{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:05:41Z","timestamp":1790366741530,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lipidjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Lipidology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jacl.2026.07.015","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:04:12Z","timestamp":1784045052000},"page":"2008-2019","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Apolipoprotein B-low-density lipoprotein cholesterol discordance refines cardiovascular risk stratification across metabolic phenotypes"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7011-1537","authenticated-orcid":false,"given":"Jee Ah","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Seung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9328-9389","authenticated-orcid":false,"given":"Eun Hye","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1154-3137","authenticated-orcid":false,"given":"Hee-Yeon","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5400-4205","authenticated-orcid":false,"given":"Hyosoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2372-0700","authenticated-orcid":false,"given":"Min-Jung","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacl.2026.07.015_bib1","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1161\/CIRCULATIONAHA.106.171016","volume":"113","author":"Poirier","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacl.2026.07.015_bib2","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1172\/JCI129186","article-title":"Metabolically healthy obesity: facts and fantasies","volume":"129","author":"Smith","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacl.2026.07.015_bib3","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.numecd.2013.07.005","article-title":"Metabolically healthy obese subjects are at risk of fatty liver but not of pre-clinical atherosclerosis","volume":"24","author":"Sung","year":"2014","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.jacl.2026.07.015_bib4","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.2337\/dc20-1760","article-title":"Association of metabolic phenotypes with coronary artery disease and cardiovascular events in patients with stable chest pain","volume":"44","author":"Kammerlander","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jacl.2026.07.015_bib5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.orcp.2024.01.006","article-title":"Relationship between metabolically healthy obesity and coronary artery calcification","volume":"18","author":"Seo","year":"2024","journal-title":"Obes Res Clin Pract"},{"key":"10.1016\/j.jacl.2026.07.015_bib6","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1016\/j.jacc.2014.03.042","article-title":"Metabolically-healthy obesity and coronary artery calcification","volume":"63","author":"Chang","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacl.2026.07.015_bib7","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/ATVBAHA.122.317526","article-title":"Different metabolic phenotypes of obesity and risk of coronary artery calcium progression and incident cardiovascular disease events: the CARDIA study","volume":"42","author":"Gao","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacl.2026.07.015_bib8","first-page":"2613","article-title":"Association of metabolically healthy obesity with subclinical coronary atherosclerosis in a Korean population","volume":"22","author":"Jung","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jacl.2026.07.015_bib9","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.numecd.2018.11.002","article-title":"Associations of metabolically healthy obesity with prevalence and progression of coronary artery calcification: results from the Heinz Nixdorf recall cohort study","volume":"29","author":"Kowall","year":"2019","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.jacl.2026.07.015_bib10","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8815","article-title":"Association of metabolically healthy obesity and elevated risk of coronary artery calcification: a systematic review and meta-analysis","volume":"8","author":"Hsueh","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.jacl.2026.07.015_bib11","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1089\/met.2020.0016","article-title":"Impact of the definition of metabolically healthy obesity on the association with incident cardiovascular disease","volume":"18","author":"Lind","year":"2020","journal-title":"Metab Syndr Relat Disord"},{"key":"10.1016\/j.jacl.2026.07.015_bib12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1161\/CIRCULATIONAHA.124.068885","article-title":"Apolipoprotein B: bridging the gap between evidence and clinical practice","volume":"150","author":"De Oliveira-Gomes","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jacl.2026.07.015_bib13","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1111\/dom.16335","article-title":"Discordance between serum cholesterol concentration and atherogenic lipoprotein particle number in people with metabolic disease: a systematic review","volume":"27","author":"Witt","year":"2025","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.jacl.2026.07.015_bib14","doi-asserted-by":"crossref","first-page":"e647","DOI":"10.1016\/j.jacl.2024.08.013","article-title":"Role of apolipoprotein B in the clinical management of cardiovascular risk in adults: An Expert Clinical Consensus from the National Lipid Association","volume":"18","author":"Soffer","year":"2024","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.jacl.2026.07.015_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/eurjpc\/zwaf750","article-title":"Impact of LDL-C and apolipoprotein B level discordance and associated lipoprotein particle alterations on cardiovascular outcomes in a large primary prevention population","author":"Du","year":"2025","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jacl.2026.07.015_bib16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCOUTCOMES.110.959247","article-title":"A meta-analysis of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B as markers of cardiovascular risk","volume":"4","author":"Sniderman","year":"2011","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jacl.2026.07.015_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106873","article-title":"Apolipoprotein B compared with low-density lipoprotein cholesterol in the atherosclerotic cardiovascular diseases risk assessment","volume":"195","author":"Galimberti","year":"2023","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jacl.2026.07.015_bib18","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.jacc.2021.01.027","article-title":"Apolipoprotein B and non-HDL cholesterol better reflect residual risk than LDL cholesterol in statin-treated patients","volume":"77","author":"Johannesen","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacl.2026.07.015_bib19","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1253\/circj.CJ-20-0692","article-title":"Discordance between apolipoprotein B and low-density lipoprotein cholesterol and progression of coronary artery calcification in middle age","volume":"85","author":"Kim","year":"2021","journal-title":"Circ J"},{"key":"10.1016\/j.jacl.2026.07.015_bib20","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1056\/NEJMoa072100","article-title":"Coronary calcium as a predictor of coronary events in four racial or ethnic groups","volume":"358","author":"Detrano","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacl.2026.07.015_bib21","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1093\/eurheartj\/ehy217","article-title":"Ten-year association of coronary artery calcium with atherosclerotic cardiovascular disease (ASCVD) events: the multi-ethnic study of atherosclerosis (MESA)","volume":"39","author":"Budoff","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacl.2026.07.015_bib22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1001\/jamacardio.2024.1310","article-title":"Individual variation in the distribution of apolipoprotein B levels across the spectrum of LDL-C or Non-HDL-C levels","volume":"9","author":"Sayed","year":"2024","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacl.2026.07.015_bib23","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1093\/eurheartj\/ehae258","article-title":"Discordance among apoB, non-high-density lipoprotein cholesterol, and triglycerides: implications for cardiovascular prevention","volume":"45","author":"Sniderman","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacl.2026.07.015_bib24","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacl.2026.07.015_bib25","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1016\/j.jacc.2018.11.002","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of blood cholesterol: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines","volume":"73","author":"Grundy","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacl.2026.07.015_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jacl.2025.10.054","article-title":"Associations of metabolic health and obesity with apolipoprotein B and low-density lipoprotein cholesterol discordance in a large Korean cohort","volume":"20","author":"Kim","year":"2026","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.jacl.2026.07.015_bib27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4093\/dmj.2018.42.1.19","article-title":"Being metabolically healthy, the most responsible factor for vascular health","volume":"42","author":"Rhee","year":"2018","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.jacl.2026.07.015_bib28","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jacl.2023.05.093","article-title":"Is hypertriglyceridemia a reliable indicator of cholesterol-depleted Apo B particles?","volume":"17","author":"De Marco","year":"2023","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.jacl.2026.07.015_bib29","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1093\/eurjpc\/zwac223","article-title":"Discordance of apolipoprotein B with low-density lipoprotein cholesterol or non-high-density lipoprotein cholesterol and coronary atherosclerosis","volume":"29","author":"Su","year":"2022","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jacl.2026.07.015_bib30","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1177\/2047487315623884","article-title":"Metabolically healthy obesity and cardiovascular events: a systematic review and meta-analysis","volume":"23","author":"Eckel","year":"2016","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jacl.2026.07.015_bib31","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/eurheartj\/ehx448","article-title":"Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis","volume":"39","author":"Lassale","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacl.2026.07.015_bib32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jacl.2014.11.005","article-title":"Discordance between apolipoprotein B and low-density lipoprotein particle number is associated with insulin resistance in clinical practice","volume":"9","author":"Varvel","year":"2015","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.jacl.2026.07.015_bib33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0009-9120(03)00078-X","article-title":"Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity","volume":"36","author":"Rashid","year":"2003","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jacl.2026.07.015_bib34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11892-018-1101-6","article-title":"Pathogenesis of lipid disorders in insulin resistance: a brief review","volume":"18","author":"Bjornstad","year":"2018","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.jacl.2026.07.015_bib35","doi-asserted-by":"crossref","first-page":"28j","DOI":"10.1016\/S0002-9149(99)00355-0","article-title":"Insulin resistance and lipid metabolism","volume":"84","author":"Howard","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacl.2026.07.015_bib36","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.kint.2016.09.011","article-title":"Normal body mass index with central obesity has increased risk of coronary artery calcification in Korean patients with chronic kidney disease","volume":"90","author":"Lee","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.jacl.2026.07.015_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003351","article-title":"Metabolically healthy obesity, transition to unhealthy metabolic status, and vascular disease in Chinese adults: a cohort study","volume":"17","author":"Gao","year":"2020","journal-title":"PLoS Med"},{"key":"10.1016\/j.jacl.2026.07.015_bib38","doi-asserted-by":"crossref","first-page":"e1154","DOI":"10.1161\/CIR.0000000000001457","article-title":"2026 ACC\/AHA\/AACVPR\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of dyslipidemia: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines","volume":"153","author":"Blumenthal","year":"2026","journal-title":"Circulation"},{"key":"10.1016\/j.jacl.2026.07.015_bib39","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk","volume":"41","author":"Mach","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacl.2026.07.015_bib40","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1001\/jama.2026.2986","article-title":"Cost-effectiveness of ApoB, Non-HDL-C, and LDL-C goals for primary prevention lipid-lowering therapy","volume":"335","author":"Luebbe","year":"2026","journal-title":"JAMA"}],"container-title":["Journal of Clinical Lipidology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287426004459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287426004459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:56:24Z","timestamp":1790366184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933287426004459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1933287426004459"],"URL":"https:\/\/doi.org\/10.1016\/j.jacl.2026.07.015","relation":{},"ISSN":["1933-2874"],"issn-type":[{"value":"1933-2874","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apolipoprotein B-low-density lipoprotein cholesterol discordance refines cardiovascular risk stratification across metabolic phenotypes","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Lipidology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacl.2026.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 National Lipid Association. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}