic gestational age of newborns","volume":"6","author":"Ladd-Acosta","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jaci.2026.06.003_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13148-023-01480-2","article-title":"DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort","volume":"15","author":"Bozack","year":"2023","journal-title":"Clin Epigenetics"},{"issue":"Pt 2","key":"10.1016\/j.jaci.2026.06.003_bib14","article-title":"Prenatal exposures to per- and polyfluoroalkyl substances and epigenetic aging in umbilical cord blood: the Healthy Start study","volume":"231","author":"Niemiec","year":"2023","journal-title":"Environ Res"},{"key":"10.1016\/j.jaci.2026.06.003_bib15","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.18632\/aging.205602","article-title":"Associations of prenatal one-carbon metabolism nutrients and metals with epigenetic aging biomarkers at birth and in childhood in a US cohort","volume":"16","author":"Bozack","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jaci.2026.06.003_bib16","doi-asserted-by":"crossref","DOI":"10.1080\/15592294.2025.2610521","article-title":"Immune pathways and prenatal\/perinatal environmental exposures contribute to epigenetic gestational age prediction and acceleration","volume":"21","author":"Eapen","year":"2026","journal-title":"Epigenetics"},{"key":"10.1016\/j.jaci.2026.06.003_bib17","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.jaci.2022.12.828","article-title":"A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome","volume":"151","author":"Morin","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.06.003_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyae011","article-title":"Cohort profile: the Mothers and Newborns (MN) Cohort of the Columbia Center for Children's Environmental Health","volume":"53","author":"Riley","year":"2024","journal-title":"Int J Epidemiol"},{"issue":"suppl 15","key":"10.1016\/j.jaci.2026.06.003_bib19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1034\/j.1399-3038.13.s.15.8.x","article-title":"The Childhood Origins of Asthma (COAST) study","volume":"13","author":"Lemanske","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2026.06.003_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2466-9-17","article-title":"The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population","volume":"9","author":"Gern","year":"2009","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.jaci.2026.06.003_bib21","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.jaci.2011.06.039","article-title":"Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood","volume":"128","author":"Havstad","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.06.003_bib22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1186\/s13104-019-4448-0","article-title":"Respiratory health, allergies, and the farm environment: design, methods and enrollment in the observational Wisconsin Infant Study Cohort (WISC): a research proposal","volume":"12","author":"Seroogy","year":"2019","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.jaci.2026.06.003_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/ije\/dyu008","article-title":"Cohort profile: Project Viva","volume":"44","author":"Oken","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaci.2026.06.003_bib24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cct.2014.02.006","article-title":"The Vitamin D Antenatal Asthma Reduction Trial (VDAART): rationale, design, and methods of a randomized, controlled trial of vitamin D supplementation in pregnancy for the primary prevention of asthma and allergies in children","volume":"38","author":"Litonjua","year":"2014","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.jaci.2026.06.003_bib25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12931-019-1088-9","article-title":"The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population","volume":"20","author":"Gern","year":"2019","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2026.06.003_bib26","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/aje\/kwad071","article-title":"The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort","volume":"192","author":"Knapp","year":"2023","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jaci.2026.06.003_bib27","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2026.06.003_bib28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4161\/epi.1.1.2643","article-title":"DNA methylation analysis as a tool for cell typing","volume":"1","author":"Baron","year":"2006","journal-title":"Epigenetics"},{"key":"10.1016\/j.jaci.2026.06.003_bib29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41586-022-05580-6","article-title":"A DNA methylation atlas of normal human cell types","volume":"613","author":"Loyfer","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2026.06.003_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2025.103638","article-title":"Examining cellular heterogeneity in human DNA methylation studies: overview and recommendations","volume":"6","author":"Fu","year":"2025","journal-title":"STAR Protoc"},{"key":"10.1016\/j.jaci.2026.06.003_bib31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12859-015-0527-y","article-title":"Cell-composition effects in the analysis of DNA methylation array data: a mathematical perspective","volume":"16","author":"Houseman","year":"2015","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jaci.2026.06.003_bib32","unstructured":"Salas LA, Koestler DC. FlowSorted.Blood.EPIC: Illumina EPIC data on immunomagnetic sorted peripheral adult blood cells, 2025. Available at: https:\/\/bioconductor.org\/packages\/FlowSorted.Blood.EPIC. Accessed October 1, 2024."},{"key":"10.1016\/j.jaci.2026.06.003_bib33","unstructured":"Salas LA, Gervin K, Jones MC, Bakulski KM, Koestler DC, Wiencke JK, et al. FlowSorted.CordBloodCombined.450k: Illumina 450K\/EPIC data on FACS and MACS umbilical cord blood cells, 2025. Available at: https:\/\/bioconductor.org\/packages\/FlowSorted.CordBloodCombined.450k. Accessed October 1, 2024."},{"key":"10.1016\/j.jaci.2026.06.003_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1614230","article-title":"Immune composition of the mononuclear cell fraction of human umbilical cord blood","volume":"16","author":"Kikuta","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.06.003_bib35","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000520638","article-title":"Comprehensive morphological assessment of cord blood: normal values and the prevalence of morphologically aberrant leukocytes","volume":"145","author":"Katz","year":"2022","journal-title":"Acta Haematol"},{"key":"10.1016\/j.jaci.2026.06.003_bib36","series-title":"R: A language and environment for statistical computing","author":"Team","year":"2021"},{"key":"10.1016\/j.jaci.2026.06.003_bib37","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2026.06.003_bib38","unstructured":"McKennan CG. Factor analysis in high dimensional biological data with dependent observations. arXiv:2009.11134 [Preprint], 2020. Available at: https:\/\/arxiv.org\/abs\/2009.11134. Accessed September 19, 2024."},{"key":"10.1016\/j.jaci.2026.06.003_bib39","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/s41592-018-0213-x","article-title":"Identification of differentially methylated cell types in epigenome-wide association studies","volume":"15","author":"Zheng","year":"2018","journal-title":"Nat Methods"},{"key":"10.1016\/j.jaci.2026.06.003_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J Stat Softw"},{"key":"10.1016\/j.jaci.2026.06.003_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v106.i01","article-title":"Elastic net regularization paths for all generalized linear models","volume":"106","author":"Tay","year":"2023","journal-title":"J Stat Softw"},{"key":"10.1016\/j.jaci.2026.06.003_bib42","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf018","article-title":"edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets","volume":"53","author":"Chen","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2026.06.003_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003118","article-title":"Software for computing and annotating genomic ranges","volume":"9","author":"Lawrence","year":"2013","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.jaci.2026.06.003_bib44","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1101\/gr.6202607","article-title":"A systems biology approach for pathway level analysis","volume":"17","author":"Draghici","year":"2007","journal-title":"Genome Res"},{"key":"10.1016\/j.jaci.2026.06.003_bib45","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.jaci.2018.02.019","article-title":"Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma","volume":"142","author":"Altman","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.06.003_bib46","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13073-022-01058-2","article-title":"Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region","volume":"14","author":"Clay","year":"2022","journal-title":"Genome Med"},{"key":"10.1016\/j.jaci.2026.06.003_bib47","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/bioinformatics\/btaa825","article-title":"methylclock: a Bioconductor package to estimate DNA methylation age","volume":"37","author":"Pelegi-Siso","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2026.06.003_bib48","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s42003-023-04584-w","article-title":"Nucleated red blood cells explain most of the association between DNA methylation and gestational age","volume":"6","author":"Haftorn","year":"2023","journal-title":"Commun Biol"},{"key":"10.1016\/j.jaci.2026.06.003_bib49","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13148-023-01552-3","article-title":"Evaluation of pediatric epigenetic clocks across multiple tissues","volume":"15","author":"Fang","year":"2023","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.jaci.2026.06.003_bib50","doi-asserted-by":"crossref","DOI":"10.1177\/2633105520942221","article-title":"DNA methylation clocks and their predictive capacity for aging phenotypes and healthspan","volume":"15","author":"Bergsma","year":"2020","journal-title":"Neurosci Insights"},{"key":"10.1016\/j.jaci.2026.06.003_bib51","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1080\/17501911.2024.2373682","article-title":"Generations of epigenetic clocks and their links to socioeconomic status in the Health and Retirement Study","volume":"16","author":"Crimmins","year":"2024","journal-title":"Epigenomics"},{"key":"10.1016\/j.jaci.2026.06.003_bib52","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14071","article-title":"Deciphering the role of immune cell composition in epigenetic age acceleration: insights from cell-type deconvolution applied to human blood epigenetic clocks","volume":"23","author":"Zhang","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.jaci.2026.06.003_bib53","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13148-017-0339-1","article-title":"Cord blood hematopoietic cells from preterm infants display altered DNA methylation patterns","volume":"9","author":"de Goede","year":"2017","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.jaci.2026.06.003_bib54","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.4049\/jimmunol.1800565","article-title":"The evolving erythrocyte: red blood cells as modulators of innate immunity","volume":"201","author":"Anderson","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2026.06.003_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006910","article-title":"Nucleated red blood cells: immune cell mediators of the antiviral response","volume":"14","author":"Nombela","year":"2018","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jaci.2026.06.003_bib56","doi-asserted-by":"crossref","first-page":"F211","DOI":"10.1136\/fn.84.3.F211","article-title":"Nucleated red blood cells in the fetus and newborn","volume":"84","author":"Hermansen","year":"2001","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jaci.2026.06.003_bib57","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.placenta.2009.09.008","article-title":"Non-linear and gender-specific relationships among placental growth measures and the fetoplacental weight ratio","volume":"30","author":"Misra","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.jaci.2026.06.003_bib58","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.placenta.2012.11.007","article-title":"Fetal sex and preterm birth","volume":"34","author":"Challis","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.jaci.2026.06.003_bib59","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s12916-014-0220-4","article-title":"Elevated risk of stillbirth in males: systematic review and meta-analysis of more than 30 million births","volume":"12","author":"Mondal","year":"2014","journal-title":"BMC Med"},{"key":"10.1016\/j.jaci.2026.06.003_bib60","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgh-2024-015475","article-title":"Birth outcomes and survival by sex among newborns and children under 2 in the Birhan Cohort: a prospective cohort study in the Amhara Region of Ethiopia","volume":"9","author":"Thompson","year":"2024","journal-title":"BMJ Glob Health"},{"issue":"3 Pt 1","key":"10.1016\/j.jaci.2026.06.003_bib61","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0091-6749(99)70456-2","article-title":"Maturation of immune responses at the beginning of asthma","volume":"103","author":"Martinez","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.06.003_bib62","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(94)91641-1","article-title":"Reduced interferon-gamma secretion in neonates and subsequent atopy","volume":"344","author":"Tang","year":"1994","journal-title":"Lancet"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926004197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926004197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:27:13Z","timestamp":1792708033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674926004197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":62,"alternative-id":["S0091674926004197"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2026.06.003","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic gestational age acceleration in cord blood is associated with activated inflammatory gene pathways and childhood asthma","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2026.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}