{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:20:14Z","timestamp":1790277614937,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004328","name":"Genentech Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jaci-global.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology: Global"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jacig.2025.100491","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T03:09:12Z","timestamp":1746587352000},"page":"100491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Health care resource utilization of patients with asthma and food allergy initiating omalizumab"],"prefix":"10.1016","volume":"4","author":[{"given":"John A.","family":"Bird","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee M.","family":"Near","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpamas","family":"Seetasith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Garmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riddhi","family":"Doshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Fleischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacig.2025.100491_bib1","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2018-1235","article-title":"The public health impact of parent-reported childhood food allergies in the United States","volume":"142","author":"Gupta","year":"2018","journal-title":"Pediatrics"},{"key":"10.1016\/j.jacig.2025.100491_bib2","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.5630","article-title":"Prevalence and severity of food allergies among US adults","volume":"2","author":"Gupta","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jacig.2025.100491_bib3","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.3389\/fimmu.2020.01907","article-title":"Research progress in atopic march","volume":"11","author":"Yang","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jacig.2025.100491_bib4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/02770900701364031","article-title":"Food allergy as a risk factor for asthma morbidity in adults","volume":"44","author":"Berns","year":"2007","journal-title":"J Asthma"},{"key":"10.1016\/j.jacig.2025.100491_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2222.2008.03160.x","article-title":"Food allergy is associated with an increased risk of asthma","volume":"39","author":"Schroeder","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jacig.2025.100491_bib6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s40521-018-0185-1","article-title":"Food allergy and asthma: is there a link?","volume":"5","author":"Emons","year":"2018","journal-title":"Curr Treat Options Allergy"},{"key":"10.1016\/j.jacig.2025.100491_bib7","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.jaci.2010.02.009","article-title":"Anaphylaxis epidemiology in patients with and patients without asthma: a United Kingdom database review","volume":"125","author":"Gonz\u00e1lez-P\u00e9rez","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2025.100491_bib8","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jaci.2010.07.026","article-title":"National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005-2006","volume":"126","author":"Liu","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2025.100491_bib9","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2010.10.008","article-title":"Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel","volume":"126","author":"Boyce","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2025.100491_bib10","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.jaci.2014.05.013","article-title":"Food allergy: a practice parameter update\u20142014","volume":"134","author":"Sampson","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2025.100491_bib11","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1111\/all.15902","article-title":"EAACI guidelines on the management of IgE-mediated food allergy","volume":"78","author":"Santos","year":"2023","journal-title":"Allergy"},{"key":"10.1016\/j.jacig.2025.100491_bib13","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1056\/NEJMoa2312382","article-title":"Omalizumab for the treatment of multiple food allergies","volume":"390","author":"Wood","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacig.2025.100491_bib14","doi-asserted-by":"crossref","first-page":"889","DOI":"10.2147\/JAA.S475517","article-title":"Does comorbid food allergy affect response to omalizumab in patients with asthma?","volume":"17","author":"Fiocchi","year":"2024","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.jacig.2025.100491_bib15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1067\/mai.2001.117880","article-title":"Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma","volume":"108","author":"Busse","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2025.100491_bib16","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jaip.2018.04.043","article-title":"Omalizumab effectiveness by biomarker status in patients with asthma: evidence from PROSPERO, a prospective real-world study","volume":"7","author":"Casale","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2025.100491_bib17","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.jaci.2009.09.021","article-title":"Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma","volume":"124","author":"Lanier","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2025.100491_bib18","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S1081-1206(10)60184-6","article-title":"Baseline characteristics of patients enrolled in EXCELS: a cohort study","volume":"103","author":"Long","year":"2009","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jacig.2025.100491_bib19","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1183\/09031936.01.00092101","article-title":"The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics","volume":"18","author":"Sol\u00e8r","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jacig.2025.100491_bib20","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1016\/j.jaip.2019.01.023","article-title":"Impact of omalizumab on food allergy in patients treated for asthma: a real-life study","volume":"7","author":"Fiocchi","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2025.100491_bib21","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","article-title":"Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data","volume":"43","author":"Quan","year":"2005","journal-title":"Med Care"},{"key":"10.1016\/j.jacig.2025.100491_bib22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/ACI.0b013e3283464c8e","article-title":"Food allergies and asthma","volume":"11","author":"Wang","year":"2011","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2025.100491_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111831","article-title":"Full range of population eliciting dose values for 14 priority allergenic foods and recommendations for use in risk characterization","volume":"146","author":"Houben","year":"2020","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jacig.2025.100491_bib24","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1542\/peds.2009-1210","article-title":"Food allergy among children in the United States","volume":"124","author":"Branum","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jacig.2025.100491_bib25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.15585\/mmwr.mm6615a2","article-title":"Restaurant food allergy practices - six selected sites, United States, 2014","volume":"66","author":"Radke","year":"2017","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jacig.2025.100491_bib26","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/jpm12020165","article-title":"Omalizumab: an optimal choice for patients with severe allergic asthma","volume":"12","author":"Kotoulas","year":"2022","journal-title":"J Pers Med"},{"key":"10.1016\/j.jacig.2025.100491_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1067\/mai.2003.49","article-title":"Omalizumab, a recombinant humanized anti-IgE antibody, reduces asthma-related emergency room visits and hospitalizations in patients with allergic asthma","volume":"111","author":"Corren","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2025.100491_bib28","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.18162","article-title":"Racial, ethnic, and socioeconomic differences in food allergies in the US","volume":"6","author":"Jiang","year":"2023","journal-title":"JAMA Network Open"},{"key":"10.1016\/j.jacig.2025.100491_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2021.12.507","article-title":"Racial and ethnic disparities in biologic prescriptions for moderate-to-severe persistent asthma","volume":"149","author":"Sylvestre","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2025.100491_bib30","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1016\/j.jaip.2021.01.039","article-title":"Lower use of biologics for the treatment of asthma in publicly insured individuals","volume":"9","author":"Akenroye","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2025.100491_bib31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1471-2288-13-119","article-title":"Assessing regression to the mean effects in health care initiatives","volume":"13","author":"Linden","year":"2013","journal-title":"BMC Med Res Methodol"}],"container-title":["Journal of Allergy and Clinical Immunology: Global"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277282932500092X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277282932500092X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:21:37Z","timestamp":1754144497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S277282932500092X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S277282932500092X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacig.2025.100491","relation":{},"ISSN":["2772-8293"],"issn-type":[{"value":"2772-8293","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Health care resource utilization of patients with asthma and food allergy initiating omalizumab","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology: Global","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacig.2025.100491","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}],"article-number":"100491"}}