{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:48:51Z","timestamp":1772120931209,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["jaci-global.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology: Global"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jacig.2025.100465","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T02:25:14Z","timestamp":1743042314000},"page":"100465","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["A newly identified pathology of episodic angioedema with hypereosinophilia (Gleich syndrome) revealed by multiomics analysis"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8271-2003","authenticated-orcid":false,"given":"Tatsuya","family":"Koreeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3723-2505","authenticated-orcid":false,"given":"Hirokazu","family":"Muraoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacig.2025.100465_bib1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jaci.2010.04.011","article-title":"Practical approach to the patient with hypereosinophilia","volume":"126","author":"Roufosse","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2025.100465_bib2","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1056\/NEJM199805283382206","article-title":"Eosinophilia","volume":"338","author":"Rothenberg","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacig.2025.100465_bib3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jaci.2012.02.019","article-title":"Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes","volume":"130","author":"Valent","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2025.100465_bib4","first-page":"25","article-title":"Episodic angioedema associated with eosinophilia","volume":"97","author":"Gleich","year":"1984","journal-title":"Trans Assoc Am Physicians"},{"key":"10.1016\/j.jacig.2025.100465_bib5","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1056\/NEJMoa025217","article-title":"A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome","volume":"348","author":"Cools","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacig.2025.100465_bib6","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1056\/NEJM199910073411503","article-title":"Abnormal clones of T cells producing interleukin-5 in idiopathic eosinophilia","volume":"341","author":"Simon","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacig.2025.100465_bib7","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ejhg.2013.46","article-title":"Whole-genome sequencing in health care: recommendations of the European Society of Human Genetics","volume":"21","author":"Van El","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.jacig.2025.100465_bib8","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(10)60452-7","article-title":"Clinical assessment incorporating a personal genome","volume":"375","author":"Ashley","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jacig.2025.100465_bib9","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1056\/NEJMoa0908094","article-title":"Whole-genome sequencing in a patient with Charcot-Marie-Tooth neuropathy","volume":"362","author":"Lupski","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacig.2025.100465_bib10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1126\/science.1186802","article-title":"Analysis of genetic inheritance in a family quartet by whole-genome sequencing","volume":"328","author":"Roach","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jacig.2025.100465_bib11","article-title":"Idiopathic hypereosinophilia is clonal disorder? Clonality identified by targeted sequencing","volume":"12","author":"Lee","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jacig.2025.100465_bib12","doi-asserted-by":"crossref","first-page":"40588","DOI":"10.18632\/oncotarget.5845","article-title":"Whole-exome sequencing and genome-wide methylation analyses identify novel disease associated mutations and methylation patterns in idiopathic hypereosinophilic syndrome","volume":"6","author":"Andersen","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jacig.2025.100465_bib13","article-title":"Complement activation in hereditary angioedema: classical and lectin pathways involvement","volume":"5","author":"Ghebrehiwet","year":"2024","journal-title":"Front Allergy"},{"key":"10.1016\/j.jacig.2025.100465_bib14","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jaci.2016.09.051","article-title":"Effect of bradykinin receptor antagonism on ACE inhibitor-associated angioedema","volume":"140","author":"Straka","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2025.100465_bib15","article-title":"Hereditary angioedema with normal C1 inhibitor and F12 mutations in 42 Brazilian families","volume":"54","author":"Basso","year":"2021","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.jacig.2025.100465_bib16","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.3390\/jcm10071442","article-title":"Hereditary angioedema: a comprehensive review of treatment options and management of acute attacks","volume":"10","author":"Mormile","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.jacig.2025.100465_bib17","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3324\/haematol.2013.091264","article-title":"Episodic angioedema with eosinophilia (Gleich syndrome) is a multilineage cell cycling disorder","volume":"100","author":"Khoury","year":"2015","journal-title":"Haematologica"},{"key":"10.1016\/j.jacig.2025.100465_bib18","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/1873-3468.14347","article-title":"Glycans on the crossroad of health and disease: challenges and opportunities","volume":"596","author":"Alves","year":"2022","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jacig.2025.100465_bib19","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/s41423-023-01074-1","article-title":"From inflammation to metastasis: glycans as dynamic regulators of macrophage heterogeneity","volume":"20","author":"Pinho","year":"2023","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jacig.2025.100465_bib20","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2006.08.019","article-title":"Glycosylation in cellular mechanisms of health and disease","volume":"126","author":"Ohtsubo","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jacig.2025.100465_bib21","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrc3982","article-title":"Glycosylation in cancer: mechanisms and clinical implications","volume":"15","author":"Pinho","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jacig.2025.100465_bib22","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.immuni.2012.03.004","article-title":"Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer","volume":"36","author":"Rabinovich","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jacig.2025.100465_bib23","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1073\/pnas.0914004107","article-title":"Cosmc is an essential chaperone for correct protein O-glycosylation","volume":"107","author":"Wang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacig.2025.100465_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10719-024-10153-y","article-title":"Aberrant glycosylation in autoimmune diseases: a review","volume":"41","author":"Koreeda","year":"2024","journal-title":"Glycoconj J"},{"key":"10.1016\/j.jacig.2025.100465_bib25","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.jaip.2018.04.022","article-title":"Angioedema due to bradykinin dysregulation","volume":"6","author":"Cicardi","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2025.100465_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1067\/mai.2002.121316","article-title":"Pathways for bradykinin formation and inflammatory disease","volume":"109","author":"Kaplan","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2025.100465_bib27","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1164\/ajrccm.153.1.8542147","article-title":"Bradykinin receptor antagonists modulate bronchial response to ultrasonically nebulized distilled water in patients with common cold","volume":"153","author":"Roisman","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jacig.2025.100465_bib28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1161\/01.HYP.25.3.343","article-title":"Glucocorticoids induce angiotensin-converting enzyme expression in vascular smooth muscle","volume":"25","author":"Fishel","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.jacig.2025.100465_bib29","first-page":"421","article-title":"Glucocorticoid-induced bradykinesia","volume":"112","author":"Sreeram","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jacig.2025.100465_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0267938","article-title":"A cardiac-null mutation of Prdm16 causes hypotension in mice with cardiac hypertrophy via increased nitric oxide synthase 1","volume":"17","author":"Kang","year":"2022","journal-title":"PLoS One"}],"container-title":["Journal of Allergy and Clinical Immunology: Global"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772829325000669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772829325000669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:19:42Z","timestamp":1754144382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772829325000669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S2772829325000669"],"URL":"https:\/\/doi.org\/10.1016\/j.jacig.2025.100465","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.09.29.24313285","asserted-by":"object"}]},"ISSN":["2772-8293"],"issn-type":[{"value":"2772-8293","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A newly identified pathology of episodic angioedema with hypereosinophilia (Gleich syndrome) revealed by multiomics analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology: Global","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacig.2025.100465","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}],"article-number":"100465"}}