{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:43:50Z","timestamp":1761831830720,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01 HL159156"],"award-info":[{"award-number":["R01 HL159156"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lipidjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Lipidology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jacl.2023.06.005","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T02:07:13Z","timestamp":1688177233000},"page":"567-570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical trials to improve outcomes in patients with elevated Lp(a) undergoing PCI: The time has arrived"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-9494","authenticated-orcid":false,"given":"Sotirios","family":"Tsimikas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3964-2989","authenticated-orcid":false,"given":"Harpreet S.","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Erlinge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacl.2023.06.005_bib0001","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jacc.2017.11.014","article-title":"NHLBI Working Group recommendations to reduce lipoprotein(a)-mediated risk of cardiovascular disease and aortic stenosis","volume":"71","author":"Tsimikas","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacl.2023.06.005_bib0002","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/clc.22880","article-title":"Elevated lipoprotein(a) and familial hypercholesterolemia in the coronary care unit: between Scylla and Charybdis","volume":"41","author":"Ellis","year":"2018","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jacl.2023.06.005_bib0003","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.003012","article-title":"Lipoprotein(a) interactions with low-density lipoprotein cholesterol and other cardiovascular risk factors in premature acute coronary syndrome (ACS)","volume":"5","author":"Afshar","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacl.2023.06.005_bib0004","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000529600","article-title":"Lipoprotein(a) is associated with thrombus burden in culprit arteries of younger patients with ST-segment elevation myocardial infarction","volume":"148","author":"Sankhesara","year":"2023","journal-title":"Cardiology"},{"key":"10.1016\/j.jacl.2023.06.005_bib0005","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1161\/ATVBAHA.116.308011","article-title":"Prevalence of elevated Lp(a) mass levels and patient thresholds in 532 359 Patients in the United States","volume":"36","author":"Varvel","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacl.2023.06.005_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacl.2023.05.094","article-title":"Association between lipoprotein(a) and long-term outcomes after percutaneous coronary intervention for lesions with in-stent restenosis","author":"Zhang","year":"2023","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.jacl.2023.06.005_bib0007","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1056\/NEJMoa1801174","article-title":"Alirocumab and cardiovascular outcomes after acute coronary syndrome","volume":"379","author":"Schwartz","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacl.2023.06.005_bib0008","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMoa1615664","article-title":"Evolocumab and clinical outcomes in patients with cardiovascular disease","volume":"376","author":"Sabatine","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacl.2023.06.005_bib0009","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.atherosclerosis.2013.01.014","article-title":"Association between baseline lipoprotein (a) levels and restenosis after coronary stenting: meta-analysis of 9 cohort studies","volume":"227","author":"Qin","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacl.2023.06.005_bib0010","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/1440-1681.12396","article-title":"Impact of high lipoprotein(a) levels on in-stent restenosis and long-term clinical outcomes of angina pectoris patients undergoing percutaneous coronary intervention with drug-eluting stents in Asian population","volume":"42","author":"Park","year":"2015","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jacl.2023.06.005_bib0011","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014581","article-title":"Predicting cardiovascular outcomes by baseline lipoprotein(a) concentrations: a large cohort and long-term follow-up study on real-world patients receiving percutaneous coronary intervention","volume":"9","author":"Liu","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacl.2023.06.005_bib0012","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/clc.23520","article-title":"Serum lipoprotein(a) and risk of periprocedural myocardial injury in patients undergoing percutaneous coronary intervention","volume":"44","author":"Huang","year":"2020","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jacl.2023.06.005_bib0013","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/j.jcin.2021.07.042","article-title":"Association of lipoprotein(a) with recurrent ischemic events following percutaneous coronary intervention","volume":"14","author":"Yoon","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jacl.2023.06.005_bib0014","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/00325481.2020.1845517","article-title":"Association of lipoprotein(a) and in-hospital outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention","volume":"133","author":"Wu","year":"2021","journal-title":"Postgrad Med"},{"key":"10.1016\/j.jacl.2023.06.005_bib0015","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jacl.2021.04.003","article-title":"Lipoprotein(a) is associated with poor long-term prognosis in patients aged 80 years and older with acute coronary syndrome","volume":"15","author":"Sang","year":"2021","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.jacl.2023.06.005_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2022.101362","article-title":"Serum lipoprotein(a) and 3-year outcomes in patients undergoing percutaneous coronary intervention","volume":"47","author":"Corpataux","year":"2022","journal-title":"Curr Probl Cardiol"},{"key":"10.1016\/j.jacl.2023.06.005_bib0017","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/clc.22712","article-title":"Association of lipoprotein(a) with long-term mortality following coronary angiography or percutaneous coronary intervention","volume":"40","author":"Feng","year":"2017","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jacl.2023.06.005_bib0018","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/j.jcin.2021.08.032","article-title":"Always present, but now rediscovered: lp(a) as a predictor of long-term outcomes in PCI","volume":"14","author":"Tsimikas","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jacl.2023.06.005_bib0019","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/370460a0","article-title":"Activation of transforming growth factor-beta is inhibited in transgenic apolipoprotein(a) mice","volume":"370","author":"Grainger","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jacl.2023.06.005_bib0020","doi-asserted-by":"crossref","first-page":"55187","DOI":"10.1074\/jbc.M409860200","article-title":"Stimulation of vascular smooth muscle cell proliferation and migration by apolipoprotein(a) is dependent on inhibition of transforming growth factor-beta activation and on the presence of kringle IV type 9","volume":"279","author":"O'Neil","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacl.2023.06.005_bib0021","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41586-018-0198-8","article-title":"Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice","volume":"558","author":"Que","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jacl.2023.06.005_bib0022","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/S0140-6736(16)31009-1","article-title":"Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials","volume":"388","author":"Viney","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jacl.2023.06.005_bib0023","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1161\/CIRCULATIONAHA.116.020838","article-title":"Oxidized phospholipids on lipoprotein(a) elicit arterial wall inflammation and an inflammatory monocyte response in humans","volume":"134","author":"van der Valk","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jacl.2023.06.005_bib0024","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1161\/CIRCRESAHA.119.316206","article-title":"Atherogenic lipoprotein(a) increases vascular glycolysis, thereby facilitating inflammation and leukocyte extravasation","volume":"126","author":"Schnitzler","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.jacl.2023.06.005_bib0025","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1093\/eurheartj\/ehaa171","article-title":"Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotein(a)","volume":"41","author":"Stiekema","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacl.2023.06.005_bib0026","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1161\/01.ATV.18.9.1393","article-title":"Apolipoprotein(a) enhances platelet responses to the thrombin receptor-activating peptide SFLLRN","volume":"18","author":"Rand","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacl.2023.06.005_bib0027","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.807925","article-title":"Benefit and risk of prolonged dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stents in patients with elevated lipoprotein(a) concentrations","volume":"8","author":"Cui","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jacl.2023.06.005_bib0028","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jacc.2022.07.027","article-title":"Aspirin for primary prevention of cardiovascular events in relation to lipoprotein(a) genotypes","volume":"80","author":"Lacaze","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacl.2023.06.005_bib0029","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jacc.2021.09.005","article-title":"2021 ACC\/AHA\/SCAI guideline for coronary artery revascularization: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines","volume":"79","author":"Lawton","year":"2022","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.jacl.2023.06.005_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2020.03.003","article-title":"The dedicated \u201cLp(a) clinic\u201d: A concept whose time has arrived?","volume":"300","author":"Tsimikas","year":"2020","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacl.2023.06.005_bib0031","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.jacc.2021.01.051","article-title":"Emerging RNA therapeutics to lower blood levels of Lp(a): JACC Focus Seminar 2\/4","volume":"77","author":"Tsimikas","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacl.2023.06.005_bib0032","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1056\/NEJMoa1905239","article-title":"Lipoprotein(a) reduction in persons with cardiovascular disease","volume":"382","author":"Tsimikas","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacl.2023.06.005_bib0033","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0140-6736(21)00249-X","article-title":"Identification of vulnerable plaques and patients by intracoronary near-infrared spectroscopy and ultrasound (PROSPECT II): a prospective natural history study","volume":"397","author":"Erlinge","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jacl.2023.06.005_bib0034","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1001\/jama.2022.5218","article-title":"Effect of alirocumab added to high-intensity statin therapy on coronary atherosclerosis in patients with acute myocardial infarction: the PACMAN-AMI randomized clinical trial","volume":"327","author":"R\u00e4ber","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.jacl.2023.06.005_bib0035","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jacc.2021.10.044","article-title":"Association of lipoprotein(a) with atherosclerotic plaque progression","volume":"79","author":"Kaiser","year":"2022","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of Clinical Lipidology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287423002143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287423002143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:39:18Z","timestamp":1761831558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933287423002143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S1933287423002143"],"URL":"https:\/\/doi.org\/10.1016\/j.jacl.2023.06.005","relation":{},"ISSN":["1933-2874"],"issn-type":[{"type":"print","value":"1933-2874"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical trials to improve outcomes in patients with elevated Lp(a) undergoing PCI: The time has arrived","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Lipidology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacl.2023.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 National Lipid Association. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}