{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:48:44Z","timestamp":1775800124971,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de recherche du Quebec Sante","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lipidjournal.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Lipidology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jacl.2024.02.007","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T17:55:28Z","timestamp":1708710928000},"page":"e413-e422","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pancreatitis polygenic risk score is associated with acute pancreatitis in multifactorial chylomicronemia syndrome"],"prefix":"10.1016","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6327-7048","authenticated-orcid":false,"given":"Simon-Pierre","family":"Guay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7555-1275","authenticated-orcid":false,"given":"Martine","family":"Paquette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lie","family":"Taschereau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Desgagn\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5913-1852","authenticated-orcid":false,"given":"Sophie","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Baass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jacl.2024.02.007_bib0001","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nrendo.2015.26","article-title":"Chylomicronaemia\u2013current diagnosis and future therapies","volume":"11","author":"Brahm","year":"2015","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"10.1016\/j.jacl.2024.02.007_bib0002","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1194\/jlr.R009720","article-title":"Genetic determinants of plasma triglycerides","volume":"52","author":"Johansen","year":"2011","journal-title":"J Lipid Res"},{"issue":"6","key":"10.1016\/j.jacl.2024.02.007_bib0003","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1001\/archinternmed.2008.599","article-title":"Hypertriglyceridemia and its pharmacologic treatment among US adults","volume":"169","author":"Ford","year":"2009","journal-title":"Arch Intern Med"},{"issue":"5","key":"10.1016\/j.jacl.2024.02.007_bib0004","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3390\/metabo13050621","article-title":"Severe hypertriglyceridaemia and chylomicronaemia syndrome-causes, clinical presentation, and therapeutic options","volume":"13","author":"Bashir","year":"2023","journal-title":"Metabolites"},{"issue":"1","key":"10.1016\/j.jacl.2024.02.007_bib0005","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12933-022-01525-5","article-title":"Elevated plasma triglyceride concentration and risk of adverse clinical outcomes in 1.5 million people: a CALIBER linked electronic health record study","volume":"21","author":"Patel","year":"2022","journal-title":"Cardiovasc Diabetol"},{"issue":"Suppl.S1","key":"10.1016\/j.jacl.2024.02.007_bib0006","article-title":"Big data and severe hypertriglyceridemia: prevalence in 297 909 individuals","volume":"39","author":"Ferrieres","year":"2018","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.jacl.2024.02.007_bib0007","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12944-017-0511-9","article-title":"Severe hypertriglyceridemia in Norway: prevalence, clinical and genetic characteristics","volume":"16","author":"Retterst\u00f8l","year":"2017","journal-title":"Lipids Health Dis"},{"issue":"4","key":"10.1016\/j.jacl.2024.02.007_bib0008","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/joim.13016","article-title":"Familial chylomicronemia syndrome: an under-recognized cause of severe hypertriglyceridaemia","volume":"287","author":"Baass","year":"2020","journal-title":"J Intern Med"},{"key":"10.1016\/j.jacl.2024.02.007_bib0009","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fendo.2020.00455","article-title":"Genetics of Hypertriglyceridemia","volume":"11","author":"Dron","year":"2020","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"1","key":"10.1016\/j.jacl.2024.02.007_bib0010","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S2213-8587(19)30264-5","article-title":"Rare dyslipidaemias, from phenotype to genotype to management: a European Atherosclerosis Society task force consensus statement","volume":"8","author":"Hegele","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"9","key":"10.1016\/j.jacl.2024.02.007_bib0011","doi-asserted-by":"crossref","first-page":"e3473","DOI":"10.1210\/clinem\/dgab360","article-title":"Rare variants in triglycerides-related genes increase pancreatitis risk in multifactorial chylomicronemia syndrome","volume":"106","author":"Paquette","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.jacl.2024.02.007_bib0012","doi-asserted-by":"crossref","first-page":"817","DOI":"10.4158\/EP-2018-0599","article-title":"External validation of a predictive model for acute pancreatitis risk in patients with severe hypertriglyceridemia","volume":"25","author":"Morkos","year":"2019","journal-title":"Endocr Pract"},{"issue":"4","key":"10.1016\/j.jacl.2024.02.007_bib0013","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.jacl.2016.02.019","article-title":"Severe hypertriglyceridemia and factors associated with acute pancreatitis in an integrated health care system","volume":"10","author":"Rashid","year":"2016","journal-title":"J Clin Lipidol"},{"issue":"11","key":"10.1016\/j.jacl.2024.02.007_bib0014","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1507\/endocrj.EJ20-0123","article-title":"Gene expression profiles of recurrent acute pancreatitis risk in patients with sustained chylomicronemia","volume":"67","author":"Tremblay","year":"2020","journal-title":"Endocr J"},{"issue":"10","key":"10.1016\/j.jacl.2024.02.007_bib0015","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1136\/gutjnl-2017-314454","article-title":"Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis","volume":"67","author":"Rosendahl","year":"2018","journal-title":"Gut."},{"issue":"12","key":"10.1016\/j.jacl.2024.02.007_bib0016","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/ng.2466","article-title":"Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis","volume":"44","author":"Whitcomb","year":"2012","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.jacl.2024.02.007_bib0017","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/MOG.0000000000000461","article-title":"Chronic pancreatitis: an update on genetic risk factors","volume":"34","author":"Weiss","year":"2018","journal-title":"Curr Opin Gastroenterol"},{"issue":"6","key":"10.1016\/j.jacl.2024.02.007_bib0018","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1053\/j.gastro.2023.01.028","article-title":"Proteome-wide mendelian randomization identifies causal links between blood proteins and acute pancreatitis","volume":"164","author":"Bourgault","year":"2023","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.jacl.2024.02.007_bib0019","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/MOL.0000000000000866","article-title":"Genetic determinants of pancreatitis: relevance in severe hypertriglyceridemia","volume":"34","author":"Hang","year":"2023","journal-title":"Curr Opin Lipidol"},{"issue":"12","key":"10.1016\/j.jacl.2024.02.007_bib0020","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1161\/ATVBAHA.122.318445","article-title":"Genetic testing for hypertriglyceridemia in academic lipid clinics: implications for precision medicine-brief report","volume":"42","author":"Deshotels","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"10.1016\/j.jacl.2024.02.007_bib0021","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"ACMG Laboratory Quality Assurance Committee. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"issue":"8","key":"10.1016\/j.jacl.2024.02.007_bib0022","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1210\/js.2019-00129","article-title":"Very severe hypertriglyceridemia in a large US County Health Care System: associated conditions and management","volume":"3","author":"Esparza","year":"2019","journal-title":"J Endocr Soc"},{"issue":"6","key":"10.1016\/j.jacl.2024.02.007_bib0023","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.pan.2019.08.002","article-title":"Subsets associated with developing acute pancreatitis in patients with severe hypertriglyceridemia and the severity of pancreatitis","volume":"19","author":"Jo","year":"2019","journal-title":"Pancreatology"},{"key":"10.1016\/j.jacl.2024.02.007_bib0024","article-title":"Diabetes and younger age are vital and independent risk factors for acute pancreatitis in patients with severe hypertriglyceridemia","volume":"2019","author":"Li","year":"2019","journal-title":"Biomed Res Int"},{"issue":"6","key":"10.1016\/j.jacl.2024.02.007_bib0025","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1056\/NEJMoa1715944","article-title":"Volanesorsen and triglyceride levels in familial chylomicronemia syndrome","volume":"381","author":"Witztum","year":"2019","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.jacl.2024.02.007_bib0026","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S2213-8587(21)00046-2","article-title":"Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial","volume":"9","author":"Gouni-Berthold","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"12","key":"10.1016\/j.jacl.2024.02.007_bib0027","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1161\/ATVBAHA.122.318621","article-title":"Is genetic testing in hypertriglyceridemia useful?","volume":"42","author":"Hegele","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacl.2024.02.007_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.818574","article-title":"Calculating polygenic risk scores (PRS) in UK Biobank: a practical guide for epidemiologists","volume":"13","author":"Collister","year":"2022","journal-title":"Front Genet"}],"container-title":["Journal of Clinical Lipidology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287424000308?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287424000308?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T04:13:48Z","timestamp":1735532028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933287424000308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S1933287424000308"],"URL":"https:\/\/doi.org\/10.1016\/j.jacl.2024.02.007","relation":{},"ISSN":["1933-2874"],"issn-type":[{"value":"1933-2874","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pancreatitis polygenic risk score is associated with acute pancreatitis in multifactorial chylomicronemia syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Lipidology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacl.2024.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 National Lipid Association. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}