{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:34:27Z","timestamp":1793313267094,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007212","name":"V\u00e4stra G\u00f6talandsregionen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jaci.2026.07.027","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:24:01Z","timestamp":1789773841000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age-stratified CD19+ B-cell reference values in children and adolescents\u2014a systematic review and meta-analysis"],"prefix":"10.1016","author":[{"given":"Diana","family":"Ljung Sass","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Camponeschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Pettersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Mellgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2026.07.027_bib1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41573-023-00709-2","article-title":"Antibody-drug conjugates come of age in oncology","volume":"22","author":"Dumontet","year":"2023","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jaci.2026.07.027_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.837457","article-title":"CD19-targeted immunotherapies for diffuse large B-cell lymphoma","volume":"13","author":"Gambella","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib3","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3389\/fimmu.2017.01245","article-title":"Therapeutic antibodies: what have we learnt from targeting CD20 and where are we going?","volume":"8","author":"Marshall","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib4","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1158\/0008-5472.CAN-21-1109","article-title":"Mechanisms of therapeutic antitumor monoclonal antibodies","volume":"81","author":"Tsao","year":"2021","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaci.2026.07.027_bib5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/ejh.14052","article-title":"Hematopoiesis and immune reconstitution after CD19 directed chimeric antigen receptor T-cells (CAR-T): a comprehensive review on incidence, risk factors and current management","volume":"112","author":"Galli","year":"2024","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.jaci.2026.07.027_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1188049","article-title":"From bench to bedside: the history and progress of CAR T cell therapy","volume":"14","author":"Mitra","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib7","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1177\/09612033211028653","article-title":"10 Years of belimumab experience: what have we learnt?","volume":"30","author":"Levy","year":"2021","journal-title":"Lupus"},{"key":"10.1016\/j.jaci.2026.07.027_bib8","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.tips.2024.06.006","article-title":"BTK inhibitors: past, present, and future","volume":"45","author":"Cool","year":"2024","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jaci.2026.07.027_bib9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/10428199509059636","article-title":"CD19 antigen in leukemia and lymphoma diagnosis and immunotherapy","volume":"18","author":"Scheuermann","year":"1995","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.jaci.2026.07.027_bib10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/archdischild-2017-314212","article-title":"PEPtalk2: results of a pilot randomised controlled trial to compare VZIG and aciclovir as postexposure prophylaxis (PEP) against chickenpox in children with cancer","volume":"104","author":"Bate","year":"2019","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2026.07.027_bib11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1053\/sonc.2002.32749","article-title":"Rituximab in combination with CHOP improves survival in elderly patients with aggressive non-Hodgkin\u2019s lymphoma","volume":"29","author":"Coiffier","year":"2002","journal-title":"Semin Oncol"},{"key":"10.1016\/j.jaci.2026.07.027_bib12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1056\/NEJMoa011795","article-title":"CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma","volume":"346","author":"Coiffier","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2026.07.027_bib13","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1200\/JCO.22.02200","article-title":"Children\u2019s Oncology Group AALL1331: phase III trial of blinatumomab in children, adolescents, and young adults with low-risk B-cell ALL in first relapse","volume":"41","author":"Hogan","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jaci.2026.07.027_bib14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.amsu.2014.09.001","article-title":"The history of monoclonal antibody development\u2014progress, remaining challenges and future innovations","volume":"3","author":"Liu","year":"2014","journal-title":"Ann Med Surg (Lond)"},{"key":"10.1016\/j.jaci.2026.07.027_bib15","article-title":"Efficacy of blinatumomab in pediatric acute lymphoblastic leukemia: a systematic review and meta-analysis of randomized controlled trials","volume":"17","author":"Ogedegbe","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.jaci.2026.07.027_bib16","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S1470-2045(06)70664-7","article-title":"CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group","volume":"7","author":"Pfreundschuh","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jaci.2026.07.027_bib17","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/cncr.21776","article-title":"Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia","volume":"106","author":"Thomas","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.jaci.2026.07.027_bib18","doi-asserted-by":"crossref","first-page":"e445","DOI":"10.1016\/S2352-3026(23)00062-5","article-title":"Effect of rituximab on immune status in children with mature B-cell non-Hodgkin lymphoma: a prespecified secondary analysis of the Inter-B-NHL Ritux 2010 trial","volume":"10","author":"Alexander","year":"2023","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.jaci.2026.07.027_bib19","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1681\/ASN.2021111472","article-title":"Long-term efficacy and safety of repeated rituximab to maintain remission in idiopathic childhood nephrotic syndrome: an international study","volume":"33","author":"Chan","year":"2022","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jaci.2026.07.027_bib20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.5507\/bp.2023.021","article-title":"B cell subsets reconstitution and immunoglobulin levels in children and adolescents with B non-Hodgkin lymphoma after treatment with single anti CD20 agent dose included in chemotherapeutic protocols: single center experience and review of the literature","volume":"168","author":"Hlavackova","year":"2024","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1016\/j.jaci.2026.07.027_bib21","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1136\/archdischild-2020-319609","article-title":"Rituximab in childhood steroid-sensitive nephrotic syndrome: are multiple subsequent courses safe and effective?","volume":"106","author":"Subun","year":"2021","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2026.07.027_bib22","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1016\/j.jaci.2018.02.017","article-title":"Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood","volume":"141","author":"Blanco","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib23","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.jaci.2022.06.006","article-title":"Normal B-cell ranges in infants: a systematic review and meta-analysis","volume":"150","author":"Borriello","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib24","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0022-3476(97)70200-2","article-title":"Immunophenotyping of blood lymphocytes in childhood. Reference values for lymphocyte subpopulations","volume":"130","author":"Comans-Bitter","year":"1997","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaci.2026.07.027_bib25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/iid3.26","article-title":"B-cell subpopulations in children: national reference values","volume":"2","author":"Duchamp","year":"2014","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.jaci.2026.07.027_bib26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-2249.2010.04206.x","article-title":"Reference values for B cell subpopulations from infancy to adulthood","volume":"162","author":"Morbach","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/cyto.b.21728","article-title":"Extended immunophenotyping reference values in a healthy pediatric population","volume":"96","author":"Garcia-Prat","year":"2019","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.jaci.2026.07.027_bib28","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jaci.2014.06.030","article-title":"Control lymphocyte subsets: can one country\u2019s values serve for another\u2019s?","volume":"134","author":"Mandala","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.935879","article-title":"Development of a standardized and validated flow cytometry approach for monitoring of innate myeloid immune cells in human blood","volume":"13","author":"van der Pan","year":"2022","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.jaci.2026.07.027_bib30","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1365-3083.2011.02609.x","article-title":"Age-matched reference values for B-lymphocyte subpopulations and CVID classifications in children","volume":"74","author":"Schatorje","year":"2011","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.clim.2009.05.020","article-title":"Refined characterization and reference values of the pediatric T- and B-cell compartments","volume":"133","author":"van Gent","year":"2009","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib32","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000101357","article-title":"Age-related lymphocyte subset changes in the peripheral blood of healthy children\u2014a meta-study","volume":"34","author":"Sack","year":"2007","journal-title":"Transfus Med Hemother"},{"key":"10.1016\/j.jaci.2026.07.027_bib33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/bjh.15232","article-title":"A tale of two antibodies: obinutuzumab versus rituximab","volume":"182","author":"Freeman","year":"2018","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaci.2026.07.027_bib34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fped.2018.00121","article-title":"An exponential regression model reveals the continuous development of B cell subpopulations used as reference values in children","volume":"6","author":"Konigs","year":"2018","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jaci.2026.07.027_bib35","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/cyto.b.21738","article-title":"Naive\/memory T-cell phenotypes in leukemic cutaneous T-cell lymphoma: putative cell of origin overlaps disease classification","volume":"96","author":"Horna","year":"2019","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.jaci.2026.07.027_bib36","series-title":"Janeway\u2019s immunobiology","author":"Murphy","year":"2017"},{"key":"10.1016\/j.jaci.2026.07.027_bib37","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/B978-0-12-385991-4.00005-2","article-title":"Pax5: a master regulator of B cell development and leukemogenesis","volume":"111","author":"Medvedovic","year":"2011","journal-title":"Adv Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib38","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nri.2017.19","article-title":"Mechanisms of central tolerance for B cells","volume":"17","author":"Nemazee","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib39","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood-2008-02-078071","article-title":"B lymphocytes: how they develop and function","volume":"112","author":"LeBien","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2026.07.027_bib40","article-title":"PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2026.07.027_bib41","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.cell.2018.06.045","article-title":"Stereotypic immune system development in newborn children","volume":"174","author":"Olin","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2026.07.027_bib42","doi-asserted-by":"crossref","first-page":"315","DOI":"10.33549\/physiolres.935296","article-title":"Maternal-fetal microchimerism: impacts on offspring\u2019s immune development and transgenerational immune memory transfer","volume":"73","author":"Malinska","year":"2024","journal-title":"Physiol Res"},{"key":"10.1016\/j.jaci.2026.07.027_bib43","article-title":"Factors predicting the presence of maternal cells in cord blood and associated changes in immune cell composition","volume":"12","author":"Haddad","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib44","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3233\/HAB-200432","article-title":"Age-stratified pediatric reference values of lymphocytes in the Moroccan population","volume":"29","author":"El Allam","year":"2021","journal-title":"Hum Antibodies"},{"key":"10.1016\/j.jaci.2026.07.027_bib45","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.imbio.2014.02.010","article-title":"Reference ranges of lymphocyte subsets in healthy adults and adolescents with special mention of T cell maturation subsets in adults of South Florida","volume":"219","author":"Valiathan","year":"2014","journal-title":"Immunobiology"},{"key":"10.1016\/j.jaci.2026.07.027_bib46","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1177\/0394632017707609","article-title":"Reference values for B-cell surface markers and co-receptors associated with primary immune deficiencies in healthy Turkish children","volume":"30","author":"Azarsiz","year":"2017","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.jaci.2026.07.027_bib47","doi-asserted-by":"crossref","first-page":"9328","DOI":"10.18632\/aging.103208","article-title":"Establishing immune scoring model based on combination of the number, function, and phenotype of lymphocytes","volume":"12","author":"Tang","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.jaci.2026.07.027_bib48","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1002\/cyto.a.22716","article-title":"Age- and sex-related reference intervals of lymphocyte subsets in healthy ethnic Han Chinese children","volume":"87","author":"Jia","year":"2015","journal-title":"Cytometry A"},{"key":"10.1016\/j.jaci.2026.07.027_bib49","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12696","article-title":"Significant age- and gender-related variability of main lymphocyte subsets in paediatric patients: Latvian data","volume":"88","author":"Nikulshin","year":"2018","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib50","doi-asserted-by":"crossref","first-page":"848","DOI":"10.18632\/aging.100894","article-title":"Aging of immune system: immune signature from peripheral blood lymphocyte subsets in 1068 healthy adults","volume":"8","author":"Qin","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jaci.2026.07.027_bib51","series-title":"V\u00e4stra G\u00f6talands regionen. B-lymfocyter (CD19\/CD20)","year":"2025"},{"key":"10.1016\/j.jaci.2026.07.027_bib52","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.aller.2016.05.003","article-title":"Variations of B cell subpopulations in peripheral blood of healthy Mexican population according to age: relevance for diagnosis of primary immunodeficiencies","volume":"44","author":"Berr\u00f3n-Ru\u00edz","year":"2016","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"4","key":"10.1016\/j.jaci.2026.07.027_bib53","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.3906\/sag-2010-176","article-title":"Reference values for T and B lymphocyte subpopulations in Turkish children and adults","volume":"51","author":"Besci","year":"2021","journal-title":"Turk J Med Sci"},{"key":"10.1016\/j.jaci.2026.07.027_bib54","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1590\/0074-0276140182","article-title":"Lymphocyte subsets in human immunodeficiency virus-unexposed Brazilian individuals from birth to adulthood","volume":"109","author":"de Moraes-Pinto","year":"2014","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.jaci.2026.07.027_bib55","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1203\/00006450-200004000-00019","article-title":"Longitudinal survey of lymphocyte subpopulations in the first year of life","volume":"47","author":"de Vries","year":"2000","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jaci.2026.07.027_bib56","doi-asserted-by":"crossref","first-page":"125","DOI":"10.24953\/turkjpediatr.2004.2784","article-title":"Peripheral blood lymphocyte subsets in healthy Turkish children","volume":"46","author":"Ikincio\u01e7ullari","year":"2004","journal-title":"Turk J Pediatr"},{"key":"10.1016\/j.jaci.2026.07.027_bib57","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/ijmr.ijmr_3282_21","article-title":"Normative data for paediatric lymphocyte subsets: a pilot study from western India","volume":"158","author":"Jodhawat","year":"2023","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.jaci.2026.07.027_bib58","doi-asserted-by":"crossref","first-page":"589","DOI":"10.7196\/SAMJnew.7914","article-title":"Observed full blood count and lymphocyte subset values in a cohort of clinically healthy South African children from a semi-informal settlement in Cape Town","volume":"105","author":"Lawrie","year":"2015","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jaci.2026.07.027_bib59","first-page":"168","article-title":"Distribution of leukocyte and lymphocyte subsets in peripheral blood. Age related normal values for preliminary evaluation of the immune status in Polish children","volume":"35","author":"Pia\u0327tosa","year":"2010","journal-title":"Cent Eur J Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib60","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/sji.12183","article-title":"Phenotypic differences in leucocyte populations among healthy preterm and full-term newborns","volume":"80","author":"Quinello","year":"2014","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib61","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1128\/CVI.00483-10","article-title":"Reference values of lymphocyte subsets in healthy, HIV-negative children in Cameroon","volume":"18","author":"Sagnia","year":"2011","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib62","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.aller.2019.12.009","article-title":"Reference values of leukocyte and lymphocytes populations in umbilical cord and capillary blood in healthy Mexican newborns","volume":"48","author":"Scheffer-Mendoza","year":"2020","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.jaci.2026.07.027_bib63","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jaci.2003.07.003","article-title":"Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study","volume":"112","author":"Shearer","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib64","first-page":"249","article-title":"Age-related changes in blood lymphocyte subsets of south Indian children","volume":"16","author":"Swaminathan","year":"2003","journal-title":"Natl Med J India"},{"key":"10.1016\/j.jaci.2026.07.027_bib65","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/cyto.a.22520","article-title":"Lymphocytes subsets reference values in childhood","volume":"87","author":"Tosato","year":"2015","journal-title":"Cytometry A"},{"key":"10.1016\/j.jaci.2026.07.027_bib66","first-page":"86","article-title":"Immunophenotyping of peripheral blood lymphocytes and its association with age in healthy Malay children","volume":"20","author":"Yusoff","year":"2024","journal-title":"Malaysian Journal of Medicine and Health Sciences"},{"key":"10.1016\/j.jaci.2026.07.027_bib67","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5603566","article-title":"Establishing reference values for peripheral blood lymphocyte subsets of healthy children in China using a single platform","volume":"2022","author":"Zhang","year":"2022","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jaci.2026.07.027_bib68","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.5336\/medsci.2012-33192","article-title":"Immunologic evaluation in the patients with infantile spasm","volume":"33","author":"\u00d6zaydin","year":"2013","journal-title":"Turkiye Klinikleri Journal of Medical Sciences"},{"key":"10.1016\/j.jaci.2026.07.027_bib69","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/s41409-022-01756-w","article-title":"Infectious complications, immune reconstitution, and infection prophylaxis after CD19 chimeric antigen receptor T-cell therapy","volume":"57","author":"Wudhikarn","year":"2022","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jaci.2026.07.027_bib70","doi-asserted-by":"crossref","first-page":"S297","DOI":"10.1016\/j.jaci.2009.08.043","article-title":"Laboratory evaluation of primary immunodeficiencies","volume":"125","author":"Oliveira","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.07.027_bib71","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/pbc.26914","article-title":"Hypogammaglobulinemia due to CAR T-cell therapy","volume":"65","author":"Doan","year":"2018","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jaci.2026.07.027_bib72","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41571-018-0075-2","article-title":"Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy","volume":"16","author":"Mahadeo","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.jaci.2026.07.027_bib73","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1056\/NEJMoa1709866","article-title":"Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia","volume":"378","author":"Maude","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2026.07.027_bib74","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/sj.bmt.1702141","article-title":"Reconstitution of lymphocyte subpopulations after paediatric bone marrow transplantation","volume":"25","author":"de Vries","year":"2000","journal-title":"Bone Marrow Transplant"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926006408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926006408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:25:56Z","timestamp":1793312756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674926006408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":74,"alternative-id":["S0091674926006408"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2026.07.027","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age-stratified CD19+ B-cell reference values in children and adolescents\u2014a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2026.07.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}