{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:24:53Z","timestamp":1790846693833,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.jad.2012.07.038","type":"journal-article","created":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T23:19:55Z","timestamp":1350947995000},"page":"191-198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Lower rate of depressive switch following antimanic treatment with second-generation antipsychotics versus haloperidol"],"prefix":"10.1016","volume":"144","author":[{"given":"J.M.","family":"Goikolea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Colom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Capapey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Valent\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Undurraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Grande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sanchez-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2012.07.038_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/026988118700100104","article-title":"Switch from depression to mania, or from mania to depression","volume":"1","author":"Angst","year":"1987","journal-title":"Journal of Psychopharmacology"},{"key":"10.1016\/j.jad.2012.07.038_bib2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMra035354","article-title":"Bipolar disorder","volume":"351","author":"Belmaker","year":"2004","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.jad.2012.07.038_bib3","unstructured":"Cipriani, A., Rendell, J.M., Geddes, J.R., 2006. Haloperidol Alone or in Combination for Acute Mania. Cochrane Database of Systematic Reviews (3), Art. no.: CD004362. doi:0.1002\/14651858.CD004362.pub2."},{"key":"10.1016\/j.jad.2012.07.038_bib4","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/S0140-6736(11)60873-8","article-title":"Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis","volume":"378","author":"Cipriani","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2012.07.038_bib5","unstructured":"Clarke, M., Oxman, A.D., 2000. Cochrane Collaboration Handbook, Version 4.0 (updated July 2000). The Cochrane Library, Oxford."},{"key":"10.1016\/j.jad.2012.07.038_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1600-0447.2010.01650.x","article-title":"The need for publishing the silent evidence from negative trials","volume":"123","author":"Colom","year":"2011","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"10.1016\/j.jad.2012.07.038_bib7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1017\/S1461145709990344","article-title":"Efficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: a meta-analysis","volume":"13","author":"Cruz","year":"2010","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2012.07.038_bib8","unstructured":"Deeks, J.J., Higgins, J.P.T., Altman, D.G. (Eds.), 2011. Analysing data and undertaking meta-analyses. In: Higgins, J.P.T., Green, S. (Eds.). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration (Chapter 9). Available from: \u3008http:\/\/www.cochrane-handbook.org\u3009."},{"key":"10.1016\/j.jad.2012.07.038_bib9","doi-asserted-by":"crossref","unstructured":"Egger, M., Smith, G.D., O'Rourke, K., 2001. Rationale, Potentials, and Promise of Systematic Reviews. In: Systematic Reviews in Health Care: Meta-Analysis in Context. BMJ Publishing Group, London, pp. 3\u201322.","DOI":"10.1002\/9780470693926.ch1"},{"key":"10.1016\/j.jad.2012.07.038_bib10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1177\/0269881109102919","article-title":"Evidence-based guidelines for treating bipolar disorder: revised second edition\u2014recommendations from the British Association for Psychopharmacology","volume":"23","author":"Goodwin","year":"2009","journal-title":"Journal of Psychopharmacology"},{"key":"10.1016\/j.jad.2012.07.038_bib11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/15622970902823202","article-title":"The world federation of societies of biological psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders: update 2009 on the treatment of acute mania","volume":"10","author":"Grunze","year":"2009","journal-title":"World Journal of Biological Psychiatry"},{"key":"10.1016\/j.jad.2012.07.038_bib12","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Statistics in Medicine"},{"key":"10.1016\/j.jad.2012.07.038_bib13","unstructured":"Higgins, J.P.T., Altman, D.G., Sterne, J.A.C. (Eds.), 2011. Assessing risk of bias in included studies. In: Higgins, J.P.T., Green, S. (Eds.). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration (Chapter 8). Available from: \u3008http:\/\/www.cochrane-handbook.org\u3009."},{"key":"10.1016\/j.jad.2012.07.038_bib14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.euroneuro.2005.02.006","article-title":"Quetiapine or haloperidol as monotherapy for bipolar mania: a 12 weeks double blind, randomised, parallel group, placebo controlled trial","volume":"15","author":"McIntyre","year":"2005","journal-title":"European Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2012.07.038_bib15","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1016\/S0140-6736(99)04149-5","article-title":"Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of reporting of meta-analyses","volume":"354","author":"Moher","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2012.07.038_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jad.2011.10.015","article-title":"New treatment guidelines for acute bipolar mania: a critical review","volume":"140","author":"Nivoli","year":"2012","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jad.2012.07.038_bib17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.euroneuro.2011.09.008","article-title":"Polarity index of pharmacological agents used for maintenance treatment of bipolar disorder","volume":"22","author":"Popovic","year":"2012","journal-title":"European Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2012.07.038_bib18","unstructured":"Review Manager (RevMan) [Computer program], 2003. Version 4.2 for Windows. Oxford: Cochrane Collaboration."},{"key":"10.1016\/j.jad.2012.07.038_bib19","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1176\/appi.ajp.159.7.1146","article-title":"Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety","volume":"159","author":"Sachs","year":"2002","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2012.07.038_bib20","first-page":"176","article-title":"Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial","volume":"21","author":"Segal","year":"1998","journal-title":"Clinical Neuropharmacology"},{"key":"10.1016\/j.jad.2012.07.038_bib21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.euroneuro.2004.06.003","article-title":"Acute and continuation risperidone monotherapy in bipolar mania: a 3 week placebo controlled trial followed by a 9 week double blind trial of risperidone and haloperidol","volume":"15","author":"Smulevich","year":"2005","journal-title":"European Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2012.07.038_bib22","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1176\/appi.ajp.160.12.2099","article-title":"The McLean\u2013Harvard first-episode mania study: prediction of recovery and first recurrence","volume":"160","author":"Tohen","year":"2003","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2012.07.038_bib23","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1001\/archpsyc.60.12.1218","article-title":"A 12-week, double-blind comparison of olanzapine vs haloperidol in the treatment of acute mania","volume":"60","author":"Tohen","year":"2003","journal-title":"Archives of General Psychiatry"},{"issue":"Suppl. 2","key":"10.1016\/j.jad.2012.07.038_bib24","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1111\/j.1399-5618.2009.00710.x","article-title":"Antipsychotic agents in the treatment of bipolar mania","volume":"11","author":"Tohen","year":"2009","journal-title":"Bipolar Disorders"},{"key":"10.1016\/j.jad.2012.07.038_bib25","doi-asserted-by":"crossref","first-page":"e271","DOI":"10.4088\/JCP.11m07166","article-title":"Risk factors for antidepressant-related switch to mania","volume":"73","author":"Valent\u00ed","year":"2012","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.jad.2012.07.038_bib26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.eurpsy.2004.12.002","article-title":"The treatment of mixed states and the risk of switching to depression","volume":"20","author":"Vieta","year":"2005","journal-title":"European Psychiatry"},{"key":"10.1016\/j.jad.2012.07.038_bib27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1192\/bjp.187.3.235","article-title":"Effectiveness of Aripiprazole vs haloperidol in acute bipolar mania: double blind, randomised, comparative 12 week trial","volume":"187","author":"Vieta","year":"2005","journal-title":"British Journal of Psychiatry"},{"key":"10.1016\/j.jad.2012.07.038_bib28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jad.2009.02.007","article-title":"Predictors of switching from mania to depression in a large observational study across Europe (EMBLEM)","volume":"118","author":"Vieta","year":"2009","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jad.2012.07.038_bib29","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1177\/0269881108099418","article-title":"Ziprasidone in the treatment of acute mania: a 12-week, placebo-controlled, haloperidol-referenced study","volume":"24","author":"Vieta","year":"2010","journal-title":"Journal of Psychopharmacology"},{"key":"10.1016\/j.jad.2012.07.038_bib30","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1399-5618.2010.00815.x","article-title":"A randomized, placebo- and active-controlled study of paliperidone extended release for the treatment of acute manic and mixed episodes of bipolar I disorder","volume":"12","author":"Vieta","year":"2010","journal-title":"Bipolar Disorders"},{"key":"10.1016\/j.jad.2012.07.038_bib31","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1017\/S146114571100040X","article-title":"Impact of geographical and cultural factors on clinical trials in acute mania: lessons from a ziprasidone and haloperidol placebo-controlled study","volume":"14","author":"Vieta","year":"2011","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2012.07.038_bib32","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/npp.2010.192","article-title":"Efficacy of antimanic treatments: meta-analysis of randomized, controlled trials","volume":"36","author":"Yildiz","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2012.07.038_bib33","doi-asserted-by":"crossref","unstructured":"Vieta, E., Cruz, N., Head to head comparisons as an alternative to placebo-controlled trials. European Neuropsychopharmacology, http:\/\/dx.doi.org\/10.1016\/j.euroneuro.2011.11.011, in press.","DOI":"10.1016\/j.euroneuro.2011.11.011"},{"key":"10.1016\/j.jad.2012.07.038_bib34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1399-5618.2009.00672.x","article-title":"Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009","volume":"11","author":"Yatham","year":"2009","journal-title":"Bipolar Disorder"},{"key":"10.1016\/j.jad.2012.07.038_bib35","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1192\/bjp.bp.108.049965","article-title":"Aripiprazole monotherapy in acute mania: 12-week randomised placebo- and haloperidol-controlled study","volume":"194","author":"Young","year":"2009","journal-title":"British Journal of Psychiatry"},{"key":"10.1016\/j.jad.2012.07.038_bib36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1176\/appi.ajp.161.1.169","article-title":"Double-blind comparison of the continued use of antipsychotic treatment versus its discontinuation in remitted manic patients","volume":"161","author":"Zarate","year":"2004","journal-title":"American Journal of Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032712005691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032712005691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:10:40Z","timestamp":1759021840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032712005691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0165032712005691"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2012.07.038","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lower rate of depressive switch following antimanic treatment with second-generation antipsychotics versus haloperidol","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2012.07.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}