{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:29:54Z","timestamp":1788924594547,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730090"],"award-info":[{"award-number":["81730090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Provincial Science and Technology Plan of Guangdong Grants","award":["2016A020215037"],"award-info":[{"award-number":["2016A020215037"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","lipidjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Lipidology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.jacl.2017.12.006","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T13:41:26Z","timestamp":1513863686000},"page":"417-427.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Treatment of coenzyme Q10 for 24\u00a0weeks improves lipid and glycemic profile in dyslipidemic individuals"],"prefix":"10.1016","volume":"12","author":[{"given":"Peiwen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaji","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huamei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jacl.2017.12.006_bib1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2337\/diacare.24.4.683","article-title":"Cardiovascular morbidity and mortality associated with the metabolic syndrome","volume":"24","author":"Isomaa","year":"2001","journal-title":"Diabetes Care"},{"issue":"21","key":"10.1016\/j.jacl.2017.12.006_bib2","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1001\/jama.288.21.2709","article-title":"The metabolic syndrome and total and cardiovascular disease mortality in middleaged men","volume":"288","author":"Lakka","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.jacl.2017.12.006_bib3","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.mito.2007.03.005","article-title":"Coenzyme Q(10)\u2013its role as a prooxidant in the formation of superoxide anion\/hydrogen peroxide and the regulation of the metabolome","volume":"7 Suppl","author":"Linnane","year":"2007","journal-title":"Mitochondrion"},{"issue":"12","key":"10.1016\/j.jacl.2017.12.006_bib4","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.cellsig.2012.07.022","article-title":"Coenzyme Q10 increases the fatty acid oxidation through AMPK-mediated PPAR\u03b1 induction in 3T3-L1 preadipocytes","volume":"24","author":"Lee","year":"2012","journal-title":"Cell Signal"},{"issue":"4","key":"10.1016\/j.jacl.2017.12.006_bib5","first-page":"192","article-title":"Antiatherogenic, hepatoprotective, and hypolipidemic effects of coenzyme Q10 in alloxan-induced type 1 diabetic rats","volume":"10","author":"Ahmadvand","year":"2014","journal-title":"ARYA Atheroscler"},{"issue":"4","key":"10.1016\/j.jacl.2017.12.006_bib6","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1161\/01.ATV.21.4.585","article-title":"Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice","volume":"21","author":"Thomas","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"10.1016\/j.jacl.2017.12.006_bib7","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1161\/ATVBAHA.113.302879","article-title":"Coenzyme Q10 promotes macrophage cholesterol efflux by regulation of the activator protein-1\/miR-378\/ATP-binding cassette transporter G1-signaling pathway","volume":"34","author":"Wang","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"10.1016\/j.jacl.2017.12.006_bib8","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/10715760290021306","article-title":"Cellular redox activity of coenzyme Q10: effect of CoQ10 supplementation on human skeletal muscle","volume":"36","author":"Linnane","year":"2002","journal-title":"Free Radic Res"},{"key":"10.1016\/j.jacl.2017.12.006_bib9","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1016\/0098-2997(94)90037-X","article-title":"Treatment of essential hypertension with coenzyme Q10","volume":"15 Suppl","author":"Langsjoen","year":"1994","journal-title":"Mol Aspects Med"},{"issue":"2","key":"10.1016\/j.jacl.2017.12.006_bib10","first-page":"231","article-title":"The effect of coenzyme Q10 supplementation on metabolic status of type 2 diabetic patients","volume":"59","author":"Kolahdouz Mohammadi","year":"2013","journal-title":"Minerva Gastroenterol Dietol"},{"key":"10.1016\/j.jacl.2017.12.006_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s40200-014-0081-6","article-title":"Effects of CoQ10 supplementation on lipid profiles and glycemic control in patients with type 2 diabetes: a randomized, double blind, placebo-controlled trial","volume":"13","author":"Zahedi","year":"2014","journal-title":"J Diabetes Metab Disord"},{"issue":"2","key":"10.1016\/j.jacl.2017.12.006_bib12","doi-asserted-by":"crossref","first-page":"e182","DOI":"10.1016\/j.atherosclerosis.2007.06.010","article-title":"Hokuriku Lipid Research Group. Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study","volume":"195","author":"Mabuchi","year":"2007","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.jacl.2017.12.006_bib13","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/cen.13288","article-title":"The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial","volume":"86","author":"Samimi","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"10.1016\/j.jacl.2017.12.006_bib14","first-page":"169","article-title":"Proposal on prevention and treatment of dyslipidemia","volume":"25","author":"Fang","year":"1997","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"issue":"8","key":"10.1016\/j.jacl.2017.12.006_bib15","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1249\/01.MSS.0000078924.61453.FB","article-title":"International physical activity questionnaire: 12-country reliability and validity","volume":"35","author":"Craig","year":"2003","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"10.1016\/j.jacl.2017.12.006_bib16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of \u201cantioxidant power\u201d: the FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal Biochem"},{"issue":"7","key":"10.1016\/j.jacl.2017.12.006_bib17","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/aje\/142.7.724","article-title":"Exploration of simple insulin sensitivity measures derived from frequently sampled intravenous glucose tolerance (FSIGT) tests. The Insulin Resistance Atherosclerosis Study","volume":"142","author":"Anderson","year":"1995","journal-title":"Am J Epidemiol"},{"issue":"8","key":"10.1016\/j.jacl.2017.12.006_bib18","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.2337\/dc08-0118","article-title":"Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction","volume":"31","author":"Chew","year":"2008","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.jacl.2017.12.006_bib19","first-page":"82","article-title":"Role of L-carnitine and Coenzyme Q10 as Adjuvant Therapy in Patients with Type 2 Diabetes Mellitus","volume":"2","author":"Mohammed-Jawad","year":"2014","journal-title":"Am J Pharmacol Sci"},{"issue":"14","key":"10.1016\/j.jacl.2017.12.006_bib20","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJMsr1203730","article-title":"The prevention and treatment of missing data in clinical trials","volume":"367","author":"Little","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacl.2017.12.006_bib21","first-page":"S4","article-title":"Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","volume":"23 Suppl 1","author":"Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","year":"2000","journal-title":"Diabetes Care"},{"issue":"17","key":"10.1016\/j.jacl.2017.12.006_bib22","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jacl.2017.12.006_bib23","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1001\/jama.294.3.326","article-title":"Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women","volume":"294","author":"Ridker","year":"2005","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.jacl.2017.12.006_bib24","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1001\/jama.2012.366","article-title":"Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis","volume":"307","author":"Boekholdt","year":"2012","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.jacl.2017.12.006_bib25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s40292-016-0163-2","article-title":"Effects of a Combined Nutraceutical on Lipid Pattern, Glucose Metabolism and Inflammatory Parameters in Moderately Hypercholesterolemic Subjects: A Double-blind, Cross-over, Randomized Clinical Trial","volume":"24","author":"Cicero","year":"2017","journal-title":"High Blood Press Cardiovasc Prev"},{"issue":"4","key":"10.1016\/j.jacl.2017.12.006_bib26","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1089\/jmf.2010.1202","article-title":"Effects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled study","volume":"14","author":"Lee","year":"2011","journal-title":"J Med Food"},{"issue":"3","key":"10.1016\/j.jacl.2017.12.006_bib27","first-page":"156","article-title":"The Effect of Coenzyme Q10 Supplementation on Circulating Levels of Novel Adipokine Adipolin\/CTRP12 in Overweight and Obese Patients with Type 2 Diabetes","volume":"125","author":"Mehrdadi","year":"2017","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.jacl.2017.12.006_bib28","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.phrs.2016.01.030","article-title":"Supplementation with coenzyme Q10 reduces plasma lipoprotein(a) concentrations but not other lipid indices: A systematic review and meta-analysis","volume":"105","author":"Sahebkar","year":"2016","journal-title":"Pharmacol Res"},{"issue":"2-4","key":"10.1016\/j.jacl.2017.12.006_bib29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/biof.5520090229","article-title":"The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus","volume":"9","author":"Eriksson","year":"1999","journal-title":"Biofactors"},{"issue":"6865","key":"10.1016\/j.jacl.2017.12.006_bib30","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jacl.2017.12.006_bib31","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1007\/s00394-015-1042-7","article-title":"The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome","volume":"55","author":"Raygan","year":"2016","journal-title":"Eur J Nutr"},{"issue":"4","key":"10.1016\/j.jacl.2017.12.006_bib32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/sj.jhh.1002138","article-title":"Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials","volume":"21","author":"Rosenfeldt","year":"2007","journal-title":"J Hum Hypertens"},{"issue":"7","key":"10.1016\/j.jacl.2017.12.006_bib33","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1089\/ars.2010.3739","article-title":"Oxidative stress as pathogenesis of cardiovascular risk associated with metabolic syndrome","volume":"15","author":"Otani","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jacl.2017.12.006_bib34","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2741\/3812","article-title":"Inflammatory markers and cardiovascular risk in the metabolic syndrome","volume":"16","author":"Espinola-Klein","year":"2011","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1016\/j.jacl.2017.12.006_bib35","article-title":"Effects of coenzyme Q10 supplementation on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials","author":"Mazidi","year":"2017","journal-title":"Pharmacol Res"},{"issue":"20","key":"10.1016\/j.jacl.2017.12.006_bib36","doi-asserted-by":"crossref","first-page":"9388","DOI":"10.1073\/pnas.92.20.9388","article-title":"The roles of coenzyme Q10 and vitamin E on the peroxidation of human low density lipoprotein subfractions","volume":"92","author":"Alleva","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacl.2017.12.006_bib37","doi-asserted-by":"crossref","first-page":"S227","DOI":"10.1002\/mnfr.201100147","article-title":"Coenzyme Q10 suppresses oxLDL-induced endothelial oxidative injuries by the modulation of LOX-1-mediated ROS generation via the AMPK\/PKC\/NADPH oxidase signaling pathway","volume":"55 Suppl 2","author":"Tsai","year":"2011","journal-title":"Mol Nutr Food Res"},{"issue":"10","key":"10.1016\/j.jacl.2017.12.006_bib38","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/01.RES.87.10.840","article-title":"Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress","volume":"87","author":"Cai","year":"2000","journal-title":"Circ Res"},{"issue":"7086","key":"10.1016\/j.jacl.2017.12.006_bib39","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature04634","article-title":"Reactive oxygen species have a causal role in multiple forms of insulin resistance","volume":"440","author":"Houstis","year":"2006","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jacl.2017.12.006_bib40","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.jacl.2017.12.006_bib41","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.phrs.2015.07.008","article-title":"Statin therapy and plasma coenzyme Q10 concentrations\u2013A systematic review and meta-analysis of placebo-controlled trials","volume":"99","author":"Banach","year":"2015","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.jacl.2017.12.006_bib42","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mayocp.2014.08.021","article-title":"Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials","volume":"90","author":"Banach","year":"2015","journal-title":"Mayo Clin Proc"},{"issue":"5","key":"10.1016\/j.jacl.2017.12.006_bib43","doi-asserted-by":"crossref","first-page":"965","DOI":"10.5114\/aoms.2017.69326","article-title":"Lipid lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel","volume":"13","author":"Cicero","year":"2017","journal-title":"Arch Med Sci"}],"container-title":["Journal of Clinical Lipidology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193328741730541X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193328741730541X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T00:31:17Z","timestamp":1535157077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193328741730541X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S193328741730541X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacl.2017.12.006","relation":{},"ISSN":["1933-2874"],"issn-type":[{"value":"1933-2874","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment of coenzyme Q10 for 24\u00a0weeks improves lipid and glycemic profile in dyslipidemic individuals","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Lipidology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacl.2017.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 National Lipid Association. All rights reserved.","name":"copyright","label":"Copyright"}]}}