{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:40:35Z","timestamp":1792708835636,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi US","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jaci.2026.07.006","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:51:30Z","timestamp":1784908290000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dupilumab for patients with allergic fungal rhinosinusitis"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6078-8010","authenticated-orcid":false,"given":"Amber U.","family":"Luong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney","family":"Schlosser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prerna","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Dakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Maloney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Yancopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Fontenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam A.","family":"Phadke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lacey R.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2026.07.006_bib1","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.jaci.2024.06.022","article-title":"Allergic fungal rhinosinusitis linked to other hyper-IgE syndromes through defective T(H)17 responses","volume":"154","author":"Sun","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.07.006_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1285598","article-title":"Exploring the immunopathology of type 2 inflammatory airway diseases","volume":"15","author":"AlBloushi","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.07.006_bib3","first-page":"72","article-title":"Allergic fungal rhinosinusitis","volume":"5","author":"Gupta","year":"2012","journal-title":"Clin Rhinol"},{"key":"10.1016\/j.jaci.2026.07.006_bib4","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1177\/19458924211069226","article-title":"The impact of climatic, socioeconomic, and geographic factors on the prevalence of allergic fungal rhinosinusitis: a worldwide ecological study","volume":"36","author":"AlQahtani","year":"2022","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaci.2026.07.006_bib5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1177\/19458924211056294","article-title":"Demographic variation in chronic rhinosinusitis by subtype and region: a systematic review","volume":"36","author":"Ma","year":"2022","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaci.2026.07.006_bib6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jaci.2018.06.023","article-title":"Allergic fungal rhinosinusitis","volume":"142","author":"Dykewicz","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.07.006_bib7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2147\/JAA.S402326","article-title":"Asthma prevalence and phenotyping in the general population: the LEAD (Lung, hEart, sociAl, boDy) study","volume":"16","author":"Schiffers","year":"2023","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.jaci.2026.07.006_bib8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/alr.21674","article-title":"Prevalence of confirmed asthma varies in chronic rhinosinusitis subtypes","volume":"6","author":"Promsopa","year":"2016","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2026.07.006_bib9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12931-018-0823-y","article-title":"Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study","volume":"19","author":"Philpott","year":"2018","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2026.07.006_bib10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/alr.22487","article-title":"Revision surgery rates in chronic rhinosinusitis with nasal polyps: meta-analysis of risk factors","volume":"10","author":"Loftus","year":"2020","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2026.07.006_bib11","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/all.14151","article-title":"Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4R\u03b1 antibody, is required to broadly inhibit type 2 inflammation","volume":"75","author":"Le Floch","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2026.07.006_bib12","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1073\/pnas.1323896111","article-title":"Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes","volume":"111","author":"Macdonald","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2026.07.006_bib13","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1073\/pnas.1324022111","article-title":"Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice","volume":"111","author":"Murphy","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2026.07.006_bib15","series-title":"European Medicines Agency DUPIXENT\u00ae (dupilumab). Summary of Product Characteristics","year":"2024"},{"key":"10.1016\/j.jaci.2026.07.006_bib17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrd4624","article-title":"Targeting key proximal drivers of type 2 inflammation in disease","volume":"15","author":"Gandhi","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jaci.2026.07.006_bib18","doi-asserted-by":"crossref","unstructured":"Hamilton JD, Ferreira MAR, Lim WK, Sidore C, Wipperman MF, Ge W, et al. Type-2-inflammatory-diseases share comorbidities, molecular signatures, IL4\/IL13 genetics, and response to IL4\/IL13 blockade. Allergy. Epub 2026 May 14.","DOI":"10.1111\/all.70380"},{"key":"10.1016\/j.jaci.2026.07.006_bib19","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1016\/j.anai.2024.08.292","article-title":"Treatment outcomes of allergic fungal rhinosinusitis with biologics: a single institution study","volume":"133","author":"Chuleerarux","year":"2024","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2026.07.006_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2022.100638","article-title":"Dupilumab: an emerging therapy in allergic fungal rhinosinusitis","volume":"15","author":"Bulkhi","year":"2022","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.jaci.2026.07.006_bib21","article-title":"Successful use of dupilumab as a salvage therapy for recalcitrant allergic fungal rhinosinusitis: a case report","volume":"14","author":"Mujahed","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.jaci.2026.07.006_bib22","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.anai.2020.07.014","article-title":"Dupilumab use in recalcitrant allergic fungal rhinosinusitis","volume":"125","author":"Lo","year":"2020","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2026.07.006_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijscr.2021.106479","article-title":"A case report of allergic fungal rhinosinusitis managed with dupilumab","volume":"88","author":"Alotaibi","year":"2021","journal-title":"Int J Surg Case Rep"},{"key":"10.1016\/j.jaci.2026.07.006_bib24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4193\/RHINOL\/24.009","article-title":"Dupilumab as an emerging treatment for refractory allergic fungal rhinosinusitis: a case series and literature review","volume":"7","author":"Alkhaldi","year":"2024","journal-title":"Rhinol Online"},{"key":"10.1016\/j.jaci.2026.07.006_bib25","first-page":"18","article-title":"Dupilumab as a treatment for allergic fungal rhinosinusitis: a case series","volume":"6","author":"Alotaibi","year":"2023","journal-title":"Rhinol Online"},{"key":"10.1016\/j.jaci.2026.07.006_bib26","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1177\/019459989411100508","article-title":"Diagnosis of allergic fungal sinusitis","volume":"111","author":"Bent","year":"1994","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2026.07.006_bib27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1749-4486.2009.01995.x","article-title":"Psychometric validity of the 22-item Sinonasal Outcome Test","volume":"34","author":"Hopkins","year":"2009","journal-title":"Clin Otolaryngol"},{"key":"10.1016\/j.jaci.2026.07.006_bib28","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0140-6736(19)31881-1","article-title":"Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials","volume":"394","author":"Bachert","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2026.07.006_bib29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/lary.29888","article-title":"Estimating clinically meaningful change of efficacy outcomes in inadequately controlled chronic rhinosinusitis with nasal polyposis","volume":"132","author":"Han","year":"2022","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2026.07.006_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2023.100776","article-title":"Meaningful changes for efficacy outcomes in patients with chronic rhinosinusitis with nasal polyps","volume":"16","author":"Braid","year":"2023","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.jaci.2026.07.006_bib31","article-title":"Allergic fungal rhinosinusitis in Saudi Arabia: a review of recent literature","volume":"13","author":"AlAhmari","year":"2021","journal-title":"Cureus"},{"key":"10.1016\/j.jaci.2026.07.006_bib32","doi-asserted-by":"crossref","first-page":"172","DOI":"10.2500\/ar.2014.5.0098","article-title":"Novel treatment of allergic fungal sinusitis using omalizumab","volume":"5","author":"Evans","year":"2014","journal-title":"Allergy Rhinol (Providence)"},{"key":"10.1016\/j.jaci.2026.07.006_bib33","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.amjoto.2015.05.008","article-title":"Omalizumab therapy for refractory allergic fungal rhinosinusitis patients with moderate or severe asthma","volume":"36","author":"Gan","year":"2015","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.jaci.2026.07.006_bib34","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ohn.1339","article-title":"Short-term efficacy of biologics in recalcitrant allergic fungal rhinosinusitis: a systematic review and meta-analysis","volume":"173","author":"Im","year":"2025","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2026.07.006_bib35","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/lary.31774","article-title":"Impact of biologics on surgery in chronic rhinosinusitis with polyps and allergic fungal sinusitis","volume":"135","author":"Bentan","year":"2025","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2026.07.006_bib36","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2147\/JAA.S217658","article-title":"Optimal management of allergic fungal rhinosinusitis","volume":"13","author":"Medikeri","year":"2020","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.jaci.2026.07.006_bib37","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00408-023-00603-z","article-title":"Prevalence and severity distribution of type 2 inflammation-related comorbidities among patients with asthma, chronic rhinosinusitis with nasal polyps, and atopic dermatitis","volume":"201","author":"Khan","year":"2023","journal-title":"Lung"},{"key":"10.1016\/j.jaci.2026.07.006_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/JAA.S420140","article-title":"Dupilumab reduces asthma disease burden and recurrent SCS use in patients with CRSwNP and coexisting asthma","volume":"17","author":"Gurnell","year":"2024","journal-title":"J Asthma Allergy"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926005221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926005221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:27:19Z","timestamp":1792708039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674926005221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":36,"alternative-id":["S0091674926005221"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2026.07.006","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dupilumab for patients with allergic fungal rhinosinusitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2026.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}