{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:27:20Z","timestamp":1786991240174,"version":"build-2736575974"},"reference-count":53,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.jad.2009.06.021","type":"journal-article","created":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T05:09:14Z","timestamp":1247893754000},"page":"9-16","source":"Crossref","is-referenced-by-count":55,"title":["Comparative efficacy of antidepressants in preventing relapse in anxiety disorders \u2014 A meta-analysis"],"prefix":"10.1016","volume":"123","author":[{"given":"Mary Rocco","family":"Donovan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Glue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheela","family":"Kolluri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birol","family":"Emir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2009.06.021_bib1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1017\/S1461145705005973","article-title":"Prevention of relapse in generalized anxiety disorder by escitalopram treatment","volume":"9","author":"Allgulander","year":"2006","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/da.20489","article-title":"Classification of anxiety and depressive disorders: problems and solutions","volume":"25","author":"Andrews","year":"2008","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.jad.2009.06.021_bib3","series-title":"An Introduction to Categorical Data Analysis","author":"Agresti","year":"2007"},{"key":"10.1016\/j.jad.2009.06.021_bib4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1017\/S1461145705005201","article-title":"Evidence-based pharmacotherapy of panic disorder","volume":"8","author":"Bakker","year":"2005","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib5","first-page":"47","article-title":"Consensus statement on panic disorder from the International Consensus Group on Depression and Anxiety","volume":"59","author":"Ballenger","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib6","first-page":"54","article-title":"Consensus statement on social anxiety disorder from the International Consensus Group on Depression and Anxiety","volume":"59","author":"Ballenger","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib7","first-page":"53","article-title":"Consensus statement on generalized anxiety disorder from the International Consensus Group on Depression and Anxiety","volume":"62","author":"Ballenger","year":"2001","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib8","first-page":"55","article-title":"Consensus statement update on posttraumatic stress disorder from the International Consensus Group on Depression and Anxiety","volume":"65","author":"Ballenger","year":"2004","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib9","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.4088\/JCP.v67n0914","article-title":"What is the threshold for symptomatic response and remission for major depressive disorder, panic disorder, social anxiety disorder, and generalized anxiety disorder?","volume":"67","author":"Bandelow","year":"2006","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib10","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/jama.297.15.1683","article-title":"Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials","volume":"297","author":"Bridge","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2009.06.021_bib11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1192\/bjp.bp.106.03825","article-title":"Distress and fear disorders: an alternative empirically based taxonomy of the \u201cmood\u201d and \u201canxiety\u201d disorders","volume":"189","author":"Clark","year":"2006","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib12","series-title":"Review Manager, Version 5.0 for Windows","year":"2008"},{"key":"10.1016\/j.jad.2009.06.021_bib13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/00004714-199810000-00004","article-title":"Discontinuation of clonazepam in the treatment of social phobia","volume":"18","author":"Connor","year":"1998","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1176\/foc.1.3.273","article-title":"Efficacy of sertraline in preventing relapse of posttraumatic stress disorder: results of a 28-week double-blind, placebo-controlled study","volume":"1","author":"Davidson","year":"2003","journal-title":"Focus"},{"key":"10.1016\/j.jad.2009.06.021_bib15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/01.jcp.0000155817.21467.6c","article-title":"Maintenance therapy with fluoxetine in posttraumatic stress disorder: a placebo-controlled discontinuation study","volume":"25","author":"Davidson","year":"2005","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib16","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.euroneuro.2008.05.002","article-title":"Duloxetine treatment for relapse prevention in adults with generalized anxiety disorder: a double-blind placebo-controlled trial","volume":"9","author":"Davidson","year":"2008","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/YIC.0b013e3282f0f0d7","article-title":"Long-term efficacy of pregabalin in generalized anxiety disorder","volume":"23","author":"Feltner","year":"2008","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4088\/JCP.v68n0108","article-title":"Relapse prevention of panic disorder in adult outpatient responders to treatment with venlafaxine extended release","volume":"68","author":"Ferguson","year":"2007","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1017\/S1461145704004675","article-title":"Evidence-based pharmacotherapy of obsessive\u2013compulsive disorder","volume":"8","author":"Fineberg","year":"2005","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib20","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.euroneuro.2006.11.005","article-title":"Escitalopram prevents relapse of obsessive\u2013compulsive disorder","volume":"17","author":"Fineberg","year":"2007","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib21","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0140-6736(03)12599-8","article-title":"Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review","volume":"361","author":"Geddes","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2009.06.021_bib22","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1089\/104454603322126313","article-title":"Impact of comorbidity on treatment response to paroxetine in pediatric obsessive\u2013compulsive disorder: is the use of exclusion criteria empirically supported in randomized clinical trials?","volume":"13","author":"Geller","year":"2003","journal-title":"J. Child Adolesc. Psychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib23","unstructured":"GlaxoSmithKline Clinical Trial Register (http:\/\/ctrgskcouk\/Summary\/paroxetine\/studylistasp) Study MY-1050\/BRL-029060\/1\/CPMS-222 (PAR 222)."},{"key":"10.1016\/j.jad.2009.06.021_bib24","unstructured":"GlaxoSmithKline Clinical Trial Register (http:\/\/ctrgskcouk\/Summary\/paroxetine\/studylistasp) Study MY-1053\/BRL-029060\/CPMS-127."},{"key":"10.1016\/j.jad.2009.06.021_bib25","series-title":"ECDEU Assessment Manual for Psychopharmacology","first-page":"218","author":"Guy","year":"1976"},{"key":"10.1016\/j.jad.2009.06.021_bib26","series-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 500 [updated February 2008] The Cochrane Collaboration","author":"Higgins","year":"2008"},{"key":"10.1016\/j.jad.2009.06.021_bib27","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.4088\/JCP.v64n0919","article-title":"Acute and long-term treatment and prevention of relapse of obsessive\u2013compulsive disorder with paroxetine","volume":"64","author":"Hollander","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.yic.0000171518.25963.63","article-title":"Placebo-controlled, randomized withdrawal study of sertraline for panic disorder in Japan","volume":"20","author":"Kamijima","year":"2005","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1192\/S0007125000298371","article-title":"Comorbidity of DSM-III-R major depressive disorder in the general population: results from the US National Comorbidity Survey","volume":"30","author":"Kessler","year":"1996","journal-title":"Br. J. Psychiatry Suppl."},{"key":"10.1016\/j.jad.2009.06.021_bib30","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1017\/S0033291704003873","article-title":"Magnitude of placebo response and drug-placebo differences across psychiatric disorders","volume":"35","author":"Khan","year":"2005","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2009.06.021_bib31","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1176\/appi.ajp.159.1.88","article-title":"Efficacy of sertraline in the long-term treatment of obsessive\u2013compulsive disorder","volume":"159","author":"Koran","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib32","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1056\/NEJM198806303182605","article-title":"An assessment of clinically useful measures of the consequences of treatment","volume":"318","author":"Laupacis","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jad.2009.06.021_bib33","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1192\/bjp.181.4.315","article-title":"Fluoxetine v placebo in prevention of relapse in post-traumatic stress disorder","volume":"181","author":"Martenyi","year":"2002","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib34","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1001\/archpsyc.49.4.318","article-title":"Clinical experiments in maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia","volume":"49","author":"Mavissakalian","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib35","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/archpsyc.56.9.821","article-title":"Long-term maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia","volume":"56","author":"Mavissakalian","year":"1999","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib36","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1192\/bjp.174.3.213","article-title":"Continuing treatment of panic disorder after acute response: randomized, placebo-controlled trial with fluoxetine. The Fluoxetine Panic Disorder Study Group","volume":"174","author":"Michelson","year":"1999","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib37","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.4088\/JCP.v66n1009","article-title":"A 24-week randomized, double-blind, placebo-controlled study of escitalopram for the prevention of generalized social anxiety disorder","volume":"66","author":"Montgomery","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib38","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/00004714-199702000-00002","article-title":"Long-term pharmacotherapy of obsessive\u2013compulsive disorder: a double-blind controlled study","volume":"17","author":"Mundo","year":"1997","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib39","first-page":"211","article-title":"A clomipramine dosage reduction study in the course of the long-term treatment of obsessive\u2013compulsive patients","volume":"26","author":"Pato","year":"1990","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.jad.2009.06.021_bib40","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1034\/j.1600-0447.2001.00263.x","article-title":"Sertraline treatment of panic disorder: results of a long-term study","volume":"104","author":"Rapaport","year":"2001","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2009.06.021_bib41","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00004714-200102000-00009","article-title":"Long-term treatment of obsessive\u2013compulsive disorder after an acute response: a comparison of fluoxetine versus placebo","volume":"21","author":"Romano","year":"2001","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib42","first-page":"30","article-title":"Placebo response in generalized anxiety: its effect on the outcome of clinical trials","volume":"58","author":"Schweizer","year":"1997","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib43","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0193-953X(03)00027-3","article-title":"Predictors of response in anxiety disorders","volume":"26","author":"Solvason","year":"2003","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.jad.2009.06.021_bib44","series-title":"Cochrane Database of Systematic Reviews","first-page":"CD001206","article-title":"Pharmacotherapy for social anxiety disorder","author":"Stein","year":"2000"},{"key":"10.1016\/j.jad.2009.06.021_bib45","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1001\/archpsyc.59.12.1111","article-title":"Efficacy of paroxetine for relapse prevention in social anxiety disorder: a 24-week study","volume":"59","author":"Stein","year":"2002","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib46","series-title":"Cochrane Database of Systematic Reviews","first-page":"CD002795","article-title":"Pharmacotherapy for post-traumatic stress disorder","author":"Stein","year":"2006"},{"key":"10.1016\/j.jad.2009.06.021_bib47","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.4088\/JCP.v67n1111","article-title":"Which factors predict placebo response in anxiety disorders and major depression? An analysis of placebo-controlled studies of escitalopram.","volume":"67","author":"Stein","year":"2006","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib48","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/00004714-199606000-00005","article-title":"Paroxetine in the treatment of generalized social phobia: open-label treatment and double-blind placebo-controlled discontinuation","volume":"16","author":"Stein","year":"1996","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib49","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4088\/JCP.v64n0305","article-title":"Efficacy and tolerability of paroxetine for the long-term treatment of generalized anxiety disorder","volume":"64","author":"Stocchi","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2009.06.021_bib50","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1586\/14737175.4.2.285","article-title":"Treatments for generalized anxiety disorder","volume":"4","author":"Struzik","year":"2004","journal-title":"Expert. Rev. Neurother."},{"key":"10.1016\/j.jad.2009.06.021_bib51","series-title":"Exploratory Data Analysis","author":"Tukey","year":"1974"},{"key":"10.1016\/j.jad.2009.06.021_bib52","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/00004714-200012000-00009","article-title":"Prevention of relapse in generalized social phobia: results of a 24-week study in responders to 20weeks of sertraline treatment","volume":"20","author":"Walker","year":"2000","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2009.06.021_bib53","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1600-0447.2000.tb10947.x","article-title":"Anxiety disorders: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors","volume":"101","author":"Zohar","year":"2000","journal-title":"Acta Psych. Scand."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032709002821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032709002821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T11:12:58Z","timestamp":1558437178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032709002821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":53,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0165032709002821"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2009.06.021","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}