{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T12:38:53Z","timestamp":1793709533737,"version":"4.6.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lipidjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Lipidology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jacl.2026.07.018","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:32:14Z","timestamp":1784071934000},"page":"1799-1815","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of remnant cholesterol with prognosis in atherosclerotic cardiovascular disease: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"20","author":[{"given":"Yanyu","family":"Pei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.jacl.2026.07.018_bib1","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.jacc.2025.08.015","article-title":"Global, regional, and national burden of cardiovascular diseases and risk factors in 204 countries and territories, 1990-2023","volume":"86","year":"2025","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.jacl.2026.07.018_bib2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.hlc.2025.07.012","article-title":"Attainment of low-density lipoprotein cholesterol goals and statin use in patients with atherosclerotic cardiovascular disease in Australian general practice: are we doing enough?","volume":"35","author":"Audehm","year":"2026","journal-title":"Heart Lung Circ"},{"issue":"3","key":"10.1016\/j.jacl.2026.07.018_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.12997\/jla.2025.14.3.247","article-title":"Triglycerides, triglyceride-rich lipoproteins, and remnant cholesterol in atherosclerotic cardiovascular disease","volume":"14","author":"Jo","year":"2025","journal-title":"J Lipid Atheroscler"},{"issue":"2","key":"10.1016\/j.jacl.2026.07.018_bib4","doi-asserted-by":"crossref","DOI":"10.31083\/RCM25985","article-title":"Remnant cholesterol and residual risk of atherosclerotic cardiovascular disease","volume":"26","author":"Li","year":"2025","journal-title":"Rev Cardiovasc Med"},{"issue":"5","key":"10.1016\/j.jacl.2026.07.018_bib5","first-page":"766","article-title":"Association between remnant cholesterol and atherosclerosis plaques in single and multiple vascular territories","volume":"50","author":"Liu","year":"2025","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.jacl.2026.07.018_bib6","article-title":"Remnant cholesterol and atherosclerotic cardiovascular disease: metabolism, mechanism, evidence, and treatment","volume":"9","author":"Wang","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"13","key":"10.1016\/j.jacl.2026.07.018_bib7","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/eurjpc\/zwaf203","article-title":"Remnant cholesterol reduction for atherosclerotic cardiovascular disease prevention: modelling in the Copenhagen General Population Study","volume":"32","author":"Hvid","year":"2025","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jacl.2026.07.018_bib8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.hjc.2023.04.007","article-title":"Remnant cholesterol in atherosclerotic cardiovascular disease: a systematic review and meta-analysis","volume":"74","author":"Delialis","year":"2023","journal-title":"Hellenic J Cardiol"},{"key":"10.1016\/j.jacl.2026.07.018_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.951523","article-title":"Prognostic value of remnant cholesterol in patients with coronary heart disease: a systematic review and meta-analysis of cohort studies","volume":"9","author":"Tian","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jacl.2026.07.018_bib10","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jacl.2026.07.018_bib11","unstructured":"G. Wells B. Shea D. O\u2019Connell The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses Ottawa (ON): Ottawa Hospital Research Institute 2009. http:\/\/www.ohri.ca\/ programs\/clinical_ epidemiology\/oxford.htm."},{"issue":"3","key":"10.1016\/j.jacl.2026.07.018_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"issue":"6","key":"10.1016\/j.jacl.2026.07.018_bib13","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1177\/0272989X05282643","article-title":"The interpretation of random-effects meta-analysis in decision models","volume":"25","author":"Ades","year":"2005","journal-title":"Med Decis Making"},{"key":"10.1016\/j.jacl.2026.07.018_bib14","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","article-title":"Analyzing data and undertaking meta-analyses","author":"Deeks","year":"2008"},{"issue":"7414","key":"10.1016\/j.jacl.2026.07.018_bib15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.jacl.2026.07.018_bib16","first-page":"15","article-title":"Assessing the influence of a single study in meta-analysis","volume":"47","author":"Tobias","year":"1999","journal-title":"Stata Tech Bull"},{"issue":"7382","key":"10.1016\/j.jacl.2026.07.018_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/bmj.326.7382.219","article-title":"Interaction revisited: the difference between two estimates","volume":"326","author":"Altman","year":"2003","journal-title":"BMJ"},{"issue":"7109","key":"10.1016\/j.jacl.2026.07.018_bib18","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.jacl.2026.07.018_bib19","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"issue":"2","key":"10.1016\/j.jacl.2026.07.018_bib20","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis","volume":"56","author":"Duval","year":"2000","journal-title":"Biometrics"},{"issue":"1","key":"10.1016\/j.jacl.2026.07.018_bib21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.atherosclerosis.2011.04.040","article-title":"Predictive value of remnant lipoprotein for cardiovascular events in patients with coronary artery disease after achievement of LDL-cholesterol goals","volume":"218","author":"Nakamura","year":"2011","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.jacl.2026.07.018_bib22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1373\/clinchem.2015.253757","article-title":"Increased remnant cholesterol explains part of residual risk of all-cause mortality in 5414 patients with ischemic heart disease","volume":"62","author":"Jepsen","year":"2016","journal-title":"Clin Chem"},{"issue":"6","key":"10.1016\/j.jacl.2026.07.018_bib23","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1253\/circj.CJ-19-0047","article-title":"Remnant lipoproteins are residual risk factor for future cardiovascular events in patients with stable coronary artery disease and on-statin low-density lipoprotein cholesterol levels <70 mg\/dL","volume":"83","author":"Fujihara","year":"2019","journal-title":"Circ J"},{"issue":"1","key":"10.1016\/j.jacl.2026.07.018_bib24","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12933-020-01076-7","article-title":"The longitudinal association of remnant cholesterol with cardiovascular outcomes in patients with diabetes and pre-diabetes","volume":"19","author":"Cao","year":"2020","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"10.1016\/j.jacl.2026.07.018_bib25","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/joim.13059","article-title":"Contribution of remnant cholesterol to cardiovascular risk","volume":"288","author":"Langsted","year":"2020","journal-title":"J Intern Med"},{"issue":"1","key":"10.1016\/j.jacl.2026.07.018_bib26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12944-020-01355-y","article-title":"Prognostic impact of estimated remnant-like particle cholesterol in patients with differing glycometabolic status: an observational cohort study from China","volume":"19","author":"Zhao","year":"2020","journal-title":"Lipids Health Dis"},{"issue":"1","key":"10.1016\/j.jacl.2026.07.018_bib27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s12967-022-03448-x","article-title":"Synergistic effect of the commonest residual risk factors, remnant cholesterol, lipoprotein(a), and inflammation, on prognosis of statin-treated patients with chronic coronary syndrome","volume":"20","author":"Liu","year":"2022","journal-title":"J Transl Med"},{"issue":"12","key":"10.1016\/j.jacl.2026.07.018_bib28","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.5551\/jat.63397","article-title":"Elevated remnant cholesterol is associated with adverse cardiovascular outcomes in patients with acute coronary syndrome","volume":"29","author":"Shao","year":"2022","journal-title":"J Atheroscler Thromb"},{"issue":"10","key":"10.1016\/j.jacl.2026.07.018_bib29","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.024366","article-title":"Remnant cholesterol predicts risk of cardiovascular events in patients with myocardial infarction with nonobstructive coronary arteries","volume":"11","author":"Gao","year":"2022","journal-title":"J Am Heart Assoc"},{"issue":"9","key":"10.1016\/j.jacl.2026.07.018_bib30","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.2337\/dc21-2511","article-title":"Remnant cholesterol and its visit-to-visit variability predict cardiovascular outcomes in patients with type 2 diabetes: findings from the ACCORD cohort","volume":"45","author":"Fu","year":"2022","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.jacl.2026.07.018_bib31","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/eurjpc\/zwac286","article-title":"Remnant cholesterol in patients admitted for acute coronary syndromes","volume":"30","author":"Cordero","year":"2023","journal-title":"Eur J Prev Cardiol"},{"issue":"17","key":"10.1016\/j.jacl.2026.07.018_bib32","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1093\/eurjpc\/zwad297","article-title":"Cumulative remnant cholesterol predicts cardiovascular outcomes in elderly patients with atherosclerotic cardiovascular disease","volume":"30","author":"Xiao","year":"2023","journal-title":"Eur J Prev Cardiol"},{"issue":"10","key":"10.1016\/j.jacl.2026.07.018_bib33","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/eurjpc\/zwae102","article-title":"The role of remnant cholesterol in patients with ST-segment elevation myocardial infarction","volume":"31","author":"Zhou","year":"2024","journal-title":"Eur J Prev Cardiol"},{"issue":"1","key":"10.1016\/j.jacl.2026.07.018_bib34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12944-024-02156-3","article-title":"The residual risk of inflammation and remnant cholesterol in acute coronary syndrome patients on statin treatment undergoing percutaneous coronary intervention","volume":"23","author":"Liao","year":"2024","journal-title":"Lipids Health Dis"},{"issue":"1","key":"10.1016\/j.jacl.2026.07.018_bib35","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12944-024-02258-y","article-title":"The prognostic role of remnant cholesterol in Asian menopausal women received percutaneous coronary intervention with acute coronary syndrome","volume":"23","author":"Feng","year":"2024","journal-title":"Lipids Health Dis"},{"issue":"6","key":"10.1016\/j.jacl.2026.07.018_bib36","doi-asserted-by":"crossref","first-page":"e905","DOI":"10.1016\/j.jacl.2024.07.005","article-title":"Remnant cholesterol as a residual risk in atherosclerotic cardiovascular disease patients under statin-based lipid-lowering therapy: a post hoc analysis of the RACING trial","volume":"18","author":"Lee","year":"2024","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.jacl.2026.07.018_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.atherosclerosis.2024.119048","article-title":"Remnant cholesterol and long-term incidence of death in coronary artery disease patients","volume":"401","author":"Drexel","year":"2025","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.jacl.2026.07.018_bib38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12933-024-02537-z","article-title":"Impact of remnant cholesterol on short-term and long-term prognosis in patients with prediabetes or diabetes undergoing coronary artery bypass grafting: a large-scale cohort study","volume":"24","author":"Li","year":"2025","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jacl.2026.07.018_bib39","article-title":"Impact of remnant cholesterol on cardiovascular outcomes in non-myocardial infarction patients undergoing percutaneous coronary intervention","volume":"22","author":"Pitaro","year":"2025","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jacl.2026.07.018_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2025.112979","article-title":"The impact of remnant lipoprotein cholesterol on the prognosis of patients undergoing PCI under different glycemic states: a prospective cohort study","volume":"230","author":"Ye","year":"2025","journal-title":"Diabetes Res Clin Pract"},{"issue":"10","key":"10.1016\/j.jacl.2026.07.018_bib41","first-page":"631","article-title":"The prognostic impact of remnant cholesterol on myocardial infarction and coronary revascularization following acute ischemic stroke","volume":"27","author":"Aker","year":"2025","journal-title":"Isr Med Assoc J"},{"issue":"10","key":"10.1016\/j.jacl.2026.07.018_bib42","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1177\/2047487319887578","article-title":"Remnant cholesterol, coronary atheroma progression and clinical events in statin-treated patients with coronary artery disease","volume":"27","author":"Elshazly","year":"2020","journal-title":"Eur J Prev Cardiol"},{"issue":"7","key":"10.1016\/j.jacl.2026.07.018_bib43","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3390\/metabo12070623","article-title":"Mathematical modelling of material transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis by lipoprotein lipase: relevance to cardioprotective role of HDL","volume":"12","author":"Schekatolina","year":"2022","journal-title":"Metabolites"},{"issue":"7","key":"10.1016\/j.jacl.2026.07.018_bib44","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3390\/jcdd12070256","article-title":"The role of non-HDL cholesterol and apolipoprotein B in cardiovascular disease: a comprehensive review","volume":"12","author":"Katsi","year":"2025","journal-title":"J Cardiovasc Dev Dis"},{"issue":"8","key":"10.1016\/j.jacl.2026.07.018_bib45","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1177\/2047487320914115","article-title":"Achievement of European guideline-recommended lipid levels post-percutaneous coronary intervention: a population-level observational cohort study","volume":"28","author":"Harris","year":"2021","journal-title":"Eur J Prev Cardiol"},{"issue":"7","key":"10.1016\/j.jacl.2026.07.018_bib46","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/00325481.2025.2548199","article-title":"Statins and kidney health: exploring cardiovascular benefits, renal protection, and risks in chronic kidney disease","volume":"137","author":"Chikatimalla","year":"2025","journal-title":"Postgrad Med"},{"issue":"7","key":"10.1016\/j.jacl.2026.07.018_bib47","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3390\/metabo14070388","article-title":"The pleiotropic effects of lipid-modifying interventions: exploring traditional and emerging hypolipidemic therapies","volume":"14","author":"Kounatidis","year":"2024","journal-title":"Metabolites"},{"issue":"5","key":"10.1016\/j.jacl.2026.07.018_bib48","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s11883-005-0050-0","article-title":"Extending the cardiovascular benefits of omega-3 Fatty acids","volume":"7","author":"Harris","year":"2005","journal-title":"Curr Atheroscler Rep"},{"issue":"13","key":"10.1016\/j.jacl.2026.07.018_bib49","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1056\/NEJMoa2507227","article-title":"Targeting APOC3 with olezarsen in moderate hypertriglyceridemia","volume":"393","author":"Bergmark","year":"2025","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.jacl.2026.07.018_bib50","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/jcph.70055","article-title":"Population pharmacokinetic modeling of subcutaneous plozasiran in healthy volunteers and patients with familial chylomicronemia syndrome, severe hypertriglyceridemia, and mixed hyperlipidemia","volume":"65","author":"Ousey","year":"2025","journal-title":"J Clin Pharmacol"},{"issue":"10","key":"10.1016\/j.jacl.2026.07.018_bib51","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1093\/eurjpc\/zwae090","article-title":"Reductions in remnant cholesterol and VLDL cholesterol through inhibition of ANGPTL3 protein synthesis: an analysis from the TRANSLATE-TIMI 70 trial","volume":"31","author":"Zimerman","year":"2024","journal-title":"Eur J Prev Cardiol"},{"issue":"21","key":"10.1016\/j.jacl.2026.07.018_bib52","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1056\/NEJMoa2210645","article-title":"Triglyceride lowering with pemafibrate to reduce cardiovascular risk","volume":"387","author":"Das Pradhan","year":"2022","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.jacl.2026.07.018_bib53","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1161\/STROKEAHA.125.051754","article-title":"Aging and sex modify the risk of carotid plaque thrombosis related to dyslipidemic profile","volume":"56","author":"Servadei","year":"2025","journal-title":"Stroke"}],"container-title":["Journal of Clinical Lipidology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287426004460?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933287426004460?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T12:19:59Z","timestamp":1793708399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933287426004460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":53,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1933287426004460"],"URL":"https:\/\/doi.org\/10.1016\/j.jacl.2026.07.018","relation":{},"ISSN":["1933-2874"],"issn-type":[{"value":"1933-2874","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of remnant cholesterol with prognosis in atherosclerotic cardiovascular disease: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Lipidology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacl.2026.07.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of National Lipid Association.","name":"copyright","label":"Copyright"}]}}