{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T03:32:08Z","timestamp":1772940728937,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lipidjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Lipidology"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.jacl.2019.10.011","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T20:51:42Z","timestamp":1571777502000},"page":"1016-1022.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Colchicine's effects on lipoprotein particle concentrations in adults with metabolic syndrome: A secondary analysis of a randomized controlled trial"],"prefix":"10.1016","volume":"13","author":[{"given":"Andrew P.","family":"Demidowich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9479-0741","authenticated-orcid":false,"given":"Anna","family":"Wolska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sierra R.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan A.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander V.","family":"Sorokin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila M.","family":"Brady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan T.","family":"Remaley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack A.","family":"Yanovski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacl.2019.10.011_bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mehy.2016.04.039","article-title":"Colchicine to decrease NLRP3-activated inflammation and improve obesity-related metabolic dysregulation","volume":"92","author":"Demidowich","year":"2016","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.jacl.2019.10.011_bib2","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1476-5381.2011.01254.x","article-title":"Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action","volume":"163","author":"Marques-da-Silva","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jacl.2019.10.011_bib3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1136\/heartjnl-2015-308542","article-title":"Cardiovascular effects and safety of long-term colchicine treatment: Cochrane review and meta-analysis","volume":"102","author":"Hemkens","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.jacl.2019.10.011_bib4","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1136\/annrheumdis-2015-207984","article-title":"Effects of colchicine on risk of cardiovascular events and mortality among patients with gout: a cohort study using electronic medical records linked with Medicare claims","volume":"75","author":"Solomon","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jacl.2019.10.011_bib5","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.jacc.2013.01.055","article-title":"Colchicine treatment for the prevention of bare-metal stent restenosis in diabetic patients","volume":"61","author":"Deftereos","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacl.2019.10.011_bib6","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jacc.2012.10.027","article-title":"Low-dose colchicine for secondary prevention of cardiovascular disease","volume":"61","author":"Nidorf","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacl.2019.10.011_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jcmg.2017.08.013","article-title":"Colchicine therapy and plaque stabilization in patients with acute coronary syndrome: a CT coronary angiography study","volume":"11","author":"Vaidya","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jacl.2019.10.011_bib8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s11239-011-0637-y","article-title":"Effect of colchicine compared with placebo on high sensitivity C-reactive protein in patients with acute coronary syndrome or acute stroke: a pilot randomized controlled trial","volume":"33","author":"Raju","year":"2012","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.jacl.2019.10.011_bib9","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.amjcard.2006.10.039","article-title":"Effect of colchicine (0.5 mg twice daily) on high-sensitivity C-reactive protein independent of aspirin and atorvastatin in patients with stable coronary artery disease","volume":"99","author":"Nidorf","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacl.2019.10.011_bib10","doi-asserted-by":"crossref","first-page":"e002128","DOI":"10.1161\/JAHA.115.002128","article-title":"Colchicine acutely suppresses local cardiac production of inflammatory cytokines in patients with an acute coronary syndrome","volume":"4","author":"Martinez","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacl.2019.10.011_bib11","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1111\/dom.13702","article-title":"Effects of colchicine in adults with metabolic syndrome: a pilot randomized controlled trial","volume":"21","author":"Demidowich","year":"2019","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.jacl.2019.10.011_bib12","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/hep.1840140648","article-title":"Role of microtubuli in secretion of very-low-density lipoprotein in isolated rat hepatocytes: early effects of thiol reagents","volume":"14","author":"Nagelkerke","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.jacl.2019.10.011_bib13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/244030a0","article-title":"Role of microtubules in lipoprotein secretion by the liver","volume":"244","author":"Orci","year":"1973","journal-title":"Nature"},{"key":"10.1016\/j.jacl.2019.10.011_bib14","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/0016-5085(83)90079-3","article-title":"Effects of colchicine on the intestinal transport of endogenous lipid. Ultrastructural, biochemical, and radiochemical studies in fasting rats","volume":"84","author":"Pavelka","year":"1983","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jacl.2019.10.011_bib15","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0016-5085(76)80145-X","article-title":"Intestinal lipoprotein formation: effect of cholchicine","volume":"70","author":"Glickman","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jacl.2019.10.011_bib16","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: an American heart association\/national heart, lung, and blood institute scientific statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacl.2019.10.011_bib17","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1177\/1932296815577424","article-title":"Does visceral fat estimated by dual-energy x-ray absorptiometry independently predict cardiometabolic risks in adults?","volume":"9","author":"Sasai","year":"2015","journal-title":"J Diabetes Sci Technol"},{"key":"10.1016\/j.jacl.2019.10.011_bib18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.clinbiochem.2014.07.015","article-title":"NMR measurement of LDL particle number using the Vantera (R) Clinical Analyzer","volume":"47","author":"Matyus","year":"2014","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jacl.2019.10.011_bib19","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.cll.2006.07.006","article-title":"Lipoprotein particle analysis by nuclear magnetic resonance spectroscopy","volume":"26","author":"Jeyarajah","year":"2006","journal-title":"Clin Lab Med"},{"key":"10.1016\/j.jacl.2019.10.011_bib20","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1373\/clinchem.2014.232918","article-title":"GlycA: a composite nuclear magnetic resonance biomarker of systemic inflammation","volume":"61","author":"Otvos","year":"2015","journal-title":"Clin Chem"},{"key":"10.1016\/j.jacl.2019.10.011_bib21","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1210\/js.2019-00103","article-title":"Advanced lipoprotein analysis shows atherogenic lipid profile that improves after metreleptin in patients with lipodystrophy","volume":"3","author":"Kinzer","year":"2019","journal-title":"J Endocr Soc"},{"key":"10.1016\/j.jacl.2019.10.011_bib22","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1161\/CIRCULATIONAHA.118.035432","article-title":"Lipoprotein particle profiles, standard lipids, and peripheral artery disease incidence","volume":"138","author":"Aday","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jacl.2019.10.011_bib23","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1002\/hep4.1267","article-title":"A pathophysiologic approach combining genetics and insulin resistance to predict the severity of nonalcoholic fatty liver disease","volume":"2","author":"Danford","year":"2018","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jacl.2019.10.011_bib24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/MOL.0000000000000552","article-title":"Colchicine: an affordable anti-inflammatory agent for atherosclerosis","volume":"29","author":"Thompson","year":"2018","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.jacl.2019.10.011_bib25","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s11926-008-0036-3","article-title":"Colchicine: its mechanism of action and efficacy in crystal-induced inflammation","volume":"10","author":"Nuki","year":"2008","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.jacl.2019.10.011_bib26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijcard.2019.01.054","article-title":"Effect of short-term colchicine treatment on endothelial function in patients with coronary artery disease","volume":"281","author":"Kajikawa","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacl.2019.10.011_bib27","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1042\/CS20160090","article-title":"Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation","volume":"130","author":"Robertson","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jacl.2019.10.011_bib28","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s10753-012-9428-7","article-title":"The effect of regular colchicine treatment on biomarkers related with vascular injury in newly diagnosed patients with familial Mediterranean fever","volume":"35","author":"Sari","year":"2012","journal-title":"Inflammation"},{"key":"10.1016\/j.jacl.2019.10.011_bib29","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1371\/journal.pmed.0050078","article-title":"Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review","volume":"5","author":"Danesh","year":"2008","journal-title":"PLoS Med"},{"key":"10.1016\/j.jacl.2019.10.011_bib30","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/eurheartj\/eht367","article-title":"Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis","volume":"35","author":"Kaptoge","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacl.2019.10.011_bib31","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/jama.286.1.64","article-title":"Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation\/CRP evaluation (PRINCE): a randomized trial and cohort study","volume":"286","author":"Albert","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jacl.2019.10.011_bib32","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein","volume":"359","author":"Ridker","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacl.2019.10.011_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.117.005549","article-title":"Atherogenic lipoprotein determinants of cardiovascular disease and residual risk among individuals with low low-density lipoprotein cholesterol","volume":"6","author":"Lawler","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacl.2019.10.011_bib34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(17)32814-3","article-title":"Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial","volume":"391","author":"Ridker","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jacl.2019.10.011_bib35","first-page":"1","article-title":"Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1beta inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis","author":"Ridker","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacl.2019.10.011_bib36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12967-017-1321-6","article-title":"GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk","volume":"15","author":"Connelly","year":"2017","journal-title":"J Transl Med"},{"key":"10.1016\/j.jacl.2019.10.011_bib37","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1373\/clinchem.2016.261636","article-title":"A novel protein glycan-derived inflammation biomarker independently predicts cardiovascular disease and modifies the association of HDL subclasses with mortality","volume":"63","author":"McGarrah","year":"2017","journal-title":"Clin Chem"},{"key":"10.1016\/j.jacl.2019.10.011_bib38","doi-asserted-by":"crossref","first-page":"e0139057","DOI":"10.1371\/journal.pone.0139057","article-title":"GlycA, a pro-inflammatory glycoprotein biomarker, and incident cardiovascular disease: relationship with C-reactive protein and renal function","volume":"10","author":"Gruppen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jacl.2019.10.011_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.116.003822","article-title":"Circulating N-linked glycoprotein side-chain biomarker, rosuvastatin therapy, and incident cardiovascular disease: an analysis from the JUPITER trial","volume":"5","author":"Akinkuolie","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacl.2019.10.011_bib40","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1161\/ATVBAHA.115.305635","article-title":"Novel protein glycan side-chain biomarker and risk of incident type 2 diabetes mellitus","volume":"35","author":"Akinkuolie","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacl.2019.10.011_bib41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cca.2015.11.001","article-title":"GlycA, a marker of acute phase glycoproteins, and the risk of incident type 2 diabetes mellitus: PREVEND study","volume":"452","author":"Connelly","year":"2016","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jacl.2019.10.011_bib42","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10557-011-6341-5","article-title":"Oxidized LDL, LOX-1 and atherosclerosis","volume":"25","author":"Mitra","year":"2011","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.jacl.2019.10.011_bib43","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1242\/jcs.182097","article-title":"Oxidized LDL induces FAK-dependent RSK signaling to drive NF-kappaB activation and VCAM-1 expression","volume":"129","author":"Yurdagul","year":"2016","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jacl.2019.10.011_bib44","doi-asserted-by":"crossref","first-page":"6862","DOI":"10.1016\/S0021-9258(19)43430-3","article-title":"A role for the microtubular system in the release of very low density lipoproteins by perfused mouse livers","volume":"248","author":"Le Marchand","year":"1973","journal-title":"J Biol Chem"},{"issue":"Suppl 1","key":"10.1016\/j.jacl.2019.10.011_bib45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000176364","article-title":"Intestinal lipoprotein formation","volume":"24","author":"Glickman","year":"1980","journal-title":"Nutr Metab"},{"key":"10.1016\/j.jacl.2019.10.011_bib46","doi-asserted-by":"crossref","first-page":"474","DOI":"10.7326\/0003-4819-150-7-200904070-00007","article-title":"Systematic review: association of low-density lipoprotein subfractions with cardiovascular outcomes","volume":"150","author":"Ip","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jacl.2019.10.011_bib47","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1161\/ATVBAHA.109.190405","article-title":"Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk","volume":"29","author":"Musunuru","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Journal of Clinical Lipidology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287419303186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287419303186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:34:08Z","timestamp":1761831248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933287419303186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S1933287419303186"],"URL":"https:\/\/doi.org\/10.1016\/j.jacl.2019.10.011","relation":{},"ISSN":["1933-2874"],"issn-type":[{"value":"1933-2874","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Colchicine's effects on lipoprotein particle concentrations in adults with metabolic syndrome: A secondary analysis of a randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Lipidology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacl.2019.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc. on behalf of National Lipid Association.","name":"copyright","label":"Copyright"}]}}