{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T11:08:14Z","timestamp":1775646494061,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","lipidjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Lipidology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.jacl.2018.06.007","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:21:00Z","timestamp":1529691660000},"page":"1157-1163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lp8 is potentially associated with partial lecithin:cholesterol acyltransferase deficiency in a patient with primary biliary cirrhosis"],"prefix":"10.1016","volume":"12","author":[{"given":"Toshiyuki","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshirou","family":"Nema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Hiruta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeyoshi","family":"Murano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang J.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Bujo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacl.2018.06.007_bib1","series-title":"The Metabolic and Molecular Bases of Inherited Disease","first-page":"2817","article-title":"Lecithin cholesterol acyltransferase deficiency and fish eye disease","author":"Santamarina-Fojo","year":"2001"},{"key":"10.1016\/j.jacl.2018.06.007_bib2","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1172\/JCI106585","article-title":"Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: physical and chemical studies of low and high density lipoproteins","volume":"50","author":"Norum","year":"1971","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacl.2018.06.007_bib3","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1172\/JCI107273","article-title":"Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency. Further studies of very low and low density lipoprotein abnormalities","volume":"52","author":"Glomset","year":"1973","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacl.2018.06.007_bib4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1365-2362.1974.tb02357.x","article-title":"Hypertriglyceridaemia secondary to liver disease","volume":"4","author":"M\u00fcller","year":"1974","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jacl.2018.06.007_bib5","first-page":"369","article-title":"Lecithin\u2013cholesterol acyltransferase and the lipoprotein abnormalities of obstructive jaundice","volume":"54","author":"Agorastos","year":"1978","journal-title":"Clin Sci Mol Med"},{"key":"10.1016\/j.jacl.2018.06.007_bib6","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1172\/JCI106085","article-title":"A lipoprotein characterizing obstructive jaundice. I. Method for quantitative separation and identification of lipoproteins in jaundiced subjects","volume":"48","author":"Seidel","year":"1969","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacl.2018.06.007_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1042\/cs0560575","article-title":"Lecithin-cholesterol acyltransferase and the lipoprotein abnormalities of parenchymal liver disease","volume":"56","author":"Day","year":"1979","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jacl.2018.06.007_bib8","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jacl.2011.04.004","article-title":"Multiple lipoprotein and electrolyte laboratory artifacts caused by lipoprotein X in obstructive biliary cholestasis secondary to pancreatic cancer","volume":"5","author":"Sivakumar","year":"2011","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.jacl.2018.06.007_bib9","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1172\/JCI103163","article-title":"Protein-lipid relationships in human plasma: in biliary cirrhosis, obstructive jaundice, and acute hepatitis","volume":"34","author":"Eder","year":"1955","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacl.2018.06.007_bib10","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1172\/JCI105676","article-title":"Plasma lipoproteins in liver disease. I. Immunologically distinct low-density lipoproteins in patients with biliary obstruction","volume":"46","author":"Switzer","year":"1967","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacl.2018.06.007_bib11","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1172\/JCI106459","article-title":"A lipoprotein characterizing obstructive jaundice. II. Isolation and partial characterization of the protein moieties of low density lipoproteins","volume":"49","author":"Seidel","year":"1970","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacl.2018.06.007_bib12","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/S0021-9258(18)71873-5","article-title":"Isolation, chemical characterization, and biophysical properties of three different abnormal lipoproteins: LP-X1, LP-X2, and LP-X3","volume":"252","author":"Patsch","year":"1977","journal-title":"J Biol Chen"},{"key":"10.1016\/j.jacl.2018.06.007_bib13","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0950-351X(05)80080-1","article-title":"Dyslipoproteinaemia of liver disease","volume":"4","author":"Miller","year":"1990","journal-title":"Baillieres Clin Endocrinol Metab"},{"key":"10.1016\/j.jacl.2018.06.007_bib14","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/hep.510280506","article-title":"Lipoprotein-X in patients with cirrhosis: its relationship to cholestasis and hypercholesterolemia","volume":"28","author":"S\u00f6r\u00f6s","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.jacl.2018.06.007_bib15","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1161\/ATVBAHA.114.303420","article-title":"Lipoprotein subfractions highly associated with renal damage in familial lecithin:cholesterol acyltransferase deficiency","volume":"34","author":"Kuroda","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacl.2018.06.007_bib16","first-page":"299","article-title":"Two novel mutations of lecithin:cholesterol acyltransferase (LCAT) gene and the influence of APOE genotypes on clinical manifestations","volume":"4","author":"Katayama","year":"2011","journal-title":"NDT Plus"},{"key":"10.1016\/j.jacl.2018.06.007_bib17","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0009-8981(77)90355-2","article-title":"A new colorimetric method for the determination of plasma lecithin-cholesterol acyltransferase activity","volume":"75","author":"Nagasaki","year":"1977","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jacl.2018.06.007_bib18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ymgme.2010.10.009","article-title":"Disturbed apolipoprotein A-I-containing lipoproteins in fish-eye disease are improved by the lecithin:cholesterol acyltransferase produced by gene-transduced adipocytes in\u00a0vitro","volume":"102","author":"Asada","year":"2011","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jacl.2018.06.007_bib19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.atherosclerosis.2013.02.034","article-title":"Amelioration of circulating lipoprotein profile and proteinuria in a patient with LCAT deficiency due to a novel mutation (Cys74Tyr) in the lid region of LCAT under a fat-restricted diet and ARB treatment","volume":"228","author":"Naito","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacl.2018.06.007_bib20","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/clinchem\/28.4.606","article-title":"Simple, direct measurement of lipoprotein X in serum","volume":"28","author":"Hashiguchi","year":"1982","journal-title":"Clin Chem"},{"key":"10.1016\/j.jacl.2018.06.007_bib21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0022-2275(20)30123-1","article-title":"A new on-line dual enzymatic method for simultaneous quantification of cholesterol and triglycerides in lipoproteins by HPLC","volume":"43","author":"Usui","year":"2002","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jacl.2018.06.007_bib22","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1161\/01.ATV.0000155017.60171.88","article-title":"Identification of unique lipoprotein subclasses for visceral obesity by component analysis of cholesterol profile in high-performance liquid chromatography","volume":"25","author":"Okazaki","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacl.2018.06.007_bib23","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1172\/JCI107004","article-title":"Liquid crystalline lipid in the plasma of humans with biliary obstruction","volume":"51","author":"Quarfordt","year":"1972","journal-title":"J Clin Invest"}],"container-title":["Journal of Clinical Lipidology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287418302654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287418302654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T05:34:45Z","timestamp":1661492085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933287418302654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S1933287418302654"],"URL":"https:\/\/doi.org\/10.1016\/j.jacl.2018.06.007","relation":{},"ISSN":["1933-2874"],"issn-type":[{"value":"1933-2874","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lp8 is potentially associated with partial lecithin:cholesterol acyltransferase deficiency in a patient with primary biliary cirrhosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Lipidology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacl.2018.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 National Lipid Association. All rights reserved.","name":"copyright","label":"Copyright"}]}}