{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:06:32Z","timestamp":1791198392523,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.jad.2007.12.223","type":"journal-article","created":{"date-parts":[[2008,3,15]],"date-time":"2008-03-15T14:48:43Z","timestamp":1205592523000},"page":"117-126","source":"Crossref","is-referenced-by-count":93,"title":["Brain structure and symptom dimension relationships in obsessive\u2013compulsive disorder: A voxel-based morphometry study"],"prefix":"10.1016","volume":"109","author":[{"given":"Andrew R.","family":"Gilbert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mataix-Cols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge R.C.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Nutche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav","family":"Diwadkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matcheri S.","family":"Keshavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jad.2007.12.223_bib1","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1600-0447.1985.tb02635.x","article-title":"Schizophrenia in early adolescence. A study illustrated by long-term cases","volume":"72","author":"Aarkrog","year":"1985","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2007.12.223_bib2","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.janxdis.2006.03.001","article-title":"Psychometric properties and construct validity of the Obsessive\u2013Compulsive Inventory \u2014 Revised: replication and extension with a clinical sample","volume":"20","author":"Abramowitz","year":"2006","journal-title":"J. Anx. Disorders."},{"issue":"7","key":"10.1016\/j.jad.2007.12.223_bib3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0166-2236(90)90107-L","article-title":"Functional architecture of basal ganglia circuits: neural substrates of parallel processing","volume":"13","author":"Alexander","year":"1990","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jad.2007.12.223_bib4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.ne.09.030186.002041","article-title":"Parallel organization of functionally segregated circuits linking basal ganglia and cortex","volume":"9","author":"Alexander","year":"1986","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.jad.2007.12.223_bib5","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","article-title":"Voxel-based morphometry\u2014the methods","volume":"11","author":"Ashburner","year":"2000","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.jad.2007.12.223_bib6","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation","volume":"26","author":"Ashburner","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.jad.2007.12.223_bib7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.pnpbp.2006.06.008","article-title":"Volumetric MRI study of key brain regions implicated in obsessive\u2013compulsive disorder","volume":"31","author":"Atmaca","year":"2007","journal-title":"Prog. Neur. Biol. Psychiatry"},{"issue":"7","key":"10.1016\/j.jad.2007.12.223_bib8","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1001\/archpsyc.1996.01830070021006","article-title":"Normal caudate nucleus in obsessive\u2013compulsive disorder assessed by quantitative neuroimaging","volume":"53","author":"Aylward","year":"1996","journal-title":"Arch. Gen. Psychiatry"},{"issue":"3","key":"10.1016\/j.jad.2007.12.223_bib9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1001\/archpsyc.1989.01810030049007","article-title":"Reduction of prefrontal cortex glucose metabolism common to three types of depression","volume":"46","author":"Baxter","year":"1989","journal-title":"Arch. Gen. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2007.12.223_bib10","first-page":"32","article-title":"Brain mediation of obsessive\u2013compulsive disorder symptoms: evidence from functional brain imaging studies in the human and nonhuman primate","volume":"1","author":"Baxter","year":"1996","journal-title":"Semin. Clin. Neuropsychiatry"},{"key":"10.1016\/j.jad.2007.12.223_bib11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2007.12.223_bib12","series-title":"Structured Clinical Interview for DSM-IV Axis II Disorders \u2014 Patient Edition","author":"First","year":"1995"},{"key":"10.1016\/j.jad.2007.12.223_bib13","series-title":"Structured Clinical Interview for DSM-IV Axis I Disorders\u2014 Patient Edition","author":"First","year":"1995"},{"issue":"6","key":"10.1016\/j.jad.2007.12.223_bib14","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/00004583-198811000-00018","article-title":"Obsessive compulsive disorder in adolescence: an epidemiological study","volume":"27","author":"Flament","year":"1988","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"issue":"4","key":"10.1016\/j.jad.2007.12.223_bib15","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1037\/1040-3590.14.4.485","article-title":"The obsessive\u2013compulsive inventory: development and validation of a short version","volume":"14","author":"Foa","year":"2002","journal-title":"Psychol. Assess."},{"issue":"1","key":"10.1016\/j.jad.2007.12.223_bib16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cpr.2005.06.010","article-title":"Neuroimaging studies of obsessive\u2013compulsive disorder in adults and children","volume":"26","author":"Friedlander","year":"2006","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.jad.2007.12.223_bib17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1001\/archpsyc.57.5.449","article-title":"Decrease in thalamic volumes of pediatric patients with obsessive\u2013compulsive disorder who are taking paroxetine","volume":"57","author":"Gilbert","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2007.12.223_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"Good","year":"2001","journal-title":"NeuroImage"},{"issue":"11","key":"10.1016\/j.jad.2007.12.223_bib19","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1001\/archpsyc.1989.01810110054008","article-title":"The Yale\u2013Brown Obsessive Compulsive Scale. II. Validity","volume":"46","author":"Goodman","year":"1989","journal-title":"Arch. Gen. Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2007.12.223_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1001\/archpsyc.55.2.181","article-title":"Structural abnormalities of frontal neocortex in obsessive\u2013compulsive disorder","volume":"55","author":"Grachev","year":"1998","journal-title":"Arch. Gen. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2007.12.223_bib21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pscychresns.2005.07.002","article-title":"Serotonin and dopamine transporter imaging in patients with obsessive\u2013compulsive disorder","volume":"140","author":"Hesse","year":"2005","journal-title":"Psychiatry Res."},{"issue":"7","key":"10.1016\/j.jad.2007.12.223_bib22","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1176\/appi.ajp.163.7.1202","article-title":"A proton MRSI study of brain N-acetylaspartate level after 12\u00a0weeks of citalopram treatment in drug-naive patients with obsessive\u2013compulsive disorder","volume":"163","author":"Jang","year":"2006","journal-title":"Am. J. Psychiatry"},{"issue":"7","key":"10.1016\/j.jad.2007.12.223_bib23","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1001\/archpsyc.1996.01830070073011","article-title":"Cerebral structural abnormalities in obsessive\u2013compulsive disorder. A quantitative morphometric magnetic resonance imaging study","volume":"54","author":"Jenike","year":"1996","journal-title":"Arch. Gen. Psychiatry"},{"issue":"3","key":"10.1016\/j.jad.2007.12.223_bib24","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1176\/appi.neuropsych.16.3.342","article-title":"Volumetric investigation of the frontal\u2013subcortical circuitry in patients with obsessive\u2013compulsive disorder","volume":"16","author":"Kang","year":"2004","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2007.12.223_bib25","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1192\/bjp.179.4.330","article-title":"Grey matter abnormalities in obsessive\u2013compulsive disorder: statistical parametric mapping of segmented magnetic resonance images","volume":"179","author":"Kim","year":"2001","journal-title":"Br. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2007.12.223_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0925-4927(03)00061-1","article-title":"Elevated thalamic and prefrontal regional cerebral blood flow in obsessive\u2013compulsive disorder: a SPECT study","volume":"123","author":"Lacerda","year":"2003","journal-title":"Psychiatry Res."},{"issue":"3","key":"10.1016\/j.jad.2007.12.223_bib27","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8","article-title":"Automated Talairach atlas labels for functional brain mapping","volume":"10","author":"Lancaster","year":"2000","journal-title":"Hum. Brain. Mapp."},{"issue":"9","key":"10.1016\/j.jad.2007.12.223_bib28","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.biopsych.2006.06.033","article-title":"Neural responses to facial expressions of disgust but not fear are modulated by washing symptoms in OCD","volume":"61","author":"Lawrence","year":"2007","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.jad.2007.12.223_bib29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1192\/bjp.167.5.629","article-title":"Regional cerebral blood flow in obsessive\u2013compulsive disordered patients at rest. Differential correlates with obsessive\u2013compulsive and anxious\u2013avoidant dimensions","volume":"167","author":"Lucey","year":"1995","journal-title":"Br. J. Psychiatry"},{"issue":"9","key":"10.1016\/j.jad.2007.12.223_bib30","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1176\/ajp.145.9.1089","article-title":"Neuroanatomical abnormalities in obsessive\u2013compulsive disorder detected with quantitative X-ray computed tomography","volume":"145","author":"Luxenberg","year":"1988","journal-title":"Am. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.jad.2007.12.223_bib31","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S1053-8119(03)00169-1","article-title":"An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets","volume":"19","author":"Maldjian","year":"2003","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.jad.2007.12.223_bib32","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-0447.1990.tb03059.x","article-title":"Obsessive\u2013compulsive disorder: a clinical, neuropsychological and positron emission tomography study","volume":"82","author":"Martinot","year":"1990","journal-title":"Acta. Psychiatr. Scand."},{"issue":"2","key":"10.1016\/j.jad.2007.12.223_bib33","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.psc.2006.02.006","article-title":"Common and distinct neural correlates of obsessive\u2013compulsive and related disorders","volume":"29","author":"Mataix-Cols","year":"2006","journal-title":"Psychiatr. Clin. North Am."},{"issue":"6","key":"10.1016\/j.jad.2007.12.223_bib34","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0006-3223(02)01504-4","article-title":"Neural correlates of anxiety associated with obsessive\u2013compulsive symptom dimensions in normal volunteers","volume":"53","author":"Mataix-Cols","year":"2003","journal-title":"Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.jad.2007.12.223_bib35","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1001\/archpsyc.61.6.564","article-title":"Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive\u2013compulsive disorder","volume":"61","author":"Mataix-Cols","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"issue":"9","key":"10.1016\/j.jad.2007.12.223_bib36","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.biopsych.2005.01.038","article-title":"Selective reduction in amygdala volume in pediatric anxiety disorders: a voxel-based morphometry investigation","volume":"57","author":"Milham","year":"2005","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.jad.2007.12.223_bib37","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1017\/S0033291799002652","article-title":"A differential neural response in obsessive\u2013compulsive disorder patients with washing compared with checking symptoms to disgust","volume":"30","author":"Phillips","year":"2000","journal-title":"Psychol. Med."},{"issue":"7","key":"10.1016\/j.jad.2007.12.223_bib38","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1001\/archpsyc.61.7.720","article-title":"Mapping structural brain alterations in obsessive\u2013compulsive disorder","volume":"61","author":"Pujol","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2007.12.223_bib39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/archpsyc.1994.03950010062008","article-title":"Regional cerebral blood flow measured during symptom provocation in obsessive\u2013compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography","volume":"51","author":"Rauch","year":"1994","journal-title":"Arch. Gen. Psychiatry"},{"issue":"5","key":"10.1016\/j.jad.2007.12.223_bib40","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/00001756-199803300-00019","article-title":"Thalamic deactivation during early implicit sequence learning: a functional MRI study","volume":"9","author":"Rauch","year":"1998","journal-title":"Neuroreport"},{"issue":"5","key":"10.1016\/j.jad.2007.12.223_bib41","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0893-133X(02)00351-2","article-title":"Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation study","volume":"27","author":"Rauch","year":"2002","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"10.1016\/j.jad.2007.12.223_bib42","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1001\/archpsyc.1995.03950170067009","article-title":"Reduced caudate nucleus volume in obsessive\u2013compulsive disorder","volume":"52","author":"Robinson","year":"1995","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2007.12.223_bib43","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0006-3223(97)00443-5","article-title":"Toward a neurodevelopmental model of obsessive\u2013compulsive disorder","volume":"43","author":"Rosenberg","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2007.12.223_bib44","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1001\/archpsyc.1997.01830210068007","article-title":"Frontostriatal measurement in treatment-naive children with obsessive\u2013compulsive disorder","volume":"54","author":"Rosenberg","year":"1997","journal-title":"Arch. Gen. Psychiatry"},{"issue":"62","key":"10.1016\/j.jad.2007.12.223_bib45","first-page":"10","article-title":"The definition and meaning of treatment-resistant depression","volume":"Suppl","author":"Sackeim","year":"2001","journal-title":"J. Clin. Psychiatry"},{"issue":"35","key":"10.1016\/j.jad.2007.12.223_bib46","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1192\/S0007125000297870","article-title":"Neuroimaging and frontal\u2013subcortical circuitry in obsessive\u2013compulsive disorder","volume":"Suppl","author":"Saxena","year":"1998","journal-title":"Br. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.jad.2007.12.223_bib47","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1176\/appi.ajp.160.3.522","article-title":"Differential brain metabolic predictors of response to paroxetine in obsessive\u2013compulsive disorder versus major depression","volume":"160","author":"Saxena","year":"2003","journal-title":"Am. J. Psychiatry"},{"issue":"6","key":"10.1016\/j.jad.2007.12.223_bib48","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1176\/appi.ajp.161.6.1038","article-title":"Cerebral glucose metabolism in obsessive\u2013compulsive hoarding","volume":"161","author":"Saxena","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2007.12.223_bib49","series-title":"MunsterT2T-Converter (3D Version)","author":"Steinstrater","year":"2003"},{"issue":"6","key":"10.1016\/j.jad.2007.12.223_bib50","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1176\/appi.ajp.161.6.1049","article-title":"Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive\u2013compulsive disorder","volume":"161","author":"Szeszko","year":"2004","journal-title":"Am. J. Psychiatry"},{"issue":"6","key":"10.1016\/j.jad.2007.12.223_bib51","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.biopsych.2005.04.021","article-title":"Regional gray matter abnormalities in obsessive\u2013compulsive disorder: a voxel-based morphometry study","volume":"58","author":"Valente","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2007.12.223_bib52","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO;2-O","article-title":"A unified statistical approach for determining significant signals in images of cerebral activation","volume":"4","author":"Worsley","year":"1996","journal-title":"Hum. Brain. Map."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032707004193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032707004193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T04:11:38Z","timestamp":1557375098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032707004193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":52,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0165032707004193"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2007.12.223","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}