{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:25:35Z","timestamp":1792697135448,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002567","name":"AAAAI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002567","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-global.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology: Global"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jacig.2026.100678","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T20:50:42Z","timestamp":1772484642000},"page":"100678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bronchial thermoplasty for severe asthma: Systematic review and meta-analysis of benefits and harms"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-3090","authenticated-orcid":false,"given":"Daniel G.","family":"Rayner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandro W.L.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Ologundudu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie M.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazmul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bonta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallav L.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk-Jan","family":"Slebos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouke","family":"Annema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiajing","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Chipps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Oppenheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Israel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Rivera-Spoljaric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara T.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmilee M.","family":"Nyenhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Hoyte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaharu","family":"Sumino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"O\u2019Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay E.","family":"Shade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon H.","family":"Guyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie G.","family":"Press","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Rangel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"McCabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Melendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dia","family":"Sue-Wah-Sing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilarry","family":"Orr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna D.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya","family":"Winders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathyrn","family":"Przywara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Rank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle","family":"Mosnaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard B.","family":"Bacharier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8269-4496","authenticated-orcid":false,"given":"Derek K.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacig.2026.100678_bib1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.2147\/JAA.S272681","article-title":"Medical costs and productivity loss due to mild, moderate, and severe asthma in the United States","volume":"13","author":"Song","year":"2020","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.jacig.2026.100678_bib2","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1164\/rccm.201901-0016OC","article-title":"The projected economic and health burden of uncontrolled asthma in the United States","volume":"200","author":"Yaghoubi","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"10379","key":"10.1016\/j.jacig.2026.100678_bib3","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0140-6736(22)02125-0","article-title":"Asthma","volume":"401","author":"Porsbjerg","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jacig.2026.100678_bib4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000488291","article-title":"Bronchial thermoplasty in severe asthma: best practice recommendations from an expert panel","volume":"95","author":"Bonta","year":"2018","journal-title":"Respiration"},{"key":"10.1016\/j.jacig.2026.100678_bib5","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jaci.2021.02.022","article-title":"Secreted heat shock proteins control airway remodeling: evidence from bronchial thermoplasty","volume":"148","author":"Fang","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2026.100678_bib6","article-title":"Bronchial thermoplasty for moderate or severe persistent asthma in adults","volume":"2014","author":"Torrego","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jacig.2026.100678_bib7","series-title":"Cochrane handbook for systematic reviews of interventions, v6.5","year":"2024"},{"issue":"7650","key":"10.1016\/j.jacig.2026.100678_bib8","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.jacig.2026.100678_bib9","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jacig.2026.100678_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2025.06.004","article-title":"Comparative efficacy and safety of biologics and systemic immunomodulatory treatments for chronic urticaria: systematic review and network meta-analysis","author":"Chu","year":"2025","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2026.100678_bib11","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.anai.2024.06.003","article-title":"Topical corticosteroids for hives and itch (urticaria): systematic review and Bayesian meta-analysis of randomized trials","volume":"133","author":"Chu","year":"2024","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jacig.2026.100678_bib12","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.jaci.2023.08.029","article-title":"Systemic treatments for atopic dermatitis (eczema): systematic review and network meta-analysis of randomized trials","volume":"152","author":"Chu","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2026.100678_bib13","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.jaci.2023.08.030","article-title":"Topical treatments for atopic dermatitis (eczema): systematic review and network meta-analysis of randomized trials","volume":"152","author":"Chu","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2026.100678_bib14","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1016\/j.jaip.2025.04.039","article-title":"Patient-facing digital inhalers for asthma: a systematic review and meta-analysis","volume":"13","author":"Ologundudu","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2026.100678_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.anai.2025.06.011","article-title":"Triple therapy vs dual inhaler therapy for moderate-to-severe asthma: an updated systematic review and meta-analysis","author":"Rayner","year":"2025","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jacig.2026.100678_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/jama.2024.22700","article-title":"Inhaled reliever therapies for asthma: a systematic review and meta-analysis","volume":"333","author":"Rayner","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.jacig.2026.100678_bib17","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.jaci.2024.05.026","article-title":"Leukotriene receptor antagonists as add-on therapy to antihistamines for urticaria: systematic review and meta-analysis of randomized clinical trials","volume":"154","author":"Rayner","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2026.100678_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2023.107302","article-title":"Comparing bronchial thermoplasty with biologicals for severe asthma: systematic review and network meta-analysis","volume":"216","author":"Fong","year":"2023","journal-title":"Respir Med"},{"key":"10.1016\/j.jacig.2026.100678_bib19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1080\/20009666.2021.1936951","article-title":"Bronchial thermoplasty in patients with severe persistent asthma: a literature review","volume":"11","author":"Aftab","year":"2021","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"10.1016\/j.jacig.2026.100678_bib20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jclinepi.2005.06.006","article-title":"Imputing missing standard deviations in meta-analyses can provide accurate results","volume":"59","author":"Furukawa","year":"2006","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jacig.2026.100678_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12874-018-0483-0","article-title":"Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review","volume":"18","author":"Weir","year":"2018","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jacig.2026.100678_bib22","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/jrsm.1429","article-title":"Optimally estimating the sample standard deviation from the five-number summary","volume":"11","author":"Shi","year":"2020","journal-title":"Res Synth Methods"},{"key":"10.1016\/j.jacig.2026.100678_bib23","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1016\/j.jaip.2021.09.035","article-title":"Translating evidence to optimize patient care using GRADE","volume":"9","author":"Chu","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2026.100678_bib24","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1016\/j.jaip.2022.06.017","article-title":"Trustworthy patient-centered guidelines: insights from atopic dermatitis and a proposal for the future","volume":"10","author":"Agarwal","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2026.100678_bib25","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.jacig.2026.100678_bib26","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/jrsm.46","article-title":"Pooling health-related quality of life outcomes in meta-analysis\u2014a tutorial and review of methods for enhancing interpretability","volume":"2","author":"Thorlund","year":"2011","journal-title":"Res Synth Methods"},{"key":"10.1016\/j.jacig.2026.100678_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-081903","article-title":"Core GRADE 1: overview of the Core GRADE approach","volume":"389","author":"Guyatt","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.jacig.2026.100678_bib28","article-title":"Core GRADE 2: choosing the target of certainty rating and assessing imprecision","volume":"389","author":"Guyatt","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.jacig.2026.100678_bib29","article-title":"Core GRADE 3: rating certainty of evidence-assessing inconsistency","volume":"389","author":"Guyatt","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.jacig.2026.100678_bib30","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-083864","article-title":"Core GRADE 4: rating certainty of evidence-risk of bias, publication bias, and reasons for rating up certainty","volume":"389","author":"Guyatt","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.jacig.2026.100678_bib31","article-title":"Core GRADE 5: rating certainty of evidence-assessing indirectness","volume":"389","author":"Guyatt","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.jacig.2026.100678_bib32","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-083866","article-title":"Core GRADE 6: presenting the evidence in summary of findings tables","volume":"389","author":"Guyatt","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.jacig.2026.100678_bib33","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-083867","article-title":"Core GRADE 7: principles for moving from evidence to recommendations and decisions","volume":"389","author":"Guyatt","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.jacig.2026.100678_bib34","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jclinepi.2019.10.014","article-title":"GRADE guidelines 26: informative statements to communicate the findings of systematic reviews of interventions","volume":"119","author":"Santesso","year":"2020","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jacig.2026.100678_bib35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jclinepi.2021.03.026","article-title":"GRADE guidelines 32: GRADE offers guidance on choosing targets of GRADE certainty of evidence ratings","volume":"137","author":"Zeng","year":"2021","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jacig.2026.100678_bib36","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jclinepi.2011.04.009","article-title":"Number needed to treat is incorrect without proper time-related considerations","volume":"65","author":"Suissa","year":"2012","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jacig.2026.100678_bib37","doi-asserted-by":"crossref","first-page":"E901","DOI":"10.1503\/cmaj.200077","article-title":"Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in randomized controlled trials and meta-analyses","volume":"192","author":"Schandelmaier","year":"2020","journal-title":"CMAJ"},{"key":"10.1016\/j.jacig.2026.100678_bib38","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1164\/rccm.200903-0354OC","article-title":"Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial","volume":"181","author":"Castro","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jacig.2026.100678_bib39","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1056\/NEJMoa064707","article-title":"Asthma control during the year after bronchial thermoplasty","volume":"356","author":"Cox","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacig.2026.100678_bib40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1164\/rccm.201911-2298OC","article-title":"Bronchial thermoplasty induced airway smooth muscle reduction and clinical response in severe asthma. The TASMA Randomized Trial","volume":"203","author":"Goorsenberg","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jacig.2026.100678_bib41","article-title":"Efficacy of bronchial thermoplasty in patients with severe asthma and frequent severe exacerbations: a randomized controlled study","volume":"86","author":"Leroux","year":"2024","journal-title":"Respir Med Res"},{"key":"10.1016\/j.jacig.2026.100678_bib42","first-page":"141","article-title":"Clinical application of bronchial thermoforming in the treatment of severe asthma","volume":"31","author":"Lv","year":"2021","journal-title":"Shenzhen Journal of Integrated Traditional Chinese and Western Medicine"},{"key":"10.1016\/j.jacig.2026.100678_bib43","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1164\/rccm.200704-571OC","article-title":"Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma","volume":"176","author":"Pavord","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jacig.2026.100678_bib44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jclinepi.2023.05.010","article-title":"The development methods of official GRADE articles and requirements for claiming the use of GRADE\u2014a statement by the GRADE guidance group","volume":"159","author":"Schunemann","year":"2023","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jacig.2026.100678_bib45","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jaci.2015.11.044","article-title":"Reduction in peripheral blood eosinophil counts after bronchial thermoplasty","volume":"138","author":"Ryan","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2026.100678_bib46","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1513\/AnnalsATS.201502-082OC","article-title":"Airway inflammation after bronchial thermoplasty for severe asthma","volume":"12","author":"Denner","year":"2015","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jacig.2026.100678_bib47","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12931-021-01774-0","article-title":"Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes\/phenotypes","volume":"22","author":"Papakonstantinou","year":"2021","journal-title":"Respir Res"},{"key":"10.1016\/j.jacig.2026.100678_bib48","first-page":"143","article-title":"Optimizing sputum cell counts prior to bronchial thermoplasty: a preliminary report. Canadian Journal of Respiratory, Critical Care, and","volume":"3","author":"Svenningsen","year":"2019","journal-title":"Sleep Medicine"},{"key":"10.1016\/j.jacig.2026.100678_bib49","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jaip.2019.10.034","article-title":"Predicting the response to bronchial thermoplasty","volume":"8","author":"Langton","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2026.100678_bib50","article-title":"Values and preferences of patients and caregivers regarding the management of moderate to severe asthma: a systematic review and qualitative evidence synthesis","author":"Rayner","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2026.100678_bib51","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.23903","article-title":"Use of placebo and nonoperative control groups in surgical trials: a systematic review and meta-analysis","volume":"5","author":"Karjalainen","year":"2022","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jacig.2026.100678_bib52","article-title":"Impact of blinding on estimated treatment effects in randomised clinical trials: meta-epidemiological study","volume":"368","author":"Moustgaard","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.jacig.2026.100678_bib53","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1093\/aje\/kwad131","article-title":"Impact of allocation concealment and blinding in trials addressing treatments for COVID-19: a methods study","volume":"192","author":"Zeraatkar","year":"2023","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jacig.2026.100678_bib54","doi-asserted-by":"crossref","first-page":"370","DOI":"10.21037\/atm-22-580","article-title":"Recent advances in bronchial thermoplasty for severe asthma: a narrative review","volume":"10","author":"Wu","year":"2022","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.jacig.2026.100678_bib55","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1016\/j.jaip.2023.04.036","article-title":"Reduced asthma exacerbations in adult patients treated with bronchial thermoplasty","volume":"11","author":"Akaba","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2026.100678_bib56","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.chest.2021.10.044","article-title":"Bronchial thermoplasty in patients with severe asthma at 5 years: the post\u2013FDA approval clinical trial evaluating bronchial thermoplasty in severe persistent asthma study","volume":"161","author":"Chupp","year":"2022","journal-title":"Chest"},{"key":"10.1016\/j.jacig.2026.100678_bib57","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-053854","article-title":"Bronchial Thermoplasty Global Registry (BTGR): 2-year results","volume":"11","author":"Torrego","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.jacig.2026.100678_bib58","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-026742","article-title":"Efficacy and safety of bronchial thermoplasty in clinical practice: a prospective, longitudinal, cohort study using evidence from the UK Severe Asthma Registry","volume":"9","author":"Burn","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.jacig.2026.100678_bib59","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S2213-2600(20)30408-2","article-title":"Safety and effectiveness of bronchial thermoplasty after 10 years in patients with persistent asthma (BT10+): a follow-up of three randomised controlled trials","volume":"9","author":"Chaudhuri","year":"2021","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jacig.2026.100678_bib60","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1001\/jama.2021.7872","article-title":"Triple vs dual inhaler therapy and asthma outcomes in moderate to severe asthma: a systematic review and meta-analysis","volume":"325","author":"Kim","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jacig.2026.100678_bib61","doi-asserted-by":"crossref","unstructured":"Ologundudu LM, Wong MM, Islam N, Rayner DG, Chu AWL, Loeb M, et al. Macrolides for asthma: a systematic review and meta-analysis of randomized trials. J Allergy Clin Immunol. 2026 Feb 5:S0091-6749(26)00078-3. doi: 10.1016\/j.jaci.2026.01.024. Epub ahead of print.","DOI":"10.1016\/j.jaci.2026.01.024"},{"key":"10.1016\/j.jacig.2026.100678_bib62","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jaci.2026.01.002","article-title":"Biologics in the treatment of severe asthma in children and adults-updates 2024-2025","volume":"157","author":"Gaberino","year":"2026","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2026.100678_bib63","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jaip.2026.01.022","article-title":"Biologics use in eosinophilic lung disease: controversies and consensus","volume":"14","author":"P\u00e9rez de Llano","year":"2026","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2026.100678_bib64","doi-asserted-by":"crossref","unstructured":"Coyle L, McDowell PJ, Heaney LG. Lessons learned regarding optimal use of biologics to achieve disease remission in severe asthma. Ann Allergy Asthma Immunol 2026 Feb 28:S1081-1206(26)00069-4. doi: 10.1016\/j.anai.2026.02.008. Epub ahead of print.","DOI":"10.1016\/j.anai.2026.02.008"}],"container-title":["Journal of Allergy and Clinical Immunology: Global"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772829326000408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772829326000408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:13:31Z","timestamp":1788264811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772829326000408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2772829326000408"],"URL":"https:\/\/doi.org\/10.1016\/j.jacig.2026.100678","relation":{},"ISSN":["2772-8293"],"issn-type":[{"value":"2772-8293","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bronchial thermoplasty for severe asthma: Systematic review and meta-analysis of benefits and harms","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology: Global","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacig.2026.100678","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}],"article-number":"100678"}}