{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:40:51Z","timestamp":1792233651225,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Spain Ministry of Science Innovation and Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jaci.2026.09.015","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T06:19:34Z","timestamp":1790576374000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["MITF-associated metabolic signature in mast cells: A potential link to food anaphylaxis"],"prefix":"10.1016","author":[{"given":"Laia","family":"Oll\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Carreras-K\u00e0tcheff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mir-Ihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Valls-Roca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariona","family":"Guitart-Mampel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00f2ria","family":"Garrabou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose C.","family":"Fernandez-Checa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Babina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Mu\u00f1oz-Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9245-4899","authenticated-orcid":false,"given":"Margarita","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2026.09.015_bib1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jaci.2017.06.003","article-title":"The pathophysiology of anaphylaxis","volume":"140","author":"Reber","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.09.015_bib2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2147\/TACG.S94267","article-title":"Mitochondrial diseases: advances and issues","volume":"10","author":"Scarpelli","year":"2017","journal-title":"Appl Clin Genet"},{"key":"10.1016\/j.jaci.2026.09.015_bib3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11882-017-0695-0","article-title":"Mitochondrial function in allergic disease","volume":"17","author":"Iyer","year":"2017","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2026.09.015_bib4","doi-asserted-by":"crossref","first-page":"877","DOI":"10.4168\/aair.2020.12.5.877","article-title":"Mitochondrial and nuclear mitochondrial variants in allergic diseases","volume":"12","author":"Jang","year":"2020","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2026.09.015_bib5","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jaci.2016.09.047","article-title":"Pyruvate dehydrogenase has a major role in mast cell function, and its activity is regulated by mitochondrial microphthalmia transcription factor","volume":"140","author":"Sharkia","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.09.015_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911591","article-title":"Inhibition of complex I of the respiratory chain, but not complex III, attenuates degranulation and cytokine secretion in human skin mast cells","volume":"23","author":"Buttgereit","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2026.09.015_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.584210","article-title":"The role played by mitochondria in Fc\u03b5RI-dependent mast cell activation","volume":"11","author":"Chelombitko","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.09.015_bib8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3390\/cells11030589","article-title":"The critical role played by mitochondrial mitf serine 73 phosphorylation in immunologically activated mast cells","volume":"11","author":"Paruchuru","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jaci.2026.09.015_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.exer.2018.02.023","article-title":"MITF acts as an anti-oxidant transcription factor to regulate mitochondrial biogenesis and redox signaling in retinal pigment epithelial cells","volume":"170","author":"Hua","year":"2018","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jaci.2026.09.015_bib10","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3390\/antiox13080920","article-title":"Oxidative stress and mitochondria are involved in anaphylaxis and mast cell degranulation: a systematic review","volume":"13","author":"Piotin","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jaci.2026.09.015_bib11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41586-021-03214-x","article-title":"Function and regulation of the divisome for mitochondrial fission","volume":"590","author":"Kraus","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2026.09.015_bib12","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.jaci.2011.02.005","article-title":"Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: relevance to atopic dermatitis","volume":"127","author":"Zhang","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.09.015_bib13","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.4049\/jimmunol.2001211","article-title":"MYO1F regulates IgE and MRGPRX2-dependent mast cell exocytosis","volume":"206","author":"Navin\u00e9s-Ferrer","year":"2021","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2026.09.015_bib14","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1111\/cea.13991","article-title":"Characterization of anaphylaxis reveals different metabolic changes depending on severity and triggers","volume":"51","author":"Perales-Chorda","year":"2021","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2026.09.015_bib15","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.4049\/jimmunol.2001278","article-title":"Metabolic consequences of IgE- and non-IgE-mediated mast cell degranulation","volume":"207","author":"Mendoza","year":"2021","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2026.09.015_bib16","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1111\/all.14843","article-title":"Immune metabolism in allergies, does it matter?\u2014a review of immune metabolic basics and adaptations associated with the activation of innate immune cells in allergy","volume":"76","author":"Goretzki","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2026.09.015_bib17","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.jaci.2017.10.043","article-title":"The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE\/mast cell-mediated anaphylaxis","volume":"142","author":"Li","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.09.015_bib18","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.jaci.2020.12.637","article-title":"Mutation in KARS: a novel mechanism for severe anaphylaxis","volume":"147","author":"Rib\u00f3","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2026.09.015_bib19","article-title":"MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway","volume":"14","author":"Guo","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2026.09.015_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-29965-8","article-title":"MRGPRX2-mediated mast cell response to drugs used in perioperative procedures and anaesthesia","volume":"8","author":"Navin\u00e9s-Ferrer","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2026.09.015_bib21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature14022","article-title":"Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions","volume":"519","author":"McNeil","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2026.09.015_bib22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.18176\/jiaci.0995","article-title":"Mast cell activation profile and TFH13 detection discriminate between food anaphylaxis and sensitization","volume":"35","author":"Oll\u00e9","year":"2025","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2026.09.015_bib23","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.jaip.2019.11.027","article-title":"Global trends in anaphylaxis epidemiology and clinical implications","volume":"8","author":"Turner","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2026.09.015_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11882-020-00982-w","article-title":"The role of lipid transfer proteins as food and pollen allergens outside the Mediterranean area","volume":"21","author":"Scheurer","year":"2021","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2026.09.015_bib25","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0145-2126(02)00343-0","article-title":"Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma\/leukemia; activation following aggregation of Fc\u03b5RI or Fc\u03b3RI","volume":"27","author":"Kirshenbaum","year":"2003","journal-title":"Leuk Res"},{"key":"10.1016\/j.jaci.2026.09.015_bib26","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3390\/ijms24043515","article-title":"MITF downregulation induces death in human mast cell leukemia cells and impairs IgE-dependent degranulation","volume":"24","author":"Proa\u00f1o-P\u00e9rez","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2026.09.015_bib27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41580-018-0092-0","article-title":"Mitochondrial proteins: from biogenesis to functional networks","volume":"20","author":"Pfanner","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaci.2026.09.015_bib28","series-title":"Mitochondrial physiology and vegetal molecules: therapeutic potential of natural compounds on mitochondrial health","first-page":"3","article-title":"Mitochondria: ultrastructure, dynamics, biogenesis, and main functions","author":"Rigoulet","year":"2021"},{"key":"10.1016\/j.jaci.2026.09.015_bib29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1073\/pnas.1014918108","article-title":"Dual role of the receptor Tom20 in specificity and efficiency of protein import into mitochondria","volume":"108","author":"Yamamoto","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2026.09.015_bib30","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.mito.2020.10.004","article-title":"Complex IV - the regulatory center of mitochondrial oxidative phosphorylation","volume":"58","author":"Kadenbach","year":"2021","journal-title":"Mitochondrion"},{"key":"10.1016\/j.jaci.2026.09.015_bib31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ccr.2012.11.020","article-title":"PGC1\u03b1 expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress","volume":"23","author":"Vazquez","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jaci.2026.09.015_bib32","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.gene.2006.12.024","article-title":"NRF-2 transcription factor is required for human TOMM20 gene expression","volume":"391","author":"Blesa","year":"2007","journal-title":"Gene"},{"key":"10.1016\/j.jaci.2026.09.015_bib33","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development","volume":"160","author":"Chen","year":"2003","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2026.09.015_bib34","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1083\/jcb.201007152","article-title":"Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells","volume":"191","author":"Otera","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2026.09.015_bib35","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1152\/physrev.00025.2007","article-title":"Transcriptional paradigms in mammalian mitochondrial biogenesis and function","volume":"88","author":"Scarpulla","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jaci.2026.09.015_bib36","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1021\/cr040463d","article-title":"DNA polymerase gamma in mitochondrial DNA replication and repair","volume":"106","author":"Graziewicz","year":"2006","journal-title":"Chem Rev"},{"key":"10.1016\/j.jaci.2026.09.015_bib37","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nrm3997","article-title":"A giant molecular proton pump: structure and mechanism of respiratory complex I","volume":"16","author":"Sazanov","year":"2015","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaci.2026.09.015_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BST20110773","article-title":"The ATP synthase: the understood, the uncertain and the unknown","volume":"41","author":"Walker","year":"2013","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jaci.2026.09.015_bib39","doi-asserted-by":"crossref","first-page":"947","DOI":"10.33549\/physiolres.934446","article-title":"Role of cytochrome c oxidase nuclear-encoded subunits in health and disease","volume":"69","author":"\u010cun\u00e1tov\u00e1","year":"2020","journal-title":"Physiol Res"},{"key":"10.1016\/j.jaci.2026.09.015_bib40","article-title":"The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity","volume":"8","author":"Sirey","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jaci.2026.09.015_bib41","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.nbd.2009.09.011","article-title":"GDAP1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance","volume":"36","author":"Niemann","year":"2009","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jaci.2026.09.015_bib42","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.matbio.2015.03.005","article-title":"The role of TIMPs in regulation of extracellular matrix proteolysis","volume":"44-46","author":"Arpino","year":"2015","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jaci.2026.09.015_bib43","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/1878-0261.12332","article-title":"Silencing of adaptor protein SH3BP2 reduces KIT\/PDGFRA receptors expression and impairs gastrointestinal stromal tumors growth","volume":"12","author":"Serrano-Candelas","year":"2018","journal-title":"Mol Oncol"},{"key":"10.1016\/j.jaci.2026.09.015_bib44","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.4049\/jimmunol.1402887","article-title":"The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival","volume":"194","author":"Ainsua-Enrich","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2026.09.015_bib45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3390\/cells10020369","article-title":"Loss of COX4I1 leads to combined respiratory chain deficiency and impaired mitochondrial protein synthesis","volume":"10","author":"\u010cun\u00e1tov\u00e1","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jaci.2026.09.015_bib46","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbadis.2009.07.013","article-title":"Cytochrome c oxidase deficiency: patients and animal models","volume":"1802","author":"Diaz","year":"2010","journal-title":"Biochim Biophys"},{"key":"10.1016\/j.jaci.2026.09.015_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf3634","article-title":"\u03b1-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson\u2019s disease","volume":"8","author":"Di Maio","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2026.09.015_bib48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3390\/cancers16020263","article-title":"Significant and various effects of ML329-induced MITF suppression in the melanoma cell line","volume":"16","author":"Nishikiori","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jaci.2026.09.015_bib49","article-title":"Glycolytic reprogramming in macrophages and MSCs during inflammation","volume":"14","author":"Li","year":"2023","journal-title":"Front Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926006731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674926006731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:43:54Z","timestamp":1792230234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674926006731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":49,"alternative-id":["S0091674926006731"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2026.09.015","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MITF-associated metabolic signature in mast cells: A potential link to food anaphylaxis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2026.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}