{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:22:07Z","timestamp":1791181327083,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.jad.2005.12.047","type":"journal-article","created":{"date-parts":[[2006,3,4]],"date-time":"2006-03-04T07:24:18Z","timestamp":1141457058000},"page":"79-90","source":"Crossref","is-referenced-by-count":46,"title":["Evidence for a vagal pathophysiology for bulimia nervosa and the accompanying depressive symptoms"],"prefix":"10.1016","volume":"92","author":[{"given":"Patricia L.","family":"Faris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke D.","family":"Eckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suck-Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Meller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose V.","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Goodale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyd K.","family":"Hartman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2005.12.047_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1540\/jsmr.33.81","article-title":"New aspects of gastric adaptive relaxation, reflex after food intake for more food: involvement of capsaicin-sensitive sensory nerves and nitric oxide","volume":"33","author":"Arakawa","year":"1997","journal-title":"J. Smooth Muscle Res."},{"key":"10.1016\/j.jad.2005.12.047_bib50","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0165-1838(93)90361-W","article-title":"Effects of 5-hydroxytryptamine (5-HT) on the discharge of vagal mechanoreceptors and motility in the upper gastrointestinal tract of the ferret","volume":"45","author":"Blackshaw","year":"1993","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.jad.2005.12.047_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0165-6147(91)90532-W","article-title":"Pharmacological approaches to appetite suppression","volume":"12","author":"Blundell","year":"1991","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jad.2005.12.047_bib3","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1017\/S0033291700028956","article-title":"Psychiatric comorbidity in patients with eating disorders","volume":"24","author":"Braun","year":"1994","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2005.12.047_bib4","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0196-9781(01)00460-0","article-title":"Ondansetron attenuates CCK-induced satiety and c-fos labeling in the dorsal medulla","volume":"22","author":"Daughters","year":"2001","journal-title":"Peptides"},{"key":"10.1016\/j.jad.2005.12.047_bib5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/ajcn\/65.1.114","article-title":"Postprandial cholecystokinin release and gastric emptying in patients with bulimia nervosa","volume":"65","author":"Devlin","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jad.2005.12.047_bib6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/0304-3959(96)03143-0","article-title":"Relationship between thresholds to thermally and to mechanically induced pain in patients with eating disorders and healthy subjects","volume":"67","author":"deZwaan","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.jad.2005.12.047_bib7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0022-3999(96)00088-8","article-title":"Pain sensitivity, alexithymia, and depression in patients with eating disorders; are they related?","volume":"41","author":"deZwaan","year":"1996","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.jad.2005.12.047_bib8","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0006-3223(92)90134-L","article-title":"Nociceptive, but not tactile thresholds are elevated in bulimia nervosa","volume":"32","author":"Faris","year":"1992","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2005.12.047_bib9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0304-3959(98)00108-0","article-title":"Effect of ondansetron, a 5-HT3 receptor antagonist, on the dynamic association between bulimic behaviors and pain thresholds","volume":"77","author":"Faris","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.jad.2005.12.047_bib10","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0140-6736(99)09062-5","article-title":"Effect of decreasing afferent vagal activity with ondansetron on symptoms of bulimia nervosa: a randomized, double-blind trial","volume":"355","author":"Faris","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2005.12.047_bib11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00001813-199204000-00001","article-title":"Selectivity of 5-HT3 antagonists and anti-emetic mechanisms of action","volume":"3","author":"Freeman","year":"1992","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.jad.2005.12.047_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1254\/jjp.59.221","article-title":"Vagal afferent fibers and peripheral 5-HT3 receptors mediate cisplatin-induced emesis in dogs","volume":"59","author":"Fukui","year":"1992","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.jad.2005.12.047_bib13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0166-4328(96)00096-4","article-title":"Electrophysiological studies of 5-hydroxytryptamine receptors on enteric neurons","volume":"73","author":"Galligan","year":"1996","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2005.12.047_bib14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/ajcn\/56.4.656","article-title":"Gastric capacity, gastric emptying, and test-meal intake in normal and bulimic women","volume":"56","author":"Geliebter","year":"1992","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jad.2005.12.047_bib15","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1056\/NEJM198809153191105","article-title":"Impaired cholecystokinin secretion in bulimia nervosa","volume":"319","author":"Geracioti","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jad.2005.12.047_bib16","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1097\/00006842-199811000-00016","article-title":"Blood pressure-related hypoalgesia in bulimia nervosa","volume":"60","author":"Girdler","year":"1998","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jad.2005.12.047_bib17","first-page":"367","article-title":"Stomach distension in extremely obese and in normal subjects","volume":"151","author":"Granstrom","year":"1985","journal-title":"Acta Chir. Scand."},{"key":"10.1016\/j.jad.2005.12.047_bib18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0195-6663(92)90200-P","article-title":"Behavioral assessment of satiety in bulimia nervosa","volume":"18","author":"Hadigan","year":"1992","journal-title":"Appetite"},{"key":"10.1016\/j.jad.2005.12.047_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0195-6663(91)90060-6","article-title":"Temporal patterns of hunger and fullness ratings and related cognitions in anorexia and bulimia","volume":"16","author":"Halmi","year":"1991","journal-title":"Appetite"},{"key":"10.1016\/j.jad.2005.12.047_bib20","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1097\/00004583-199209000-00006","article-title":"Psychiatric comorbidity in treatment-seeking anorexics and bulimics","volume":"31","author":"Herzog","year":"1992","journal-title":"J. Am. Acad. Child Adolesc. Psych."},{"key":"10.1016\/j.jad.2005.12.047_bib21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0014-2999(89)90700-0","article-title":"Binding of 5-HT3 ligand [3H] GR65630, to rat area postrema, vagus nerve, and the brains of several species","volume":"157","author":"Kilpatrick","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jad.2005.12.047_bib22","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/0031-9384(96)00086-8","article-title":"A direct measure of satiety disturbance in patients with bulimia nervosa","volume":"60","author":"Kissileff","year":"1996","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jad.2005.12.047_bib23","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1528-1157.1998.tb01155.x","article-title":"Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation","volume":"39","author":"Krahl","year":"1998","journal-title":"Epilepsia"},{"key":"10.1016\/j.jad.2005.12.047_bib24","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/00006842-199011000-00008","article-title":"Pain perception in patients with eating disorders","volume":"52","author":"Lautenbacher","year":"1990","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jad.2005.12.047_bib25","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0031-9384(91)90557-5","article-title":"Dieting and pain sensitivity: a validation of clinical findings","volume":"50","author":"Lautenbacher","year":"1991","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jad.2005.12.047_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-3223(91)90249-L","article-title":"Pain sensitivity in anorexia nervosa and bulimia nervosa","volume":"29","author":"Lautenbacher","year":"1991","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2005.12.047_bib27","first-page":"1997","article-title":"Serotonin released from intestinal enterochromaffin cells mediates luminal non-cholecystokinin-stimulated pancreatic secretion in rats","volume":"118","author":"Li","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jad.2005.12.047_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0304-3959(00)00237-2","article-title":"Low intensity vagal nerve stimulation lowers human thermal pain thresholds","volume":"86","author":"Ness","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.jad.2005.12.047_bib29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF02193748","article-title":"Assessment of somatosensory indicators of polyneuropathy in patients with eating disorders","volume":"241","author":"Pauls","year":"1991","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2005.12.047_bib30","first-page":"R1626","article-title":"Gastric volume detection after selective vagotomies in rats","volume":"274","author":"Phillips","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jad.2005.12.047_bib31","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0091-3057(84)80107-0","article-title":"{D-Ala] Methionine enkephalin-amide reflexively induces antinociception by activating vagal afferents","volume":"21","author":"Randich","year":"1984","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jad.2005.12.047_bib32","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1152\/jn.1993.69.5.1530","article-title":"Vagal afferent stimulation-produced effects on nociception in capsaicin-treated rats","volume":"69","author":"Ren","year":"1993","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.jad.2005.12.047_bib34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0014-2999(89)90884-4","article-title":"Localization of 5-HT3 receptor binding sites in human dorsal vagal complex","volume":"174","author":"Reynolds","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jad.2005.12.047_bib33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0006-8993(91)91654-J","article-title":"Cisplatin-evoked induction of c-fox protein in the brainstem of the ferret: the effect of cervical vagotomy and the anti-emetic 5-HT3 receptor antagonist granisetron (BRL 43694)","volume":"565","author":"Reynolds","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.jad.2005.12.047_bib35","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1523\/JNEUROSCI.09-06-01985.1989","article-title":"Ultrastructural demonstration of a gastric monosynaptic vagal circuit in the nucleus of the solitary tract in rat","volume":"9","author":"Rinaman","year":"1989","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2005.12.047_bib36","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00004714-199802000-00005","article-title":"Fluoxetine normalizes increased cardiac vagal tone in bulimia nervosa","volume":"18","author":"Rissanen","year":"1998","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2005.12.047_bib37","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/0022-3999(88)90008-6","article-title":"Gastric control of food intake","volume":"32","author":"Robinson","year":"1988","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.jad.2005.12.047_bib38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0149-7634(95)00040-L","article-title":"Vagal control of digestion: modulation by central neural and peripheral endocrine factors","volume":"20","author":"Rogers","year":"1996","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2005.12.047_bib39","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0006-3223(99)00304-2","article-title":"Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multi-center study","volume":"47","author":"Rush","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2005.12.047_bib40","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1172\/JCI118699","article-title":"P-glycoprotein in the blood\u2013brain barrier of mice influences the brain penetration and pharmacological activity of many drugs","volume":"97","author":"Schinkel","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jad.2005.12.047_bib41","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0149-7634(95)00039-H","article-title":"Sub-diaphragmatic vagal afferent integration of meal-related gastrointestinal signals","volume":"20","author":"Schwartz","year":"1996","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2005.12.047_bib42","first-page":"R1141","article-title":"Gastric loads potentiate inhibition of food intake produced by cholecystokinin analogue","volume":"261","author":"Schwartz","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jad.2005.12.047_bib43","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/BF02247730","article-title":"Concentration of ondansetron in cerebrospinal fluid following oral dosing in volunteers","volume":"109","author":"Simpson","year":"1992","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2005.12.047_bib44","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/1098-108X(199312)14:4<403::AID-EAT2260140403>3.0.CO;2-X","article-title":"Comorbidity of DSM-III-R eating disorders and personality disorders","volume":"14","author":"Skodol","year":"1993","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.jad.2005.12.047_bib45","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1749-6632.1989.tb53233.x","article-title":"Animal models of human eating disorders","volume":"575","author":"Smith","year":"1989","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.jad.2005.12.047_bib46","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S1091-255X(03)00071-4","article-title":"Functional neuroimaging of gastric distention","volume":"7","author":"Stephan","year":"2003","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.jad.2005.12.047_bib47","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0304-3959(91)90138-N","article-title":"Quantitative characterization and spinal substrates of antinociception produced by electrical stimulation of the subdiaphragmatic vagus in rats","volume":"44","author":"Thurston","year":"1991","journal-title":"Pain"},{"key":"10.1016\/j.jad.2005.12.047_bib48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0167-0115(97)02127-7","article-title":"Role of vagal fibers and bombesin\/gastrin-releasing peptide-neurons in distention-induced gastrin release in rats","volume":"69","author":"Weigert","year":"1997","journal-title":"Regulatory Pept."},{"key":"10.1016\/j.jad.2005.12.047_bib49","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1469-7793.2001.0431k.x","article-title":"Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat","volume":"530","author":"Zhu","year":"2001","journal-title":"J. Physiol."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032705004076?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032705004076?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T01:18:34Z","timestamp":1555463914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032705004076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0165032705004076"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2005.12.047","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1047538.497502","asserted-by":"object"}]},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}