{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:21:57Z","timestamp":1789230117918,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lipidjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Lipidology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jacl.2025.09.003","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:43:01Z","timestamp":1756946581000},"page":"1234-1242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early triglyceride-lowering therapy in acute pancreatitis with extremely high triglyceride levels"],"prefix":"10.1016","volume":"19","author":[{"given":"Lanting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-9541","authenticated-orcid":false,"given":"Enrique","family":"de-Madaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longxiang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8093-5073","authenticated-orcid":false,"given":"Lu","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jacl.2025.09.003_bib0001","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.cgh.2019.11.017","article-title":"Worldwide variations in demographics, management, and outcomes of acute pancreatitis","volume":"18","author":"Matta","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.jacl.2025.09.003_bib0002","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s10620-023-08172-0","article-title":"Etiological Changes and Prognosis of Hospitalized Patients with Acute Pancreatitis Over a 15-Year Period","volume":"69","author":"Lai","year":"2024","journal-title":"Dig Dis Sci"},{"issue":"4","key":"10.1016\/j.jacl.2025.09.003_bib0003","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jama.2020.20317","article-title":"Acute pancreatitis: a review","volume":"325","author":"Mederos","year":"2021","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.jacl.2025.09.003_bib0004","doi-asserted-by":"crossref","first-page":"419","DOI":"10.14309\/ajg.0000000000002645","article-title":"American college of gastroenterology guidelines: management of acute pancreatitis","volume":"119","author":"Tenner","year":"2024","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"10.1016\/j.jacl.2025.09.003_bib0005","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.hpb.2019.01.015","article-title":"Hypertriglyceridaemia-associated acute pancreatitis: diagnosis and impact on severity","volume":"21","author":"Zhang","year":"2019","journal-title":"HPB (Oxford)"},{"issue":"10","key":"10.1016\/j.jacl.2025.09.003_bib0006","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1038\/ajg.2015.261","article-title":"Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis","volume":"110","author":"Nawaz","year":"2015","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"10.1016\/j.jacl.2025.09.003_bib0007","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.pan.2020.03.018","article-title":"Hypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases","volume":"20","author":"Mosztbacher","year":"2020","journal-title":"Pancreatology"},{"issue":"1","key":"10.1016\/j.jacl.2025.09.003_bib0008","doi-asserted-by":"crossref","DOI":"10.1172\/JCI184785","article-title":"Prospective observational study and mechanistic evidence showing lipolysis of circulating triglycerides worsens hypertriglyceridemic acute pancreatitis","volume":"135","author":"Rajalingamgari","year":"2024","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.jacl.2025.09.003_bib0009","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1136\/gutjnl-2014-308043","article-title":"Peripancreatic fat necrosis worsens acute pancreatitis independent of pancreatic necrosis via unsaturated fatty acids increased in human pancreatic necrosis collections","volume":"65","author":"Noel","year":"2016","journal-title":"Gut"},{"issue":"6 Pt A","key":"10.1016\/j.jacl.2025.09.003_bib0010","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.clnu.2017.09.028","article-title":"A systematic review of the epidemiology, pathophysiology and current management of hyperlipidaemic pancreatitis","volume":"37","author":"Adiamah","year":"2018","journal-title":"Clin Nutr"},{"issue":"5","key":"10.1016\/j.jacl.2025.09.003_bib0011","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.pan.2020.06.005","article-title":"Hypertriglyceridemia and acute pancreatitis","volume":"20","author":"Yang","year":"2020","journal-title":"Pancreatology"},{"issue":"4","key":"10.1016\/j.jacl.2025.09.003_bib0012","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/ajg.2009.27","article-title":"Hypertriglyceridemic pancreatitis: presentation and management","volume":"104","author":"Tsuang","year":"2009","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.jacl.2025.09.003_bib0013","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1186\/s12916-024-03755-8","article-title":"Triglyceride-lowering therapies in hypertriglyceridemia-associated acute pancreatitis in China: a multicentre prospective cohort study","volume":"22","author":"Zhou","year":"2024","journal-title":"BMC Med"},{"issue":"2","key":"10.1016\/j.jacl.2025.09.003_bib0014","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/jca.22043","article-title":"Guidelines on the use of therapeutic Apheresis in clinical practice\u2014evidence-based approach from the writing committee of the American society for Apheresis: the ninth special issue","volume":"38","author":"Connelly-Smith","year":"2023","journal-title":"J Clin Apher"},{"issue":"1","key":"10.1016\/j.jacl.2025.09.003_bib0015","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/trf.16724","article-title":"Clinical analysis of the therapeutic effect of plasma exchange on hypertriglyceridemic acute pancreatitis: a retrospective study","volume":"62","author":"Lin","year":"2022","journal-title":"Transfusion"},{"issue":"1","key":"10.1016\/j.jacl.2025.09.003_bib0016","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12944-024-02057-5","article-title":"Analysis of the clinical profile and treatment efficiency of hyperlipidemic acute pancreatitis","volume":"23","author":"Zhou","year":"2024","journal-title":"Lipids Health Dis"},{"issue":"12","key":"10.1016\/j.jacl.2025.09.003_bib0017","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/1751-2980.12659","article-title":"Continuous intravenous infusion of insulin and heparin versus plasma exchange in hypertriglyceridemia-induced acute pancreatitis","volume":"19","author":"Jin","year":"2018","journal-title":"J Dig Dis"},{"issue":"6","key":"10.1016\/j.jacl.2025.09.003_bib0018","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00134-017-4722-3","article-title":"Plasmapheresis therapy has no triglyceride-lowering effect in patients with hypertriglyceridemic pancreatitis","volume":"43","author":"Miyamoto","year":"2017","journal-title":"Intensive Care Med"},{"issue":"12","key":"10.1016\/j.jacl.2025.09.003_bib0019","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.eprac.2023.09.002","article-title":"Triglyceride clearance in hypertriglyceridemic pancreatitis: time course and its implications for management","volume":"29","author":"Majumdar","year":"2023","journal-title":"Endocr Pract"},{"issue":"4","key":"10.1016\/j.jacl.2025.09.003_bib0020","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/MPA.0000000000000507","article-title":"Double filtration plasma apheresis shortens hospital admission duration of patients with severe hypertriglyceridemia-associated acute pancreatitis","volume":"45","author":"Chang","year":"2016","journal-title":"Pancreas"},{"issue":"5","key":"10.1016\/j.jacl.2025.09.003_bib0021","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/jca.21922","article-title":"Effect of TPE versus medical management on patient outcomes in the setting of hypertriglyceridemia-induced acute pancreatitis with severely elevated triglycerides","volume":"36","author":"Webb","year":"2021","journal-title":"J Clin Apher"},{"key":"10.1016\/j.jacl.2025.09.003_bib0022","volume":"8","author":"Cao","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jacl.2025.09.003_bib0023","unstructured":"Gelrud A., Whitcomb DC UpToDate. Hypertriglyceridemia-induced acute pancreatitis. 2021. Available online at: https:\/\/www.uptodate.com\/contents\/hypertriglyceridemia-induced-acute-pancreatitis. (Accessed 30 June 2021)."},{"issue":"1","key":"10.1016\/j.jacl.2025.09.003_bib0024","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis\u20132012: revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"Banks","year":"2013","journal-title":"Gut"},{"issue":"4)(suppl 2","key":"10.1016\/j.jacl.2025.09.003_bib0025","first-page":"e1","article-title":"IAP\/APA evidence-based guidelines for the management of acute pancreatitis","volume":"13","year":"2013","journal-title":"Pancreatology"},{"key":"10.1016\/j.jacl.2025.09.003_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102774","article-title":"Prevalence of exocrine pancreatic insufficiency at 12 months after acute pancreatitis: a prospective, multicentre, longitudinal cohort study","volume":"75","author":"Phillips","year":"2024","journal-title":"EClinicalMedicine"},{"issue":"3","key":"10.1016\/j.jacl.2025.09.003_bib0027","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13916","article-title":"Mechanisms linking hypertriglyceridemia to acute pancreatitis","volume":"237","author":"Kiss","year":"2023","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.jacl.2025.09.003_bib0028","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13017-019-0247-0","article-title":"2019 WSES guidelines for the management of severe acute pancreatitis","volume":"14","author":"Lepp\u00e4niemi","year":"2019","journal-title":"World J Emerg Surg"},{"issue":"3","key":"10.1016\/j.jacl.2025.09.003_bib0029","article-title":"Guidelines for the management of patients with severe acute pancreatitis, 2021","volume":"41","author":"Jaber","year":"2022","journal-title":"Anaesth Crit Care Pain Med"},{"issue":"5","key":"10.1016\/j.jacl.2025.09.003_bib0030","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/jca.21811","article-title":"The role of double filtration plasmapheresis in hypertriglyceridemic pancreatitis: a propensity score matching analysis","volume":"35","author":"Lu","year":"2020","journal-title":"J Clin Apher"},{"key":"10.1016\/j.jacl.2025.09.003_bib0031","article-title":"Comparative efficacy of therapeutic plasma exchange and insulin in hypertriglyceridemia-induced acute pancreatitis","author":"Thanh","year":"2024","journal-title":"Indian J Gastroenterol"},{"issue":"1","key":"10.1016\/j.jacl.2025.09.003_bib0032","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13613-024-01285-3","article-title":"Impact of therapeutic plasmapheresis on the duration of organ failure in patients with hypertriglyceridemia-associated acute pancreatitis","volume":"14","author":"Wang","year":"2024","journal-title":"Ann Intensive Care"},{"issue":"6","key":"10.1016\/j.jacl.2025.09.003_bib0033","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.20802","article-title":"Early plasmapheresis among patients with hypertriglyceridemia-associated acute pancreatitis","volume":"6","author":"Cao","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"1","key":"10.1016\/j.jacl.2025.09.003_bib0034","article-title":"Initiation time of double-filtration plasma apheresis affects the risk of persistent organ failure in hypertriglyceridaemia-induced acute pancreatitis: a retrospective study","volume":"13","author":"Su","year":"2023","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jacl.2025.09.003_bib0035","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1744-9987.2009.00731.x","article-title":"Treatment of hyperlipidemic acute pancreatitis with plasma exchange: a single-center experience","volume":"13","author":"Gubensek","year":"2009","journal-title":"Ther Apher Dial"},{"issue":"9","key":"10.1016\/j.jacl.2025.09.003_bib0036","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1177\/08850666211054365","article-title":"Hypertriglyceridemia induced pancreatitis: plasmapheresis or conservative management?","volume":"37","author":"Dichtwald","year":"2022","journal-title":"J Intensive Care Med"},{"issue":"10","key":"10.1016\/j.jacl.2025.09.003_bib0037","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1007\/s00134-022-06793-z","article-title":"Plasma exchange in the intensive care unit: a narrative review","volume":"48","author":"Bauer","year":"2022","journal-title":"Intensive Care Med"},{"issue":"6","key":"10.1016\/j.jacl.2025.09.003_bib0038","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S2213-8587(25)00028-2","article-title":"Futility of plasmapheresis, insulin in normoglycaemic individuals, or heparin in the treatment of hypertriglyceridaemia-induced acute pancreatitis","volume":"13","author":"Syed-Abdul","year":"2025","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"2","key":"10.1016\/j.jacl.2025.09.003_bib0039","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.pan.2025.01.008","volume":"25","author":"Zhou","year":"2025","journal-title":"Pancreatology"},{"issue":"1","key":"10.1016\/j.jacl.2025.09.003_bib0040","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/MPA.0000000000001463","article-title":"Timely reduction of triglyceride levels is associated with decreased persistent organ failure in hypertriglyceridemic pancreatitis","volume":"49","author":"Lu","year":"2020","journal-title":"Pancreas"}],"container-title":["Journal of Clinical Lipidology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287425003885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287425003885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:17:49Z","timestamp":1778833069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933287425003885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1933287425003885"],"URL":"https:\/\/doi.org\/10.1016\/j.jacl.2025.09.003","relation":{},"ISSN":["1933-2874"],"issn-type":[{"value":"1933-2874","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early triglyceride-lowering therapy in acute pancreatitis with extremely high triglyceride levels","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Lipidology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacl.2025.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 National Lipid Association. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}