{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:25:56Z","timestamp":1783131956790,"version":"3.54.6"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institutes of Health National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23AI171085"],"award-info":[{"award-number":["K23AI171085"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institutes of Health National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32 AI083216-15"],"award-info":[{"award-number":["T32 AI083216-15"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"Clinical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-global.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology: Global"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jacig.2026.100722","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:38:25Z","timestamp":1777606705000},"page":"100722","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating eosinophils in patients with hypereosinophilic syndrome have heterogeneous immunophenotypes"],"prefix":"10.1016","volume":"5","author":[{"given":"Krishan D.","family":"Chhiba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kasjanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Makiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paneez","family":"Khoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy D.","family":"Klion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9570-3806","authenticated-orcid":false,"given":"Fei Li","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacig.2026.100722_bib1","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.jaci.2013.06.037","article-title":"Marked and persistent eosinophilia in the absence of clinical manifestations","volume":"133","author":"Chen","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2026.100722_bib2","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jaci.2012.07.024","article-title":"Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD)","volume":"130","author":"Bochner","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2026.100722_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/JLB.5MR0118-028R","article-title":"Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD)","volume":"104","author":"Khoury","year":"2018","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jacig.2026.100722_bib4","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.jaip.2022.02.006","article-title":"An international, retrospective study of off-label biologic use in the treatment of hypereosinophilic syndromes","volume":"10","author":"Chen","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2026.100722_bib5","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.3389\/fimmu.2020.01765","article-title":"Eosinophilia associated with CD3-CD4+ T cells: characterization and outcome of a single-center cohort of 26 patients","volume":"11","author":"Carpentier","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jacig.2026.100722_bib6","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/all.12843","article-title":"Clinical features predict responsiveness to imatinib in platelet-derived growth factor receptor-alpha-negative hypereosinophilic syndrome","volume":"71","author":"Khoury","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jacig.2026.100722_bib7","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jaip.2017.06.006","article-title":"Hypereosinophilic syndrome subtype predicts responsiveness to glucocorticoids","volume":"6","author":"Khoury","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2026.100722_bib8","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.jaip.2018.04.033","article-title":"Long-term clinical outcomes of high-dose mepolizumab treatment for hypereosinophilic syndrome","volume":"6","author":"Kuang","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jacig.2026.100722_bib9","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1182\/blood-2003-11-3850","article-title":"Familial eosinophilia: a benign disorder?","volume":"103","author":"Klion","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jacig.2026.100722_bib10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jaci.2018.02.011","article-title":"A critical role for IL-18 in transformation and maturation of naive eosinophils to pathogenic eosinophils","volume":"142","author":"Venkateshaiah","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2026.100722_bib11","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1159\/000452654","article-title":"Possible noninvasive biomarker of eosinophilic esophagitis: clinical and experimental evidence","volume":"10","author":"Venkateshaiah","year":"2016","journal-title":"Case Rep Gastroenterol"},{"key":"10.1016\/j.jacig.2026.100722_bib12","author":"Wei"},{"key":"10.1016\/j.jacig.2026.100722_bib13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/imm.13051","article-title":"Intestinal overexpression of IL-18 promotes eosinophils-mediated allergic disorders","volume":"157","author":"Verma","year":"2019","journal-title":"Immunology"},{"key":"10.1016\/j.jacig.2026.100722_bib14","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.jaci.2009.09.022","article-title":"Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy","volume":"124","author":"Ogbogu","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2026.100722_bib15","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1111\/all.15751","article-title":"Eosinophils from A to Z","volume":"78","author":"Gigon","year":"2023","journal-title":"Allergy"},{"key":"10.1016\/j.jacig.2026.100722_bib16","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1165\/ajrcmb.18.6.3159","article-title":"CD44 and CD69 represent different types of cell-surface activation markers for human eosinophils","volume":"18","author":"Matsumoto","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jacig.2026.100722_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1165\/ajrcmb\/7.3.261","article-title":"Altered adhesion molecule expression and endothelial activation accompany the recruitment of human granulocytes to the lung following segmental antigen challenge","volume":"7","author":"Georas","year":"1992","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jacig.2026.100722_bib18","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1111\/all.15909","article-title":"Blood CD62Llow inflammatory eosinophils are related to the severity of asthma and reduced by mepolizumab","volume":"78","author":"Vultaggio","year":"2023","journal-title":"Allergy"},{"key":"10.1016\/j.jacig.2026.100722_bib19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1164\/ajrccm.149.2.8306028","article-title":"Immunophenotyping of eosinophils recovered from blood and BAL of allergic asthmatics","volume":"149","author":"Mengelers","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"issue":"5 suppl","key":"10.1016\/j.jacig.2026.100722_bib20","doi-asserted-by":"crossref","first-page":"S292","DOI":"10.1067\/mai.2000.110164","article-title":"Systemic activation of basophils and eosinophils: markers and consequences","volume":"106","author":"Bochner","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jacig.2026.100722_bib21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1365-2222.1993.tb00882.x","article-title":"Down modulation of L-Selectin expression on eosinophils recovered from bronchoalveolar lavage fluid after allergen provocation","volume":"23","author":"Mengelers","year":"1993","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jacig.2026.100722_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0091-6749(92)90068-D","article-title":"In vivo expression of CD69 on lung eosinophils in eosinophilic pneumonia\u2014CD69 as a possible activation marker for eosinophils","volume":"90","author":"Nishikawa","year":"1992","journal-title":"J Allerg Clin Immunol"},{"key":"10.1016\/j.jacig.2026.100722_bib23","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1182\/blood.V99.11.4039","article-title":"Translocation of the tetraspanin CD63 in association with human eosinophil mediator release","volume":"99","author":"Mahmudi-Azer","year":"2002","journal-title":"Blood"}],"container-title":["Journal of Allergy and Clinical Immunology: Global"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772829326000846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772829326000846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:11:58Z","timestamp":1783131118000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772829326000846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2772829326000846"],"URL":"https:\/\/doi.org\/10.1016\/j.jacig.2026.100722","relation":{},"ISSN":["2772-8293"],"issn-type":[{"value":"2772-8293","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating eosinophils in patients with hypereosinophilic syndrome have heterogeneous immunophenotypes","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology: Global","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacig.2026.100722","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}],"article-number":"100722"}}