{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:05:43Z","timestamp":1787580343527,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.jad.2011.10.002","type":"journal-article","created":{"date-parts":[[2011,11,7]],"date-time":"2011-11-07T21:40:51Z","timestamp":1320702051000},"page":"716-723","source":"Crossref","is-referenced-by-count":67,"title":["Pro-inflammatory cytokines are elevated in adolescent females with emotional disorders not treated with SSRIs"],"prefix":"10.1016","volume":"136","author":[{"given":"Eva","family":"Henje Blom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Lekander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ingvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"\u00c5sberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariborz","family":"Mobarrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Serlachius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jad.2011.10.002_bb0040","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1017\/S003329179700593X","article-title":"Puberty and depression: the roles of age, pubertal status and pubertal timing","volume":"28","author":"Angold","year":"1998","journal-title":"Psychological Medicine"},{"issue":"7","key":"10.1016\/j.jad.2011.10.002_bb0050","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/hup.717","article-title":"IL-6 levels decrease with SSRI treatment in patients with major depression","volume":"20","author":"Basterzi","year":"2005","journal-title":"Human Psychopharmacology"},{"issue":"9","key":"10.1016\/j.jad.2011.10.002_bb0075","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/PSY.0b013e3181bc756b","article-title":"Preadolescents' somatic and cognitive\u2013affective depressive symptoms are differentially related to cardiac autonomic function and cortisol: the TRAILS study","volume":"71","author":"Bosch","year":"2009","journal-title":"Psychosomatic Medicine"},{"issue":"3","key":"10.1016\/j.jad.2011.10.002_bb0025","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0165-0327(02)00315-4","article-title":"Interleukin-1beta and tumor necrosis factor-alpha in children with major depressive disorder or dysthymia","volume":"78","author":"Brambilla","year":"2004","journal-title":"Journal of Affective Disorders"},{"issue":"6","key":"10.1016\/j.jad.2011.10.002_bb0105","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0006-3223(02)01372-0","article-title":"Development and natural history of mood disorders","volume":"52","author":"Costello","year":"2002","journal-title":"Biological Psychiatry"},{"issue":"8","key":"10.1016\/j.jad.2011.10.002_bb0110","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archpsyc.60.8.837","article-title":"Prevalence and development of psychiatric disorders in childhood and adolescence","volume":"60","author":"Costello","year":"2003","journal-title":"Archives of General Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.jad.2011.10.002_bb0185","first-page":"S49","article-title":"Using non-steroidal anti-inflammatory drugs in the treatment of depression","volume":"22","author":"Davis","year":"2011","journal-title":"Psychiatria Danubina."},{"issue":"11","key":"10.1016\/j.jad.2011.10.002_bb0140","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jpsychires.2009.05.010","article-title":"Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression","volume":"43","author":"Dhabhar","year":"2009","journal-title":"Journal of Psychiatric Research"},{"issue":"1","key":"10.1016\/j.jad.2011.10.002_bb0145","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/YCO.0b013e328315a561","article-title":"Inflammatory markers in depression","volume":"22","author":"Dinan","year":"2009","journal-title":"Current Opinion in Psychiatry"},{"issue":"5","key":"10.1016\/j.jad.2011.10.002_bb0190","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biological Psychiatry"},{"issue":"1\u20132","key":"10.1016\/j.jad.2011.10.002_bb0020","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jad.2008.07.022","article-title":"Immune system dysregulation in adolescent major depressive disorder","volume":"115","author":"Gabbay","year":"2009","journal-title":"Journal of Affective Disorders"},{"issue":"4","key":"10.1016\/j.jad.2011.10.002_bb0030","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1089\/cap.2008.0140","article-title":"A preliminary study of cytokines in suicidal and nonsuicidal adolescents with major depression","volume":"19","author":"Gabbay","year":"2009","journal-title":"Journal of Child and Adolescent Psychopharmacology"},{"issue":"4","key":"10.1016\/j.jad.2011.10.002_bb0015","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1744-6163.2009.00229.x","article-title":"PTSD is associated with an excess of inflammatory immune activities","volume":"45","author":"Gill","year":"2009","journal-title":"Perspectives in Psychiatric Care"},{"issue":"11","key":"10.1016\/j.jad.2011.10.002_bb0125","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1097\/00004583-200111000-00015","article-title":"Psychometric properties of the strengths and difficulties questionnaire","volume":"40","author":"Goodman","year":"2001","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"issue":"5","key":"10.1016\/j.jad.2011.10.002_bb0120","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1469-7610.2000.tb02345.x","article-title":"The development and well-being assessment: description and initial validation of an integrated assessment of child and adolescent psychopathology","volume":"41","author":"Goodman","year":"2000","journal-title":"Journal of Child Psychology and Psychiatry"},{"issue":"6","key":"10.1016\/j.jad.2011.10.002_bb0115","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00421-009-1089-3","article-title":"Heart rate variability is related to self-reported physical activity in a healthy adolescent population","volume":"106","author":"Henje Blom","year":"2009","journal-title":"European Journal of Applied Physiology"},{"issue":"4","key":"10.1016\/j.jad.2011.10.002_bb0060","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1651-2227.2009.01657.x","article-title":"Heart rate variability (HRV) in adolescent females with anxiety disorders and major depressive disorder","volume":"99","author":"Henje Blom","year":"2010","journal-title":"Acta Paediatrica"},{"issue":"3","key":"10.1016\/j.jad.2011.10.002_bb0130","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jad.2009.07.006","article-title":"The differentiation between depressive and anxious adolescent females and controls by behavioural self-rating scales","volume":"122","author":"Henje Blom","year":"2010","journal-title":"Journal of Affective Disorders"},{"issue":"2","key":"10.1016\/j.jad.2011.10.002_bb0195","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bbi.2010.10.010","article-title":"Cytokine levels in the blood may distinguish suicide attempters from depressed patients","volume":"25","author":"Janelidze","year":"2011","journal-title":"Brain, Behavior, and Immunity"},{"issue":"5","key":"10.1016\/j.jad.2011.10.002_bb0100","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2796.2004.01403.x","article-title":"Inflammatory markers and heart rate variability in women with coronary heart disease","volume":"256","author":"Janszky","year":"2004","journal-title":"Journal of Internal Medicine"},{"key":"10.1016\/j.jad.2011.10.002_bb0010","doi-asserted-by":"crossref","first-page":"65704","DOI":"10.1155\/2007\/65704","article-title":"Plasma levels of tumor necrosis factor-alpha and interleukin-6 in obsessive compulsive disorder","volume":"2007","author":"Konuk","year":"2007","journal-title":"Mediators of Inflammation"},{"issue":"3","key":"10.1016\/j.jad.2011.10.002_bb0135","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/hup.1011","article-title":"The psychoneuroimmunology of depression","volume":"24","author":"Leonard","year":"2009","journal-title":"Human Psychopharmacology"},{"issue":"3","key":"10.1016\/j.jad.2011.10.002_bb0150","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.biopsych.2009.01.030","article-title":"Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity","volume":"66","author":"Lindqvist","year":"2009","journal-title":"Biological Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2011.10.002_bb0165","first-page":"7","article-title":"Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways","volume":"32","author":"Maes","year":"2011","journal-title":"Neuro Endocrinology Letters"},{"issue":"4","key":"10.1016\/j.jad.2011.10.002_bb0180","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0889-1591(03)00057-6","article-title":"Pathways linking depression, adiposity, and inflammatory markers in healthy young adults","volume":"17","author":"Miller","year":"2003","journal-title":"Brain, Behavior, and Immunity"},{"issue":"5","key":"10.1016\/j.jad.2011.10.002_bb0160","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1192\/bjp.bp.109.076430","article-title":"Association of high-sensitivity C-reactive protein with de novo major depression","volume":"197","author":"Pasco","year":"2010","journal-title":"The British Journal of Psychiatry"},{"issue":"8\u201310","key":"10.1016\/j.jad.2011.10.002_bb0035","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.psyneuen.2007.07.001","article-title":"Elevated morning serum interleukin (IL)-6 or evening salivary cortisol concentrations predict posttraumatic stress disorder in children and adolescents six months after a motor vehicle accident","volume":"32","author":"Pervanidou","year":"2007","journal-title":"Psychoneuroendocrinology"},{"issue":"5","key":"10.1016\/j.jad.2011.10.002_bb0200","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1017\/S1461145710000465","article-title":"Of depression and immunity: does sex matter?","volume":"13","author":"Pitychoutis","year":"2010","journal-title":"The International Journal of Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.jad.2011.10.002_bb0170","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1136\/hrt.80.2.156","article-title":"Five minute recordings of heart rate variability for population studies: repeatability and age\u2013sex characteristics","volume":"80","author":"Sinnreich","year":"1998","journal-title":"Heart"},{"issue":"Suppl. 2","key":"10.1016\/j.jad.2011.10.002_bb0080","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.3949\/ccjm.76.s2.05","article-title":"Vagal tone and the inflammatory reflex","volume":"76","author":"Thayer","year":"2009","journal-title":"Cleveland Clinic Journal of Medicine"},{"issue":"3","key":"10.1016\/j.jad.2011.10.002_bb0085","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0165-0327(00)00338-4","article-title":"A model of neurovisceral integration in emotion regulation and dysregulation","volume":"61","author":"Thayer","year":"2000","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jad.2011.10.002_bb0095","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1196\/annals.1366.014","article-title":"Beyond heart rate variability: vagal regulation of allostatic systems","volume":"1088","author":"Thayer","year":"2006","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"4","key":"10.1016\/j.jad.2011.10.002_bb0090","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0006-3223(95)00136-0","article-title":"Autonomic characteristics of generalized anxiety disorder and worry","volume":"39","author":"Thayer","year":"1996","journal-title":"Biological Psychiatry"},{"issue":"Suppl. 4","key":"10.1016\/j.jad.2011.10.002_bb0070","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/2047-783X-14-S4-280","article-title":"Respiratory sinus arrhythmia is reduced in adolescent major depressive disorder","volume":"14","author":"Tonhajzerova","year":"2009","journal-title":"European Journal of Medical Research"},{"issue":"4","key":"10.1016\/j.jad.2011.10.002_bb0065","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.pnpbp.2010.02.023","article-title":"Cardiac autonomic regulation is impaired in girls with major depression","volume":"34","author":"Tonhajzerova","year":"2010","journal-title":"Progress in Neuro-Psychopharmacology & Biological Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2011.10.002_bb0175","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1172\/JCI30555","article-title":"Physiology and immunology of the cholinergic antiinflammatory pathway","volume":"117","author":"Tracey","year":"2007","journal-title":"The Journal of Clinical Investigation"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032711005805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032711005805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T13:58:55Z","timestamp":1713103135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032711005805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0165032711005805"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2011.10.002","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}