{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:27:15Z","timestamp":1786991235155,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lipidjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Lipidology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jacl.2020.10.005","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T02:28:08Z","timestamp":1604111288000},"page":"61-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Ketogenic diets, not for everyone"],"prefix":"10.1016","volume":"15","author":[{"given":"Ira J.","family":"Goldberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0634-3448","authenticated-orcid":false,"given":"Nouran","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9166-9006","authenticated-orcid":false,"given":"Cindy","family":"Bredefeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Foo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Gutman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1751-9661","authenticated-orcid":false,"given":"Lesley-Ann","family":"Huggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Hegele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacl.2020.10.005_bib1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1001\/jama.2017.20639","article-title":"Interest in the Ketogenic diet grows for weight loss and type 2 diabetes","volume":"319","author":"Abbasi","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.jacl.2020.10.005_bib2","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1017\/S0007114513000548","article-title":"Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials","volume":"110","author":"Bueno","year":"2013","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jacl.2020.10.005_bib3","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3945\/ajcn.115.112581","article-title":"Comparison of low- and high-carbohydrate diets for type 2 diabetes management: a randomized trial","volume":"102","author":"Tay","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jacl.2020.10.005_bib4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/ejcn.2013.116","article-title":"Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets","volume":"67","author":"Paoli","year":"2013","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jacl.2020.10.005_bib5","doi-asserted-by":"crossref","first-page":"e6273","DOI":"10.7717\/peerj.6273","article-title":"Low-carbohydrate diets differing in carbohydrate restriction improve cardiometabolic and anthropometric markers in healthy adults: A randomised clinical trial","volume":"7","author":"Harvey","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.jacl.2020.10.005_bib6","doi-asserted-by":"crossref","first-page":"e128308","DOI":"10.1172\/jci.insight.128308","article-title":"Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss","volume":"4","author":"Hyde","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jacl.2020.10.005_bib7","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.3390\/ijerph110202092","article-title":"Ketogenic diet for obesity: friend or foe?","volume":"11","author":"Paoli","year":"2014","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jacl.2020.10.005_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1467-789X.2006.00222.x","article-title":"Low-carbohydrate diets: nutritional and physiological aspects","volume":"7","author":"Adam-Perrot","year":"2006","journal-title":"Obes Rev"},{"key":"10.1016\/j.jacl.2020.10.005_bib9","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jacl.2015.09.002","article-title":"National lipid association recommendations for patient-centered management of dyslipidemia: part 2","volume":"9","author":"Jacobson","year":"2015","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.jacl.2020.10.005_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1210\/er.2017-00253","article-title":"The science of obesity management: an endocrine society scientific statement","volume":"39","author":"Bray","year":"2018","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jacl.2020.10.005_bib11","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0140-6736(11)60813-1","article-title":"The global obesity pandemic: shaped by global drivers and local environments","volume":"378","author":"Swinburn","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jacl.2020.10.005_bib12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/obr.12230","article-title":"Do ketogenic diets really suppress appetite? A systematic review and meta-analysis","volume":"16","author":"Gibson","year":"2015","journal-title":"Obes Rev"},{"key":"10.1016\/j.jacl.2020.10.005_bib13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fpsyg.2015.00027","article-title":"Ketosis, ketogenic diet and food intake control: a complex relationship","volume":"6","author":"Paoli","year":"2015","journal-title":"Front Psychol"},{"key":"10.1016\/j.jacl.2020.10.005_bib14","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1056\/NEJMoa022207","article-title":"A randomized trial of a low-carbohydrate diet for obesity","volume":"348","author":"Foster","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacl.2020.10.005_bib15","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1056\/NEJM199103283241306","article-title":"Normal plasma cholesterol in an 88-year-old man who eats 25 eggs a day. Mechanisms of adaptation","volume":"324","author":"Kern","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacl.2020.10.005_bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12920-020-0669-2","article-title":"Six years' experience with LipidSeq: clinical and research learnings from a hybrid, targeted sequencing panel for dyslipidemias","volume":"13","author":"Dron","year":"2020","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.jacl.2020.10.005_bib18","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1056\/NEJMoa1606148","article-title":"Body-weight fluctuations and outcomes in coronary disease","volume":"376","author":"Bangalore","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacl.2020.10.005_bib19","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/ejhg.2008.202","article-title":"The expression of type III hyperlipoproteinemia: involvement of lipolysis genes","volume":"17","author":"Henneman","year":"2009","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.jacl.2020.10.005_bib20","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1161\/01.ATV.19.11.2722","article-title":"Severe hyperlipidemia in apolipoprotein E2 homozygotes due to a combined effect of hyperinsulinemia and an SstI polymorphism","volume":"19","author":"Sijbrands","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacl.2020.10.005_bib21","first-page":"169","article-title":"Familial hypercholesterolemia","volume":"33","author":"Bouhairie","year":"2015","journal-title":"Cardiol Clin"},{"key":"10.1016\/j.jacl.2020.10.005_bib22","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1161\/CIR.0000000000000297","article-title":"The agenda for familial hypercholesterolemia: a scientific statement from the American Heart Association","volume":"132","author":"Gidding","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jacl.2020.10.005_bib23","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/ATVBAHA.108.179564","article-title":"The LDL receptor","volume":"29","author":"Goldstein","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacl.2020.10.005_bib24","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1093\/eurheartj\/ehw028","article-title":"Mutations causative of familial hypercholesterolaemia: screening of 98 098 individuals from the Copenhagen General Population Study estimated a prevalence of 1 in 217","volume":"37","author":"Benn","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacl.2020.10.005_bib25","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jacl.2019.08.003","volume":"13","author":"Kirkpatrick","year":"2019","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.jacl.2020.10.005_bib26","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s00394-018-1636-y","article-title":"Overweight and diabetes prevention: is a low-carbohydrate-high-fat diet recommendable?","volume":"57","author":"Brouns","year":"2018","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.jacl.2020.10.005_bib27","doi-asserted-by":"crossref","first-page":"104324","DOI":"10.1016\/j.appet.2019.104324","article-title":"Food choice motivations: Profiling low-carbohydrate, high-fat dieters","volume":"141","author":"Clarke","year":"2019","journal-title":"Appetite"},{"key":"10.1016\/j.jacl.2020.10.005_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nut.2014.06.011","article-title":"Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base","volume":"31","author":"Feinman","year":"2015","journal-title":"Nutrition"},{"key":"10.1016\/j.jacl.2020.10.005_bib29","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1113\/JP276703","article-title":"Keto diets: good, bad or ugly?","volume":"596","author":"Evans","year":"2018","journal-title":"J Physiol"},{"key":"10.1016\/j.jacl.2020.10.005_bib30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1179\/1476830514Y.0000000162","article-title":"The impact of the modified Atkins diet on lipid profiles in adults with epilepsy","volume":"19","author":"Cervenka","year":"2016","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.jacl.2020.10.005_bib31","doi-asserted-by":"crossref","first-page":"8681959","DOI":"10.1155\/2019\/8681959","article-title":"Improvement in glycemic and lipid profiles in type 2 diabetics with a 90-day ketogenic diet","volume":"2019","author":"Walton","year":"2019","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.jacl.2020.10.005_bib32","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ejpn.2014.03.006","article-title":"Effects of ketogenic diet on vascular function","volume":"18","author":"Kapetanakis","year":"2014","journal-title":"Eur J Paediatric Neurol"},{"key":"10.1016\/j.jacl.2020.10.005_bib33","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1016\/j.clnu.2017.11.001","article-title":"10 patients, 10 years - long term follow-up of cardiovascular risk factors in Glut1 deficiency treated with ketogenic diet therapies: A prospective, multicenter case series","volume":"37","author":"Heussinger","year":"2018","journal-title":"Clin Nutr"},{"key":"10.1016\/j.jacl.2020.10.005_bib34","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1177\/0883073813476140","article-title":"Can children with hyperlipidemia receive ketogenic diet for medication-resistant epilepsy?","volume":"28","author":"Liu","year":"2013","journal-title":"J Child Neurol"}],"container-title":["Journal of Clinical Lipidology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193328742030324X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193328742030324X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:35:57Z","timestamp":1761831357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193328742030324X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S193328742030324X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacl.2020.10.005","relation":{},"ISSN":["1933-2874"],"issn-type":[{"value":"1933-2874","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ketogenic diets, not for everyone","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Lipidology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacl.2020.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 National Lipid Association. All rights reserved.","name":"copyright","label":"Copyright"}]}}