{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:00:09Z","timestamp":1780318809880,"version":"3.54.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.jad.2009.12.017","type":"journal-article","created":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T10:03:34Z","timestamp":1265709814000},"page":"335-340","source":"Crossref","is-referenced-by-count":30,"title":["Alterations of niacin skin sensitivity in recurrent unipolar depressive disorder"],"prefix":"10.1016","volume":"124","author":[{"given":"Stefan","family":"Smesny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kati","family":"Baur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Nenadic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl","key":"10.1016\/j.jad.2009.12.017_bib1","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.1007\/BF02637069","article-title":"Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression","volume":"31","author":"Adams","year":"1996","journal-title":"Lipids"},{"key":"10.1016\/j.jad.2009.12.017_bib2","doi-asserted-by":"crossref","unstructured":"Beck, A.T., Steer, R.A., 1995. Beck-Depression-Inventar: (BDI). In: Hautzinger M. [Hrsg.], Bailer M, Worall H, Keller F: Testhandbuch. 2, \u00fcberarbeitete Auflage.","DOI":"10.1037\/t00742-000"},{"key":"10.1016\/j.jad.2009.12.017_bib3","first-page":"134S","article-title":"The topical niacin flush test \u2014 a new assessment scale","volume":"2","author":"Berger","year":"2001","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2009.12.017_bib4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.psychres.2005.10.010","article-title":"Niacin skin flushing in schizophrenic and depressed patients and healthy controls","volume":"143","author":"Bosveld-van Haandel","year":"2006","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2009.12.017_bib5","doi-asserted-by":"crossref","first-page":"S142","DOI":"10.1042\/bst026s142","article-title":"Depletion of docosahexaenoic acid in red blood cell membranes of depressive patients","volume":"26","author":"Edwards","year":"1998","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.jad.2009.12.017_bib6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0165-0327(97)00166-3","article-title":"Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients","volume":"48","author":"Edwards","year":"1998","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2009.12.017_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0952-3278(96)90139-8","article-title":"Membrane fatty acids, niacin flushing and clinical parameters","volume":"55","author":"Glen","year":"1996","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.jad.2009.12.017_bib8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2009.12.017_bib9","first-page":"12","article-title":"Fish consumption and major depression","author":"Hibbeln","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2009.12.017_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ajcn\/62.1.1","article-title":"Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy","volume":"62","author":"Hibbeln","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jad.2009.12.017_bib11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/026990598122674","article-title":"Interpretive risks: the use of the Hopkins Symptom Checklist 90-Revised (SCL 90-R) with brain tumour patients","volume":"12","author":"Kaplan","year":"1998","journal-title":"Brain Inj."},{"key":"10.1016\/j.jad.2009.12.017_bib12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0165-1781(99)00014-1","article-title":"Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients","volume":"85","author":"Maes","year":"1999","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2009.12.017_bib13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0165-0327(95)00092-5","article-title":"Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl esters and increased C20: 4 omega 6\/C20:5 omega 3 ratio in cholesteryl esters and phospholipids","volume":"38","author":"Maes","year":"1996","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2009.12.017_bib14","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1176\/appi.ajp.160.5.996","article-title":"A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression","volume":"160","author":"Marangell","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2009.12.017_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1461145704004249","article-title":"Ethyl-eicosapentaenoate and dexamethasone resistance in therapy-refractory depression","volume":"7","author":"Murck","year":"2004","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2009.12.017_bib16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1176\/appi.ajp.159.3.477","article-title":"Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder","volume":"159","author":"Nemets","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2009.12.017_bib17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.plefa.2006.07.012","article-title":"Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls","volume":"75","author":"Nieminen","year":"2006","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.jad.2009.12.017_bib18","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2466\/PR0.10.3.799-812","article-title":"The Brief Psychiatric Rating Scale","volume":"10","author":"Overall","year":"1962","journal-title":"Psychol. Rep."},{"key":"10.1016\/j.jad.2009.12.017_bib19","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1176\/appi.ajp.163.6.969","article-title":"Omega-3 fatty acids and mood disorders","volume":"163","author":"Parker","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2009.12.017_bib20","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.plefa.2003.08.020","article-title":"Eicosapentaenoic acid in the treatment of schizophrenia and depression: rationale and preliminary double-blind clinical trial results","volume":"69","author":"Peet","year":"2003","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.jad.2009.12.017_bib21","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1001\/archpsyc.59.10.913","article-title":"A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs","volume":"59","author":"Peet","year":"2002","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2009.12.017_bib22","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1001\/archpsyc.1994.03950080077012","article-title":"Arachidonic acid: a common link in the biology of schizophrenia?","volume":"51","author":"Peet","year":"1994","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2009.12.017_bib23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0006-3223(97)00206-0","article-title":"Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients","volume":"43","author":"Peet","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2009.12.017_bib24","first-page":"7","article-title":"Fatty acids and anxiety disorders","volume":"7","author":"Ross","year":"2009","journal-title":"Neurobiol. Lipids"},{"key":"10.1016\/j.jad.2009.12.017_bib25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jad.2003.11.005","article-title":"Delayed vasodilatory response to methylnicotinate in patients with unipolar depressive disorder","volume":"82","author":"Ross","year":"2004","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2009.12.017_bib26","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/0006-3223(91)90202-W","article-title":"Niacin test in schizophrenia and affective illness","volume":"29","author":"Rybakowski","year":"1991","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2009.12.017_bib27","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0022-3956(03)00006-2","article-title":"Potential use of the topical niacin skin test in early psychosis \u2014 a combined approach using optical reflection spectroscopy and a descriptive rating scale","volume":"37","author":"Smesny","year":"2003","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2009.12.017_bib28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.plefa.2007.08.006","article-title":"Endophenotype properties of niacin sensitivity as marker of impaired prostaglandin signalling in schizophrenia","volume":"77","author":"Smesny","year":"2007","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.jad.2009.12.017_bib29","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1515\/bmte.2001.46.10.280","article-title":"Quantitative measurement of induced skin reddening using optical reflection spectroscopy\u2014methodology and clinical application","volume":"46","author":"Smesny","year":"2001","journal-title":"Biomed. Tech."},{"key":"10.1016\/j.jad.2009.12.017_bib30","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1038\/sj.npp.1301343","article-title":"Cannabinoids influence lipid\u2013arachidonic acid pathways in schizophrenia","volume":"32","author":"Smesny","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2009.12.017_bib31","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jpsychires.2004.01.007","article-title":"The influence of age and gender on niacin skin test results \u2014 implications for the use as a biochemical marker in schizophrenia","volume":"38","author":"Smesny","year":"2004","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2009.12.017_bib32","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.plefa.2005.02.007","article-title":"Impaired niacin sensitivity in acute first-episode but not in multi-episode schizophrenia","volume":"72","author":"Smesny","year":"2005","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.jad.2009.12.017_bib33","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1176\/appi.ajp.163.6.1100","article-title":"Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicidal risk","volume":"163","author":"Sublette","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2009.12.017_bib34","first-page":"138S","article-title":"Niacin test in schizophrenia and in major depression","volume":"2","author":"Tavares","year":"2001","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2009.12.017_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-9964(02)00281-5","article-title":"Increased phospholipase A2 activity in schizophrenia with absent response to niacin","volume":"61","author":"Tavares","year":"2003","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jad.2009.12.017_bib36","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/ajcn\/78.1.40","article-title":"Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study","volume":"78","author":"Tiemeier","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jad.2009.12.017_bib37","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/archpsyc.58.5.512","article-title":"Fish consumption, depression, and suicidality in a general population","volume":"58","author":"Transkanen","year":"2001","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2009.12.017_bib38","first-page":"396S","article-title":"Niacin skin response and phospholipids in psychiatry","volume":"2","author":"Ward","year":"2001","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2009.12.017_bib39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1054\/plef.2000.0193","article-title":"Potential diagnostic aids for abnormal fatty acid metabolism in a range of neurodevelopmental disorders","volume":"63","author":"Ward","year":"2000","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.jad.2009.12.017_bib40","series-title":"Strukturiertes Klinisches Interview f\u00fcr DSM-IV","author":"Wittchen","year":"1979"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032709005692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032709005692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T17:19:13Z","timestamp":1558804753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032709005692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0165032709005692"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2009.12.017","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}