{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:43:52Z","timestamp":1775537032138,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.jad.2008.05.014","type":"journal-article","created":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T08:31:24Z","timestamp":1223022684000},"page":"36-49","source":"Crossref","is-referenced-by-count":128,"title":["Aripiprazole monotherapy in the treatment of acute bipolar I mania: A randomized, double-blind, placebo- and lithium-controlled study"],"prefix":"10.1016","volume":"112","author":[{"given":"P.E.","family":"Keck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"Orsulak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Cutler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Torbeyns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.N.","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.D.","family":"McQuade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.H.","family":"Carson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2008.05.014_bib1","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"APA","year":"2000"},{"key":"10.1016\/j.jad.2008.05.014_bib2","first-page":"1","article-title":"Practice guideline for the treatment of patients with bipolar disorder (revision)","volume":"159","author":"APA","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib3","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1192\/bjp.154.5.672","article-title":"A rating scale for drug-induced akathisia","volume":"154","author":"Barnes","year":"1989","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4088\/JCP.v66n0116","article-title":"A randomized, double-blind, placebo-controlled efficacy and safety study of quetiapine or lithium as monotherapy for mania in bipolar disorder","volume":"66","author":"Bowden","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1124\/jpet.102.033175","article-title":"Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors","volume":"302","author":"Burris","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jad.2008.05.014_bib6","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1399-5618.2005.00234.x","article-title":"Metabolic syndrome in bipolar disorder: findings from the Bipolar Disorder Center for Pennsylvanians","volume":"7","author":"Fagiolini","year":"2005","journal-title":"Bipolar. Disord."},{"key":"10.1016\/j.jad.2008.05.014_bib7","series-title":"US Department of Health, Education, and Welfare publication (ADM) 76\u2013338","first-page":"534","article-title":"Abnormal Involuntary Movement Scale (AIMS). ECDEU Assessment Manual for Psychopharmacology","author":"Guy","year":"1976"},{"key":"10.1016\/j.jad.2008.05.014_bib8","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1176\/appi.ajp.161.6.1057","article-title":"Rapid antimanic effect of risperidone monotherapy: a 3-week multicenter, double-blind, placebo-controlled trial","volume":"161","author":"Hirschfeld","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The Positive And Negative Syndrome Scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jad.2008.05.014_bib10","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.4088\/JCP.v68n1003","article-title":"Aripiprazole monotherapy for maintaining efficacy in bipolar I disorder: a 100-week, double-blind study versus placebo","volume":"68","author":"Keck","year":"2007","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib11","doi-asserted-by":"crossref","first-page":"626","DOI":"10.4088\/JCP.v67n0414","article-title":"A randomized, double-blind, placebo-controlled 26-week trial of aripiprazole in recently manic patients with bipolar I disorder","volume":"67","author":"Keck","year":"2006","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib12","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1176\/appi.ajp.160.9.1651","article-title":"A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania","volume":"160","author":"Keck","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib13","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1176\/appi.ajp.160.4.741","article-title":"Ziprasidone in the treatment of acute bipolar mania: a three-week, placebo-controlled, double-blind, randomized trial","volume":"160","author":"Keck","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1192\/bjp.187.3.229","article-title":"Risperidone in the treatment of acute mania: double-blind, placebo-controlled study","volume":"187","author":"Khanna","year":"2005","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib15","doi-asserted-by":"crossref","first-page":"634","DOI":"10.4088\/JCP.v65n0507","article-title":"Are mood disorders and obesity related? A review for the mental health professional","volume":"65","author":"McElroy","year":"2004","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.euroneuro.2005.02.006","article-title":"Quetiapine or haloperidol as monotherapy for bipolar mania: a 12-week, double-blind, randomised, parallel-group, placebo-controlled trial","volume":"15","author":"McIntyre","year":"2005","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2008.05.014_bib17","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1177\/070674370605100502","article-title":"Obesity in bipolar disorder and major depressive disorder: results from a national community health survey on mental health and well-being","volume":"51","author":"McIntyre","year":"2006","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib18","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jad.2007.04.020","article-title":"Olanzapine versus lithium in the acute treatment of bipolar mania: a double-blind, randomized, controlled trial","volume":"105","author":"Niufan","year":"2008","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2008.05.014_bib20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/01.jcp.0000169068.34322.70","article-title":"Ziprasidone in acute bipolar mania: a 21-day randomized, double-blind, placebo-controlled replication trial","volume":"25","author":"Potkin","year":"2005","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2008.05.014_bib21","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/0269881106059693","article-title":"Aripiprazole in the treatment of acute manic or mixed episodes in patients with bipolar I disorder: a 3-week placebo-controlled study","volume":"20","author":"Sachs","year":"2006","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jad.2008.05.014_bib22","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/sj.npp.1300203","article-title":"Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology","volume":"28","author":"Shapiro","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2008.05.014_bib23","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0447.1970.tb02066.x","article-title":"A rating scale for extrapyramidal side effects","volume":"212","author":"Simpson","year":"1970","journal-title":"Acta Psychiatr. Scand., Suppl."},{"key":"10.1016\/j.jad.2008.05.014_bib25","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.euroneuro.2004.06.003","article-title":"Acute and continuation risperidone monotherapy in bipolar mania: a 3-week placebo-controlled trial followed by a 9-week double-blind trial of risperidone and haloperidol","volume":"15","author":"Smulevich","year":"2005","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2008.05.014_bib26","doi-asserted-by":"crossref","first-page":"870","DOI":"10.4088\/JCP.v66n0710","article-title":"The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder","volume":"66","author":"Suppes","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib27","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1001\/archpsyc.60.12.1218","article-title":"A 12-week, double-blind comparison of olanzapine vs haloperidol in the treatment of acute mania","volume":"60","author":"Tohen","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib28","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1001\/archpsyc.57.9.841","article-title":"Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzipine HGGW Study Group","volume":"57","author":"Tohen","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib29","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1176\/ajp.156.5.702","article-title":"Olanzapine versus placebo in the treatment of acute mania. Olanzapine HGEH Study Group","volume":"156","author":"Tohen","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1192\/bjp.187.3.235","article-title":"Effectiveness of aripiprazole v. haloperidol in acute bipolar mania: double-blind, randomised, comparative 12-week trial","volume":"187","author":"Vieta","year":"2005","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2008.05.014_bib31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000082021","article-title":"The use of placebo in clinical trials on bipolar disorder: a new approach for an old debate","volume":"74","author":"Vieta","year":"2005","journal-title":"Psychother. Psychosom."},{"key":"10.1016\/j.jad.2008.05.014_bib32","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1185\/030079905X46340","article-title":"Quetiapine monotherapy for mania associated with bipolar disorder: combined analysis of two international, double-blind, randomised, placebo-controlled studies","volume":"21","author":"Vieta","year":"2005","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.jad.2008.05.014_bib33","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000285058","article-title":"Empirical assessment of the factorial structure of clinical symptoms in schizophrenia. A multisite, multimodel evaluation of the factorial structure of the Positive and Negative Syndrome Scale. The PANSS Study Group","volume":"30","author":"White","year":"1997","journal-title":"Psychopathology"},{"key":"10.1016\/j.jad.2008.05.014_bib34","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br. J. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032708002309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032708002309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T06:26:38Z","timestamp":1684563998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032708002309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":34,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0165032708002309"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2008.05.014","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}