{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:06:47Z","timestamp":1792408007481,"version":"4.4.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.jad.2008.11.008","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T09:40:24Z","timestamp":1231494024000},"page":"80-87","source":"Crossref","is-referenced-by-count":24,"title":["Persistent versus transient depressive symptoms in relation to platelet hyperactivation: A longitudinal analysis of dementia caregivers"],"prefix":"10.1016","volume":"116","author":[{"given":"Kirstin","family":"Aschbacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Roepke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"von K\u00e4nel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent T.","family":"Mausbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel E.","family":"Dimsdale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Ancoli-Israel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2008.11.008_bib1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1109\/TAC.1974.1100705","article-title":"A new look at the statistical model identification","volume":"19","author":"Akaike","year":"1974","journal-title":"IEEE Transactions on Automatic Control"},{"key":"10.1016\/j.jad.2008.11.008_bib2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00001648-199307000-00003","article-title":"Depressed affect, hopelessness, and the risk of ischemic heart disease in a cohort of U.S. adults","volume":"4","author":"Anda","year":"1993","journal-title":"Epidemiology"},{"key":"10.1016\/j.jad.2008.11.008_bib3","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1161\/01.CIR.102.15.1773","article-title":"Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans. Cardiovascular Health Study Collaborative Research Group","volume":"102","author":"Ariyo","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jad.2008.11.008_bib4","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/01.JGP.0000227969.36850.eb","article-title":"Increasing dementia of the care receiver predicts procoagulant response in Alzheimer caregivers","volume":"14","author":"Aschbacher","year":"2006","journal-title":"American Journal of Geriatric Psychiatry"},{"key":"10.1016\/j.jad.2008.11.008_bib5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bbi.2007.10.002","article-title":"Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregivers","volume":"22","author":"Aschbacher","year":"2008","journal-title":"Brain, Behavior & Immunity"},{"key":"10.1016\/j.jad.2008.11.008_bib6","article-title":"Longitudinal platelet reactivity to acute psychological stress among older men and women","author":"Aschbacher","year":"2008","journal-title":"Stress"},{"key":"10.1016\/j.jad.2008.11.008_bib7","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1161\/01.CIR.93.11.1976","article-title":"Symptoms of depression, acute myocardial infarction, and total mortality in a community sample","volume":"93","author":"Barefoot","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.jad.2008.11.008_bib8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1207\/S15327906Mb340203","article-title":"Structural equation modeling with small samples: test statistics","volume":"34","author":"Bentler","year":"1999","journal-title":"Multivariate Behavioral Research"},{"key":"10.1016\/j.jad.2008.11.008_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00221-001-0979-3","article-title":"Forced swimming test and fluoxetine treatment: in vivo evidence that peripheral 5-HT in rat platelet-rich plasma mirrors cerebral extracellular 5-HT levels, whilst 5-HT in isolated platelets mirrors neuronal 5-HT changes","volume":"143","author":"Bianchi","year":"2002","journal-title":"Experimental Brain Research"},{"key":"10.1016\/j.jad.2008.11.008_bib10","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.ehj.2003.08.021","article-title":"The adhesion molecule P-selectin and cardiovascular disease","volume":"24","author":"Blann","year":"2003","journal-title":"European Heart Journal"},{"key":"10.1016\/j.jad.2008.11.008_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.31887\/DCNS.2007.9.1\/bbondy","article-title":"Common genetic factors for depression and cardiovascular disease","volume":"9","author":"Bondy","year":"2007","journal-title":"Dialogues in Clinical Neuroscience"},{"key":"10.1016\/j.jad.2008.11.008_bib12","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.1083968","article-title":"Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene","volume":"301","author":"Caspi","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jad.2008.11.008_bib13","first-page":"54","article-title":"P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis and cancer growth and metastasis","author":"Chen","year":"2006","journal-title":"Archivum Immunologiae et Therapiae Experimentalis"},{"key":"10.1016\/j.jad.2008.11.008_bib14","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00005344-198811001-00002","article-title":"Functional expression of the amplification reaction between serotonin and epinephrine on platelets","volume":"11","author":"De Clerck","year":"1988","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1016\/j.jad.2008.11.008_bib15","series-title":"The Brief Symptom Inventory: Administration, Scoring and Procedures Manual-II","author":"Derogatis","year":"1992"},{"key":"10.1016\/j.jad.2008.11.008_bib16","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1017\/S0033291700048017","article-title":"The Brief Symptom Inventory: an introductory report","volume":"13","author":"Derogatis","year":"1983","journal-title":"Psychological medicine"},{"key":"10.1016\/j.jad.2008.11.008_bib17","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/sj.mp.4001546","article-title":"Gene\u2013environment interaction analysis of serotonin system markers with adolescent depression","volume":"9","author":"Eley","year":"2004","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.jad.2008.11.008_bib18","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1001\/archpsyc.63.3.283","article-title":"Onset of major depression associated with acute coronary syndromes","volume":"63","author":"Glassman","year":"2006","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jad.2008.11.008_bib19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1037\/0022-006X.52.2.321","article-title":"Norms for the elderly on the Brief Symptom Inventory","volume":"52","author":"Hale","year":"1984","journal-title":"Journal of Consulting & Clinical Psychology"},{"key":"10.1016\/j.jad.2008.11.008_bib20","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.bbi.2006.01.001","article-title":"Inflammatory and hemostatic responses to repeated mental stress: individual stability and habituation over time","volume":"20","author":"Hamer","year":"2006","journal-title":"Brain, Behavior & Immunity"},{"key":"10.1016\/j.jad.2008.11.008_bib21","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1365-2141.2000.02269.x","article-title":"Progress in the assessment of platelet function","volume":"111","author":"Harrison","year":"2000","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.jad.2008.11.008_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10705519909540118","article-title":"Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives","volume":"6","author":"Hu","year":"1999","journal-title":"Structural Equation Modeling"},{"key":"10.1016\/j.jad.2008.11.008_bib23","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1161\/01.CIR.0000081765.88440.51","article-title":"Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans","volume":"108","author":"Koyama","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jad.2008.11.008_bib24","first-page":"3","article-title":"Gene\u2013environment interaction and the genetics of depression","author":"Lesch","year":"2004","journal-title":"Review, Journal of Psychiatry & Neuroscience"},{"key":"10.1016\/j.jad.2008.11.008_bib25","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1111\/j.1471-4159.1993.tb03522.x","article-title":"Primary structure of the human platelet serotonin uptake site-identity with the brain serotonin transporter","volume":"60","author":"Lesch","year":"1993","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.jad.2008.11.008_bib26","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1161\/01.CIR.100.13.1374","article-title":"Evidence for prothrombotic effects of exercise and limited protection by aspirin","volume":"100","author":"Li","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jad.2008.11.008_bib27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.thromres.2003.08.026","article-title":"Aspirin treatment does not attenuate platelet or leukocyte activation as monitored by whole blood flow cytometry","volume":"111","author":"Li","year":"2003","journal-title":"Thrombosis Research"},{"key":"10.1016\/j.jad.2008.11.008_bib28","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and atherosclerosis","volume":"105","author":"Libby","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jad.2008.11.008_bib29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1037\/0278-6133.26.5.539","article-title":"Depression and distress predict time to cardiovascular disease in dementia caregivers","volume":"26","author":"Mausbach","year":"2007","journal-title":"Health Psychology"},{"key":"10.1016\/j.jad.2008.11.008_bib30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jpsychores.2006.10.011","article-title":"Effects of placement and bereavement on psychological well-being and cardiovascular risk in Alzheimer's caregivers: a longitudinal analysis","volume":"62","author":"Mausbach","year":"2007","journal-title":"Journal of Psychosomatic Research"},{"key":"10.1016\/j.jad.2008.11.008_bib31","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1161\/01.CIR.102.16.1931","article-title":"P-selectin expression on platelets determines size and stability of platelet aggregates","volume":"102","author":"Merten","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jad.2008.11.008_bib32","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/00062752-199909000-00012","article-title":"Laboratory markers of platelet activation and their clinical significance","volume":"6","author":"Michelson","year":"1999","journal-title":"Current Opinion in Hematology"},{"key":"10.1016\/j.jad.2008.11.008_bib33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/meth.2000.1006","article-title":"Evaluation of platelet function by flow cytometry","volume":"21","author":"Michelson","year":"2000","journal-title":"Methods"},{"key":"10.1016\/j.jad.2008.11.008_bib34","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1001\/archpsyc.55.7.580","article-title":"The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment","volume":"55","author":"Musselman","year":"1998","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jad.2008.11.008_bib35","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1001\/archpsyc.57.9.875","article-title":"Platelet reactivity in depressed patients treated with paroxetine: preliminary findings","volume":"57","author":"Musselman","year":"2000","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jad.2008.11.008_bib36","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1067\/mhj.2000.109978","article-title":"Are platelets the link between depression and ischemic heart disease?","volume":"140","author":"Nemeroff","year":"2000","journal-title":"American Heart Journal"},{"key":"10.1016\/j.jad.2008.11.008_bib37","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1176\/appi.ajp.2007.06101617","article-title":"Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the heart and soul study","volume":"164","author":"Otte","year":"2007","journal-title":"American Journal of Psychiatry,"},{"key":"10.1016\/j.jad.2008.11.008_bib38","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/clinchem\/40.2.288","article-title":"Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter","volume":"40","author":"Owens","year":"1994","journal-title":"Clinical Chemistry"},{"key":"10.1016\/j.jad.2008.11.008_bib39","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1001\/archpsyc.56.10.889","article-title":"Minor and major depression and the risk of death in older persons","volume":"56","author":"Penninx","year":"1999","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jad.2008.11.008_bib40","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0022-3956(00)00034-0","article-title":"Elevated P-selectin on platelets in depression: response to bupropion","volume":"34","author":"Piletz","year":"2000","journal-title":"Journal of Psychiatric Research"},{"key":"10.1016\/j.jad.2008.11.008_bib41","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/00004714-200004000-00004","article-title":"Evaluation of platelet activation in depressed patients with ischemic heart disease after paroxetine or nortriptyline treatment","volume":"20","author":"Pollock","year":"2000","journal-title":"Journal of Clinical Psychopharmacology"},{"key":"10.1016\/j.jad.2008.11.008_bib42","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1469-8986.1992.tb01712.x","article-title":"Myocardial and peripheral vascular responses to behavioral challenges and their stability in black and white Americans","volume":"29","author":"Saab","year":"1992","journal-title":"Psychophysiology"},{"key":"10.1016\/j.jad.2008.11.008_bib43","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1001\/jama.282.23.2215","article-title":"Caregiving as a risk factor for mortality: the Caregiver Health Effects Study","volume":"282","author":"Schulz","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2008.11.008_bib44","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/geront\/35.6.771","article-title":"Psychiatric and physical morbidity effects of dementia caregiving: prevalence, correlates and causes","volume":"35","author":"Schulz","year":"1995","journal-title":"Gerontologist"},{"key":"10.1016\/j.jad.2008.11.008_bib45","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1001\/archinte.160.12.1761","article-title":"Association between depression and mortality in older adults: the Cardiovascular Health Study","volume":"160","author":"Schulz","year":"2000","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.jad.2008.11.008_bib46","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1176\/appi.ajp.162.6.1165","article-title":"Relationship between release of platelet\/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression","volume":"162","author":"Serebruany","year":"2005","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2008.11.008_bib47","series-title":"Essential Pharmocology: Neuroscientific Basis and Practical Applications","author":"Stahl","year":"2000"},{"key":"10.1016\/j.jad.2008.11.008_bib48","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1037\/1040-3590.2.2.134","article-title":"Depression screening scale validation in an elderly, community-dwelling population","volume":"2","author":"Stukenberg","year":"1990","journal-title":"Psychological Assessment"},{"key":"10.1016\/j.jad.2008.11.008_bib49","article-title":"Symptoms of depression and impaired endothilial function in healthy adolescent women","author":"Tomfohr","year":"2007","journal-title":"Journal of Behavioral Medicine"},{"key":"10.1016\/j.jad.2008.11.008_bib50","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1600-0447.2004.00308.x","article-title":"Platelet hyperactivity in clinical depression and the beneficial effect of antidepressant drug treatment: how strong is the evidence?","volume":"110","author":"Von K\u00e4nel","year":"2004","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"10.1016\/j.jad.2008.11.008_bib51","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000113649","article-title":"Increased Framingham coronary heart disease risk score in dementia caregivers relative to non-caregiving controls","volume":"54","author":"Von K\u00e4nel","year":"2008","journal-title":"Gerontology"},{"key":"10.1016\/j.jad.2008.11.008_bib52","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/archinte.156.5.553","article-title":"Change in depression as a precursor of cardiovascular events. SHEP Cooperative Research Group (Systoloc Hypertension in the elderly)","volume":"156","author":"Wassertheil-Smoller","year":"1996","journal-title":"Archives of Internal Medicine,"},{"key":"10.1016\/j.jad.2008.11.008_bib53","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1001\/archinte.164.3.289","article-title":"Depression and cardiovascular sequelae in postmenopausal women. The Women's Health Initiative (WHI)","volume":"164","author":"Wassertheil-Smoller","year":"2004","journal-title":"Archives of internal medicine,"},{"key":"10.1016\/j.jad.2008.11.008_bib54","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1037\/0033-295X.96.2.234","article-title":"Health complaints, stress and distress: exploring the central role of negative affectivity","volume":"96","author":"Watson","year":"1989","journal-title":"Psychological Review"},{"key":"10.1016\/j.jad.2008.11.008_bib55","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1176\/appi.ajp.158.12.2074","article-title":"Influence of serotonin-transporter-linked promoter region polymorphism on platelet activation in geriatric depression","volume":"158","author":"Whyte","year":"2001","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2008.11.008_bib56","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00006842-200103000-00016","article-title":"Central nervous system serotonin function and cardiovascular responses to stress","volume":"63","author":"Williams","year":"2001","journal-title":"Psychosomatic Medicine"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032708004448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032708004448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T17:53:22Z","timestamp":1632938002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032708004448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":56,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0165032708004448"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2008.11.008","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}