{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:02:23Z","timestamp":1773975743896,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007123","name":"Stanley Medical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.jad.2006.11.025","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T07:20:12Z","timestamp":1169018412000},"page":"275-281","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Open-label aripiprazole in the treatment of acute bipolar depression: A prospective pilot trial"],"prefix":"10.1016","volume":"101","author":[{"given":"Susan L.","family":"McElroy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trisha","family":"Suppes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Frye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori L.","family":"Altshuler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Stanford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Martens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele S.","family":"Leverich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Post","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Paul E.","family":"Keck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2006.11.025_bib1","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"10.1016\/j.jad.2006.11.025_bib2","series-title":"Neuropharmacology and Behavior","first-page":"23","article-title":"Hypersensitive serotonergic receptors involved in clinical depression \u2014 a theory","author":"Aprison","year":"1978"},{"key":"10.1016\/j.jad.2006.11.025_bib3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/10401230490521954","article-title":"Aripiprazole augmentation in treatment-resistant depression","volume":"16","author":"Barbee","year":"2004","journal-title":"Ann. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib4","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1192\/bjp.154.5.672","article-title":"A rating scale for drug induced akathisia","volume":"154","author":"Barnes","year":"1989","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1089\/cap.2004.14.593","article-title":"The effectiveness and tolerability of aripiprazole for pediatric bipolar disorders: a retrospective chart review","volume":"14","author":"Barzman","year":"2004","journal-title":"J. Child Adolesc. Psychopharmacol."},{"key":"10.1016\/j.jad.2006.11.025_bib6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0165-0327(98)00046-9","article-title":"The incidence of akathisia in bipolar affective disorder treated with neuroleptics \u2014 a preliminary report","volume":"53","author":"Brune","year":"1999","journal-title":"J. Affect. Disord."},{"issue":"Suppl. 5","key":"10.1016\/j.jad.2006.11.025_bib7","first-page":"26","article-title":"Clinical highlights in bipolar depression: focus on atypical antipsychotics","volume":"66","author":"Calabrese","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib8","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1176\/appi.ajp.162.7.1351","article-title":"A randomized double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression","volume":"162","author":"Calabrese","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib9","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1399-5618.2005.00234.x","article-title":"Metabolic syndrome in bipolar disorder: findings from the Bipolar Disorder Center for Pennsylvanians","volume":"7","author":"Fagiolini","year":"2005","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2006.11.025_bib10","series-title":"Structured Clinical Interview for DSM-IV Axis I disorders (Research Version, 2\/96 Final)","author":"First","year":"1996"},{"key":"10.1016\/j.jad.2006.11.025_bib11","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1517\/14656566.6.12.2091","article-title":"Aripiprazole","volume":"6","author":"Fleischhacker","year":"2005","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.jad.2006.11.025_bib12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2165\/00002018-200629040-00002","article-title":"Long-term treatment with atypical antipsychotics and the risk of weight gain: a literature analysis","volume":"29","author":"Gentile","year":"2006","journal-title":"Drug Safety"},{"key":"10.1016\/j.jad.2006.11.025_bib13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pnpbp.2005.10.014","article-title":"Extrapyramidal side effects with atypical neuroleptics in bipolar disorder","volume":"30","author":"Ghaemi","year":"2006","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib14","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1176\/appi.ajp.161.3.564","article-title":"Preliminary randomized, double-blind, placebo-controlled trial of pramipexole added to mood stabilizers for treatment-resistant bipolar depression","volume":"161","author":"Goldberg","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib15","series-title":"ECDEU Assessment Manual for Psychopharmacology: Publication ADM 76\u2013338","first-page":"534","year":"1976"},{"key":"10.1016\/j.jad.2006.11.025_bib16","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.pnpbp.2004.06.016","article-title":"Aripiprazole as an adjunctive treatment for refractory major depression","volume":"28","author":"Hellerstein","year":"2004","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib17","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.4088\/JCP.v64n1205","article-title":"Bipolar disorder, obesity, and pharmacotherapy-associated weight gain","volume":"64","author":"Keck","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib18","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1517\/eoid.12.4.655.23750","article-title":"Aripiprazole: a partial dopamine D2 receptor agonist antipsychotic","volume":"12","author":"Keck","year":"2003","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.jad.2006.11.025_bib19","first-page":"1651","article-title":"A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania","volume":"160","author":"Keck","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib20","doi-asserted-by":"crossref","first-page":"626","DOI":"10.4088\/JCP.v67n0414","article-title":"A randomized, double-blind, placebo-controlled 26-week trial of aripiprazole in recently manic patients with bipolar disorder","volume":"67","author":"Keck","year":"2006","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/10401230600801176","article-title":"Adjunctive aripiprazole in treatment-resistant bipolar depression","volume":"18","author":"Ketter","year":"2006","journal-title":"Ann. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0920-9964(03)00050-1","article-title":"Aripiprazole in the treatment of schizophrenia: safety and tolerability in short-term, placebo-controlled trials","volume":"61","author":"Marder","year":"2003","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jad.2006.11.025_bib22","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br. J. Psychiatry"},{"issue":"Suppl","key":"10.1016\/j.jad.2006.11.025_bib23","first-page":"1","article-title":"From clinical research to clinical practice: a 4-year review of ziprasidone","volume":"10","author":"Nemeroff","year":"2005","journal-title":"CNS Spectr."},{"key":"10.1016\/j.jad.2006.11.025_bib24","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.4088\/JCP.v65n1116","article-title":"Possible induction of mania or hypomania by atypical antipsychotics: an updated review of reported cases","volume":"65","author":"Rachid","year":"2004","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib25","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/0269881106059693","article-title":"Aripiprazole in the treatment of acute manic or mixed episodes in patients with bipolar I disorder: a 3-week placebo-controlled study","volume":"20","author":"Sachs","year":"2006","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jad.2006.11.025_bib26","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1517\/14740338.4.5.849","article-title":"The safety and tolerability of atypical antipsychotics in bipolar disorder","volume":"4","author":"Seem\u00fcller","year":"2005","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.jad.2006.11.025_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0165-1781(97)00123-6","article-title":"Modification of the Clinical Global Impression (CGI) scale for use in bipolar illness (BP): the CGI-BP","volume":"73","author":"Spearing","year":"1997","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2006.11.025_bib28","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1111\/j.1600-0447.1970.tb02066.x","article-title":"A rating scale for extrapyramidal side effects","volume":"212","author":"Simpson","year":"1970","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2006.11.025_bib29","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1001\/archpsyc.60.11.1079","article-title":"Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression","volume":"60","author":"Tohen","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1192\/bjp.187.3.235","article-title":"Effectiveness of aripiprazole v. haloperidol in acute bipolar mania: double-blind, randomized, comparative 12-week trial","volume":"187","author":"Vieta","year":"2005","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib31","series-title":"Psychopharmacology. The Fourth Generation of Progress","first-page":"921","article-title":"Dopaminergic mechanisms in depression and mania","author":"Willner","year":"1995"},{"key":"10.1016\/j.jad.2006.11.025_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00004850-200501000-00002","article-title":"Aripiprazole as an augmenter of selective serotonin reuptake inhibitors in depression and anxiety disorder patients","volume":"20","author":"Worthington","year":"2005","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2006.11.025_bib33","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.psc.2005.01.001","article-title":"Atypical antipsychotics for bipolar disorder","volume":"28","author":"Yatham","year":"2005","journal-title":"Psychiatr. Clin. North Am."},{"issue":"Suppl. 5","key":"10.1016\/j.jad.2006.11.025_bib34","first-page":"40","article-title":"Atypical antipsychotics in bipolar depression: potential mechanisms of action","volume":"66","author":"Yatham","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib35","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2006.11.025_bib36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.biopsych.2004.03.013","article-title":"Pramipexole for bipolar II depression: a placebo-controlled proof of concept study","volume":"56","author":"Zarate","year":"2004","journal-title":"Biol. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032706005076?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032706005076?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:07:22Z","timestamp":1759021642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032706005076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":37,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0165032706005076"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2006.11.025","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Open-label aripiprazole in the treatment of acute bipolar depression: A prospective pilot trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2006.11.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}