{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:48:39Z","timestamp":1792586919721,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lipidjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Lipidology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jacl.2026.01.006","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:23:51Z","timestamp":1768868631000},"page":"541-552","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of cumulative low-density lipoprotein cholesterol on prognosis in coronary heart disease patients: A retrospective study based on time-weighted cumulative exposure"],"prefix":"10.1016","volume":"20","author":[{"given":"Xiuying","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yike","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianglin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5878-1127","authenticated-orcid":false,"given":"Mengjiao","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"25","key":"10.1016\/j.jacl.2026.01.006_bib1","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: update from the GBD 2019 Study","volume":"76","author":"Roth","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"2877","key":"10.1016\/j.jacl.2026.01.006_bib2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1126\/science.111.2877.166","article-title":"The role of lipids and lipoproteins in atherosclerosis","volume":"111","author":"Gofman","year":"1950","journal-title":"Science"},{"key":"10.1016\/j.jacl.2026.01.006_bib3","series-title":"Endotext","article-title":"Introduction to lipids and lipoproteins","author":"Feingold","year":"2000"},{"issue":"32","key":"10.1016\/j.jacl.2026.01.006_bib4","first-page":"2459","article-title":"Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel","volume":"38","author":"Ference","year":"2017","journal-title":"Eur\u00a0Heart J"},{"issue":"11","key":"10.1016\/j.jacl.2026.01.006_bib5","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S0022-2275(20)38428-5","article-title":"Large lipoproteins are excluded from the arterial wall in diabetic cholesterol-fed rabbits","volume":"29","author":"Nordestgaard","year":"1988","journal-title":"J Lipid Res"},{"issue":"16","key":"10.1016\/j.jacl.2026.01.006_bib6","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.106.676890","article-title":"Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications","volume":"116","author":"Tabas","year":"2007","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jacl.2026.01.006_bib7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2015.01.036","article-title":"A century of cholesterol and coronaries: from plaques to genes to statins","volume":"161","author":"Goldstein","year":"2015","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jacl.2026.01.006_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrcardio.2010.223","article-title":"Lipid parameters for measuring risk of cardiovascular disease","volume":"8","author":"Arsenault","year":"2011","journal-title":"Nat Rev Cardiol"},{"issue":"12","key":"10.1016\/j.jacl.2026.01.006_bib9","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1001\/jama.2016.13985","article-title":"Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: a systematic review and meta-analysis","volume":"316","author":"Silverman","year":"2016","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.jacl.2026.01.006_bib10","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.jacc.2018.06.046","article-title":"Impact of lipids on cardiovascular health: JACC Health Promotion Series","volume":"72","author":"Ference","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.jacl.2026.01.006_bib11","first-page":"249","article-title":"How to live to 100 before developing clinical coronary artery disease: a suggestion","volume":"43","author":"Braunwald","year":"2022","journal-title":"Eur\u00a0Heart J"},{"issue":"12","key":"10.1016\/j.jacl.2026.01.006_bib12","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1001\/jamacardio.2021.3508","article-title":"Association between cumulative low-density lipoprotein cholesterol exposure during young adulthood and middle age and risk of cardiovascular events","volume":"6","author":"Zhang","year":"2021","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacl.2026.01.006_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.735679","article-title":"Baseline and cumulative blood pressure in predicting the occurrence of cardiovascular events","volume":"8","author":"Zuo","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"1","key":"10.1016\/j.jacl.2026.01.006_bib14","article-title":"Association between cumulative atherogenic index of plasma exposure and risk of myocardial infarction in the general population","volume":"22","author":"Zhang","year":"2023","journal-title":"Cardiovasc\u00a0Diabetol"},{"issue":"1","key":"10.1016\/j.jacl.2026.01.006_bib15","article-title":"Relationship between the cumulative exposure to atherogenic index of plasma and ischemic stroke: a retrospective cohort study","volume":"22","author":"Zheng","year":"2023","journal-title":"Cardiovasc\u00a0Diabetol"},{"key":"10.1016\/j.jacl.2026.01.006_bib16","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.atherosclerosis.2021.03.009","article-title":"Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors","volume":"324","author":"Won","year":"2021","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.jacl.2026.01.006_bib17","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCGENETICS.111.962456","article-title":"Discriminative ability of LDL-cholesterol to identify patients with familial hypercholesterolemia: a cross-sectional study in 26,406 individuals tested for genetic FH","volume":"5","author":"Huijgen","year":"2012","journal-title":"Circ Cardiovasc Genet"},{"issue":"6","key":"10.1016\/j.jacl.2026.01.006_bib18","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1515\/CCLM.2008.135","article-title":"Development of sensitive and specific age- and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial hypercholesterolaemia in cascade testing","volume":"46","author":"Starr","year":"2008","journal-title":"Clin Chem Lab Med"},{"issue":"12","key":"10.1016\/j.jacl.2026.01.006_bib19","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1056\/NEJMoa054013","article-title":"Sequence variations in PCSK9, low LDL, and protection against coronary heart disease","volume":"354","author":"Cohen","year":"2006","journal-title":"N Engl J Med"},{"issue":"16","key":"10.1016\/j.jacl.2026.01.006_bib20","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1161\/CIRCULATIONAHA.122.063399","article-title":"Association between achieved low-density lipoprotein cholesterol levels and long-term cardiovascular and safety outcomes: an analysis of FOURIER-OLE","volume":"147","author":"Gaba","year":"2023","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.jacl.2026.01.006_bib21","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s11883-013-0312-1","article-title":"The role of early LDL lowering to prevent the onset of atherosclerotic disease","volume":"15","author":"Ference","year":"2013","journal-title":"Curr Atheroscler Rep"},{"issue":"20","key":"10.1016\/j.jacl.2026.01.006_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009778","article-title":"Eradicating the burden of atherosclerotic cardiovascular disease by lowering apolipoprotein B lipoproteins earlier in life","volume":"7","author":"Robinson","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacl.2026.01.006_bib23","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g3047","article-title":"Taking a longer term view of cardiovascular risk: the causal exposure paradigm","volume":"348","author":"Sniderman","year":"2014","journal-title":"BMJ"},{"issue":"10263","key":"10.1016\/j.jacl.2026.01.006_bib24","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(20)32233-9","article-title":"Elevated LDL cholesterol and increased risk of myocardial infarction and atherosclerotic cardiovascular disease in individuals aged 70-100 years: a contemporary primary prevention cohort","volume":"396","author":"Mortensen","year":"2020","journal-title":"Lancet"},{"issue":"10263","key":"10.1016\/j.jacl.2026.01.006_bib25","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S0140-6736(20)32332-1","article-title":"Efficacy and safety of lowering LDL cholesterol in older patients: a systematic review and meta-analysis of randomised controlled trials","volume":"396","author":"Gencer","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jacl.2026.01.006_bib26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/eurjpc\/zwaa052","article-title":"Effects of individual and integrated cumulative burden of blood pressure, glucose, low-density lipoprotein cholesterol, and C-reactive protein on cardiovascular risk","volume":"29","author":"Chen","year":"2022","journal-title":"Eur J Prev Cardiol"},{"issue":"1","key":"10.1016\/j.jacl.2026.01.006_bib27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12933-023-01967-5","article-title":"Relationship between cumulative exposure to triglyceride-glucose index and heart failure: a prospective cohort study","volume":"22","author":"Zheng","year":"2023","journal-title":"Cardiovasc Diabetol"},{"issue":"10","key":"10.1016\/j.jacl.2026.01.006_bib28","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1001\/jamacardio.2019.2604","article-title":"2019 ACC\/AHA guideline on the primary prevention of cardiovascular disease: part 1, lifestyle and behavioral factors","volume":"4","author":"Arnett","year":"2019","journal-title":"JAMA Cardiol"},{"issue":"24","key":"10.1016\/j.jacl.2026.01.006_bib29","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/eurheartj\/ehz962","article-title":"Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel","volume":"41","author":"Bor\u00e9n","year":"2020","journal-title":"Eur Heart J"},{"issue":"14","key":"10.1016\/j.jacl.2026.01.006_bib30","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1001\/archinte.167.14.1503","article-title":"Health literacy and mortality among elderly persons","volume":"167","author":"Baker","year":"2007","journal-title":"Arch Intern Med"},{"issue":"9967","key":"10.1016\/j.jacl.2026.01.006_bib31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0140-6736(14)61462-8","article-title":"Health, functioning, and disability in older adults--present status and future implications","volume":"385","author":"Chatterji","year":"2015","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jacl.2026.01.006_bib32","first-page":"574","article-title":"Proportion and risk indicators of nonadherence to statin therapy: a meta-analysis","volume":"28","author":"Lemstra","year":"2012","journal-title":"Can J Cardiol"},{"issue":"8","key":"10.1016\/j.jacl.2026.01.006_bib33","doi-asserted-by":"crossref","first-page":"533","DOI":"10.7326\/M14-1430","article-title":"Cost-effectiveness and population impact of statins for primary prevention in adults aged 75 years or older in the United States","volume":"162","author":"Odden","year":"2015","journal-title":"Ann Intern Med"}],"container-title":["Journal of Clinical Lipidology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287426000085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287426000085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:31:04Z","timestamp":1775215864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933287426000085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1933287426000085"],"URL":"https:\/\/doi.org\/10.1016\/j.jacl.2026.01.006","relation":{},"ISSN":["1933-2874"],"issn-type":[{"value":"1933-2874","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of cumulative low-density lipoprotein cholesterol on prognosis in coronary heart disease patients: A retrospective study based on time-weighted cumulative exposure","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Lipidology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacl.2026.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 National Lipid Association. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}