{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:31:57Z","timestamp":1788478317606,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"1-3","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.jad.2012.05.047","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T18:01:00Z","timestamp":1345831260000},"page":"160-165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Subthreshold symptoms and time to relapse\/recurrence in a community cohort of bipolar disorder outpatients"],"prefix":"10.1016","volume":"143","author":[{"given":"C.","family":"De Dios","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ezquiaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Agud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Soler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Garc\u00eda-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2012.05.047_bib1","first-page":"17","article-title":"Lamotrigine plus quetiapine combination therapy in treatment-resistant bipolar depression","volume":"23","author":"Ahn","year":"2011","journal-title":"Annals of Clinical Psychiatry"},{"key":"10.1016\/j.jad.2012.05.047_bib2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1399-5618.2010.00812.x","article-title":"Morbidity in 303 first-episode bipolar I disorder patients","volume":"12","author":"Baldessarini","year":"2010","journal-title":"Bipolar Disorder"},{"key":"10.1016\/j.jad.2012.05.047_bib3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1399-5618.2011.00889.x","article-title":"Does stage of illness impact treatment response in bipolar disorder? Empirical treatment data and their implication for the staging model and early intervention","volume":"13","author":"Berk","year":"2011","journal-title":"Bipolar Disorder"},{"key":"10.1016\/j.jad.2012.05.047_bib4","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.neubiorev.2010.10.001","article-title":"Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors","volume":"35","author":"Berk","year":"2010","journal-title":"Neuroscience & Biobehavioral Reviews"},{"issue":"Suppl. 1","key":"10.1016\/j.jad.2012.05.047_bib5","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1016\/S0924-977X(97)00420-3","article-title":"Development and validation of a social functioning scale, the social adaptation self-evaluation scale","volume":"7","author":"Bosc","year":"1997","journal-title":"European Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2012.05.047_bib6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jad.2003.10.008","article-title":"Effects of stress and social support on recurrence in bipolar disorder","volume":"82","author":"Cohen","year":"2004","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jad.2012.05.047_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jad.2006.01.032","article-title":"Clinical and therapeutic implications of predominant polarity in bipolar disorder","volume":"93","author":"Colom","year":"2006","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jad.2012.05.047_bib8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jad.2009.12.006","article-title":"Time spent with symptoms in a cohort of bipolar disorder outpatients in Spain: a prospective, 18-month follow-up study","volume":"125","author":"De Dios","year":"2010","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jad.2012.05.047_bib9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jad.2006.04.009","article-title":"The stress sensitization hypothesis: understanding the course of bipolar disorder","volume":"95","author":"Dienes","year":"2006","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jad.2012.05.047_bib10","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1176\/ajp.147.9.1194","article-title":"Life events and the course of bipolar disorder","volume":"147","author":"Ellicott","year":"1990","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2012.05.047_bib11","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1176\/ajp.152.11.1635","article-title":"Relapse and impairment in bipolar disorder","volume":"152","author":"Gitlin","year":"1995","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2012.05.047_bib12","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1600-0447.1987.tb02841.x","article-title":"Inter-episode major and subclinical symptoms in affective disorder","volume":"75","author":"Goodnick","year":"1987","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"10.1016\/j.jad.2012.05.047_bib13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"Journal of Neurology, Neurosurgery & Psychiatry"},{"key":"10.1016\/j.jad.2012.05.047_bib14","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1176\/ajp.154.6.856","article-title":"Stress reactivity in bipolar patients and its relation to prior history of disorder","volume":"154","author":"Hammen","year":"1997","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2012.05.047_bib15","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1037\/0021-843X.106.3.449","article-title":"Negative life events and time to recovery from episodes of bipolar disorder","volume":"106","author":"Johnson","year":"1997","journal-title":"Journal of Abnormal Psychology"},{"key":"10.1016\/j.jad.2012.05.047_bib16","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1037\/0033-2909.117.3.434","article-title":"Life events and bipolar disorder: implications from biological theories","volume":"117","author":"Johnson","year":"1995","journal-title":"Psychological Bulletin"},{"key":"10.1016\/j.jad.2012.05.047_bib17","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1001\/archpsyc.65.4.386","article-title":"Residual symptom recovery from major affective episodes in bipolar disorders and rapid episode relapse\/recurrence","volume":"65","author":"Judd","year":"2008","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jad.2012.05.047_bib18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1001\/archpsyc.1992.01820050035005","article-title":"Subsyndromal symptoms in bipolar disorder. a comparison of standard and low serum levels of lithium","volume":"49","author":"Keller","year":"1992","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jad.2012.05.047_bib19","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1017\/S0033291702005251","article-title":"Inter-episodic morbidity and drop-out under carbamazepine and lithium in the maintenance treatment of bipolar disorder","volume":"32","author":"Kleindienst","year":"2002","journal-title":"Psychological Medicine"},{"key":"10.1016\/j.jad.2012.05.047_bib20","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1017\/S0033291799002706","article-title":"Social rhythm disruption and stressful life events in the onset of bipolar and unipolar episodes","volume":"30","author":"Malkoff-Schwartz","year":"2000","journal-title":"Psychological Medicine"},{"key":"10.1016\/j.jad.2012.05.047_bib21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1176\/appi.ajp.163.2.217","article-title":"Predictors of recurrence in bipolar disorder: primary outcomes from the systematic treatment enhancement program for bipolar disorder (STEP-BD)","volume":"163","author":"Perlis","year":"2006","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2012.05.047_bib22","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1176\/ajp.149.8.999","article-title":"Transduction of psychosocial stress into the neurobiology of recurrent affective disorder","volume":"149","author":"Post","year":"1992","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2012.05.047_bib23","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s12640-010-9182-2","article-title":"Mechanisms of illness progression in the recurrent affective disorders","volume":"18","author":"Post","year":"2010","journal-title":"Neurotoxicity Research"},{"key":"10.1016\/j.jad.2012.05.047_bib24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/YIC.0b013e3283409419","article-title":"Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany","volume":"26","author":"Post","year":"2011","journal-title":"International Clinical Psychopharmacology"},{"key":"10.1016\/j.jad.2012.05.047_bib25","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1017\/S0954579401003091","article-title":"Developmental vulnerabilities to the onset and course of bipolar disorder","volume":"13","author":"Post","year":"2001","journal-title":"Development and Psychopathology"},{"issue":"Suppl 20","key":"10.1016\/j.jad.2012.05.047_bib26","first-page":"22","article-title":"The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.jad.2012.05.047_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0165-1781(97)00123-6","article-title":"Modification of the clinical global impressions (CGI) scale for use in bipolar illness (BP): the CGI-BP","volume":"73","author":"Spearing","year":"1997","journal-title":"Psychiatry Research"},{"key":"10.1016\/j.jad.2012.05.047_bib28","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1192\/bjp.bp.105.020321","article-title":"Influence of sub-syndromal symptoms after remission from manic or mixed episodes","volume":"189","author":"Tohen","year":"2006","journal-title":"British Journal of Psychiatry"},{"key":"10.1016\/j.jad.2012.05.047_bib29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1399-5618.2009.00726.x","article-title":"The international society for bipolar disorders (ISBD) task force report on the nomenclature of course and outcome in bipolar disorders","volume":"11","author":"Tohen","year":"2009","journal-title":"Bipolar Disorder"},{"key":"10.1016\/j.jad.2012.05.047_bib30","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1176\/appi.ajp.160.12.2099","article-title":"The McLean\u2013Harvard first-episode mania study: prediction of recovery and first recurrence","volume":"160","author":"Tohen","year":"2003","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2012.05.047_bib31","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"British Journal of Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032712004077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032712004077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T08:01:17Z","timestamp":1542787277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032712004077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":31,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0165032712004077"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2012.05.047","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Subthreshold symptoms and time to relapse\/recurrence in a community cohort of bipolar disorder outpatients","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2012.05.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}